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Reimagining large river management using the Resist-Accept-Direct(RAD)framework in the Upper Mississippi River

Ecological Processes 2023年第1期12卷 645-664页

作者： Nicole K.Ward Abigail J.Lynch Erik A.Beever Joshua Booker Kristen L.Bouska Holly Embke Jeffrey N.Houser John F.Kocik Joshua Kocik David J.Lawrence Mary Grace Lemon Doug Limpinsel Madeline R.Magee Bryan M.Maitland Owen McKenna Andrew Meier John M.Morton Jeffrey D.Muehlbauer robert newman Devon C.Oliver Heidi M.Rantala Greg G.Sass Aaron Shultz Laura M.Thompson Jennifer L.Wilkening Minnesota Department of Natural Resources Lake CityMN 55041USA U.S.Geological Survey National Climate Adaptation Science CenterRestonVA 22041USA U.S.Geological Survey Northern Rocky Mountain Science CenterBozemanMT 59715USA Department of Ecology Montana State UniversityBozemanMT 59715USA U.S.Fish and Wildlife Service National Wildlife Refuge SystemOak HarborOH 43449USA U.S.Geological Survey Upper Midwest Environmental Sciences CenterLa CrosseWI 54603USA U.S.Geological Survey Midwest Climate Adaptation Science CenterSt.PaulMN 55108USA NOAA NEFSC OronoME 04473USA University of Nebraska-Lincoln LincolnNE 68503USA National Park Service Climate Change Response ProgramFort CollinsCO 80525USA U.S.Fish and Wild-life Service National Wildlife Refuge SystemBloomingtonMN 55437USA Habitat Conservation Division NOAAAlaska RegionAnchorageAK 99513USA Wisconsin Department of Natural Resources MadisonWI 53703USA Aquatic Sciences Center Center for LimnologyUW-MadisonMadisonWI 53706USA U.S.Geological Survey Northern Prairie Wildlife Research Center and Midwest Climate Adaptation Science CenterJamestownND 58401USA U.S.Army Corps of Engineers La CrescentMN 55947USA Alaska Wildlife Alliance AnchorageAK 99520USA U.S.Geological Survey Alaska Cooperative Fish and Wildlife Research UnitUniversity of Alaska FairbanksFairbanksAK 99775USA University of North Dakota Grand ForksND 58202USA Minnesota Department of Natural Resources DuluthMN 55804USA Wisconsin Department of Natural Resources Boulder JunctionWI 54512USA Great Lakes Indian Fish and Wildlife Commission(GLIFWC) OdanahWI 54861USA U.S.Geological Survey National Climate Adaptation Science Centerand School of Natural ResourcesUniversity of TennesseeKnoxvilleTN 37996USA U.S.Fish and Wildlife Service National Wildlife Refuge SystemFort CollinsCO 80526USA

Background Large-river decision-makers are charged with maintaining diverse ecosystem services through unprec-edented social-ecological transformations as climate change and other global stressors *** interconnected,dendritic habitats of rivers,which often demarcate jurisdictional boundaries,generate complex management ***,we explore how the Resist–Accept–Direct(RAD)framework may enhance large-river management by promoting coordinated and deliberate responses to social-ecological trajectories of *** RAD frame-work identifies the full decision space of potential management approaches,wherein managers may resist change to maintain historical conditions,accept change toward different conditions,or direct change to a specified future with novel *** the Upper Mississippi River System,managers are facing social-ecological transformations from more frequent and extreme high-water *** illustrate how RAD-informed basin-,reach-,and site-scale decisions could:(1)provide cross-spatial scale framing;(2)open the entire decision space of potential management approaches;and(3)enhance coordinated inter-jurisdictional management in response to the trajectory of the Upper Mississippi River *** The RAD framework helps identify plausible long-term trajectories in different reaches(or subbasins)of the river and how the associated social-ecological transformations could be managed by altering site-scale *** reach-scale objectives may reprioritize how,where,and when site conditions could be altered to contribute to the basin goal,given the basin’s plausible trajectories of change(e.g.,by coordinating action across sites to alter habitat connectivity,diversity,and redundancy in the river mosaic).Conclusions When faced with long-term systemic transformations(e.g.,>50 years),the RAD framework helps explicitly consider whether or when the basin vision or goals may no longer be achievable,and direct options may open y

关键词： Ecosystem Management Transformation Social-ecological system Anthropocene Climate change Basin planning Cross-scale interactions

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Development of a multiple level underground limestone mine from geology through mine planning

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International Journal of Mining Science and Technology 2020年第1期30卷 63-67页

作者： Christopher newman David newman robert Dupuy Appalachian Mining&Engineering Inc.LexingtonKYUSA Rogers Group Inc.NashvilleTNUSA

The development of a multiple level underground mine is a complex task in which geology,engineering,ground control,and unit operations are integrated into a single mine *** components are interdependent and must function cohesively to ensure a profitable underground mining *** optimize reserve recovery,mine planning should begin from the lowest level and progress *** limits any misjudgments or oversights of a given level affecting the underlying levels and ensures the ability to maximize recovery from each *** planning should start with the exploration and characterization of the geologic *** the reserve geology and quality is well understood,then mine planning can begin with respect to the following:(1)orientation of mine works with respect to horizontal stress;(2)access to the reserve;(3)determination of opening widths;(4)selection of back,floor horizons and pillar centers;(5)selection of development and secondary mining heights;(6)appropriate inter-burden thicknesses;and(7)examining the stability of the multiple level mine through numerical *** multiple level mine design process and decisions are presented through a case history *** theme is that there is one opportunity to"get it right"and many chances to overlook a small aspect within the design that will plague the mine throughout all levels and through the entirety of its operating life.

关键词： Limestone Mine planning Geology Multiple level Rock mechanics

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华蟾素治疗肝癌、肺癌、胰腺癌的Ⅰ期临床研究:初步报道

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中国癌症杂志 2007年第5期17卷 376-379页

作者：孟志强沈晔华杨培英 robert newman 贝文英张颖葛勇前 Lorenzo Cohen Razelle Kurzrock 刘鲁明复旦大学附属肿瘤医院国际整合医学肿瘤中心复旦大学上海医学院肿瘤学系 Department of Experimental Therapeutics The University of Texas M.D.Anderson Cancer CenterTX77030 Department of Behavioral Science The University of Texas M.D.Anderson Cancer CenterTX77030 Phase I Program Division of Cancer MedicineThe University of Texas M.D.Anderson Cancer CenterTX77030

背景与目的:华蟾素目前广泛应用于肿瘤的治疗中,由于在80年代上市,未进行临床Ⅰ期研究,无法确定其最大耐受剂量。因此本文旨在观察华蟾素治疗肝细胞癌、肺癌和胰腺癌的最大耐受剂量和不良反应,同时评价治疗疗效。方法:Ⅲ、Ⅳ期肝细胞癌... 详细信息

背景与目的:华蟾素目前广泛应用于肿瘤的治疗中,由于在80年代上市,未进行临床Ⅰ期研究,无法确定其最大耐受剂量。因此本文旨在观察华蟾素治疗肝细胞癌、肺癌和胰腺癌的最大耐受剂量和不良反应,同时评价治疗疗效。方法:Ⅲ、Ⅳ期肝细胞癌、非小细胞肺癌和胰腺癌接受华蟾素治疗,采用静脉滴注,连续14 d,21 d为一疗程。如果没有出现剂量限制性毒性,治疗将持续2个疗程。剂量递增的方案为:10、20、40、60、90和120 m l/(m2.d)。结果:入组15例患者(每个剂量组为3例)中,11例为肝癌,2例胰腺癌和2例肺癌。第五剂量组结束时没有发现剂量限制性毒性(DLT)。其中14例患者可评价疗效,6例(42.9%)为SD,8例(57.1%)为PD。在第一剂量组中,1例肝癌患者肿瘤缩小20%并维持11个月。结论:本研究最高剂量达到常规剂量的8倍,尚未出现剂量限制性毒性。部分患者获得了肿瘤缩小或稳定的疗效。

关键词：华蟾素 Ⅰ期临床肝癌非小细胞肺癌胰腺癌

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A pilot double-blind, randomized, placebo-controlled trial of curcumin/bioperine for lung cancer chemoprevention in patients with chronic obstructive pulmonary disease

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Advances in Lung Cancer 2013年第3期2卷 62-69页

作者： Amir Sharafkhaneh J. Jack Lee Diane Liu Ruth Katz Nancy Caraway Cherise Acosta Ignacio I. Wistuba Bharat Aggarwal Burton Dickey Seyed J. Moghaddam Nicola Hanania robert newman Hanan Abdel-Monem Nga Bich Nguyen Carol J. Farhangfar Waun K. Hong Jonathan M. Kurie Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston USA Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center Houston USA Department of Medicine Baylor College of Medicine Houston USA Department of Pathology The University of Texas MD Anderson Cancer Center Houston USA Department of Pulmonary Medicine The University of Texas MD Anderson Cancer Center Houston USA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer Center Houston USA Division of Cancer Medicine The University of Texas MD Anderson Cancer Center Houston USA

Chronic obstructive pulmonary disease is an inflammatory condition with increased risk of lung cancer. We hypothesized that curcumin/ bioperine (CB), which has anti-inflammatory effects, may reduce cytological abnormalities in the sputum of patients with COPD. We conducted a 3-month, three-to-one randomized, doubleblind, pilot trial of escalating doses of CB in patients with moderate or worse COPD who were capable of producing sputum. The primary efficacy endpoint was changed in sputum cytology. We also explored changes in fluorescence in situ hybridization (FISH). We obtained sputum samples for cytology and chromosome abnormalities at baseline and each monthly follow-up visit. We enrolled 57 participants, with 35 completing the study. The participants’ mean age (standard deviation [SD]) was 66.6 (8.2) years, and they were mainly male (91.2%), with an average of 63.8 pack-years of smoking history. Also, 42.1% of participants were active smokers and the mean (SD) FEV1 was 37% (13%). At baseline, 13 subjects had moderate or worse dysplasia (22.8%). Subjects with moderate to severe sputum dysplasia had more chromosome abnormalities in epithelial cells and neutrophils, as measured by deletion and aneuploidy in 10q22.3. The changes in sputum cytology and chromosome abnormalities did not differ between the active and placebo arms. CB was well tolerated at the bid doses of 1, 1.5, and 2 gm of curcumin and 5 mg of bioperine, with minor side effects related to the gastrointestinal tract. In this short pilot trial, CB compared to placebo did not alter cytological and chromosomal abnormalities seen in sputum of patients with COPD.

关键词： Lung Cancer Inflammation Nutraceutical Agents COPD Cytological Abnormalities

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华蟾素治疗肝癌、肺癌、胰腺癌的Ⅰ期临床研究:初步报道

华蟾素治疗肝癌、肺癌、胰腺癌的Ⅰ期临床研究:初步报道

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2007医学前沿论坛暨第十届全国肿瘤药理与化疗学术会议

作者：孟志强沈晔华杨培英 robert newman 贝文英张颖葛勇前 Lorenzo Cohen Razelle Kurzrock 刘鲁明复旦大学附属肿瘤医院国际整合医学肿瘤中心 Department of Experimental Therapeutics The University of Texas M.D.Anderson Cancer Center TX 73030 Department of Behavioral Science Phase I Program Division of Cancer Medicine The University of Texas M.D.Anderson Cancer CenterTX 73030

目的:观察华蟾素治疗肝细胞肝癌、肺癌和胰腺癌的最大耐受剂量和不良反应,同时评价治疗疗效。方法:Ⅲ、Ⅳ期肝细胞肝癌、非小细胞肺癌和胰腺癌接受华蟾素治疗,采用静脉滴注,连续14天,21天为一疗程。如果没有出现剂量限制性毒性,治疗将持...

目的:观察华蟾素治疗肝细胞肝癌、肺癌和胰腺癌的最大耐受剂量和不良反应,同时评价治疗疗效。方法:Ⅲ、Ⅳ期肝细胞肝癌、非小细胞肺癌和胰腺癌接受华蟾素治疗,采用静脉滴注,连续14天,21天为一疗程。如果没有出现剂量限制性毒性,治疗将持续2疗程。剂量递增的方案为(ml/m/天):10,20,40,60,90,120。结果:共入组15例病人(每个剂量组为3例),其中11例为肝癌,2例胰腺癌和2例肺癌。第五剂量组结束时没有发现剂量限制性毒性(DLT)。其中14例病人可评价疗效,6例(42．9%)为 SD,8例(57．1%)为 PD。在第一剂量组中,一例肝癌病人肿瘤缩小20%并维持11个月。结论:在研究中,最高剂量达到常规剂量的8倍,尚没有达到剂量限制性毒性。部分病人获得了肿瘤缩小或稳定的疗效。

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IN VIVO STUDY OF A HERBAL MEDICINE BY USING LC/MS/MS

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质谱学报 1999年第Z1期 4-4页

作者： WANG Xiaomin, Takeo Sakuma, robert newman (~Perkin-Elmer Sciex Instruments, 71 Four Valley Drive, Concord, Ont. Canada L4K 4V8 MD Anderson Cancer Center, University of Texas, 15 15 Holcombe Blvd., Houston, Texas 77030,USA)

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Demystifying airline syncope

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World Journal of Cardiology 2020年第3期12卷 107-109页

作者： Thomas Kingsley robert Kirchoff James S newman Rahul Chaudhary Division of Hospital Internal Medicine Department of Internal MedicineHospital Internal MedicineMayo ClinicRochesterMN 55905United States Indiana University Purdue University Indianapolis IndianapolisIA 46202United States

Syncope forms a major part of medical in-flight emergencies contributing one-infour in-flight medical events accounting to 70%of flight *** such patients,it is important to elucidate the pathophysiology of syncope prior to *** hypotension is the most common etiology of in-flight syncopal ***,individuals without any underlying autonomic dysfunction can still experience syncope from hypoxia also known as airline *** steps in managing such patients include positioning followed by the airway,breathing and circulation of *** interventions need to be in close coordination with ground control to determine decision for flight *** which have been tried for prevention include mental challenge and increased salt and fluid *** current paper enhances the understanding of airline syncope by summarizing the associated pathophysiologic mechanisms and the management medical personnel can initiate with limited resources.

关键词： Syncope Airline syncope Aviation Pathophysiology Hypoxic syncope Inflight emergency

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Transport in the Aftermath of COVID-19: Lessons Learned and Future Directions

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Journal of Transportation Technologies 2021年第2期11卷 109-127页

作者： robert Earley Peter newman EQ Consulting (Beijing) Ltd. Beijing China Curtin University Perth Australia

This paper is a review of the impact on transport in the Asian region where enforced lockdowns and transport reductions have come with real human costs in the areas of economic development and access to jobs, society and services from various perspectives including urban planning and transport, economy, GHG and air pollutant emissions and gender as some of the areas of focus in the Sustainable Development Goals. Transportation systems with a high level of planning, flexible modes of transport and good communication with the public have proved more resilient than others. Furthermore, digital infrastructure has proven to be a key transport solution through this crisis. Data collection and real-time analysis have proven that their time has come to be effective in urban planning and transport management. Digital infrastructure is also driving online shopping and urban delivery services that allow people seeking to be socially distant to access daily necessities in a fast and relatively inexpensive manner. Making use of new global data sets and computing techniques can help cities and countries to plan better. Developing countries will need to improve their ability to gather relevant data from public and private sources and furthermore use the data to achieve more resilient, sustainable transportation. Achieving Sustainable Development Goals will require a reprioritization of funding and efforts to ensure that countries are building optimized infrastructure that provide transport and mobility services with minimal financial burdens including new leapfrog transit systems.

关键词： COVID-19 Asia-Pacific Transportation Impacts Pandemic Recovery Transport Resiliency

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Parallel Algorithms and Software for Nuclear,Energy,and Environmental *** Ⅱ:Multiphysics Software

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Communications in Computational Physics 2012年第8期12卷 834-865页

作者： Derek Gaston Luanjing Guo Glen Hansen Hai Huang Richard Johnson Dana Knoll Chris newman Hyeong Kae Park robert Podgorney Michael Tonks Richard Williamson Nuclear Science and Technology Idaho National LaboratoryIdaho FallsID 83415USA Energy and Environment Science and Technology Idaho National LaboratoryIdaho FallsID 83415USA Multiphysics Simulation Technologies Dept.(1444) Sandia National LaboratoriesAlbuquerqueNM 87185USA Fluid Dynamics and Solid Mechanics Group(T-3) Los Alamos National LaboratoryLos AlamosNM 87545USA.

This paper is the second part of a two part sequence on multiphysics algorithms and *** first[1]focused on the algorithms;this part treats the multiphysics software framework and applications based on *** coupling is typically designed into the analysis application at inception,as such an application is strongly tied to a composite nonlinear solver that arrives at the final solution by treating all equations *** applicationmust also take care tominimize both time and space error between the physics,particularly if more than one mesh representation is needed in the solution *** paper presents an application framework that was specifically designed to support tightly coupled multiphysics *** Multiphysics Object Oriented Simulation Environment(MOOSE)is based on the Jacobian-freeNewton-Krylov(JFNK)method combined with physics-based preconditioning to provide the underlying mathematical structure for *** report concludes with the presentation of a host of nuclear,energy,and environmental applications that demonstrate the efficacy of the approach and the utility of a well-designed multiphysics framework.

关键词： Multiphysics simulation Jacobian-free Newton Krylov finite element applications physics-based preconditioning

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Surgical Science 2019年第3期10卷 106-112页

作者： Alexander Oti Acheampong Merley newman-Nartey Solomon Obiri-Yeboah Jonathan Mensah Ama Amuasi Daniel Sabbah Jonathan Olesu Elijah Ebenezer Asamoah robert Nii Lamy Larmie Peter Donkor School of Medicine and Dentistry Kwame Nkrumah University of Science and Technology Kumasi Ghana School of Medicine and Dentistry University of Ghana Accra Ghana KomfoAnokye Teaching Hospital Kumasi Ghana

Background: Motorcycle related injuries have become a major public health problem because the increased use of motorcycles has been accompanied with a corresponding increase of road traffic accidents. Objective: The purpose of this study was to evaluate the occurrence of oral and maxillofacial injuries associated with motorcycles as seen at the second largest Teaching Hospital in Ghana, the Komfo Anokye Teaching Hospital (KATH). Method and Materials: The compiled data that were reviewed for this retrospective study were obtained from the Accident and Emergency unit of KATH. These comprised 135 successive maxillofacial trauma patient records entered from August 2017 to August 2018. Results: Total number of road traffic related injuries seen at OMFS was 135 during the study period. Out of this number, 66 were related to motorcycle injuries. This represented 48.7% of the Road Traffic Accidents seen at oral and maxillofacial surgery department (OMFS). The age range was from 3 to 64 years. The average age was 26.7 years. 62 (93.9%) were males and 4 (6.1%) were females. 16 (24.2%) of the motorcycle injuries were caused by the “Okada”, 2 (3.0%) by “Pragia” and 48 (72.8%) by the “Aboboyaa”. 46 (69.7%) of the motorcycles victims were themselves the riders, 12 (18.2%) were pedestrians and 8 (12.1%) were passengers. There were 8 deaths. 6 (75.0%) of the deaths were caused by the “Aboboyaa”. “Okada” accounted for only 2 (15.0%) deaths. Concerning the riders and the passengers, only 8 (14.8%) of the victims were helmeted. The majority were unhelmeted (85.2%). Conclusion: Motorcycle transportation is the cause of many oral and maxillofacial injuries. Majority of the victims suffered multiple facial bone fractures. Males were more often affected than females and the majority were unhelmeted.

关键词： Motorcycle Oral Maxillofacial Injuries Kumasi

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