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第六届海南省生命科学联合学术会议

作者： Shigan Fu Junli Guo Xuezhi Cui Brenda Su robert m.hamilton Department of Physiology Cardiovascular Disease Research InstituteHainan Medical College

α-Catenin is a key cell adhesion protein that is thought to indispensably link the cadherin-based adhesion complex to the actin cytoskeleton.α-catenin appears to play a central role in cell-cell contact *** dilated cardiomyopathy,interaction with adherens junction protein,biochemical,structural and live-cell imaging studies ofα-catenin are observed in cardiomyocytes and tissues in vivo or in vitro,its physiological function and relationships with expression of intercalated disc proteins in HL-1 cell line remain *** objective of this study was to assess the expression and/or localization of intercalated disks proteins,and communication and electric conduction of gap junction inα-catenin knockout HL-1 ***-1 mouse myocyte cells were transfected withα-catenin siRNA and negative contorl(NC)*** of intercalated disks proteins was characterized by immunoblotting and Immuno-fluorescence microscopy inα-catenin siRNA and NC siRNA transfected HL-1 *** of cells was counted after trypsinization using a *** or necrotic of HL-1 cells were determined with annexin-V-Fluos staining assay ***-cardiomyocyte coupling was determined by Lucifer yellow(LY)dye *** conduction of gap junctions were studied by microelectrode arrays(mEA).With the concetration ofα-catenin siRNA gradually increase,anti-α-catenin antibody expression in HL-1 cell line was reduced gradually and showed significant dose-dependence decreasing *** of HL-1 cells were reduced at 96h and 120h inα-catenin transfected HL-1cells,even decreased to 50%compared with none siRNA group and NC ***,apoptosis or necrosis of HL-1 cardiomyocytes were exhibited at 48h and 72h inα-catenin transfected HL-1cells,and showed early than reduction of number of *** levels of other adherens junctionβ-catenin,γ-catenin),gap junction(Cx43)and ZO-1 proteins were significantly decrease at 96h inα-catenin siRNA trans

关键词： small interfering RNA a-catenin apoptosis proliferation cell communication intercalated disc protein HL-1 cell line

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Colorful facial markings are associated with foraging rates and affiliative relationships in a wild group-living cichlid fish

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Current Zoology 2024年第1期70卷 70-78页

作者： Brett m.Culbert James B.Barnett Isaac Y.Ligocki matthew G.Salena marian Y.L.Wong Ian m.hamilton Sigal Balshine Department of Integrative Biology University of GuelphGuelphOntarioCanada Department of Psychology Neuroscience&BehaviourMcMaster UniversityHamiltonOntarioCanada Department of Evolution Ecologyand Organismal BiologyThe Ohio State UniversityColumbusOHUSA Department of Biology Millersville UniversityMillersvillePAUSA School of Earth Atmospheric and Life SciencesUniversity of WollongongWollongongNew South WalesAustralia Department of mathematics The Ohio State UniversityColumbusOHUSA

many animals use color to signal their quality and/or behavioral *** signals have been well studied in the contexts of competi-tion and mate choice;however,the role of these signals in nonsexual,affiliative relationships is not as well ***,we used wild social groups of the cichlid fish Neolamprologus pulcher to investigate whether the size of a brightly colored facial patch was related to 1)individual quality,2)social dominance,and/or 3)affiliative *** with larger patches spent more time foraging and tended to perform more aggressive acts against conspecific territory *** did not find any evidence that the size of these yellow patches was related to social rank or body size,but dominant males tended to have larger patches than dominant ***,patch size had a rank-specific relationship with the number of affiliative interactions that individuals engaged *** males with large patches received fewer affiliative acts from their groupmates compared to dominant males with small ***,subordinates with large patches tended to receive more affiliative acts from their groupmates while performing fewer affiliative acts *** together,our results suggest that patch size reflects interindividual variation in foraging effort in this cichlid fish and offer some of the first evidence that colorful signals may shape affiliative relationships withinwildsocialgroups.

关键词： affiliation foraging Lake Tanganyika Neolamprologus pulcher visual signals

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An explainable AI framework for robust and transparent data-driven wind turbine power curve models

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Energy and AI 2024年第1期15卷 312-327页

作者： Simon Letzgus Klaus-robert müller machine Learning Group Technische Universitβe BerlinStraβe des 17.Juni 135Berlin10623Germany Berlin Institute for the Foundations of Learning and Data Berlin10587Germany Department of Artificial Intelligence Korea UniversitySeoul136-713South Korea max Planck Institute for Informatics Saarbrücken66123Germany

In recent years,increasingly complex machine learning methods have become state-of-the-art in modelling wind turbine power curves based on operational *** these methods often exhibit superior performance on test sets,they face criticism due to a perceived lack of transparency and concerns about their robustness in dynamic,non-stationary environments encountered by wind *** this work,we address these issues and present a framework that leverages explainable artificial intelligence methods to gain systematic insights into data-driven power curve *** its core,we propose a metric to quantify how well a learned model strategy aligns with the underlying physical principles of the *** novel tool enables model validation beyond the conventional error metrics in an automated *** demonstrate,for instance,its capacity as an indicator for model generalization even when limited data is ***,it facilitates understanding how decisions made during the machine learning development process,such as data selection,pre-processing,or training parameters,affect learned *** a result,we obtain physically more reasonable models,a prerequisite not only for robustness but also for meaningful insights into turbine operation by domain *** latter,we illustrate in the context of wind turbine performance *** summary,the framework aims to guide researchers and practitioners alike toward a more informed selection and utilization of data-driven wind turbine power curve models.

关键词： Explainable AI(XAI) machine learning Wind energy Wind turbine power curve SCADA Condition monitoring

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Heart failure with preserved ejection fraction and the first law of thermodynamics

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World Journal of Cardiology 2024年第10期16卷 608-610页

作者： robert m Peters Department of Cardiology Zucker School of MedicineHemsteadNY 11549United States

In heart failure with preserved ejection fraction,significant left ventricular diastolic abnormalities are present,despite a normal systolic ejection *** article will consider whether this is consistent with the law o... 详细信息

关键词： Diastolic dysfunction Heart failure with preserved ejection fraction Thermodynamics

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A detailed rock density model of the Hong Kong territories

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Geodesy and Geodynamics 2024年第1期15卷 75-81页

作者： Albertini Nsiah Ababio robert Tenzer Department of Land Surveying and Geo-Informatics Hong Kong Polytechnic UniversityHong KongChina

We used the geological map and published rock density measurements to compile the digital rock density model for the Hong Kong *** then estimated the average density for the whole *** to our result,the rock density values in Hong Kong vary from 2101 to 2681 kg·m^(-3).These density values are typically smaller than the average density of 2670 kg·m^(-3),often adopted to represent the average density of the upper continental crust in physical geodesy and gravimetric geophysics *** finding reflects that the geological configuration in Hong Kong is mainly formed by light volcanic formations and lava flows with overlying sedimentary deposits at many locations,while the percentage of heavier metamorphic rocks is very low(less than 1%).This product will improve the accuracy of a detailed geoid model and orthometric heights.

关键词： Density model Rock types Gravimetric modeling Hong Kong

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Epidemiology of insertional and midportion Achilles tendinopathy in runners:A prospective cohort study

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Journal of Sport and Health Science 2024年第2期13卷 256-263页

作者： Wenbo Chen Kyra L.A.Cloosterman Sita m.A.Bierma-Zeinstra marienke van middelkoop robert-Jan de Vos Department of Orthopaedic Surgery and Sports medicine Erasmus MC University Medical CenterRotterdam 3015GDthe Netherlands Department of General Practice Erasmus MC University Medical CenterRotterdam 3015GDthe Netherlands Department of Sports medicine Huashan HospitalFudan UniversityShanghai 200040China

Background:Achilles tendinopathy(AT)is a common problem among *** is only limited evidence for risk factors for AT,and most studies have not defined the AT *** study has compared the incidence and risk factors between insertional AT and midportion AT,though they are considered *** study aimed to assess incidence and risk factors of AT based on data from a large prospective *** secondary aim was to explore differences in risk factors between insertional and midportion ***:Participants were recruited from among registered runners at registration for running *** were completed at baseline,1 month before the event,1 week before the event,and 1 month after the *** concerning demographics,training load,registered events,and running-related injuries were collected at *** follow-up questionnaires collected information about new injuries.A pain map was used to diagnose midportion and insertional *** primary outcome was the incidence of *** logistic regression analysis was applied to identify risk factors for the ***:We included 3379 participants with a mean follow-up of 20.4 *** incidence of AT was 4.2%.The proportion of insertional AT was 27.7%and of midportion AT was 63.8%;the remaining proportion was a combined type of insertional and midportion *** had a significantly higher incidence(5%,95%confidence interval(95%CI):4.1%-6.0%)than women(2.8%,95%CI:2.0%-3.8%).AT in the past12 months was the most predominant risk factor for new-onset AT(odds ratio(OR)=6.47,95%CI:4.27-9.81).This was similar for both subcategories of AT(insertional:OR=5.45,95%CI:2.51-11.81;midportion:OR=6.96,95%CI:4.24-11.40).Participants registering for an event with a distance of 10/10.55 km were less likely to develop a new-onset AT(OR=0.59,95%CI:0.36-0.97)or midportion AT(OR=0.47,95%CI:0.23-0.93).Higher age had a significant negative association with insertional AT(OR=0.97,95%CI:0.9

关键词： Achilles tendon injury Incidence Risk factor Running-related injury

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Excess dietary Lys reduces feed intake, stimulates jejunal CCK secretion and alters essential and non‑essential blood AA profile in pigs

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1336-1346页

作者： maximiliano muller Elout Van Liefferinge Alan Tilbrook robert van Barneveld Eugeni Roura Centre for Nutrition and Food Sciences Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandBrisbaneQueensland 4072Australia Laboratory of Animal Nutrition and Animal Product Quality(LANUPRO) Department of Animal Sciences and Aquatic EcologyGhent University339000 GhentFlandersBelgium Centre for Animal Science Queensland Alliance for Agriculture and Food Innovation and the School of Veterinary ScienceThe University of QueenslandBrisbaneQueensland 4072Australia SunPork Group BrisbaneQueensland 4009Australia

Background Commercial diets are frequently formulated to meet or exceed nutrient levels including those of lim-iting essential amino acids(AA)covering potential individual variations within the ***,the provision of dietary excess of AA,such as Lys,may lead to reduced appetite and growth in *** mechanisms modulat-ing these responses have not been extensively *** study evaluated the effect of Lys dietary excesses on performance and satiety biomarkers in post weaning *** Twenty-four pigs aged 21 d and weighing 6.81±0.12kg(mean±SEm)were individually housed and offered 1 of 4 dietary treatments for 3weeks:a diet containing a standardized ileal digestible Lys reaching 100%(T0),120%(T1),150%(T2)or 200%(T3)of the NRC(2012)*** the end of the experiment,blood samples from the cephalic vein of the T0 and T3 groups were obtained for AA *** addition,primary intestinal cultures from T0 pigs were used,following their humane killing,to evaluate the effect of Lys on gut hormone secretion and AA sensors gene expression under ex vivo *** Feed intake was linearly reduced(Pmetabotropic glutamate receptor 1 and the solute carrier family 7 member 2(Pmal jejunum tissues incubated with Lys at 20mmol/L when compared to the control(Lys 0mmol/L).Plasma Lys and Glu(Pmpared to T0 *** contrast,plasma levels of His,Val,Thr,Leu(Pm that excess dietary Lys inhibits hunger in ***,the results provide evidence of pre-and post-absorptive mechanisms modulating these *** dietary excesses should be nar-rowed,when possible,to avoid negative effects of

关键词： Amino acid Blood Cholecystokinin Feed intake Lysine Pig Satiety

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Deciding on life-saving treatment after a violent suicide attempt:an ethical case report

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General Psychiatry 2024年第2期37卷 289-291页

作者： robert Wichers Hanna m Heller Sisco van Veen Department of Child and Adolescent Psychiatry&Psychosocial Care Amsterdam University Medical CenterLocation AMCAmsterdamThe Netherlands Amsterdam Public Health Mental Health programAmsterdamThe Netherlands Department of Hospital Psychiatry Amsterdam University Medical CenterLocation VUmcAmsterdamThe Netherlands Research Department 113 Suicide PreventionAmsterdamThe Netherlands Department of Psychiatry&Department of Ethics Law and HumanitiesAmsterdam University Medical CenterAmsterdamThe Netherlands GGZ inGeest mental Health Care AmsterdamThe Netherlands

To the editor:In the USA alone,there were 1.7 million suicide attempts in 2021.1 Although the majority of suicide attempts are not fatal,immediate medical attention is often necessary,especially when violent methods are used.2 These methods include jumping from heights,using a firearm,crashing a motor vehicle,and lying down or jumping in front of a moving object.

关键词： treatment editor alone

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NeuroPNm:model reduction of pore network models using neural networks

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Particuology 2024年第3期86卷 239-251页

作者： robert Jendersie Ali mjalled Xiang Lu Lucas Reineking Abdolreza Kharaghani martin monnigmann Christian Lessig Otto-von-Guericke-Universitat magdeburg Universitatsplatz 2Magdeburg39106Germany Ruhr-Universitat-Bochum Universitatstraβe 150Bochum44801Germany

Reacting particle systems play an important role in many industrial applications,for example biomass drying or the manufacturing of *** numerical modeling and simulation of such systems is therefore of great importance for an efficient,reliable,and environmentally sustainable operation of the *** complex thermodynamical,chemical,and flow processes that take place in the particles are a particular challenge in a ***,typically a large number of particles is involved,rendering an explicit treatment of individual ones impossible in a reactor-level *** approach for overcoming this challenge is to compute effective,physical parameters from single-particle,high-resolution *** can be combined with model reduction methods if the dynamical behaviour of particles must be *** network models with their unrivaled resolution have thereby been used successfully as high-resolution models,for instance to obtain the macroscopic diffusion coeffcient of *** parameter identification and model reduction have recently gained new impetus by the dramatic progress made in machine learning in the last *** report results on the use of neural networks for parameter identification and model reduction based on three-dimensional pore network models(PNm).We believe that our results provide a powerful complement to existing methodologies for reactor-level simulations with many thermally-thick particles.

关键词： Porenetwork models Neural networks Parameter estimation Reduced order model

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Potential of contemporary earth-sheltered buildings to achieve Plus Energy status in various European climates during the heating season

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Building Simulation 2024年第1期17卷 41-52页

作者： Aleksandar Nesovic Nebojsa Jurisevic robert Kowalik lvana Terzic Faculty of Engineering University of KragujevacSestre Janjic 634000 KragujevacSerbia Faculty of Environmental Geomatic and Energy EngineeringKielce University of TechnologyTysigclecia Panstwa Polskiego725-314 KielcePoland

This study investigates the potential of contemporary Earth-Sheltered Buildings to contribute to sustainable societies by achieving Plus Energy Building status during the heating *** buildings analyzed are intended to house a four-member family(102.5 m^(2)).The house is equipped with a ground source heat pump,geothermal vertical probes,floor heating panels,an energy recovery ventilator,and building-integrated photovoltaic panels installed on the exposed building *** numerical analysis(using EnergyPlus software)was carried out for nine European sites covering five different climatic zones(namely:southern,Atlantic,continental,alpine,and northern climate)and three latitude belts spanning Europe from south to *** above 65°N(northern and alpine climate)could not achieve Plus Energy status with 20% efficient *** 15% efficient BIPVs,the building above 59°N(northern climate)was incapable of achieving this as *** the monthly time step,the buildings in the southern and Atlantic climates with 15% efficient BiPVs were able to produce an energy surplus every month,as was the building in theAlps with 20% efficientBIPVs.

关键词： civil engineering earth-sheltered buildings renewable energy sustainable societies Plus Energy Buildings Energy Plus software

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