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Prognostic relevance of normocytic anemia in elderly patients affected by cardiovascular disease

Journal of Geriatric Cardiology 2021年第8期18卷 654-662页

作者： Liana Spazzafumo Fabiola Olivieri Jacopo Sabbatinelli roberta galeazzi Rina Recchioni Fiorella Marcheselli Paola Tamburrini Roberto Antonicelli Epidemiologic Observatory Regional Health AgencyRegione MarcheAnconaItaly Department of Clinical and Molecular Sciences UniversitàPolitecnica delle MarcheAnconaItaly Center of Clinical Pathology and Innovative Therapy Italian National Research Centre on AgingIRCCS INRCAAnconaItaly SOD Medicina di Laboratorio Azienda Ospedaliero Universitaria Ospedali RiunitiAnconaItaly Clinical Laboratory and Molecular Diagnostic Italian National Research Center on AgingIRCCS INRCAAnconaItaly Department of Cardiology-CCU Italian National Research Centre on AgingIRCCS INRCAAnconaItaly

BACKGROUND Anemia associated with cardiovascular diseases(CVD) is a common condition in older persons. Prevalence and prognostic role of anemia were extensively studied in patients with myocardial infarction(MI) or congestive heart failure(CHF) whereas limited data were available on patients with atrial fibrillation(AF). This study was conducted to assess the clinical prevalence and prognostic relevance of anemia in elderly patients affected by AF and other *** A total of 866 elderly patients(430 men and 436 women, age: 65-98 years, mean age: 85 ± 10 years) were *** these patients, 267 patients had acute non-ST-segment elevation MI(NSTEMI), 176 patients had acute CHF, 194 patients had acute AF and 229 patients were aged-matched healthy persons(CTR). All parameters were measured at the hospital admission and cardiovascular mortality was assessed during twenty-four months of *** The prevalence of anemia was higher in NSTEMI, CHF and AF patients compared to CTR subjects(50% vs. 15%, P <0.05), with normocytic anemia being the most prevalent type(90%). Adjusted mortality risk was higher in anemic patient versus non-anemic patient in all the groups of patients [NSTEMI: hazard ratio(HR) = 1.81, 95% CI: 1.06-2.13;CHF: HR = 2.49, 95% CI:1.31-4.75;AF: HR = 1.98, 95% CI: 1.01-3.88]. Decreased hemoglobin levels(P = 0.001) and high reticulocyte index(P = 0.023) were associated with higher mortality in CVD *** The significant associations between CVD and anemia and the prognostic relevance of anemia for elderly patients with CVD were confirmed in this study. The presence of anemia in AF patients is associated with a two-fold increased mortality risk compared with non-anemic AF patients. Low hemoglobin and high reticulocyte count independently predict mortality in elderly patients with CVD.

关键词： patients anemia cardiovascular

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Effect of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 on the healthy gut microbiota composition at phyla and species level: A preliminary study

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World Journal of Gastroenterology 2017年第15期23卷 2696-2704页

作者： Marco Toscano roberta De Grandi Laura Stronati Elena De Vecchi Lorenzo Drago Laboratory of Clinical Microbiology Department of Biomedical Science for HealthUniversity of Milan Department of Cellular Biotechnology and Hematology Laboratory of Clinical Chemistry and Microbiology IRCCS Galeazzi Orthopaedic InstituteUniversity of Milan

AIMTo evaluate the ability of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 to colonize the intestinal environment of healthy subjects and modify the gut microbiota *** healthy Italian volunteers, eight males and twelve females, participated in the study. Ten subjects took a sachet containing 4 × 109 colony-forming units (CFU) of Bifidobacterium longum BB536 and 109 CFU of Lactobacillus rhamnosus HN001, 30 min before breakfast (pre-prandial administration), while ten subjects took a sachet of probiotic product 30 min after breakfast (post-prandial administration). The ability of Lactobacillus rhamnosus HN001 and Bifidobacterium longum BB536 to colonize human gut microbiota was assessed by means of quantitative real-time PCR, while changes in gut microbiota composition were detected by using Ion Torrent Personal Genome *** after 1-mo of probiotic administration, B. longum BB536 and L. rhamnosus HN001 load was increased in the majority of subjects in both pre-prandial and post-prandial groups. This increase was found also 1 mo after the end of probiotic oral intake in both groups, if compared to samples collected before probiotic consumption. At phyla level a significant decrease in Firmicutes abundance was detected immediately after 1-mo of B. longum BB536 and L. rhamnosus HN001 oral intake. This reduction persisted up to 1 mo after the end of probiotic oral intake together with a significant decrease of Proteobacteria abundance if compared to samples collected before probiotic administration. Whereas, at species level, a higher abundance of Blautia producta, Blautia wexlerae and Haemophilus ducrey was observed, together with a reduction of Holdemania filiformis, Escherichia vulneris, Gemmiger formicilis and Streptococcus sinensis abundance. In addition, during follow-up period we observed a further reduction in Escherichia vulneris and Gemmiger formicilis, together with a decrease in

关键词： Probiotics Gut microbiota Bifidobacterium Lactobacillus Human health

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