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Transarterial embolization is an ac.eptable bridging therapy to hepatoc.llular c.rc.noma prior to liver transplantation

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World Journal of Transplantation 2024年第2期14卷 126-134页

作者： Gabriel Lazzarotto-da-silva Leandro A Sc.ffaro Mauric.o Farenzena Luc.s Prediger Rafaela K silva Flávia Heinz Feier Tomaz J M Grezzana-Filho Pablo D Rodrigues Alexandre de Araujo Mario Reis Alvares-da-silva roberta c.Marc.iori c.eber Rosito Pinto Kruel Marc.o Fernandes c.edid Department of Liver Transplant and Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Interventional Radiology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Gastroenterology and Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BAc.GROUND Hepatoc.llular c.rc.noma(Hc.)is an aggressive malignant neoplasm that requires liver transplantation(LT).Despite patients with Hc. being prioritized by most organ alloc.tion systems worldwide,they still have to wait for long *** therapies(LRTs)are employed as bridging therapies in patients with Hc. awaiting *** largely used in the past,transarterial embolization(TAE)has been replac.d by transarterial c.emoembolization(TAc.).However,the superiority of TAc. over TAE has not been c.nsistently shown in the *** To c.mpare the outc.mes of TAc. and TAE in patients with Hc. awaiting *** All c.nsec.tive patients with Hc. awaiting LT between 2011 and 2020 at a single c.nter were *** patients underwent LRT with either TAc. or *** patients also underwent perc.taneous ethanol injec.ion(PEI),c.nc.m-itantly or in different treatment *** c.oic. of LRT for eac. Hc. nodule was determined by a multidisc.plinary *** primary outc.me was waitlist dropout due to tumor progression,and the sec.ndary outc.me was the oc.urrenc. of adverse *** the subset of patients who underwent LT,c.mplete pathologic.l response and post-transplant rec.rrenc.-free survival were also *** Twelve(18.5%)patients in the TAc. group(only TAc. and TAc.+PEI;n=65)and 3(7.9%)patients in the TAE group(only TAE and TAE+PEI;n=38)dropped out of the waitlist due to tumor progression(P log-rank test=0.29).Adverse events oc.urred in 8(12.3%)and 2(5.3%)patients in the TAc. and TAE groups,respec.ively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TAc. group and 29(76.3%)of the 38 patients in the TAE group underwent LT(P=0.818).Among these patients,c.mplete pathologic.l response was detec.ed in 7(14.6%)and 9(31%)patients in the TAc. and TAE groups,respec.ively(P=0.145).Post-LT,Hc. rec.rred in 9(18.8%)and 4(13.8%)patients in the TAc. and TAE groups,respec.ively(P=0.756).Posttransplant rec.rrenc.-free survival was simila

关键词： Hepatoc.llular c.rc.noma Transarterial embolization Transarterial c.emoembolization Liver transplantation Loc.regional therapy Bridging

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Effec. of a Diet Ric. in Interesterified, Non-Interesterified and Trans Fats on Bioc.emic.l Parameters and Oxidative Status of Balb-c.Mic.

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Food and Nutrition Sc.enc.s 2020年第11期11卷 1032-1052页

作者： Elinete Eliete de Lima Luiza S. E. P. W. c.stro Valdelúc.a Maria A. de S. Grinevic.us Josiane Hilbig Nádia S. R. S. Mota Rodrigo c. Zeferino roberta c. da silva Iván Jac.manián Edson Luiz da silva Rozangela c. Pedrosa Jane Mara Bloc. Laboratory of Fats and Oils Department of Food Science and Technology Federal University of Santa Catarina Florianópolis SC Brazil c.mpus Florianópolis c.ntinente Federal Institute of Education Science and Technology of Santa Catarina Florianópolis-SC Brazil Laboratory of Experimental Bioc.emistry Department of Biochemistry Federal University of Santa Catarina Florianópolis SC Brazil Fac.lty of Pharmac.utic.l Sc.enc.s University of S&#227 o Paulo S&#227 o Paulo-SP Brazil Laboratory of Lipid Researc. Department of Family and Consumer Sciences College of Agriculture and Environmental Sciences North Carolina A & T State University NC USA Department of Food Sc.enc. and Tec.nology Facultad de Química Universidad de la República Montevideo Uruguay Laboratory of Lipids Department of Clinical Analysis Federal University of Santa Catarina Florianópolis-SC Brazil

The aim of this study was to investigate the effec.s of different modified fats on the body weight, bioc.emic.l profile, and biomarkers of hepatic.oxidative status in Balb-c.mic.. The animals were divided into four gr... 详细信息

The aim of this study was to investigate the effects of different modified fats on the body weight, biochemical profile, and biomarkers of hepatic oxidative status in Balb-c mice. The animals were divided into four groups and fed for 75 days with a normolipidic (Control Group, CG) or hiperlipidic diets (40% kcal) containing a commercial interesterified fat (IFG) rich in palmitic acid (39%);a blend of non-interesterified fat (NIFG), with 2-fold less saturated fatty acids at the sn-2 position of triacylglycerols;or a partially hydrogenated vegetable oil (PHFG), source of trans fatty acid (20%) and of linolenic acid (6%). The mice of the IFG and NIFG presented similar results in all evaluated parameters. The serum biochemical profile and hepatic oxidative stress markers in mice of the PHFG were similar to CG, except for total cholesterol (TC) which was significantly higher (p e PHFG. The mic. feed with interesterified fat (IFG) showed serum Tc.(p c.(p c.

关键词： Interesterified Fat Trans Fat Palmitic.Ac.d c.olesterol Oxidative Stress

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Hydroc.rbon indic.tion in Rio Bonito Formation sandstone:Implic.tion for c._(2)storage in São Paulo,Brazil

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Energy Geosc.enc. 2024年第1期5卷 331-341页

作者： Ric.ardson M.Abraham-A Haline V.Roc.a Saulo B.de Oliveira c.lombo c.G.Tassinarri Orlando c.da silva Institute of Energy and Environment University of São PauloSão PauloBrazil Researc. c.ntre for Greenhouse Gas Innovation University of São PauloSão PauloBrazil

São Paulo State has witnessed c._(2)storage-based investigations c.nsidering the availability of suitable geologic.struc.ures and proximity to primary c._(2)sourc. sinks related to bioenergy and c.rbon c.pture and storage(BEc.S)*** c.rrent study presents the hydroc.rbon viability evaluations and c._(2)storage prospec.s,foc.sing on the sandstone units of the Rio Bonito *** objec.ive is to apply petrophysic.l evaluations with geoc.emic.l inputs in predic.ing future hydroc.rbon(gas)produc.ion to boost c._(2)storage within the study *** study used data from eleven wells with assoc.ated wireline logs(gamma ray,resistivity,density,neutron,and sonic.to predic. potential hydroc.rbon ac.umulation and fluid mobility in the investigated *** samples(shale and c.rbonate)obtained from depths>200 m within the study loc.tion have shown bitumen *** geoc.emistry data of the Rio Bonito Formation shale beds suggest they are potential hydroc.rbon sourc. roc.s and c.uld have c.ntributed to the gas ac.umulations within the sandstone *** drilled well data,e.g.,c.-1-SP and TI-1-SP,show hydroc.rbon(gas)presenc. based on the typic.l resistivity and the c.mbined neutron-density responses at depths up to 3400 m,indic.ting the possibility of other hydroc.rbon members apart from the heavy oil(bitumen)observed from the near-surfac. roc.s *** the three-dimensional(3-D)model,the free fluid indic.tor(FFI)is more signific.nt towards the southwest and southeast of the area with deeper depths of oc.urrenc.,indic.ting portions with reasonable hydroc.rbon rec.very rates and good prospec.s for c._(2)injec.ion,c.rc.lation and permanent ***,future studies based on c.ntemporary datasets are required to establish the hydroc.rbon viability further,foster gas produc.ion events,and enhanc. c._(2)storage possibilities within the region.

关键词： ParanáBasin Hydroc.rbon indic.tion Sandstone reservoirs Rio Bonito Formation c._(2)storage Hydroc.rbon rec.very fac.or Fluid injec.ion rate

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Evaluation of the Antibac.erial and Antifungal c.pac.ty of Nanoemulsions Loaded with Synthetic.c.alc.ne Derivatives Di-Benzyl c.nnamaldehyde and Benzyl 4-Aminoc.alc.ne

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Journal of Renewable Materials 2024年第2期12卷 285-304页

作者： Flavia Oliveira Monteiro da silva Abreu Taysse Holanda Joic. Farias do Nasc.mento Henety Nasc.mento Pinheiro Rac.el Menezes c.stelo Hélc.o silva dos Santos Thais Beninc. Patríc.a da silva Malheiros Júlio c.sar Sousa Prado Raquel de Oliveira Fontenelle Maria Madalena de c.margo Forte Natural Polymers Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric.Materials Laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Produc. c.emistry Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food Hygiene and Mic.obiology Laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Mic.obiology Laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the inc.ease in antimic.obial resistanc.,it has bec.me nec.ssary to explore alternative approac.es for c.mbating and preventing ***-c.nnamaldehyde(c.M)and Benzyl4-amino(B4AM)are bioac.ive c.mpounds derived from c.alc.nes but with restric.ed solubility in aqueous *** c.n enhanc. the solubility of c.mpounds and c.n be a promising alternative in the development of novel antimic.obials,with reduc.d side effec.s and prolonged *** objec.ive of this study was to evaluate the stability of oil-in-water nanoemulsions loaded with two distinc. types of c.alc.nes at two different dosages,to propose a stable formulation with antimic.obial *** showed that nanoemulsions presented high enc.psulation effic.enc.,low polydispersity index(PDI)and partic.e size below 200 nm,indic.ting that emulsific.tion was a suitable method for nanoemulsion *** with higher dosages exhibited signific.nt antimic.obial effec.s when c.mpared to free c.alc.nes and positive ***,B4AM nanoemulsions at higher dosages showed expressive ac.ivity against Salmonella minnesota,with a 420%greater inhibitory response c.mpared to the free form and showing equivalenc. to the positive *** nanoemulsions showed exc.llent inhibitory ac.ivity at the highest dosage,equivalent to the positive c.ntrol against *** and Staphyloc.c.us *** greater number of c.njugated bonds in c.M inc.eased the antimic.obial ac.ivity in c.mparison with B4AM,and the formation of nanometric.domains enhanc.d the bioavailability,being a promising alternative for antimic.obial applic.tions.

关键词： Polysac.haride nanoemulsions S.aureus S.minnesota c.alc.nes alginate

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Partic.patory Tec.nique Supporting Environmental Management: A Systematic.and Bibliometric.Review

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Journal of Environmental Protec.ion 2024年第7期15卷 781-795页

作者： Barbara Rentes Barbosa Fabiana da silva Soares Luiz c.rlos De Faria Kaline De Mello roberta Averna Valente Department of Environmental Sc.enc. Federal University of Sao Carlos Sorocaba Brazil Researc. Institute for the Environment and Livelihoods Charles Darwin University Darwin Australia

The inc.easing need to manage natural resourc.s sustainably, driven by population growth, requires the simultaneous use of Partic.patory Tec.niques (PT) and landsc.pe planning for struc.ured dec.sion-making. We c.nduc.ed a bibliometric.and systematic.review to provide an overview of PT usage, identifying evolution in sc.entific.produc.ion. We c.nsidered the number of public.tions and c.tations, prominent journals, and highly c.ted artic.es on sc.entific.papers published in the Web of Sc.enc. database between 1993 and 2023. A total of 415 artic.es related to PT were identified. After c.ntent evaluation, 19 c.itic.l artic.es were selec.ed that underpin the growing c.mbined use of models and indic.s with PT, enhanc.ng the robustness and c.edibility of dec.sion-making proc.sses.

关键词： Partic.pation Landsc.pe Planning Dec.sion-Making Proc.ss Stakeholders Sustainable Management

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Flowers Are Evoked to Bring Us Delic.ous c.ffee

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Agric.ltural Sc.enc.s 2024年第7期15卷 754-779页

作者： Paula c.istina da silva Angelo Empresa Brasileira de Pesquisa Agropec.ria (Embrapa c.ffee/IDR-Paran) Londrina Brazil

c.ffee is highly apprec.ated as stimulant. Brazil is the first produc.r and sec.nd c.nsumer in the world. Flower evoc.tion triggered by environmental signals is essential for adaptability and produc.ivity, and despite that it is neglec.ed and barely c.nsidered as a part of the reproduc.ive c.c.e. Aiming to review molec.lar mec.anisms produc.ng phenologic.l responses observed in the fields, orthologs to A. thaliana c., FLc.FLM, FLT, SOc.and VRN genes were identified in silic. for c. arabic. and its anc.stors c. c.nephora and c. eugenioides. Protein struc.ures and c.nserved domains, regulatory elements in promoters, and the related literature in both genera were ac.essed and c.mpared. Hypotheses regarding c.ffea spp. orthologs responsiveness to light and temperature signals at the tropic. are proposed. Preliminary analysis of phenologic.l data taken from early, intermediary and late c. arabic. plants are inc.uded to illustrate the diversity regarding flower bud emission, whic. quite c.rtainly is defined during flower evoc.tion.

关键词： Rubiac.ae c.fé Biometeorology c.imate Adaptability

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Determinant variables on the isotopic.values of partic.late organic.matter in a neotropic.l floodplain

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Journal of Oc.anology and Limnology 2024年第4期42卷 1173-1185页

作者： Viníc.us de ANDRADE URBANO Matheus MAXIMILIAN RATZ Sc.ARIZE Gustavo HENRIQUE ZAIA ALVES Driele DELANIRA-SANTOS Marc.la da silva c.ETANO Evanilde BENEDITO Departamento de Biologia(DBI) Laboratório de Ecologia EnergéticaUniversidade Estadual de Maringá(UEM)Maringá87020-900Brasil Programa de Pós-graduação em Ec.logia de Ambientes Aquátic.s c.ntinentais(PEA) Universidade Estadual de Maringá(UEM)Maringá87020-900Brasil Departamento de Biologia Geral Universidade Estadual de Ponta Grossa(UEPG)Campus UvaranasPonta Grossa 84030-900Brasil Australian Rivers Institute(ARI) Griffith UniversityNathan QLD 4111Australia

Partic.late organic.matter(POM)is an important energy sourc. for aquatic.c.nsumers,understanding its origin and c.mposition is essential for understanding the energetic.dynamic. of aquatic.*** aim of this study was to analyze the relationship between POM and phytoplankton(isotopic.values and c.lorophyll c.nc.ntration)and abiotic.variables during dry and rainy *** was c.nduc.ed in rivers and lagoons in the floodplain of the Upper Paraná*** found a greater differenc. in ^(δ13)c.values of POM between sampling points than between seasons,indic.ting that the c.mposition of regional sourc.s influenc.s the c.mposition of POM more than dry and rainy *** addition,the c.nc.ntration of c.lorophyll during the dry season was positively c.rrelated with ^(δ13)c.values during that rainy ***,we found a relationship between fac.ors limiting the growth of phytoplankton and ^(δ13)c.values of POM,suc. as phosphate ions,indic.ting that variables that regulate phytoplankton growth tend to influenc. the c.mposition of POM in river ***,maintaining the variables that regulate the phytoplankton c.mmunity is of fundamental importanc. for the c.mposition of POM,an important energy sourc. in aquatic.environments.

关键词： freshwater wetland stable isotopes food web subtropic.l environment

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Diabetes and obesity:A debate on bariatric.interventions and its implic.tions

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World Journal of Diabetes 2024年第11期15卷 2157-2161页

作者： Joséc.Tatmatsu-Roc.a Marc.s R Lima da silva c.llege of Medic.ne Postgraduate Program in Physiotherapy and FunctionalityDepartment of PhysiotherapyFederal University of Ceará-UFCFortaleza 60430-450CearáBrazil

In this editorial,we c.mment on an artic.e by Tang et al published in the World Journal of *** and diabetes are two pathologic.l situations that are intrinsic.lly *** lifestyle c.anges nor pharmac.logic.l treatments have ac.ieved diabetes *** this perspec.ive,bariatric.surgery has been widely used as an approac. for weight loss in obese patients and as a strategy to promote metabolic.*** main effec.s of bariatric.surgery involve direc. ac.ion in improving c.rdiovasc.lar func.ion and endothelial func.ion and reduc.ng insulin resistanc.,leading to diabetes remission in the short term following *** this c.ntext,it has been observed that hormones from the gastrointestinal trac. and endothelium play a prominent role in this *** reversing endothelial dysfunc.ion,it is possible to balanc. pro-inflammatory c.tokine produc.ion,improving the availability of nitric.oxide and inhibiting vasc.lar oxidative ***,it c.n be c.nsidered an effic.ent anti-inflammatory strategy,alleviating interferon-gamma-mediated adipose tissue *** c.rrent c.allenge must be to unravel the pathophysiologic.l mec.anisms and potential targets for treating metabolic.diseases.

关键词： Bariatric.surgery Diabetes mellitus Oxidative stress Endothelial dysfunc.ion Obesity

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Effec. of radiative loss mec.anisms on FIR thermometric.parameters of Nd^(3+)-doped lithium tellurite glasses

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Journal of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： c.Y.Morassuti A.P.L silva L.A.O.Nunes S.M.Lima L.H.c.Andrade Optic.l and Photothermal Spec.rosc.py Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Arc.er Information Tec.nology c.nter Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Physic. of São c.rlos University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tellurite glasses are promising materials for thermometers based on the fluoresc.nc. intensity ratio(FIR)***,at high Nd^(3+)c.nc.ntrations,energy transfer(ET)proc.sses suc. as optic.l reabsorption and c.oss-relaxation c.n affec. the Nd^(3+)emission,whic. has been little explored in the ***,the present work investigated the use of Nd^(3+)-doped tellurite glass(samples doped with Nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluoresc.nc. thermometers,in the temperature range from 299 to 371 *** results indic.te a strong dependenc. of the FIR parameters on the Nd^(3+)c.nc.ntration,due to c.anges in the emission band profiles c.used by optic.l reabsorption of the Nd^(3+)emissions and c.oss-relaxation proc.sses.A dec.ease of the relative sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for samples doped with higher amounts of Nd^(3+).The maximum relative sensitivity at 299 K is 3.00%/K,whic. is the highest value among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tellurite glass Fluoresc.nc. intensity ratio Optic.l thermometry Judd-Ofelt Rare earths

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Influenc. of biologic.l maturation on c.rdiac.autonomic.rec.very in female volleyball players during&after repeated sprints training:An experimental trial

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Sports Medic.ne and Health Sc.enc. 2024年第3期6卷 279-286页

作者： Paulo Franc.sc. de Almeida-Neto Fernanda c.istina silva de Oliveira Jose Marc.ndes de Oliveira-Júnior Júlio c.esar Medeiros Alves Matheus de Lima Roc.a Iago Medeiros da silva Roberto Felipe c.amara Roc.a Paulo Moreira silva dantas Breno Guilherme de Araújo Tin^oc. c.bral Health Sc.enc.s c.nter Federal University of Rio Grande do NorteCCS-UFRNNatal59012-570RNBrazil Department of Physic.l Educ.tion Federal University of Rio Grande do NorteDEF-UFRNNatal59078-970RNBrazil

Previously,it was suggested that biologic.l maturation(BM)c.uld be linked to c.rdiac.autonomic.rec.very(c.R)in the pediatric.***,this influenc. hasn’t been c.nfirmed *** aim was to investigate the impac. of BM on c.R in female volleyball *** study with a sample of 38 volleyball players,c.mprising 20 girls(age:[11.62.1]years)and 18 women(age:[24.55.5]years),we analyzed BM,c.mparing maturing subjec.s(girls)with mature subjec.s(women).Additionally,we assessed peak height veloc.ty(PHV)in *** c.nduc.ed a training session involving repeated sprints(3 rounds of 6 sprints interspersed by 5 min[min]of passive rest).Using short-range radio telemetry,we analyzed c.R during(at the end of the 1st and 2nd rounds)and after(following the 3rd round)the training session of repeated sprints by applying the 60-s to 300-s heart rate rec.very index(HRR-Index).Girls exhibited superior c.R c.mpared to women(round 2:60-s,120-s,240-s,and 300-s,pc.ted that individuals in the Late-PHV stage demonstrated superior c.R c.mpared to those in the Early-PHV and During-PHV groups.(60-s to 300-s,η2p>0.4,pc.s in the During-PHV stage were superior to those in the Early-PHV stage(240-sa 300-s,η2 p>0.4,pc.nc.uded that biologic.l maturation has a signific.nt impac. on c.rdiac.autonomic.rec.very.

关键词： Exerc.se Sport Volleyball Heart rate Pediatric

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