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Acceptability of an adjunct equine-assisted activities and therapies program for veterans with posttraumatic stress disorder and/or traumatic brain injury

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journal of Integrative Medicine 2020年第2期18卷 169-173页

作者： Louisa Sylvia Emerson West Allyson M.Blackburn Carina Gupta Eric Bui Tara Mahoney Geraldine Duncan Edward C.wright Simon Lejeune Thomas j.Spencer Home Base:A Red Sox Foundation and Massachusetts General Hospital Program Massachusetts General HospitalCharlestownMA 02129USA Harvard Medical School BostonMA 02115USA Dauten Family Center for Bipolar Treatment Innovation Massachusetts General HospitalBostonMA 02114USA Equine Immersion ProgramsTM USA Pediatric Psychopharmacology and Adult ADHD Program Massachusetts General HospitalBostonMA 02114USA

Objective: Equine-assisted activities and therapies(EAATs) have been a growing adjunctive integrative health modality, as they allow participants to practice mindfulness, emotional regulation, and self-mastery or self-esteem building skills. Preliminary evidence suggests that these programs may be helpful in reducing posttraumatic stress disorder(PTSD), anxiety, and depressive symptoms. The current study examines the acceptability of integrating an EAAT program as part of a two-week, intensive clinical program for veterans with PTSD and/or traumatic brain injury(TBI).Methods: A family member or support person could accompany veterans and participate in the *** hundred and six participants(veteran n = 62, family n = 44) left the urban environment in an intensive outpatient program(IOP) to attend a two-day, weekend EAAT in rural New Hampshire. Satisfaction surveys were conducted on the last day of the program and examined using thematic ***: The following themes were reported in the surveys: ability of horses to catalyze emotional rehabilitation, effectiveness of immersion in equine-assisted activities, program’s ability to foster interpersonal relationships and necessity of education about PTSD for staff. Participants also reported enjoying the program as highlighted by qualitative feedback, a mean score of 9.76(standard deviation[SD] = 0.61) as reported by veterans and a mean score of 9.91(SD = 0.29) as reported by family members on a 10-point visual analog scale with higher scores indicating a greater overall ***: These data offer preliminary evidence that an adjunct EAAT program is acceptable for veterans with PTSD and/or TBI participating in an IOP.

关键词： Posttraumatic stress disorder Military personnel Traumatic brain injury Complementary and alternative medicine Equine-assisted therapy

Domestication of native plant species for seed production and planting in Arctic and sub-arctic Alaska

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Domestication of native plant species for seed production an...

ⅩⅪ International Grassland Congress and the Ⅷ International Rangeland Congress

作者： S.j.wright Dept.Natural Resources Div.AgriculturePlant Materials CenterState of Alaska

＜正＞Introduction Much of the Alaska landmass is covered by treeless vegetation regions referred to as tundra or maritime tundra （Viereck ＆ Little,1972）.Most of the tundra areas fall on the cold side of the 10°C july isotherm line and is classified as *** most unique grassland or tundra area in Alaska is the Aleutian Island archipelago.

关键词： Alaska native species seed production Arctic sub-arctic domestication

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高速直喷式柴油机的设计和研制

汽车与新动力 1996年第2期28卷 18-28页

作者： wright M j 熊继昌

介绍瞄准客车和轻型货车市场的一台成功的低排放高速直喷式柴油机所需的设计考虑。为获得满意的性能,同时具有低排放和低噪声,还是以4气门、喷油器布置在中央的结构为好。虽然一般的自然吸气式发动机适用于某些货车,但为了得到令人满意... 详细信息

介绍瞄准客车和轻型货车市场的一台成功的低排放高速直喷式柴油机所需的设计考虑。为获得满意的性能,同时具有低排放和低噪声,还是以4气门、喷油器布置在中央的结构为好。虽然一般的自然吸气式发动机适用于某些货车,但为了得到令人满意的功率和排放指标,必需采取增压和中冷。研制中需要优化燃烧和进排气系统,并对汽车的噪声和振动特性予以充分关注。

关键词：高速柴油机直接喷射柴油机研制

农药亚致死剂量对小菜蛾及其天敌优姬蜂的影响

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植物保护学报 1994年第3期21卷 265-268页

作者：古德就 j.K.Waage D.j.wright 华南农业大学植保系广州510642 英国英联邦农业局国际生防研究所英国帝国理工学院

作者总结了在农业生态系统中农药亚致死剂量对害虫天敌影响的四条通径。在模拟农药—作物—小菜蛾—优姬蜂的生态系统中,系统地分析了农药—小菜蛾—优姬蜂种群动力学,用生命表技术,以控制效应(CE)来评判系统中农药亚致死剂量对小菜蛾... 详细信息

作者总结了在农业生态系统中农药亚致死剂量对害虫天敌影响的四条通径。在模拟农药—作物—小菜蛾—优姬蜂的生态系统中,系统地分析了农药—小菜蛾—优姬蜂种群动力学,用生命表技术,以控制效应(CE)来评判系统中农药亚致死剂量对小菜蛾和优姬蜂种群的影响,以及在农药亚致死剂量影响下,优姬蜂对小菜蛾种群的控制作用。结果表明,农梦特亚致死剂量对优姬蜂的控制效应大于对小菜蛾的控制效应,受农梦特亚致死剂量影响的优姬蜂仍能对小菜蛾种群起一定的控制作用。

关键词：杀虫剂亚致死剂量小菜蛾优姬蜂

Ureteroscopy and stones:Current status and future expectations

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World journal of Nephrology 2014年第4期3卷 243-248页

作者： Anna E wright Nicholas j Rukin Bhaskar K Somani Department of Urology New Cross Hospital Department of Urology University Hospital Southampton NHS Trust

Urolithaisis is becoming an ever increasing urological,nephrological and primary care *** a lifetime prevalence approaching 10% and increasing morbidity due to stone disease,the role of ureteroscopy and stone removal is becoming more *** discuss the current status of stone disease and review the ever increasing role that ureteroscopy has to play in its *** discuss technological advances that have been made in stone management and give you an overview of when,how and why ureteroscopy is the most common treatment option for stone *** touch on the role of robotic ureteroscopy and the future of ureteroscopy in the next 10 years.

关键词： Ureteroscopy Techniques Ureteral stones Calculi Treatment Advances

Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in nonalcoholic steatohepatitis patients

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Acta Pharmaceutica Sinica B 2023年第1期13卷 1-28页

作者： Solène Marie Kayla L.Frost Raymond K.Hau Lucy Martinez-Guerrero jailyn M.Izu Cassandra M.Myers Stephen H.wright Nathan j.Cherrington College of Pharmacy Department of Pharmacology&ToxicologyUniversity of ArizonaTucsonAZ 85721USA College of Medicine Department of PhysiologyUniversity of ArizonaTucsonAZ 85724USA

The liver plays a central role in the pharmacokinetics of drugs through drug metabolizing enzymes and ***-alcoholic steatohepatitis(NASH)causes disease-specific alterations to the absorption,distribution,metabolism,and excretion(ADME)processes,including a decrease in protein expression of basolateral uptake transporters,an increase in efflux transporters,and modifications to enzyme *** can result in increased drug exposure and adverse drug reactions(ADRs).Our goal was to predict drugs that pose increased risks for ADRs in NASH *** research identified 71 drugs with reported ADRs in patients with liver disease,mainly non-alcoholic fatty liver disease(NAFLD),54 of which are known substrates of transporters and/or metabolizing *** NASH is the progressive form of NAFLD but is most frequently undiagnosed,we identified other drugs at risk based on NASH-specific alterations to ADME ***,we present another list of 71 drugs at risk of pharmacokinetic disruption in NASH,based on their transport and/or metabolism *** encompasses drugs from various pharmacological classes for which ADRs may occur when used in NASH patients,especially when eliminated through multiple pathways altered by the ***,these results may inform clinicians regarding the selection of drugs for use in NASH patients.

关键词： Non-alcoholic steatohepatitis Hepatic elimination Transporter Enzyme Pharmacokinetics Drug-drug interaction Liver Adverse drug reaction

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国际橡胶技术会议50年

合成橡胶工业 1990年第S1期13卷 2-6页

作者： j.M.wright 周国楹 Consulant of Rubber and Plastics AUSTRALIA

50年来国际橡胶会议难能可贵地记录了橡胶技术的进展、成就以及人们对它的认识。橡胶原材料供应者和橡胶机械生产者为此作出了出色的贡献。由革命性生产技术才获得的聚氨酯弹性体和聚氯酯泡沫材料,在1938年时,还未为人所知。

关键词：橡胶工业技术会议橡胶制品橡胶机械天然橡胶国际橡胶会议促进剂合成橡胶防老剂 1938年

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Nitric oxide-mediated S-nitrosylation of IAA17 protein in intrinsically disordered region represses auxin signaling

作者：埃德加·赖特 Edgar·wright导演

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journal of Genetics and Genomics 2023年第7期50卷 473-485页

作者： Hongwei jing Xiaolu Yang Ryan j.Emenecker jian Feng jian Zhang Marcelo Rodrigues Alves de Figueiredo Patarasuda Chaisupa R.Clay wright Alex S.Holehouse Lucia C.Strader jianru Zuo State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Biology Duke UniversityDurhamNC 27008USA Department of Neurobiology Duke University Medical CenterDurhamNC 27710USA Department of Biochemistry and Molecular Biophysics Washington University School of MedicineSt.LouisMO 63110USA Center for Biomolecular Condensates(CBC) Washington University in St.LouisSt.LouisMO 63130USA Department of Biological Systems Engineering Virginia TechBlacksburgVA 24061USA The Translational Plant Sciences Center(TPSC) Virginia TechBlacksburgVA 24061USA CAS Center for Excellence in Molecular Plant Sciences Chinese Academy of SciencesBeijing 100101China

The phytohormone auxin plays crucial roles in nearly every aspect of plant growth and *** signaling is activated through the phytohormone-induced proteasomal degradation of the Auxin/INDOLE-3-ACETIC ACID(Aux/IAA)family of transcriptional ***,many auxin-modulated physiological processes are also regulated by nitric oxide(NO)that executes its biological effects predominantly through protein S-nitrosylation at specific cysteine ***,little is known about the molecular mechanisms in regulating the interactive NO and auxin ***,we show that NO represses auxin signaling by inhibiting IAA17 protein *** induces the S-nitrosylation of Cys-70 located in the intrinsically disordered region of IAA17,which inhibits the TIR1-IAA17 interaction and consequently the proteasomal degradation of *** accumulation of a higher level of IAA17 attenuates auxin ***,an IAA17^(C70W)nitrosomimetic mutation renders the accumulation of a higher level of the mutated protein,thereby causing partial resistance to auxin and defective lateral root *** together,these results suggest that S-nitrosylation of IAA17 at Cys-70 inhibits its interaction with TIR1,thereby negatively regulating auxin *** study provides unique molecular insights into the redox-based auxin signaling in regulating plant growth and development.

关键词： Arabidopsis thaliana Auxin Aux/IAA Nitric oxide S-nitrosylation Intrinsically disordered region