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Transarterial embolization is an acceptable bridging therapy to hepatocellular carcinoma prior to liver transplantation

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World Journal of Transplantation 2024年第2期14卷 126-134页

作者： Gabriel Lazzarotto-da-Silva Leandro A Scaffaro mauricio Farenzena Lucas Prediger Rafaela K Silva Flávia Heinz Feier Tomaz J m Grezzana-Filho Pablo D Rodrigues Alexandre de Araujo mario Reis Alvares-da-Silva roberta c m.rchiori cleber Rosito Pinto Kruel marcio Fernandes chedid Department of Liver Transplant and Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Interventional Radiology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Gastroenterology and Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BAcKGROUND Hepatocellular carcinoma(Hcc)is an aggressive malignant neoplasm that requires liver transplantation(LT).Despite patients with Hcc being prioritized by most organ allocation systems worldwide,they still have to wait for long *** therapies(LRTs)are employed as bridging therapies in patients with Hcc awaiting *** largely used in the past,transarterial embolization(TAE)has been replaced by transarterial chemoembolization(TAcE).However,the superiority of TAcE over TAE has not been consistently shown in the *** To compare the outcomes of TAcE and TAE in patients with Hcc awaiting *** All consecutive patients with Hcc awaiting LT between 2011 and 2020 at a single center were *** patients underwent LRT with either TAcE or *** patients also underwent percutaneous ethanol injection(PEI),concom-itantly or in different treatment *** choice of LRT for each Hcc nodule was determined by a multidisciplinary *** primary outcome was waitlist dropout due to tumor progression,and the secondary outcome was the occurrence of adverse *** the subset of patients who underwent LT,complete pathological response and post-transplant recurrence-free survival were also *** Twelve(18.5%)patients in the TAcE group(only TAcE and TAcE+PEI;n=65)and 3(7.9%)patients in the TAE group(only TAE and TAE+PEI;n=38)dropped out of the waitlist due to tumor progression(P log-rank test=0.29).Adverse events occurred in 8(12.3%)and 2(5.3%)patients in the TAcE and TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TAcE group and 29(76.3%)of the 38 patients in the TAE group underwent LT(P=0.818).Among these patients,complete pathological response was detected in 7(14.6%)and 9(31%)patients in the TAcE and TAE groups,respectively(P=0.145).Post-LT,Hcc recurred in 9(18.8%)and 4(13.8%)patients in the TAcE and TAE groups,respectively(P=0.756).Posttransplant recurrence-free survival was simila

关键词： Hepatocellular carcinoma Transarterial embolization Transarterial chemoembolization Liver transplantation Locoregional therapy Bridging

Imaging approach for jaw and maxillofacial bone tumors with updates from the 2022 World Health Organization classification

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World Journal of Radiology 2024年第8期16卷 294-316页

作者： Woongsoon John choi Peggy Lee Penelope c Thomas Tanya J Rath monique A mogensen roberta W Dalley Pattana Wangaryattawanich Division of Neuroradiology Department of RadiologyUniversity of Washington School of MedicineSeattleWA 98195United States Department of Radiology M&S Radiology AssociatesSan AntonioTX 78217United States Division of Oral Radiology University of Washington School of DentistrySeattleWA 98195United States Division of Neuroradiology Department of RadiologyMayo ClinicPhoenixAZ 85054United States

Jaw and maxillofacial bone lesions encompass a wide variety of both neoplastic and non-neoplastic *** lesions can arise from various tissues,including bone,cartilage,and soft tissue,each presenting distinct challenges in diagnosis and *** some pathologies exhibit characteristic imaging features that aid in diagnosis,many others are *** overlap often necessitates a multimodal imaging approach,combining techniques such as radiographs,computed tomography,and magnetic resonance imaging to achieve a diagnosis or narrow the diagnostic *** article provides a comprehensive review of the imaging approach to jaw and maxillofacial bone tumors,including updates on the 2022 World Health Organization classification of these *** relevant anatomy of the jaw and dental structures that is important for accurate imaging interpretation is discussed.

关键词： mandible maxilla maxillofacial Jaw Tumor Neoplasm

Epidemiology,therapy and outcome of hepatocellular carcinoma between 2010 and 2019 in Piedmont,Italy

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 761-772页

作者： christian Bracco marta Gallarate marco Badinella martini corrado magnino Salvatore D'Agnano roberta canta Giulia Racca Remo melchio cristina Serraino Valentina Polla mattiot Giovanni Gollè Luigi Fenoglio Department of Internal medicine Santa Croce e Carle General HospitalCuneo 12100Italy Department of medical Sciences "City of Health and Science"University HospitalTorino 10100Italy

BAcKGROUND Hepatocellular carcinoma(Hcc)is the most common primary liver malignancy and the second leading cause of cancer deaths *** is often diagnosed at an advanced stage and therefore its prognosis remains poor with a low 5-year survival *** patients have increasingly complex and constantly changing characteristics,thus up-to-date and comprehensive data are *** To analyze the epidemiology and main clinical characteristics of Hcc patients in a referral center hospital in the northwest of Italy between 2010 and *** In this retrospective study,we analyzed the clinical data of all consecutive patients with a new diagnosis of Hcc recorded at"Santa croce e carle"Hospital in cuneo(Italy)between 1 January 2010 and 31 December *** highlight possible changes in Hcc patterns over the 10-year period,we split the population into two 5-year groups,according to the diagnosis period(2010-2014 and 2015-2019).RESULTS Of the 328 Hcc patients who were included(m/F 255/73;mean age 68.9±11.3 years),154 in the first period,and 174 in the *** c virus infection was the most common Hcc risk factor(41%,135 patients).The alcoholic etiology rate was 18%,the hepatitis B virus infection etiology was 5%,and the non-viral/non-alcoholic etiology rate was 22%.The child-Pugh score distribution of the patients was:class A 75%,class B 21%and class c 4%.The average mayo end-stage liver disease score was 10.6±3.7.A total of 55 patients(17%)were affected by portal vein thrombosis and 158(48%)by portal *** average nodule size of the Hcc was 4.6±3.1 cm.A total of 204 patients(63%)had more than one nodulemetastatic stage of the *** Barcelona clinic Liver cancer(BcLc)staging distribution of all patients was:4%very early,32%early,23%intermediate,34%advanced,and 7%*** survival rate was 1.6±0.3 *** 20%of the patients underwent ***,presence of ascites,BcLc stage and therapy w

关键词： Hepatocellular carcinoma Hepatitis virus Alcoholic hepatitis Non-alcoholic fatty liver disease Diagnosis Etiology Treatment

Bioremediation Potential of the macroalga Ulva lactuca (chlorophyta) for Ammonium Removal in Elastomer Industry Wastewater

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Advances in Bioscience and Biotechnology 2024年第6期15卷 325-343页

作者： Diego Lelis Alex Enrich-Prast camille R. chaves Thuane mendes Anacleto roberta R. c. Pereira Vinicius P. de Oliveira Programa de Ps-Graduao em Biotecnologia Vegetal e Bioprocessos Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Unidade multiusurio de Anlises Ambientais Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Institute of marine Science Federal University of So Paulo (IMar/UNIFESP) Santos Brazil Department of Thematic StudiesEnvironmental change and Biogas Solutions Research center (BSRc) Linkping University Linkping Sweden Department of marine Biology Institute of Biology Federal University of Rio de Janeiro Rio de Janeiro Brazil

During the production of nitrile rubber, significant amounts of nitrogen in the form of ammonium are generated in the wastewater. The discharge of this high-nitrogen wastewater can lead to serious environmental issues, including eutrophication, disruption of aquatic ecosystems, and groundwater contamination. To mitigate these impacts, this research explored the bioremediation capabilities of the macroalgae Ulva lactuca (chlorophyta) for removing nitrogen from nitrile rubber production wastewater. The study employed single-phase and michaelis-menten decay models based on ammonium consumption, using various dilutions of wastewater to identify the optimal concentration for treatment. The physiological state of the macroalgae was monitored by measuring the photosynthetic capacity and specific growth rate during the experiments. In the presence of U. lactuca, ammonium concentrations decreased in all treatment groups, confirming that the ammonium kinetics conformed to both applied models. Our results show that U. lactuca effectively reduces ammonium concentrations, with an approximate removal rate of 0.020 µm·g−1·min−1 across different wastewater concentrations (70%, 80%, 90%, and 100%). Notably, the treatments with 70%, 80%, and 90% wastewater strength achieved about 67% reduction in ammonium, demonstrating the alga’s capacity to treat high-nitrogen wastewater. The photosynthetic performance of U. lactuca initially declined in control conditions but stabilized across all treatments, highlighting its adaptability. The kinetic analysis using the michaelis-menten model indicated a Vmax of 1342 μm·g−1·Dmh−1, suggesting a robust capacity for ammonium uptake when fully saturated. Our study underscores the potential of Ulva lactuca as a cost-effective and efficient agent for wastewater bioremediation, particularly in settings with high nitrogen loads.

关键词： Photosynthetic Quantum Yield One-Phase Decay model michaelis-menten model Nitrogen Physiological Parameters Elastomers

Senior fitness test manual / roberta E. Rikli, c. Jessie Jones.

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Iatrogenic atrial septal defects after transseptal puncture for percutaneous left atrial appendage occlusion and their hemodynamic effects

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作者： roberta E. Rikli c. Jessie Jones.

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Journal of Geriatric cardiology 2022年第9期19卷 675-684页

作者： Ioannis Drosos roberta De Rosa Philipp c.Seppelt Sebastian cremer Silvia mas-Peiro Katrin Hemmann Jana Oppermann Recha Blessing mariuca Vasa-Nicotera Andreas m.Zeiher Zisis Dimitriadis Division of cardiology Department of Medicine IIIUniversity Hospital FrankfurtGoethe University Frankfurt am MainFrankfurtGermany German center for cardiovascular Research(DZHK) BerlinGermany cardiopulmonary Institute(cPI) FrankfurtGermany center of cardiology University Medical Center MainzMainzGermany Di-vision of cardiology and Intensive care Department of Internal MedicineSt.Ansgar HospitalHöxterGermany

Background Percutaneous left atrial appendage occlusion(LAAO)requires puncture of the interatrial *** immediate hemodynamic effects of iatrogenic atrial septal defects(iASD)after LAAO have not been examined so *** aimed at evaluat-ing these effects through invasive measurements of pressure and oxygen ***,we assessed the incidence of per-sistent iASD at three *** Forty-eight patients scheduled for percutaneous LAAO were prospectively included in the *** and oxygen saturation were measured(1)in the right atrium(RA)before transseptal puncture,(2)in the left atrium(LA)through the transseptal sheath after transseptal puncture,(3)in the LA after removal of introducer sheath,and(4)in the RA after removal of introducer *** echocardiography was performed at three months to detect *** Pressure in the RA increased significantly after removing the introducer sheath(P=0.034),whereas no difference was found in oxygen saturation in the RA(P=0.623).Pressure measurement in the LA showed no significant difference after re-moving the introducer sheath(P=0.718).Oxygen saturation in the LA also showed no significant difference(P=0.129).Follow-up transesophageal echocardiogram at 3 months revealed a persistent iASD in 4 patients(8.5%).cONcLUSIONS Our study suggests that iASD after percutaneous LAAO does not result in significant shunts directly after the procedure,although a significant increase of mean right atrial pressure can be *** iASDs after percutaneous LAAO seem to be relatively rare at three months.

关键词： atrial septal puncture

Nonalcoholic fatty liver disease: is the IFNL4 rs368234815 variant protective from liver damage?

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Hepatobiliary Surgery and Nutrition 2018年第3期7卷 209-211页

作者： Enrico Galmozzi roberta D'Ambrosio "A. m. and A. migliavacca" center for Liver Disease Division of Gastroenterology and HepatologyFondazione IRCCS Cà Granda Ospedale Maggiore PoliclinicoUniversità degli Studi di MilanoMilanItaly

Nonalcoholic fatty liver disease (NAFLD) consists of a spectrum of disorders characterized predominantly by hepatic steatosis in the absence of significant alcohol consumption, potentially evolving to nonalcoholic ste... 详细信息

关键词： damage liver NAFLD

Dispersive liquid-liquid microextraction,an effective tool for the determination of synthetic cannabinoids in oral fluid by liquid chromatography-tandem mass spectrometry

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Journal of Pharmaceutical Analysis 2021年第3期11卷 292-298页

作者： Pierpaolo Tomai Alessandra Gentili roberta curini Rossella Gottardo Franco Tagliaro Salvatore Fanali Department of chemistry Sapienza UniversityP.le Aldo Moro 500185RomeItaly Department of Diagnostics and Public Health University of VeronaVeronaItaly and Institute of Translational Medicine and BiotechnologySechenov First Moscow State Medical UniversityMoscowRussia Teaching committee of Ph.D.School in Natural Science and Engineering University of Verona VeronaItaly

In the present work,dispersive liquid-liquid microextraction(DLLmE)was used to extract six synthetic cannabinoids(JWH-018,JWH-019,JWH-073,JWH-200,or WIN 55,225,JWH-250,and Am-694)from oral fluids.A rapid baseline separation of the analytes was achieved on a bidentate octadecyl silica hydride phase(cogent Bidentate c18;4.6 mm×250 mm,4μm)maintained at 37℃,by eluting in isocratic conditions(water:acetonitrile(25:75,V/V)).Detection was performed using positive electrospray ionization-tandem mass *** parameters affecting DLLmE(pH and ionic strength of the aqueous phase,type and volume of the extractant and dispersive solvent,vortex and centrifugation time)were optimized for maximizing *** particular,using 0.5 mL of oral fluid,acetonitrile(1 mL),was identified as the best option,both as a solvent to precipitate proteins and as a dispersing solvent in the DLLmE *** select an extraction solvent,a low transition temperature mixture(LTTm;composed of sesamol and chlorine chloride with a molar ratio of 1:3)and dichloromethane were compared;the latter(100μL)was proved to be a better extractant,with recoveries ranging from 73%to 101%by vortexing for 2 *** method was validated according to the guidelines of Food and Drug Administration bioanalytical methods:intra-day and inter-day precisions ranged between 4%and 18%depending on the spike level and analyte;limits of detection spanned from 2 to 18 ng/mL;matrixmatched calibration curves were characterized by determination coefficients greater than ***,the extraction procedure was compared with previous methods and with innovative techniques,presenting superior reliability,rapidity,simplicity,inexpensiveness,and efficiency.

关键词： microextraction techniques Dispersive liquid-liquid microextraction Illicit drugs Synthetic cannabinoids Silica c-based column

Schwann-like adipose-derived stem cells as a promising therapeutic tool for peripheral nerve regeneration:effects of cholinergic stimulation

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Neural Regeneration Research 2021年第6期16卷 1218-1220页

作者： roberta Piovesana Alessandro Faroni Ada maria Tata Adam J.Reid Department of Biology and Biotechnologies“charles Darwin” SapienzaUniversity of RomeRomeItaly Blond mcIndoe Laboratories Division of Cell Matrix Biology and Regenerative MedicineSchool of Biological SciencesFaculty of BiologyMedicine and HealthThe University of ManchesterManchester Academic Health Science CentreManchesterUK Research centre of Neurobiology“Daniel Bovet” SapienzaUniversity of RomeRomeItaly Department of Plastic Surgery&Burns Wythenshawe HospitalManchester University NHS Foundation TrustManchester Academic Health Science CentreManchesterUK

Schwann-like adipose-derived stem cells and nerve injury:Peripheral nerve injuries(PNIs)are a common clinical problem usually as a consequence of *** optimal surgical management,PNI has a lifelong impact on function and wellbeing of the *** peripheral nervous system(PNS)has regenerative capability,in contrast to the central nervous system(cNS),and is dependent on the plasticity of the peripheral glia,Schwann cells(Scs).Despite this regenerative capability,PNI recovery of sensorial and motor function is always incomplete causing pain,cold intolerance,paralysis and impairment of activities of daily living.

关键词： stimulation injuries paralysis