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放疗前周围血淋巴细胞敏感性是骨盆放疗所致疾病的预示因素(英文)

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新乡医学院学报 2002年第6期19卷 445-455页

作者：李同光 Ron R.Allison Kevin F.O’Brien roberta m.johnke Karen I.Christie James L.Naves Ulf L.Karlsson Leo W.Jenkins癌症中心放射肿瘤科东卡罗来纳大学公共卫生学院生物统计中心

目的　探讨前列腺癌 (PC)治疗前体外照射诱导的Go淋巴细胞微核量是否与放疗 (xRT)相关疾病的发生有关。方法　对 3 8例PC周围血淋巴细胞 (PBL)以细胞因子阻止的微核法进行前瞻性观察。患者平均年龄 68.7± 1.0岁。临床分期 :T116例 ,T2... 详细信息

目的　探讨前列腺癌 (PC)治疗前体外照射诱导的Go淋巴细胞微核量是否与放疗 (xRT)相关疾病的发生有关。方法　对 3 8例PC周围血淋巴细胞 (PBL)以细胞因子阻止的微核法进行前瞻性观察。患者平均年龄 68.7± 1.0岁。临床分期 :T116例 ,T2 16例 ,T36例。治疗前前列腺癌特异性抗原 (PSA)≤ 4ng·ml-1者 5例 ,4～ 10ng·ml-1者 19例 ,>10ng·ml-1者 14例。所有患者均接受标准的骨盆外xRT(41.4～ 5 0 .4Gy) ,追加剂量 (16.4～ 2 6Gy)。平均随访 3 2 .8± 4.6个月。随访末 ,按RTOG标准对胃肠道 (GI)或泌尿生殖道 (GU)xRT相关疾病的发生率进行评定。结果　发生xRT相关疾病 2 4例为高敏 (HS) ,未发生者 14例为正常敏感性 (NS) ,HS患者均有GI(1～ 3级 )或GU(1～ 2级 )xRT相关疾病。体外照射暴露的血标本 ,与照射剂量相关的PBL微核量在HS和NS患者之间有显著差异 ,特别是当剂量≥ 3Gy时。xRT相关疾病的发生与治疗前PBL微核量相关 ,而与病情无关。

关键词：放疗周围血淋巴细胞微核剂量反应关系前列腺癌

Bedrock geology interacts with altitude in affecting leaf growth and foliar nutrient status of mountain vascular plants

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Journal of Plant Ecology 2017年第5期10卷 839-850页

作者： Renato Gerdol roberta marchesini Paola Iacumin Department of Life Sciences and Biotechnology University of FerraraCorso Ercole I d’Este 32I-44121 FerraraItaly Department of Physics and Earth Sciences University of ParmaViale delle Scienze 158/AI-43124 ParmaItaly

Aims Altitude is often used as a proxy for ascertaining how warming affects plant growth and leaf level ***,we have a poor understanding of how the effects of altitude-related warming varies across ***,this study examined the independ-ent and interactive effects of altitude and geology and species on plant growth and foliar nutrient *** We determined leaf growth rates and concentrations of major nutrients(nitrogen,N and phosphorus,P)in leaves of five spe-cies across two altitudinal gradients(1200-2200 m)in the Dolomites(south-eastern Alps,Italy).the two transects were located on carbonate bedrock and silicate bedrock,*** also determined concentrations of inorganic and organic N and P forms in soils,andδ15N signature in leaves and *** Findings Foliar N concentrations were unrelated to bedrock *** negative foliarδ^(15)N signature suggested that organic N was the primary source of N supply across the *** P concentrations were strongly affected by bedrock geology and their altitudinal patterns depended on the concentrations of organic and inorganic P forms in the *** and organic P appeared to be the main sources of P *** growth rates increased with higher altitude on silicate bedrock and decreased with higher altitude on carbonate bedrock and presented a significant positive correlation with foliar N:*** conclusion,bedrock geology inter-acted with altitude in controlling the foliar nutrient status mainly owing to availability of soil P and its effect on foliar nutrient stoichiometry.

关键词： altitude mycorrhiza plant functional type soil chemistry ^(15)N

Oil-in-water nanoemulsions loaded with lycopene extracts encapsulated by spray drying:Formulation,characterization and optimization

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Chinese Journal of Chemical Engineering 2024年第6期70卷 73-81页

作者： Junyang Li roberta Campardelli Giuseppe Firpo Jingtao Zhang Patrizia Perego Department of Civil Chemical and Environmental Engineering(DICCA)University of GenoaVia Opera Pia 15Genova 16145Italy Department of Physics University of GenoaVia Dodecaneso 32Genova 16146Italy School of Food and Bioengineering Zhengzhou University of Light IndustryZhengzhou 450002China

Lycopene is very susceptible to degradation once released from the protective chromoplast *** this study,oil-in-water(O/W)nanoemulsions coupled with spray drying technology were applied for the encapsulation and stabilization of lycopene extracted from tomato *** extract was obtained by ultrasound-assisted *** were prepared by a high-speed rotor stator using isopropyl myristate as the oil phase and Pluronic F-127 as the emulsifier for the aqueous external *** effect of emulsification process parameters was *** drying of the produced emulsions was attempted to obtain a stabilized dry powder after the addition of a coating *** effect of different coating agents(maltodextrin,inulin,gum arabic,pectin,whey and polyvinylpyrrolidone),drying temperature(120-170℃),and feed flow rate(3-9 ml·min^(-1))on the obtained particles was *** revealed that the emulsion formulation of 20/80(O/W)with 1.5%(mass fraction)of Pluronic F-127 as stabilizer in the aqueous phase resulted in a stable nanoemulsion with droplet sizes in the range of 259-276 nm with a unimodal and sharp size *** extract in the nanoemulsion was well protected at room temperature with a degradation rate of lycopene of about 50%during a month of storage *** most stable emulsions were then processed by spray drying to obtain a dry *** drying was particularly successful when using maltodextrin as a coating agent,obtaining dried spherical particles with mean diameters of(4.87±0.17)μm with a smooth *** possibility of dissolving the spray dried powder in order to *** original emulsion was also successfully verified.

关键词： Emulsions Powders Stability Isopropyl myristate Lycopene Spray-drying

multiple aspects of the maternal reproductive investmentin a polytocous species:What do mothers really control?

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Current Zoology 2023年第2期69卷 136-142页

作者： Rudy Brogi roberta Chirichella Enrico merli marco Apollonio Department of Veterinary medicine University of Sassarivia Vienna 2I-07100 SassariItaly Department of Humanities and Social Sciences University of Sassarivia Roma 151I-07100 SassariItaly

One of the factors facilitating the expansion and proliferation of wild boar Sus scrofa is the plasticity of its reproductive ***,the real influence of maternal and environmental factors on number and sex of the offspring is stll *** the litter size was shown to be related with the maternal condition,the strength of this relation remains to be understood,together with the possible role played by environmental ***,it is unclear whether wild boar females can adjust their offspring *** investigated multiple aspects of wild boar maternal investment by means of a 10-year dataset of female reproductive traits and a set of biologically meaningful environmental *** maternal condition slightly affected the litter size but not the offspring sex,and environment did not affect the litter size or the offspring ***,mothers did not cope with the higher costs entailed by producing sons by placing them in the most advantageous intrauterine position,nor by allocating less resources on *** set of results showed that the female reproductive investment is quite rigid in comparison with other aspects of wild boar reproductive *** boar females seem to adopt a typical rstrategy,producing constantly large litters and allocating resources on both sexes regardless of internal and external *** strategy may be adaptive to cope with environmental unpredictability and an intense human harvest,contributing to explain the extreme success of wild boar within human-dominated landscapes.

关键词： investment life history litter size reproduction sex allocation wild boar

Empirical assessment of adaptation to climate change impacts of mountain households:development and application of an Adaptation Capability Index

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Journal of mountain Science 2016年第8期13卷 1503-1514页

作者： Rajiv PANDEY Nandini mAITHANI roberta ARETANO Giovanni ZURLINI Kelli m ARCHIE Ajay K GUPTA Vishnu Prasad PANDEY Biodiversity and Climate Change Division ICFREDehradun 248 006India Forest Research Institute Dehradun 248006India Department of Biological and Environmental Sciences and Technologies University of SalentoLecee 73100Italy Climate Change Research Institute Victoria University of WellingtonWellington 6140New Zealand Asian Institute of Technology and management(AITm) Lalitpur 44700Nepal

The present study proposes an index to assess the potential for adaptation to climate change for households in the mountainous regions. The index provides a realistic approach to recognize social and natural factors which contribute to successful adaptation and addresses several household functions, such as social networking, livelihood strategy, adjustment strategies, resource availability and accessibility. The proposed Adaptation Capability Index （ACI） is analytically defined, mathematically formulated and field tested on mountainous households in urban and semi-urban regions of the Uttarakhand Himalaya in India. To gather data on the topic relevant to the ACI, a household scale questionnaire was developed and administered to 12o heads of households through face-to-face interviews. The results highlight higher adaptive capability of urban households and low adaptation capacity of rural households due to poor farm productivity, low accessibility and availability of resources and technological input. Future programs and policies must include and implement regulations to remedy attributive factors responsible for higher adaptation. This paper may be applicable to other mountainous regions and may provide insights for effective adaptation strategies to climate change.

关键词： Adaptation strategy Adjustmentpractice Climate change Vulnerability Resilience Social networking

Nonalcoholic fatty liver disease: is the IFNL4 rs368234815 variant protective from liver damage?

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Hepatobiliary Surgery and Nutrition 2018年第3期7卷 209-211页

作者： Enrico Galmozzi roberta D'Ambrosio "A. m. and A. migliavacca" Center for Liver Disease Division of Gastroenterology and HepatologyFondazione IRCCS Cà Granda Ospedale Maggiore PoliclinicoUniversità degli Studi di MilanoMilanItaly

Nonalcoholic fatty liver disease (NAFLD) consists of a spectrum of disorders characterized predominantly by hepatic steatosis in the absence of significant alcohol consumption, potentially evolving to nonalcoholic ste... 详细信息

关键词： damage liver NAFLD

A rationale for the development of thermally stable nanostructured CeO_2-ZrO_2-containing mixed oxides

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Journal of Rare Earths 2008年第2期26卷 136-140页

作者： roberta Di monte Jan Kapar Heather Bradshaw Colin Norman Department of Chemistry Sciences Interuniversity Consortium INCA University of Trieste Via L.Giorgieri34127 Trieste Italy mEL Chemicals P.O. Box 6 Clifton Junction SwintonManchester M27 8LS England

CeO2-ZeO2 solid solutions are extensively used as oxygen storage promoters in the current automotive three-way catalysts. High thermal stability of the textural properties is one of the most important requirements for practical application since temperatures up to 1273 K are easily experienced by these materials under real working conditions. In the present paper, we investigated how hydrothermal treatments applied to cakes of doped and undoped ZrO2-rich CeO2-ZrO2 precursors might improve the thermal stability of the final CeO2-ZrO2 solid solution. A rationale was developed that allowed to correlate the morphology of the hydrothermaUy treated cake with the thermal stability at 1273 K of the final product, which did not depend on the composition of the mixed oxides.

关键词： CeO2-ZrO2 mixed oxides CeO2-ZrO2 solid solution CeO2-ZrO2 mixed oxides, thermal stability of three-way catalysts oxygen storage capacity rare earths

Hepatitis B virus recurrence after liver transplantation: An old tale or a clear and present danger?

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World Journal of Gastroenterology 2020年第18期26卷 2166-2176页

作者： Ilaria Lenci martina milana Giuseppe Grassi Tommaso m manzia Carlo Gazia Giuseppe Tisone roberta Angelico Leonardo Baiocchi Hepatology and Liver Transplant Unit University of Tor VergataRome 00133Italy Hepato-Pancreato-Biliary and Transplant Department of SurgeryUniversity of Rome Tor VergataRome 00133Italy

Hepatitis B virus(HBV) recurrence after liver transplantation(LT) has been described more than 50 years ago. Similarly, to other clinical conditions, in which impairment of host immune defense favors viral replication, early reports described in details recurrence and reactivation of HBV in liver transplant recipients. The evidence of a possible, severe, clinical evolution of HBV reappearance in a significant percentage of these patients, allowed to consider,for some years, HBV positivity a contraindication for LT. moving from the old to the new millennium this picture has changed dramatically. Several studies contributed to establish efficient prophylactic protocols for HBV recurrence and with the advent of more potent anti-viral drugs an increased control of infection was achieved in transplanted patients as well as in the general immunecompetent HBV population. Success obtained in the last decade led some authors to the conclusion that HBV is now to consider just as a "mere nuisance".However, with regard to HBV and LT, outstanding issues are still on the table:(1)A standard HBV prophylaxis protocol after transplant has not yet been clearly defined;(2) The evidence of HBV resistant strains to the most potent antiviral agents is claiming for a new generation of drugs;and(3) The possibility of prophylaxis withdrawal in some patients has been demonstrated, but reliable methods for their selection are still lacking. The evolution of LT for HBV is examined in detail in this review together with the description of the strategies adopted to prevent HBV recurrence and their pros and cons.

关键词： Liver transplant Hepatitis B virus Viral recurrence Prophylaxis minimization Antiviral drug

Hermeneutics and the Empeiria of the Soul in Panikkar

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Journal of Philosophy Study 2016年第8期6卷 486-495页

作者： m. roberta Cappellini CIRPIT

Pathos, that ＂passion of life and thought,＂ essentially based on the profound aspiration to the beyond, to the unknown, to mystery, characterized Panikkar＇s entire existence and thought, always placed ＂beyond borders.＂ It is through this ＂empeiria of the soul＂ that the philosopher re-reads the complex issue of faith, connoting it as a constitutive, mystical dimension or ontonomical relationship and consequently as an orthopraxis. From this point of view pathos represents the foundation of his ＂philo-sophia＂ in its etymological meaning of ＂wisdom of love,＂ which opens to the pursuit of ＂the fullness of life,＂ an aspiration of every human being. Today, this generates challenges, which only an intra-inter-cultural dialogical approach, open to different perspectives and based on a diatopical hermeneutics, able to put in contact radically different human horizons, can respond.

关键词： Pathos Wisdom of Love deep faith mystical dimension intra-inter-cultural dialogue diatopical herrneneutics