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Protection of rutaecarpine against myocardial ischemia—reperfusion injury in rats：possible involvement of vanilloid receptors

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中国药理学与毒理学杂志 2002年第6期16卷 425-426页

作者： HuCP lins DepartmentofPharmacology SchoolofPharmaceuticalSciencesCentralSouthUniversityChangsha410078China DepartmentofPharmacology SchoolofPharmaceuticalSciencesCentralSouthUniversityChang

Previous investigations have shown that calcitonin gen-related peptide(CgRP) protects against myocardial ischemia-reperfusion injury and that rutaecarpine activates vanilloid receptors to evoke CgRP *** the present study,SD rats were pretreated with rutaecarpine 10min before the experiment,and then the left main coronary artery was subjected to 60min occlusion followed by 3h *** with rutaecarpine(100 or 300μg·kg^-1,iv) significantly reduced infarce size and creatine kinase release concomitantly with a significant increase in plasma concentrations of *** effects of rutaecarpine were completely abolished by pretreatment with capsazepine(38mg·kg^-1,ic),a competitive vanilloid receptor antagonist or capsaicin (50mg·kg^-1,sc),which selectively depletes transmitters in capsaicin-sensitive sensory *** results suggest that the kprotection of rutaecarpine against myocardial ischemia-reperfusion injury is due to stimulation of endogenous CgRP release via activating vanilloid receptors in rats.

关键词：心肌缺血再灌注损伤吴茱萸次碱

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Why Quantitative Variables Should Not Be Recoded as Categorical

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Journal of Applied Mathematics and Physics 2019年第7期7卷 1519-1530页

作者： Antonio Fernandes Caio Malaquias Dalson Figueiredo Enivaldo da Rocha Rodrigo lins Department of Political Science Federal University of Pernambuco (UFPE) Recife Brazil

The transformation of quantitative variables into categories is a common practice in both experimental and observational studies. The typical procedure is to create groups by splitting the original variable distribution at some cut point on the scale of measurement (e.g. mean, median, mode). Allegedly, dichotomization improves causal inference by simplifying statistical analyses. In this article, we address some of the adverse consequences of recoding quantitative variables into categories. In particular, we provide evidence that categorization usually leads to inefficient and biased estimates. We believe that considerable progress in our understanding of data analysis can occur if scholars follow the recommendations presented in this article. The recodification of quantitative variables as categorical is a poor methodological strategy, and scientists must stay away from it.

关键词： Dichotomization Inefficiency Bias

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Ultrasound-guided Peribulbar Block with Blunt Canula for Cataract Surgery: A Review of Historical Case-Series

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Open Journal of Ophthalmology 2022年第3期12卷 322-334页

作者： Hugo C. T. Siqueira Clarissa M. M. Stoffel De Siqueira Marlon Miguel Bianchi De Lima Leonardo T. C. lins Department of Anesthesiology Centro de Estudos e Pesquisas Oculistas Associados (CEPOA) Rio de Janeiro Brazil Department of Ophthalmology Centro de Estudos e Pesquisas Oculistas Associados (CEPOA) Rio de Janeiro Brazil Department of Oculoplastics Centro de Estudos e Pesquisas Oculistas Associados (CEPOA) Rio de Janeiro Brazil

Introduction: Cataract surgery is one of the procedures most performed worldwide. Those are several options for anesthetic management, with many factors that affect the choice of any given technique, depending on patients’ needs, surgeons’ preferences and institutional facilities and processes. Although being more invasive than topic anesthesia, and with possible hazardous side effects, peribulbar block is still an effective and successful technique. The utilization of blunt canula and ultrasound guidance might enhance the safety pattern for this technique. Methods: This article presents a revision of 1089 consecutive cases from February 2016 to January 2022, of patients submitted to cataract surgery under peribulbar anesthesia with blunt canula and ultrasound guidance. Results: 1318 surgical records were selected, with 1089 filling the inclusion criteria. There was a higher prevalence of the feminine gender (54%), with a median age of 64.3 (28 - 102) years. Mean IAV was 2.9 mL (sd 0.16 mL, 2.5 - 3.0 mL), with total HOS 91.1%;OR to reach g2 or above for each (ISB/IMB) was 11.0;CA was 47.9%, with mean FAV of 4.29 mL (sd 2.17mL, 2.5 - 15 mL). In 8.9% patients, HOS could not be fully observed. ISB, IMB, CA and FAV were calculated for both groups (non-HOS and HOS-only). OR for CA (non-HOS/HOS-only) was 126.21. The main adverse effects were chemosis (2.9%), hyposphagma (5.7%) and high IOP (7.5%). No procedure was postponed due to anesthesia-associated adverse events. Discussion: This study points towards the feasibility of the described technique in an outpatient fashion, with low, mild and tolerable side effects associated.

关键词： Cataract Surgery Local Anesthesia Ultrasound

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高海拔下锌的高浸出率——谢里特为中国西部矿业公司进行的锌氧压浸出研究

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中国有色冶金 2009年第3期38卷 16-21页

作者： M.J.Collins R.J.Kalanchey I.M.Masters N.E.Tuffrey 杨征谢里特国际公司西部矿业股份有限公司青海西宁811600

西部矿业(WMC)甘河精炼厂海拔高,WMC矿山生产的精矿含铁高,这两点是WMC为其新的锌精炼厂选择氧压浸出工艺的关键因素。谢里特公司在萨斯喀彻温堡用WMC从中国青海省提供的精矿样品进行了氧压浸出试验,本论文描述了该试验的结果。小型间... 详细信息

西部矿业(WMC)甘河精炼厂海拔高,WMC矿山生产的精矿含铁高,这两点是WMC为其新的锌精炼厂选择氧压浸出工艺的关键因素。谢里特公司在萨斯喀彻温堡用WMC从中国青海省提供的精矿样品进行了氧压浸出试验,本论文描述了该试验的结果。小型间断氧压浸出试验和四天连续扩大试验的结果都进行了报告。连续扩大试验包括两段氧压浸出、中和及除铁的连续操作,产出无铁硫酸锌溶液。氧压浸出取得了大于98%的锌浸出率,同时产出含有约9 g/L硫酸和2 g/L铁的溶液。中和及除铁后,溶液约含170g/L锌和g/L的铁。从锌精矿原料到元素硫副产品的总硫回收率约为85%,从中和渣中可回收原料中75～80%的铟。试验结果显示了谢里特锌氧压浸出工艺的技术和经济优势,并且为工程设计提供了所需数据。

关键词：氧压浸出高海拔高铁锌精矿高浸出率

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香砂六君丸对非酒精性脂肪肝大鼠肝脏线粒体的影响

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温州医科大学学报 2017年第11期47卷 796-800页

作者：娄林洁游艳婷马柯陈泽伟孙晓敏周琳温州医科大学附属第一医院中医科浙江温州325015 南方医科大学中医药学院广东广州510515 南方医科大学南方医院内分泌科广东广州510515

目的:研究香砂六君丸对非酒精性脂肪肝大鼠模型肝脏组织内线粒体的影响。方法:24只正常成年雄性SD大鼠随机分为正常对照组、模型组和治疗组。采用高脂饲料喂养法来制作非酒精性脂肪肝大鼠模型,给予香砂六君丸(1.35 g·kg^(-1)·d^(-1))... 详细信息

目的:研究香砂六君丸对非酒精性脂肪肝大鼠模型肝脏组织内线粒体的影响。方法:24只正常成年雄性SD大鼠随机分为正常对照组、模型组和治疗组。采用高脂饲料喂养法来制作非酒精性脂肪肝大鼠模型,给予香砂六君丸(1.35 g·kg^(-1)·d^(-1))灌胃4周治疗后取材。检测各组大鼠的体质量、肝脏湿重、肝脏HE染色结果、血液生化指标。用Real time PCR法、紫外分光光度计法对肝脏组织线粒体DNA(mt DNA)拷贝数、线粒体复合物Ⅰ、Ⅳ活性的变化进行测定。结果:与正常对照组相比,模型组大鼠肝脏湿重和质量指数(肝脏湿重/体质量)显著升高,血清总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)水平明显升高,肝脏组织mt DNA显著降低,肝脏组织线粒体复合物Ⅰ、Ⅳ活性显著降低,差异均有统计学意义(P<0.05)。与模型组大鼠相比,治疗组大鼠肝脏湿重和质量指数显著降低,血清TC和LDL-C水平明显降低,肝脏组织mt DNA显著升高,肝脏组织线粒体复合物Ⅰ、Ⅳ活性显著升高,差异均有统计学意义(P<0.05)。肝脏HE染色结果显示,模型组大鼠肝细胞出现大量脂肪空泡,细胞核固缩;治疗组大鼠肝细胞出现脂肪空泡量显著减少,细胞核固缩情况减轻。结论:香砂六君丸可能通过调节mt DNA拷贝数与呼吸链酶复合物活性对非酒精性脂肪肝起到治疗作用。

关键词：非酒精性脂肪肝香砂六君丸线粒体呼吸链酶复合物 DNA 线粒体

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