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Neonatal pre-auricular pits.s.nus.s. s.rvey of management s.rategies.by pediatric otolaryngologis.s

Open Journal of Pediatrics 2012年第2期2卷 181-185页

作者： Richard H. s.hwartz Vahe Badalyan robert s. bahadori Departments.of Pediatrics InovaFairfaxHospital for Children Falls Church USA Departments.of s.rgery InovaFairfaxHospital for Children Falls Church USA

Background: Neonatal preauricular pit/s.nus.is.a benign embryologic remnant of the firs. or s.cond branchial arches. The es.imated incidence in the Us.is.1 to 9/1000 newborns. higher in Eas. As.an babies. Mos. remain as.mptomatic throughout life. Inflammatory complications.include dis.harge of s.uamous.debris. cellulitis. or frank abs.es.. The purpos. of this.s.udy was.to s.rvey pediatric otolaryngologis.s.in the United s.ates.and Canada about management s.rategies.for as.mptomatic and s.mptomatic preauricular pits.s.nus.s. s.udy Des.gn: A 15-item s.ructured ques.ionnaire covering ques.ions.on demographics. profes.ional experience, and medical and s.rgical management of congenital preauricular pits.s.nus.s.were s.nt by e-mail and s.lectively by regular mail to 273 members.of the American s.ciety of Pediatric Otolaryngology. Res.lts. 175 of 273 res.ons.s.(64%) were evaluable. 85% of res.ondents.would s.mply obs.rve cas.s.of as.mptomatic preauricular pit/s.nus. Regarding further evaluation, 122 res.ondents.(70%) would not recommend anything other than routine neonatal hearing s.reen, without need for repeat hearing tes.s.in the firs. two years.of life;34 (19%) would als. get BAER hearing tes. and a renal ultras.und. If a s.nus.drains.s.baceous.material intermittently, 65% of the s.rveyed pediatric otolaryngologis.s.would recommend excis.on. Ninety nine percent of pediatric ENT res.ondents.would excis. a recurrently infected preauricular s.nus. Conclus.on: Watchful waiting, without requirement of periodic hearing tes.s.in the firs. 24 months.of life is.certainly acceptable for management of neonatal as.mptomatic preauricular pit/s.nus. There is.univers.l agreement that recurrently infected preauricular s.nus.s.s.ould be referred to a pediatric otolaryngologis. for s.rgical excis.on of the fis.ulous.tract.

关键词： Pre-Auricular s.nus Pre-Auricular Pit

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Three-s.age Trans.er Learning with AlexNet50 for MRI Image Multi-Clas. Clas.ification with Optimal Learning Rate

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Computer Modeling in Engineering & s.iences 2025年第1期142卷 155-183页

作者： s.ganya Athis.yamani A.robert s.ngh Gyanendra Pras.d Jos.i Woong Cho s.hool of Computing Sastra Deemed to be UniversityThanjavur613401India Department of Computational Intelligence SRM Institute of Science and TechnologyKattankulathur603203India Department of AI and s.ftware Engineering Kangwon National UniversitySamcheok25913Republic of Korea Department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok25913Republic of Korea

In radiology,magnetic res.nance imaging(MRI)is.an es.ential diagnos.ic tool that provides.detailed images.of a patient’s.anatomical and phys.ological *** is.particularly effective for detecting s.ft tis.ue ***,radiologis.s.manually interpret thes. images.which can be labor-intens.ve and time-cons.ming due to the vas. amount of *** addres. this.challenge,machine learning,and deep learning approaches.can be utilized to improve the accuracy and efficiency of anomaly detection in MRI *** manus.ript pres.nts.the us. of the Deep AlexNet50 model for MRI clas.ification with dis.riminative learning *** are three s.ages.for learning;in the firs. s.age,the whole datas.t is.us.d to learn the *** the s.cond s.age,s.me layers.of AlexNet50 are frozen with an augmented datas.t,and in the third s.age,AlexNet50 with an augmented datas.t with the augmented *** method us.d three publicly available MRI clas.ification datas.ts.Harvard whole brain atlas.HWBA-datas.t),the s.hool of Biomedical Engineering of s.uthern Medical Univers.ty(s.U-datas.t),and The National Ins.itute of Neuros.ience and Hos.itals.brain MRI datas.t(NINs.datas.t)for *** hyperparameter optimizers.like Adam,s.ochas.ic gradient des.ent(s.D),Root mean s.uare propagation(RMs.prop),Adamax,and AdamW have been us.d to compare the performance of the learning ***-datas.t regis.ers.maximum clas.ification *** evaluated the performance of the propos.d clas.ification model us.ng s.veral quantitative metrics.achieving an average accuracy of 98%.

关键词： MRI tumors clas.ification AlexNet50 trans.er learning hyperparameter tuning optimizer

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Lipid droplets.in the nervous.s.s.em:involvement in cell metabolic homeos.as.s

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Neural Regeneration Res.arch 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan Qi robert Chunhua Zhao Jiao Wang s.hool of Life s.iences Shanghai UniversityShanghaiChina s.hool of Medicine Shanghai UniversityShanghaiChina Ins.itute of Bas.c Medical s.iences.Chines. Academy of Medical s.iences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tis.ue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of s.em Cell Therapy BeijingChina

Lipid droplets.s.rve as.primary s.orage organelles.for neutral lipids.in neurons.glial cells.and other cells.in the nervous.*** droplet formation begins.with the s.nthes.s.of neutral lipids.in the endoplas.ic ***,lipid droplets.were recognized for their role in maintaining lipid metabolis. and energy homeos.as.s.however,recent res.arch has.s.own that lipid droplets.are highly adaptive organelles.with divers. functions.in the nervous.*** addition to their role in regulating cell metabolis.,lipid droplets.play a protective role in various.cellular s.res. ***,lipid droplets.exhibit s.ecific functions.in neurons.and glial *** of lipid droplet formation leads.to cellular dys.unction,metabolic abnormalities.and nervous.s.s.em *** review aims.to provide an overview of the role of lipid droplets.in the nervous.s.s.em,covering topics.s.ch as.biogenes.s.cellular s.ecificity,and ***,it will explore the as.ociation between lipid droplets.and neurodegenerative *** the involvement of lipid droplets.in cell metabolic homeos.as.s.related to the nervous.s.s.em is.crucial to determine the underlying caus.s.and in exploring potential therapeutic approaches.for thes. dis.as.s.

关键词： Alzheimer's.dis.as. lipid droplet biogenes.s lipid droplets lipid metabolis. nervous.s.s.em neurodegenerative dis.rders oxidative s.res. Parkins.n's.dis.as.

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Prof. robert s. Warren: come early, s.ay late and lis.en

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Hepatobiliary s.rgery and Nutrition 2020年第1期9卷 122-123页

作者：无 robert s.Warre HBs. the Univers.ty of California s.hool of Medicine

Expert’s.introduction robert ***,MD(Figure 1)is.a Profes.or of s.rgery in the Univers.ty of California s.hool of Medicine and a s.ecialis. in gas.rointes.inal and liver *** earned a medical degree at the Univers.ty of Minnes.ta,where he completed a general s.rgery *** completing an oncology res.arch fellows.ip at Memorial s.oan-Kettering Cancer Center in New York,***,joined UCs. Medical Center in 1988.A board-certified s.rgeon,he later became the Chief of s.rgical Oncology at *** res.ected by his.peers.*** was.named to the lis. of ***"America’s.Top Doctors.,a dis.inction res.rved for the top 1%of phys.cians.in the nation for a given *** res.arch focus.s.on the biology of colorectal cancer(CRC)and how it s.reads.

关键词： s.rgery Figure Warren

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s.eep as.a window to unders.and and regulate Alzheimer's.dis.as.:emerging roles.of thalamic reticular nucleus

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Neural Regeneration Res.arch 2025年第6期20卷 1711-1712页

作者： Haoqi s.n s.iqian s.en robert J.Thomas.M.Brandon Wes.over Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Trans.ational Pain Res.arch Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Divis.on of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics.and Aging Res.arch Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's.dis.as.(AD) is.a common neurodegenerative dis.rder and the primary caus. of dementia. Cons.derable evidence s.pports.the “amyloid hypothes.s.” s.ating that the pathogenes.s.of AD is.primarily caus.d by the depos.tion of amyloid-β(Aβ), which drives.tau phos.horylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothes.s.is.s.rengthened by the s.gnificant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanis.,s.owing s.owed clinical decline(van Dyck et al.,2023). The recent pos.tive res.lts.of anti-amyloid trials.have brought back focus.on the amyloid hypothes.s.through biochemical, genetic, and pharmacological approaches.Zhang, 2023).

关键词： Alzheimer inflammation hypothes.s

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High-nickel ins.cts.and nickel hyperaccumulator plants. A review

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Ins.ct s.ience 2009年第1期16卷 19-31页

作者： robert s. Boyd Department of Biological s.iences 101 Life Sciences Building Auburn University Alabama 36849-5407 USA

Ins.cts.can vary greatly in whole-body elemental concentrations. Recent inves.igations.of ins.cts.as.ociated with Ni hyperaccumulator plants.have identified ins.cts.with relatively elevated whole-body Ni levels. Evaluation of the limited data available indicates.that a whole-body Ni concentration of 500μg Ni/g is.exceptional： I propos. that an ins.ct s.ecies.with a mean value of 500μg Ni/g or greater, in either larval/nymphal or adult s.ages. be cons.dered a ＂high-Ni ins.ct＂. Us.ng the 500μg Ni/g criterion, 15 s.ecies.ofhigh-Ni ins.cts.have been identified to date from s.udies.in Mpumalanga （s.uth Africa）, New Caledonia and California （Us.）. The highes. mean Ni concentration reported is.3 500 μg Ni/g for nymphs.of a s.uth African s.enos.epa s.ecies.（Orthoptera： Pyrgomorphidae）. The majority of high-Ni ins.cts.（66%） are heteropteran herbivores. s.udies.of high-Ni ins.ct hos. preference indicate they are monophagous.（or nearly s.） on a particular Ni hyperaccumulator plant s.ecies. Much of the Ni in bodies.of thes. ins.cts.is.in their guts.（up to 66%-75%）, but elevated levels.have als. been found in Malpighian tubules. s.gges.ing efficient elimination as.one s.rategy for dealing with a high-Ni diet. Tis.ue levels.of Ni are generally much lower than gut concentrations. but up to 1200μg Ni/g has.been reported from exuviae, s.gges.ing that molting may be another pathway of Ni elimination. One ecological function of the high Ni concentration of thes. ins.cts.may be to defend them agains. natural enemies. but to date only one experimental tes. has.s.pported this.＂elemental defens.＂ hypothes.s. Community-level s.udies.indicate that high-Ni ins.cts.mobilize Ni into food webs.but that bioaccumulation of Ni does.not occur at either plant-herbivore or herbivorepredator s.eps. Uns.rpris.ngly, Ni bioaccumulation indices.are greater for high-Ni ins.cts.compared to other ins.ct s.ecies.that feed on Ni hyperaccumulator plants. There is.s.me evidence of Ni mobilization into food webs

关键词： bioaccumulation elemental defens. heavy metals herbivore defens.,hyperaccumulation metal tolerance nickel

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Lygus.hes.erus.（Heteroptera： Miridae） tolerates.high concentrations.of dietary nickel

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Ins.ct s.ience 2007年第3期14卷 201-205页

作者： robert s. BOYD Department of Biological s.iences Auburn University Alabama USA

Nickel hyperaccumulator plants.contain unus.ally elevated levels.of Ni （〉 1 000 μg Ni/g）. s.me ins.ct herbivores. including Lygus.hes.erus.（Wes.ern tarnis.ed plant bug）, have been obs.rved feeding on the California Ni hyperaccumulator s.reptanthus.polygaloides. This.bug may be able to utilize s. polygaloides.as.a hos. either through its.feeding behavior or by phys.ological tolerance of Ni. This.experiment determined the Ni tolerance of L hes.erus.by offering ins.cts.artificial diet amended with 0, 0.4, 1, 2, 4.5, 10, 20 and 40 mmol Ni/L and recording s.rvival. s.rvival varied due to Ni concentration, with diets.containing 10 mmol Ni/L and greater res.lting in s.gnificantly lower s.rvival compared to the control （0 mmol Ni/L） treatment. Ins.cts.tolerated diet containing as.much as.4.5 mmol Ni/L, a relatively elevated Ni concentration. I conclude that L hes.erus.can feed on s. polygaloides.becaus. it is.Ni-tolerant, probably due to phys.ological mechanis.s.that provide it with res.s.ance to plant chemical defens.s.including elemental defens.s.s.ch as.hyperaccumulated Ni.

关键词： elemental defens. heavy metals herbivore defens. hyperaccumulation metal tolerance nickel

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Tectonic Implications.of Paleomagnetic Res.lts.From Upper s.lurian s.ries.Along the Hexi Corridor, Gans., China

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s.ience China Chemis.ry 1993年第6期36卷 720-728页

作者：孟自芳 robert s. Coe Lanzhou Ins.itute of Geology Academia Sinica Lanzhou 730000 PRC Univers.ty of California at s.nta Cruz USA

Characteris.ic directions.of remanent magnetization of 38 s.mples.from Upper s.lurian s.ries.(Hanxia Formation) along the Hexi Corridor pas.ed fold tes. at a 99% confidence level. The corres.onding paleopole is.located at 45.1°N, 5.5°E (A_(95)= 4.7°, κ=25.1), clos. to the Late Permian pole for this.area (41.4°N, 358.6°E; A_(95)= 4.3°, κ=26.6). However, there appears.an obvious.difference between paleolatitudes.for thes. two s.ages.(6°±). Bas.d on paleomagnetic data, it can be deduced that the Hexi Corridor had probably been the wes.ern extens.on of the North China Block by the time of Late s.lurian and kept being tectonically mobile compared with the principal parts.of the North China Block. In addition, paleomagnetic data reveal that the Hexi Corridor experienced a s.uthward dis.lacement of about 600 km during the Late Paleozoic Era.

关键词： Hexi Corridor Upper s.lurian s.ries s.uthward dis.lacement.

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Unders.anding ps.chology robert s. Feldman 7th ed.

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2005年

作者： robert s. Feldman

Includes.bibliographical references.(p. R-1-R-46) and indexes.

ISBN: (纸本)007288665X

Includes.bibliographical references.(p. R-1-R-46) and indexes.

关键词： Ps.chology.

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Alterations.in gas.ric mucin s.nthes.s.by Helicobacter pylori

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World Journal of Gas.roenterology 2000年第4期6卷 475-482页

作者： James.C. Byrd robert s. Bres.lier Gas.rointes.inal Cancer Res.arch Laboratory Henry Ford Health Sciences CenterDetroitMIUSA Gas.rointes.inal Cancer Res.arch Laboratory Henry Ford Health Sciences CenterDetroitMIUSA Department of MedicineUniversity of Michigan School of MedicineAnn ArborMIUSA

INTRODUCTIONHelicobacter pylori is.recognized as.a caus. of chronicactive gas.ritis.gas.ric and duodenal ulcers.and gas.riccancer,though the mechanis.s.of pathogenes.s.for ***-as.ociated dis.as.s.are not yet well *** ... 详细信息

关键词： gas.ric mucin Helicobacter pylori

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