检索结果-南通市图书馆

Transarterial embolization is an acceptable bridging therapy to hepatocellular carcinoma prior to liver transplantation

引用

World Journal of Transplantation 2024年第2期14卷 126-134页

作者： Gabriel Lazzarotto-da-Silva Leandro A Scaffaro Mauricio Farenzena Lucas Prediger Rafaela K Silva Flávia Heinz Feier Tomaz J M Grezzana-Filho Pablo D Rodrigues Alexandre de Araujo Mario Reis Alvares-da-Silva roberta C Marchiori Cleber Rosito Pinto Kruel Marcio Fernandes Chedid Department of Liver Transplant and Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Interventional Radiology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Gastroenterology and Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive malignant neoplasm that requires liver transplantation(LT).Despite patients with HCC being prioritized by most organ allocation systems worldwide,they still have to wait for long *** therapies(LRTs)are employed as bridging therapies in patients with HCC awaiting *** largely used in the past,transarterial embolization(TAE)has been replaced by transarterial chemoembolization(TACE).However,the superiority of TACE over TAE has not been consistently shown in the *** To compare the outcomes of TACE and TAE in patients with HCC awaiting *** All consecutive patients with HCC awaiting LT between 2011 and 2020 at a single center were *** patients underwent LRT with either TACE or *** patients also underwent percutaneous ethanol injection(PEI),concom-itantly or in different treatment *** choice of LRT for each HCC nodule was determined by a multidisciplinary *** primary outcome was waitlist dropout due to tumor progression,and the secondary outcome was the occurrence of adverse *** the subset of patients who underwent LT,complete pathological response and post-transplant recurrence-free survival were also *** Twelve(18.5%)patients in the TACE group(only TACE and TACE+PEI;n=65)and 3(7.9%)patients in the TAE group(only TAE and TAE+PEI;n=38)dropped out of the waitlist due to tumor progression(P log-rank test=0.29).Adverse events occurred in 8(12.3%)and 2(5.3%)patients in the TACE and TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TACE group and 29(76.3%)of the 38 patients in the TAE group underwent LT(P=0.818).Among these patients,complete pathological response was detected in 7(14.6%)and 9(31%)patients in the TACE and TAE groups,respectively(P=0.145).Post-LT,HCC recurred in 9(18.8%)and 4(13.8%)patients in the TACE and TAE groups,respectively(P=0.756).Posttransplant recurrence-free survival was simila

关键词： Hepatocellular carcinoma Transarterial embolization Transarterial chemoembolization Liver transplantation Locoregional therapy Bridging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

α-Synuclein oligomers and fibrils:partners in crime in synucleinopathies

引用

Neural Regeneration Research 2023年第11期18卷 2332-2342页

作者： Alessandra Bigi roberta Cascella Cristina Cecchi Department of Experimental and Clinical Biomedical Sciences Section of BiochemistryUniversity of FlorenceFlorenceItaly

The misfolding and aggregation of a-synuclein is the general hallmark of a group of devastating neurodegenerative pathologies referred to as synucleinopathies,such as Parkinson’s disease,dementia with Lewy bodies,and multiple system *** such conditions,a range of different misfolded aggregates,including oligomers,protofibrils,and fibrils,are present both in neurons and glial *** expe rimental evidence supports the proposition that solu ble oligomeric assemblies,formed during the early phases of the aggregation process,are the major culprits of neuronal toxicity;at the same time,fibrillar confo rmers appear to be the most efficient at propagating among interconnected neurons,thus contributing to the spreading ofα-synuclein ***,α-synuclein fibrils have been recently repo rted to release soluble and highly toxic oligomeric species,responsible for an immediate dysfunction in the recipient *** this review,we discuss the current knowledge about the plethora of mechanisms of cellular dysfunction caused byα-synuclein oligome rs and fibrils,both contributing to neurodegeneration in synucleinopathies.

关键词： amyloid aggregation neurodegeneration Parkinson’s disease protein aggregation protein misfolding

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multiple aspects of the maternal reproductive investmentin a polytocous species:What do mothers really control?

引用

Current Zoology 2023年第2期69卷 136-142页

作者： Rudy Brogi roberta Chirichella Enrico Merli Marco Apollonio Department of Veterinary Medicine University of Sassarivia Vienna 2I-07100 SassariItaly Department of Humanities and Social Sciences University of Sassarivia Roma 151I-07100 SassariItaly

One of the factors facilitating the expansion and proliferation of wild boar Sus scrofa is the plasticity of its reproductive ***,the real influence of maternal and environmental factors on number and sex of the offspring is stll *** the litter size was shown to be related with the maternal condition,the strength of this relation remains to be understood,together with the possible role played by environmental ***,it is unclear whether wild boar females can adjust their offspring *** investigated multiple aspects of wild boar maternal investment by means of a 10-year dataset of female reproductive traits and a set of biologically meaningful environmental *** maternal condition slightly affected the litter size but not the offspring sex,and environment did not affect the litter size or the offspring ***,mothers did not cope with the higher costs entailed by producing sons by placing them in the most advantageous intrauterine position,nor by allocating less resources on *** set of results showed that the female reproductive investment is quite rigid in comparison with other aspects of wild boar reproductive *** boar females seem to adopt a typical rstrategy,producing constantly large litters and allocating resources on both sexes regardless of internal and external *** strategy may be adaptive to cope with environmental unpredictability and an intense human harvest,contributing to explain the extreme success of wild boar within human-dominated landscapes.

关键词： investment life history litter size reproduction sex allocation wild boar

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gut-brain axis:does intestinal inflammation affect hippocampal neurogenesis and medulloblastoma development?

引用

Neural Regeneration Research 2023年第11期18卷 2381-2382页

作者： Arianna Casciati Mariateresa Mancuso roberta Vitali Simonetta Pazzaglia Biomedical Technologies Laboratory Agenzia Nazionale per le Nuove Tecnologiel’Energia e lo Sviluppo Economico Sostenibile(ENEA)RomeItaly

Gut-brain axis:does intestinal inflammation affect hippocampal neurogenesis and medulloblastoma development?Inflammatory bowel diseases (IBD) are a group of disorders that cause chronic inflammation in the intestines,associated with altered intestinal permeability,which in turn causes an immune response to enteric antigens in a gen etically susceptible *** incidence is high in industrialized countries and continuously rises in emerging economies.

关键词： inflammation diseases continuously

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genotyping ex situ trees of Abies nebrodensis translocated from the original Sicilian population to enrich the gene pool

引用

Journal of Forestry Research 2023年第4期34卷 1095-1106页

作者： Anna De Rogatis Fulvio Ducci Serena Guerri Angela Teani roberta Proietti CREA Research Centre for Agriculture and EnvironmentVia di Saliceto 8040123 BolognaItaly CREA Research Centre for Forestry and WoodViale Santa Margherita 8052100 ArezzoItaly Comprehensive Institute Venturino Venturi of Loro Ciuff enna Arezzo Via Genova 1252024 Loro Ciuff enna(AR)Italy

As a dynamic ex situ conservation strategy,a clonal seed orchard was started in a nursery in Pomaio(POM)in central Italy in 1993 for an assisted migration experiment of Abies nebrodensis(Lojac.)*** artifi cial ex situ populations were planted with this gene pool:a seedling arboretum in Pieve Santo Stefano(PSS)and a small dendrological collection in Papiano(PAP),both originating from the Sicilian relict ***,using AFLP markers,we estimated the relatedness among the relocated genotypes of the three collections to check whether the three collections had suffi cient genetic variability to be considered as additional sources of variability to the original gene pool for the assisted migration *** individual genetic variability was found in the collections;each plant had a diff erent genotype and was confi rmed to belong to its population of *** and PSS trees were shown to be only from the original population of *** species and were derived from a limited set of maternal fertile *** on the Sicilian fi r population inventory,nursery production in Sicily,and structure clustering analysis,close genetic relationships among POM,PAP and several PSS trees(1–35)were ***,the PSS group(36–78)was genetically close to tree 1 of POM and in a lesser proportion to plants 7 and 9 of *** sampling of seedlings used to form batches in the nursery might have infl uenced the structure of the resultant *** genotypes will be useful for enriching the original gene pool.

关键词： Sicilian fir Genotyping Ex situ conservation Gene pool Assisted migration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prophylactic drains in totally laparoscopic distal gastrectomy:are they always necessary?

引用

World Journal of Gastroenterology 2022年第3期28卷 399-401页

作者： Tommaso Maria Manzia Alessandro Parente roberta Angelico HPB and Transplant Unit Department of Surgery ScienceUniversity of Rome Tor VergataRome 00133Italy Queen Elizabeth Hospital Liver UnitUniversity of BirminghamBirmingham UK and HPB and Transplant UnitDepartment of Surgery ScienceUniversity of Rome Tor VergataRome 00133Italy

Prophylactic drains have always been a useful tool to detect early complications and prevent postoperative fluid collections,particularly in gastrointestinal ***,the utilization of such drains has been debated,due to mounting evidence that they could be harmful rather than *** on recent published articles,Liu et al reported that the routine use of prophylactic drains in total laparoscopic distal gastrectomy might not be necessary for all ***,we express our opinion regarding this interesting publication.

关键词： Gastric cancer Prophylactic drainage Totally laparoscopic gastrectomy Enhanced recovery after surgery Minimally invasive surgery Early gastric cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Epidemiology and Clinical Features of Mycobacterium avium Complex Pulmonary Disease in a Brazilian Amazon Cohort

引用

Advances in Microbiology 2024年第6期14卷 287-302页

作者： Jose Tadeu Colares Monteiro Adriana Rodrigues Barretto Ruan Seguin Azevedo Quaresma Bianca Miranda Gouveia Ismari Perini Furlaneto Victória Menezes da Costa Yan Corrêa Rodrigues Layana Rufino Ribeiro Ricardo J. de Paula Souza e Guimarães Alex Brito Souza Ana roberta Fusco da Costa Karla Valéria Batista Lima Joao de Barros Barreto University Hospital Federal University of Par Belm Brazil Center for Biological and Health Sciences Ph.D. Program in Parasitic Biology in the Amazon Region (PPGBPA) State University of Par (UEPA) Belm Brazil Department of Medicine Centro Universitrio do Par CESUPA Belm Brazil Bacteriology and Mycology Section Evandro Chagas Institute (SABMI/IEC) Ministry of Health Ananindeua Brazil Geoprocessing Laboratory Evandro Chagas Institute/SVSA/MS Ananineua Brazil

The incidence of Mycobacterium avium complex pulmonary disease (MACPD) has been globally increasing. The present study aims to provide a comprehensive analysis of clinical characteristics and treatment response among patients in the Amazon region of Brazil and conduct a retrospective cohort study at a prominent referral hospital in the State of Par, Brazil, from 2012 to 2020. The M. avium group represented 58.9% of cases, followed by M. intracellulare (35.7%), M. colombiense (3.6%), and M. chimaera (1.8%). The majority of patients (73.2%) were female and with an average age of 63 years. Primary clinical manifestations included persistent cough and sputum production. The Charlson comorbidity index (CCI) averaged 2.47, with 36.3% of patients having a CCI score equal to higher than 3. Notably, over 70% of patients had received treatment for pulmonary tuberculosis before initiating treatment for MAC infection. The fibrocavitary radiologic form was the most prevalent (55.4%), frequently exhibiting a bilateral distribution (53.6%). Antimicrobial susceptibility revealed a significant prevalence of MAC resistance to drugs in the therapeutic regimen. Despite this, most of the patients experienced clinical improvement (50%). In conclusion, this study highlights a higher prevalence of MAC infections among middle-aged women, with a history of pulmonary tuberculosis treatment and presenting the fibrocavitary radiological form was predominant.

关键词： MACDP Nontuberculous Mycobacteria Mycobacterium avium Lung Disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification of BRAF V600E mutation in odontogenic tumors by high-performance MALDI-TOF analysis

引用

International Journal of Oral Science 2022年第2期14卷 212-219页

作者： Lucrezia Togni Antonio Zizzi roberta Mazzucchelli Andrea Santarelli Corrado Rubini Marco Mascitti Department of Clinical Specialistic and Dental Sciences Marche Polytechnic Universityvia Tronto 10AnconaItaly Department of Biomedical Sciences and Public Health Marche Polytechnic Universityvia Tronto 10AnconaItaly Dentistry Clinic National Institute of Health and Science of AgingIRCCS INRCAvia Tronto 10AnconaItaly

Odontogenic tumors are rare lesions with unknown *** of them are benign,but local aggressiveness,infiltrative potential,and high recurrence rate characterize some *** MAP-kinase pathway activation can represent a primary critical event in odontogenic ***,the BRAF V600E mutation has been involved in 80%–90%of ameloblastic lesions,offering a biological rationale for developing new targeted *** study aims to evaluate the BRAF V600E mutation in odontogenic lesions,comparing three different detection methods and focusing on the Sequenom MassARRAY System.81 surgical samples of odontogenic lesions were subjected to immunohistochemical analysis,Sanger Sequencing,and Matrix-Assisted Laser Desorption/Ionization-Time of Flight mass spectrometry(Sequenom).The BRAF V600E mutation was revealed only in ameloblastoma ***,the presence of BRAF V600E was significantly associated with the mandibular site(ρ=0.627;P value<0.001)and the unicystic histotype(ρ=0.299,P value<0.001).However,any significant difference of 10-years disease-free survival time was not ***,Sequenom showed to be a 100%sensitive and 98.1%specific,suggesting its high-performance diagnostic *** results suggest the MAP-kinase pathway could contribute to ameloblastic ***,they could indicate the anatomical specificity of the driving mutations of mandibular ameloblastomas,providing a biological rational for developing new targeted ***,the high diagnostic accuracy of Sequenom was confirmed.

关键词： V600E BRAF specificity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

It is time to mate: population-level plasticity of wild boar reproductive timing and synchrony in a changing environment

引用

Current Zoology 2022年第4期68卷 371-380页

作者： Rudy Brogi Enrico Merli Stefano Grignolio roberta Chirichella Elisa Bottero Marco Apollonio Department of Veterinary Medicine University of Sassarivia Vienna 2Sassari I-07100Italy

On a population level,individual plasticity in reproductive phenology can provoke either anticipations or delays in the average reproductive timing in response to environmental ***,a rigid reliance on photoperiodism can constraint such plastic responses in populations inhabiting temperate *** regulation of breeding season length may represent a further tool for populations facing changing ***,this skill was reported only for equatorial,nonphotoperiodic *** goal was to evaluate whether species living in temperate regions and relying on photoperiodism to trigger their reproduction may also be able to regulate breeding season *** 10 years,we collected 2,500 female reproductive traits of a mammal model species(wild boar Sus scrofa)and applied a novel analytical approach to reproductive patterns in order to observe population-level variations of reproductive timing and synchrony under different weather and resources availability *** favorable conditions,breeding seasons were anticipated and population synchrony increased(i.e.,shorter breeding seasons).Conversely,poor conditions induced delayed and less synchronous(i.e.,longer)breeding *** potential to regulate breeding season length depending on environmental conditions may entail a high resilience of the population reproductive patterns against environmental changes,as highlighted by the fact that almost all mature females were reproductive every year.

关键词： breeding season length phenology photoperiodism population ecology reproduction wild boar

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characterization of volatile organic compounds in grafted tomato plants upon potyvirus necrotic infection

引用

Journal of Integrative Agriculture 2023年第8期22卷 2426-2440页

作者： roberta SPANò Mariarosaria MASTROCHIRICO Francesco LONGOBARDI Salvatore CERVELLIERI Vincenzo LIPPOLIS Tiziana MASCIA Department of Soil Plant and Food SciencesUniversity of Bari“Aldo Moro”Via Amendola 165/ABari 70126Italy Department of Chemistry University of Bari“Aldo Moro”Via Orabona 4Bari 70126Italy National Research Council(CNR) Institute of Sciences of Food Production(ISPA)Via Amendola 122/OBari 70126Italy

A headspace solid-phase microextraction-gas chromatography-mass spectrometry(HS-SPME/GC-MS)method was used to study the volatile organic compounds(VOCs)associated with the differential immune response of tomato plants infected with the recombinant strain of potato virus Y(PVY^(C)-to),necrogenic to *** was carried out in UC82(UC),a virus susceptible tomato variety,comparing the same UC plants grafted or not onto a virus tolerant tomato ecotype,Manduria(Ma);the three types of samples used for the GC-MS analysis were mock-inoculated UC/Ma plants,UC/Ma+PVY^(C)-to and UC+PVY^(C)-to plants;the VOCs obtained were *** from symptomatic PVY^(C)-to-infected UC plants showed a VOCs composition enriched in alcohols,fatty acid derivates,benzenoids,and salicylic acid derivatives,while in mock-inoculated UC/Ma plants VOCs were mainly characterized by methyl ester *** VOC profile was in line with RNAseq data analyses,denoting that PVY^(C)-to viral RNA accumulation and disease symptoms induce the specific transcriptional activation of genes involved in VOCs ***,principal component analysis highlighted that VOCs of PVY^(C)-to-infected and mock-inoculated grafted plants were much closer each other than that of symptomatic PVY^(C)-to-infected non-grafted UC *** results suggest that VOCs profiles of tomato plants are related to the viral RNA accumulation,disease intensity and graft-derived tolerance to PVY^(C)-to infection.

关键词： tomato potyvirus VOCs defense grafted plants

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：