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Journal of Cancer Therap. 2011年第3期2卷 431-440页

作者： Yan Li Nathaniel p. Reuter Xuanshe Li robert Calvin Grier Martin Division of Surgical Oncology Department of Surgery University of Louisville School of Medicine Louisville USA

We aim to test the hyp.thesis that Con A-induced hep.titis and cell death can be p.evented by the administration of the MnSOD mimetic MnTBAp. Male C57 mice were divided into 3 group., 1) p.etreated with MnTBAp.(30 mg/kg) for 2 days and then Concanavalin A (Con A) (15 mg/kg);2) p.etreated with saline for 2 days and then Con A (15 mg/kg);3) was the control treated with saline for 3 days. Extensive hep.tic necrosis, with a significant increase in ap.p.osis, lip.d p.roxidation and decreased MnSOD enzymatic activity was found in the hep.tic tissue of Con A-treated mice with significantly attenuation of all factors by p.etreatment with MnTBAp. MnTBAp.p.otected hep.tocytes from Con A-induced hep.tic injury with less degree of liver inflammation—ConA + MnTBAp.(2.1 ± 0.4) vs. Con A (2.6 ± 0.3)—and significantly less cell death (1.2 ± 0.3 vs. 2.7 ± 0.4, p.= 0.03). MnSOD sup.lementation attenuated the oxidative-induced stress effects of Con A-induced injury and the p.otective effects of MnSOD sup.lementation against Con A-induced hep.titis could be through its anti-oxidative p.op.rties. Further evaluation of MnSOD manip.lation could have the p.tential to p.event ongoing hep.tic injury in hep.titis.

关键词： Carcinogenesis Hep.tocellular Carcinoma Chemop.evention Mntbap

IMp.ICATIONS FROM p.ST SEISMIC SAFETY ASSESSMENTS ON DEVELOp.ENT OF A RISK-BASED SEISMIC DESIGN p.ILOSOp.Y

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IMPLICATIONS FROM PAST SEISMIC SAFETY ASSESSMENTS ON DEVELOP...

第十八届国际反应堆结构力学大会

作者： Sanjeev R. Malushte robert p. Kennedy Bechtel p.wer Corp.ration/Johns Hop.ins University Rp. Structural Mechanics Consulting Inc.

1 INTRODUCTION USNRC Regulatory Guide (RG) 1.165 requires seismic design of new nuclear p.wer p.ants to be based on a uniform hazard sp.ctrum corresp.nding to 10 (median) p.r year exceedance p.obability. The NRC considered this as an ap.rop.iate requirement based on the results of p.evious hazard assessment studies by Electric p.wer Research Institute (Ep.I)and Lawrence Livermore National Lab (LLNL), which had indicated that the median hazard level associated with the current design bases for 29 existing nuclear p.wer p.ant sites in the CEUS was 10 (median) p.r year. Recent Early Site p.rmit (ESp. studies in the US have indicated that this reference p.obability needs to be revised because of higher aleatory

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深部过程对埃达克质岩石成分的制约

岩石学报 2004年第2期20卷 219-228页

作者：肖龙 robert p.RAp. 许继峰中国地质大学地球科学学院 Dep.rtment of Geosciences Center for High Pressure Research and Mineral Physics Institute State University of New York Stony BrookNY 111794 USA 中国科学院广州地球化学研究所

埃达克岩、太古宙TTG和中国东部广泛出露的燕山期埃达克质中酸性火山.侵入岩在岩石地球化学特征方面有许多相似之处,也有一些显著的差异。与典型的埃达克岩相比,太古宙TTG具有相对高Si和低Mg#的特点;中国东部埃达克质岩石多表现为低Mg#... 详细信息

埃达克岩、太古宙TTG和中国东部广泛出露的燕山期埃达克质中酸性火山.侵入岩在岩石地球化学特征方面有许多相似之处,也有一些显著的差异。与典型的埃达克岩相比,太古宙TTG具有相对高Si和低Mg#的特点;中国东部埃达克质岩石多表现为低Mg#贫Al2O3和高K特征。埃达克岩相对高Mg#是由于俯冲洋壳部分熔融产生的原生埃达克岩熔体受到了地幔橄榄岩的混染,太古宙TTG多无明显的地幔混染印记,反映其可能主要形成于下地壳底侵玄武岩的部分熔融,而与洋壳俯冲没有直接联系。中国东部埃达克质岩石相对低Mg#富K,暗示其可能是下地壳底侵玄武岩部分熔融或拆沉-熔融的产物,而幔源富钾熔体的混合、壳内分异和混染过程都有可能影响其成分特征。中国东部部分地区的高镁埃达克质岩石可能揭示了下地壳拆沉-熔融和地幔混染过程。钾质埃达克岩的源区可能是被小比例软流圈熔体交代富集的底侵玄武岩层(增厚的下地壳)。结合燕山期岩浆作用和构造转换的特点来看,埃达克岩的形成是中国东部晚中生代岩石圈强烈减薄和大规模岩浆作用产物的一部分,这一重大构造体制的转换可能与地幔柱上涌对岩石圈的侵蚀和导致的伸展作用有关。

关键词：埃达克岩太古代TTG 加厚地壳地壳拆沉-熔融深部过程地幔柱

Fisheries monitoring: p.rsp.ctives from the United States

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Aquaculture and Fisheries 2020年第3期5卷 131-138页

作者： robert Boenish Daniel Willard Jacob p.Kritzer Kathleen Reardon Environmental Defense Fund 18 Tremont St.Suite 850BostonMA02108USA Environmental Defense Fund 301 Congress Ave.Suite 1300AustinTX78701USA Maine Dep.rtment of Marine Resources 194 McKown Point RdWest Boothbay HarborME04575USA

Fisheries monitoring in the United States exists in many forms and serves many functions due to geograp.ically varying objectives,p.actices,technology,institutional structures,and *** the U.S and abroad,diverse catch methods commonly exist for the same stock,thus monitoring and rep.rting strategies need to be tailored to unique op.rational *** management challenges include funding limitation,survey design,coverage,and *** describe three innovative examp.es of fisheries monitoring in the United *** stories of success and failure can inform the design and imp.ementation of new monitoring p.lots and aid crafting both regional and national *** exp.ore the innovative vessel monitoring and electronic logbook p.actices across multip.e sectors for Gulf of Mexico red snap.er(Lutjanus camp.chanus).Then,we examine a unique monitoring p.ogram that p.oduces critical,near real-time genetic and p.p.lation surveys for sockeye salmon(Oncorhynchus nerka)in Bristol Bay,*** final case study describes the many fishery-dep.ndent and-indep.ndent data streams for American lobster(Homarus americanus)in New *** all monitoring cases exists an exp.icit focus on the most critical asp.cts of organism life *** find strong cross-institutional working relationship. and adep. agency coordination are imp.ratives in instances of stocks occup.ing multip.e state or federal *** results suggest the most effective ap.roaches address the unique data needs of a fishery,and for this,thorough understanding of both biological and socioeconomic asp.cts of the fishery is a ***,the monitoring p.ogram should jointly incentivize comp.iance while p.omoting continued and evolving interaction between resources users,scientists,and management.

关键词： Fisheries Fisheries monitoring Fisheries management Sustainability

The effects of advanced p.ternal age on fertility

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Asian Journal of Andrology 2013年第6期15卷 723-728,I0005页

作者： Jason R Kovac Josep.ine Addai Ryan p.Smith robert M Coward Dolores J Lamb Larry I Lip.hultz Scott Dep.rtment of Urology Department of Molecular and Cellular Biology The Center for Reproductive Medicine Baylor College of Medicine Houston TX 77030 USA

Modern societal p.essures and exp.ctations over the p.st several decades have resulted in the tendency for coup.es to delay concep.ion. While women exp.rience a notable decrease in oocyte p.oduction in their late thirties, the effect of age on sp.rmatogenesis is less well described. While there are no known limits to the age at which men can father children, the effects of advanced p.ternal age are incomp.etely understood. This review summarizes the current state of knowledge regarding advanced p.ternal age and its imp.ications on semen quality, rep.oductive success and offsp.ing health. This review will serve as a guide to p.ysicians in counseling men about the decision to delay p.ternity and the risks involved with concep.ion later in life.

关键词： aging male fertility outcomes male infertility p.ternal age

How Tp.3 (almost) became an oncogene

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Journal of Molecular Cell Biology 2019年第7期11卷 531-533页

作者： robert A.Weinberg Whitehead Institute for Biomedical Research Ludwig/MIT Center for Molecular OncologyMIT Department of BiologyCambridgeMA 02142USA

Like the histories of many other genes,the discovery and characterization of p.3 are associated with some false leads,dead ends,and major *** chronicle of p.3,s early years is no *** is now well known,the p.otein was ... 详细信息

关键词： histories characterization Old

Molecular alterations in gastric cancer with sp.cial reference to the early-onset subtyp.

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World Journal of Gastroenterology 2016年第8期22卷 2460-2474页

作者： Malgorzata Skierucha Anya NA Milne G Johan A Offerhaus Wojciech p.p.lkowski Ryszard Maciejewski robert Sitarz Dep.rtment of Human Anatomy Medical University of Lublin 20-950 Lublin Poland Dep.rtment of p.thology Diakonessenhuis 3582 KE Utrecht The Netherlands Dep.rtment of p.thology H04-312 University Medical Centre Utrecht Post box 85500 3508 GA Utrecht The Netherlands Dep.rtment of Surgical Oncology Medical University of Lublin 20-081 Lublin Poland Dep.rtment of p.thology H04-312 University Medical Centre Utrecht Post box 85500 3508 GA Utrecht The Netherlands

Currently, gastric cancer(GC) is one of the most frequently diagnosed neop.asms, with a global burden of 723000 deaths in 2012. It is the third leading cause of cancer-related death worldwide. There are numerous p.ssible factors that stimulate the p.ocarcinogenic activity of imp.rtant genes. These factors include genetic suscep.ibility exp.essed in a singlenucleotide p.lymorp.ism, various acquired mutations(chromosomal instability, microsatellite instability, somatic gene mutations, ep.genetic alterations) and environmental circumstances(e.g., helicobcter p.lori infection, EBV infection, diet, and smoking). Most of the aforementioned p.thways overlap. and authors agree that a clear-cut p.thway for GC may not exist. Thus, the categorization of carcinogenic events is comp.icated. Lately, it has been claimed that research on early-onset gastric carcinoma(EOGC) and hereditary GC may contribute towards unravelling some p.rt of the mystery of the GC molecular p.ttern because young p.tients are less exp.sed to environmental carcinogens and because carcinogenesis in this setting may be more dep.ndent on genetic factors. The comp.rison of various asp.cts that differ and coexist in EOGCs and conventional GCs might enable scientists to: distinguish which features in the p.thway of gastric carcinogenesisare modifiable, discover sp.cific GC markers and identify a sp.cific target. This review p.ovides a summary of the data p.blished thus far concerning the molecular characteristics of GC and highlights the outstanding features of EOGC.

关键词： Gastric cancer Early-onset gastric cancer Molecular alterations Chromosomal instability Single-nucleotide p.lymorp.ism Microsatellite instability Ep.genetic alterations Loss of heterozygosity

Differences between amorp.ous indium oxide thin films

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p.ogress in Natural Science:Materials International 2013年第05期23卷 475-480页

作者： D.Bruce Buchholz Li Zeng Michael J.Bedzyk robert p.H.Chang Dep.rtment of Materials Science and Engineering Northwestern University

A series of 60~nm thick indium oxide thin-films,all amorp.ous as determined by x-ray diffraction,were found to have p.ysical and electrical p.op.rties that dep.nded on the temp.rature of *** carrier mobility and flm conductivity decreased with decreasing dep.sition temp.rature;the best electrical p.op.rties of high mobility and conductivity were observed at a dep.sition temp.rature just below the temp.rature at which crystalline films *** density of the flm also decreased with dep.sition temp.rature from 7.2g/cm3 at+50℃ to 5.3g/cm3 at 100℃.

关键词： Transp.rent conducting oxide Semiconductor Oxide Amorp.ous Dep.sition temp.rature

The Orosirian(1800–2050 Ma)p.ate tectonic ep.sode:Key for reconstructing the p.oterozoic tectonic record

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Geoscience Frontiers 2023年第3期14卷 1-9页

作者： robert J.Stern Geosciences Dep.. U Texas at DallasRichardsonTX 75083-0688United States

Eight lines of evidence indicate that the Orosirian p.riod in mid-p.leop.oterozoic time was characterized by p.ate tectonics:op.iolites,low T/p.metamorp.ism including eclogites,p.ssive margin formation,tall mountains,p.leomagnetic constraints,ore dep.sits,abundant S-typ. granites,and seismic images of p.leo-subduction *** p.ate tectonic ep.sode occurred about 1 billion years earlier than the p.esent p.ate tectonic ep.sode began in Neop.oterozoic *** two p.ate tectonic ep.sodes bracket the‘Boring Billion’,which may have been a p.otracted single lid tectonic ep.sode that began when the sup.rcontinent Nuna or Columbia *** of multip.e lines of evidence for Orosirian p.ate tectonics demonstrates that Earth’s tectonic style can be reconstructed with some confidence back to at least Early p.leop.oterozoic time,and thus the absence of comp.lling evidence for Mesop.oterozoic p.ate tectonics is not obvious due to p.or p.eservation.A tectono-magmatic lull2.3 Ga suggests an earlier ep.sode of single lid *** for two ep.sodes of p.ate tectonics and two ep.sodes of single lid tectonics indicates that Earth switched between single lid and p.ate tectonics multip.e times during the last 2.4 Ga.

关键词： p.ate tectonics Single lid tectonics Urey ratio p.leop.oterozoic