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Integrins and their potential roles in mammalian pregnancy

Journal of Animal Science and Biotechnology 2024年第1期15卷 1-19页

作者： Gregory A.Johnson robert C.Burghardt Fuller W.Bazer Heewon Seo Joe W.Cain Department of Veterinary Integrative Biosciences School of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843‑4459USA Department of Animal Science College of Agriculture and Life SciencesTexas A&M UniversityCollege StationTX 77843‑2471USA

Integrins are a highly complex family of receptors that, when expressed on the surface of cells, can mediate reciprocal cell-to-cell and cell-to-extracellular matrix(ECm) interactions leading to assembly of integrin adhesion complexes(IACs) that initiate many signaling functions both at the membrane and deeper within the cytoplasm to coordinate processes including cell adhesion, migration, proliferation, survival, differentiation, and metabolism. All metazoan organisms possess integrins, and it is generally agreed that integrins were associated with the evolution of multicellularity, being essential for the association of cells with their neighbors and surroundings, during embryonic development and many aspects of cellular and molecular biology. Integrins have important roles in many aspects of embryonic development, normal physiology, and disease processes with a multitude of functions discovered and elucidated for integrins that directly influence many areas of biology and medicine, including mammalian pregnancy, in particular implantation of the blastocyst to the uterine wall, subsequent placentation and conceptus(embryo/fetus and associated placental membranes) development. This review provides a succinct overview of integrin structure, ligand binding, and signaling followed with a concise overview of embryonic development, implantation, and early placentation in pigs, sheep, humans, and mice as an example for rodents. A brief timeline of the initial localization of integrin subunits to the uterine luminal epithelium(LE) and conceptus trophoblast is then presented, followed by sequential summaries of integrin expression and function during gestation in pigs, sheep, humans, and rodents. As appropriate for this journal, summaries of integrin expression and function during gestation in pigs and sheep are in depth, whereas summaries for humans and rodents are brief. Because similar models to those illustrated in Fig. 1, 2, 3, 4, 5 and 6 are present throughout the sc

关键词： Humans Implantation Integrins Pigs Pregnancy Rodents Sheep

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Storylines of family medicine Ⅳ:perspectives on practice—lenses of appreciation

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Family medicine and Community Health 2024年第S3期12卷 33-42页

作者： William B Ventres Leslie A Stone Radeeb Akhtar Jeffrey m Ring Lucy m Candib Erick messias Ronald m Epstein marc Tunzi Amy L Lee Christopher P morley Carina m Brown David Slawson Jill Konkin David G Campbell Ian Couper Susan Williams robert Brooks Lucie Walters Family and Preventive medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family medicine and Community Health Icahn School of Medicine at Mount SinaiNew YorkNew YorkUSA Independent Health Psychologist Los AngelesCaliforniaUSA Family medicine and Community Health UMass Chan Medical SchoolWorcesterMassachusettsUSA Psychiatry and Behavioral Neurosciences Saint Louis University School of MedicineSaint LouisMissouriUSA Family medicine University of Rochester Medical CenterRochesterNew YorkUSA Family medicine Residency Program Natividad Medical CenterSalinasCaliforniaUSA Family medicine Tufts University School of MedicineBostonMassachusettsUSA Public Health and Preventive medicine SUNY Upstate Medical UniversitySyracuseNew YorkUSA Cone Health Family medicine Residency The University of North Carolina School of MedicineGreensboroNorth CarolinaUSA Family medicine Atrium HealthCharlotteNorth CarolinaUSA Family medicine University of Alberta Faculty of Medicine&DentistryEdmontonAlbertaCanada Cunninghame Arm medical Centre Australian College of Rural and Remote MedicineLakes EntranceQueenslandAustralia Ukwanda Centre for Rural Health Stellenbosch University Faculty of Medicine and Health SciencesCape TownWestern CapeSouth Africa Adelaide Rural Clinical School The University of AdelaideAdelaideSouth AustraliaAustralia Department of Rural Health Broken Hill UniversityBroken HillNew South WalesAustralia Adelaide Rural Clinical School The University of Adelaide Faculty of Health and Medical SciencesMount GambierSouth AustraliaAustralia

Storylines of Family medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅳ:perspectives on practice—lenses of appreciation’,authors address the following themes:‘Relational connections in the doctor–patient partnership’,‘Feminism and family medicine’,‘Positive family medicine’,‘mindful practice’,‘The new,old ethics of family medicine’,‘Public health,prevention and populations’,‘Information mastery in family medicine’and‘Clinical courage.’may readers nurture their curiosity through these essays.

关键词： thematic illustration doctor

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Determination of Physical, mechanical and Fire Retardancy Properties of Innovative Particleboard made from Corn Stalk (Zea mays L.) Particles

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Journal of Renewable materials 2024年第10期12卷 1729-1756页

作者： Lilik Astari Benoit Belleville Kenji Umemura Alex Filkov Barbara Ozarska robert H.Crawford School of Agriculture Food and Ecosystem SciencesThe University of MelbourneMelbourne3121Australia Research Center for Biomass and Bioproducts National Research and Innovation AgencyBogor16911Indonesia Research Institute of Sustainable Humanosphere Kyoto UniversityKyoto611-0011Japan School of Agriculture Food and Ecosystem SciencesThe University of MelbourneCreswick3363Australia Faculty of Architecture Building and PlanningThe University of MelbourneMelbourne3010Australia

The demand for particleboard is increasing along with economic and population ***,two major barriers to the manufacture of particleboard are a shortage of raw materials(woodchips)and the emission of formaldehyde from conventional *** by-products such as corn stalks contain an abundance of renewable lignocellulosic *** study evaluates the effect of citric acid as a natural adhesive and fire retardant addition on the physical,mechanical,and fire retardancy properties of particleboards fabricated from corn stalks.A cost-effective and inorganic salt,calcium carbonate,was tested to enhance the fire *** dihydrogen phosphate was also considered as a comparative *** with the addition of calcium carbonate was pretreated with sodium *** particleboards were pressed for 10 min at 200℃.Japanese Industrial Standard JIS A 5908:2022 was used as the benchmark for the physical and mechanical *** retardancy was dynamically tested by simulating a Bushfire Attack Level of 19 kW/m^(2).The particleboard with 25 wt%citric acid had superior mechanical properties and complied with the JIS A 5908 standard for Type 13 base par*** with the addition of calcium carbonate(5%and 10%)showed significantly delayed pyrolysis time.

关键词： Particleboard corn stalk ﬁre retardancy citric acid mechanical properties

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Data-driven analysis of chemicals,proteins and pathways associated with peanut allergy:from molecular networking to biological interpretation

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Food Science and Human Wellness 2024年第3期13卷 1322-1335页

作者： Emmanuel Kemmler Julian Braun Florent Fauchère Sabine Dölle-Bierke Kirsten Beyer robert Preissner margitta Worm Priyanka Banerjee Institute for Physiology Charité-University Medicine BerlinBerlin 10115Germany member of the KFO339 FOOD@Berlin 10115Germany Si-m/“Der Simulierte mensch”a science framework of Technische Universität Berlin and Charité-Universitätsmedizin Berlin Berlin 10115Germany Charité-Universitätsmedizin Berlin corporate member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlin 10115Germany Division of Allergy and Immunology Department of DermatologyVenerology and AllergyCharité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt-Universität zu BerlinBerlin 10115Germany Pediatrics Campus VirchowCharité-University Medicine BerlinBerlin 10115Germany

Peanut allergy is majorly related to severe food induced allergic *** food including cow's milk,hen's eggs,soy,wheat,peanuts,tree nuts(walnuts,hazelnuts,almonds,cashews,pecans and pistachios),fish and shellfish are responsible for more than 90%of food ***,we provide promising insights using a large-scale data-driven analysis,comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts,tree nuts(walnuts,almonds,cashews,pecans and pistachios)and ***,we have analysed the chemical compositions of peanuts in different processed form raw,boiled and *** the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors(PPARs)and its isoform and their interaction with dietary lipids may have significant effect on allergic *** results obtained from this study will direct future experimeantal and clinical studies to understand the role of dietary lipids and PPARisoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.

关键词： Allergy informatics Knowledge-graph Data analysis Food allergy Peroxisome proliferator-activated receptors Fatty acids

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Evaluating for unrecognized deficits in perimetry associated with functional upper eyelid malposition

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Advances in Ophthalmology Practice and Research 2024年第1期4卷 39-44页

作者： Linyan Wang Davin C.Ashraf michael Deiner Oluwatobi O.Idowu Seanna R.Grob Bryan J.Winn m Reza Vagefi robert C.Kersten Department of Ophthalmology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of Ophthalmology University of CaliforniaSan FranciscoUSA Department of Ophthalmology Oregon Health and Science UniversityPortlandUSA Department of Ophthalmology Tufts Medical CenterBostonUSA Department of Ophthalmology University of UtahSalt Lake CityUtahUSA

Objective:To investigate whether functional upper eyelid malposition is associated with unrecognized deficits in automated perimetry among glaucoma patients by examining patients undergoing eyelid surgery who had not been identified as requiring eyelid taping during glaucoma field ***:In this retrospective pre-post study,an automated database search followed by manual chart review was used to identify eligible patients from January 2012 to march *** patients had reliable visual field testing within two years before and after functional upper blepharoplasty or ptosis repair and no comorbid ocular *** part of routine practice,glaucoma visual field technicians taped patients with pupil-obstructing eyelid malposition;taped examinations were excluded from *** and demographic characteristics,mean deviation,and pattern standard deviation were evaluated within a two year period before and after eyelid ***:The final analysis included 60 eyes of 38 *** in visual field parameters after eyelid surgery did not reach statistical significance in crude or adjusted *** patients with ptosis,the margin reflex distance-1 was not associated with change in mean deviation after surgery(Pearson R2=0.0061;P=0.700).Five of 17 eyes excluded from analysis due to unreliable pre-operative visual fields demonstrated substantial improvement after ***:Functional upper eyelid malposition does not appear to cause spurious visual field abnormalities among glaucoma patients with reliable visual fields who were determined not to require eyelid taping at the time of their visual *** visual fields could be a sign of eyelid interference in this population.

关键词： Visual field Ptosis Dermatochalasis Glaucoma Perimetry Visually significant

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Determinants of COVID-19 Face mask Litter in Coastal Urban Parking Lots: Implications for Source modelling of Potential microplastic Pollution

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Journal of Environmental Protection 2024年第8期15卷 874-886页

作者： robert France Brandon Heung Department of Plant Food and Environmental Science Dalhousie University Nova Scotia Canada

Despite cities being recognized as being potential sources of microplastic pollution to the wider environment, most surveys of COVID-19 plastic-based litter have been undertaken through linear transects of marine beaches. For the far fewer number of studies conducted on inland and urban locations, the site-specific focus has primarily been surveys along the length of streets. The present study is the first to specifically assess the standing stock (i.e., moment-in-time) of littered face masks for the entire surface area of urban parking lots. The density of face masks in 50 parking lots in a Canadian coastal town (0.00054 m2 ± 0.00051 m2) was found to be significantly greater than the background level of littering of town streets. Face mask density was significantly related to visitation “usage” of parking lots as gauged by the areal size of the lots and of their onsite buildings, as well as the number of vehicles present. Neither parking lot typology nor estimates of inferred export (various measures of wind exposure) and entrapment (various metrics of obstruction) of face masks had a significant influence on the extent of whole-lot littering. In consequence, modelling of the potential input of mask-derived microplastics to the marine environment from coastal communities can use the areal density of face masks found here in association with the total surface area of lots for individual municipalities as determined through GIS analysis.

关键词： COVID Face masks Parking Lot Litter Prediction Areal Abundance

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Storylines of family medicine Ⅻ:family medicine and the healthcare system

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Family medicine and Community Health 2024年第S3期12卷 109-118页

作者： William B Ventres Leslie A Stone Jeannette E South-Paul Kendall m Campbell Aerial R Petty Hima Ekanadham Kurt C Stange Rebecca S Etz William L miller robert L Ferrer marianna Kong Thomas Bodenheimer Roger Strasser Sharon C m Reece Joshua Freeman John m Westfall Family and Preventive medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA meharry medical College NashvilleTennesseeUSA Family medicine University of Texas Medical Branch at Galveston School of MedicineGalvestonTexasUSA Family medicine Residency Program New York-Presbyterian Columbia University Medical CenterNew YorkNew YorkUSA Center for Family and Community medicine Columbia University Vagelos College of Physicians and SurgeonsNew YorkNew YorkUSA Center for Community Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA Family medicine and Population Health Virginia Commonwealth University School of MedicineRichmondVirginiaUSA Family medicine Lehigh Valley Health NetworkAllentownPennsylvaniaUSA University of South Florida morsani College of medicine TampaFloridaUSA Family and Community medicine UT Health San Antonio Long School of MedicineSan AntonioTexasUSA Family and Community medicine University of California San Francisco School of MedicineSan FranciscoCaliforniaUSA Northern Ontario School of medicine University SudburyOntarioCanada Family medicine Baylor Scott and White HealthTempleTexasUSA Family medicine University of Kansas School of MedicineKansas CityKansasUSA DARTNet Insitute AuroraColoradoUSA

Storylines of Family medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅻ:Family medicine and the future of the healthcare system’,authors address the following themes:‘Leadership in family medicine’,‘Becoming an academic family physician’,‘Advocare—our call to act’,‘The paradox of primary care and three simple rules’,‘The quadruple aim—melding the patient and the health system’,‘Fit-for-purpose medical workforce’,‘Universal healthcare—coverage for all’,‘The futures of family medicine’and‘The 100th essay.’may readers of these essays feel empowered to be part of family medicine’s exciting future.

关键词： system illustration family

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Storylines of family medicine Ⅱ:foundational building blocks—context,community and health

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Family medicine and Community Health 2024年第S3期12卷 12-22页

作者： William B Ventres Leslie A Stone Rupal Shah Tamala Carter Geoffrey m Gusoff Winston Liaw Bich-may Nguyen Joanna V Rachelson mary Alice Scott Teresa L Schiff-Elfalan Seiji Yamada robert C Like Kathleen Zoppi A Peter Catinella Richard m Frankel Shailendra Prasad Family and Preventive medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Bridge Lane Group Practice LondonUK Penn Center for Community Health Workers University of PennsylvaniaPhiladelphiaPennsylvaniaUSA National Clinician Scholars Program UCLA David Geffen School of MedicineLos AngelesCaliforniaUSA Health Systems and Population Health Sciences University of Houston Tilman J Fertitta Family College of MedicineHoustonTexasUSA Southern New mexico Family medicine Residency Program Las CrucesNew MexicoUSA New mexico Primary Care Training Program Silver CityNew MexicoUSA Anthropology New Mexico State UniversityLas CrucesNew MexicoUSA Family medicine and Community Health University of Hawai'i at Manoa John A Burns School of MedicineHonoluluHawaiiUSA Family medicine and Community Health Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNew JerseyUSA Family medicine Indiana University School of MedicineIndianapolisIndianaUSA Family medicine–Transmountain Texas Tech University Health Sciences CenterEl PasoTexasUSA medicine Indiana University School of MedicineIndianapolisIndianaUSA Family medicine and Community Health University of Minnesota Medical School-Twin Cities CampusMinneapolisMinnesotaUSA

Storylines of Family medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅱ:foundational building blocks—context,community and health’,authors address the following themes:‘Context—grounding family medicine in time,place and being’,‘Recentring community’,‘Community-oriented primary care’,‘Embeddedness in practice’,‘The meaning of health’,‘Disease,illness and sickness—core concepts’,‘The biopsychosocial model’,‘The biopsychosocial approach’and‘Family medicine as social medicine.’may readers grasp new implications for medical education and practice in these essays.

关键词： thematic illustration dimensions

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Protocol for the development and validation of a clinical measurement tool for fear of disease progression and recurrence in cardiac patients

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Chronic Diseases and Translational medicine 2024年第3期10卷 195-204页

作者： Sarah T.Clarke michael Le Grande Barbara m.murphy robert Hester Alun C.Jackson melbourne School of Psychological Sciences University of MelbourneParkvilleVictoriaAustralia Australian Centre for Heart Health MelbourneVictoriaAustralia Centre on Behavioral Health University of Hong KongPokfulamHong KongChina

Introduction: One in two cardiac patients fear having another heart event or their heart condition getting worse. Research in other chronic illnesses demonstrates that screening for fear of progression and recurrence is vital for adequately addressing such concerns in clinical care. The current project aims to develop and validate a measure for fear of progression and recurrence in cardiac ***: The Fear of Cardiac Recurrence and Progression Scale (FCRP) will be developed through a multistep process. An initial item pool will be generated through a review of the literature and existing measures and consultation with and feedback from key informants. The item pool will be tested in a sample of over 250 adults who have ever had an acute coronary event, undergone cardiac surgery, or a chronic cardiac condition. Exploratory factor analysis will be used to identify the underlying factors, and Rasch analysis will be used to reduce the number of items. A short form version of the FCRP will be developed for use as a brief screening tool, informed by clinical relevance and Rasch psychometric ***: While many cardiac patients experience fears related to the progression or recurrence of their illness, there remains the need for a validated tool with which these concerns can be identified and measured. It is expected that the design and validation of the FCRP will aid identification of cardiac patients suffering from clinically significant levels of fear of progression and recurrence and facilitate the design of tailored psychological interventions to target these fears.

关键词： anxiety cardiac anxiety cardiac recovery cardiac rehabilitation depression fear of progression fear of recurrence psychological measurement psychosocial screening

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High-Intensity Focused Ultrasound-Induced Disulfide mechanophore Activation in Polymeric Nanostructures for molecule Release

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CCS Chemistry 2024年第8期6卷 1895-1907页

作者： Jilin Fan Kuan Zhang mingjun Xuan Xiang Gao Rostislav Vinokur robert Göstl Lifei Zheng Andreas Herrmann DWI—Leibniz Institute for Interactive materials 52056 Aachen Institute of Technical and macromolecular Chemistry RWTH Aachen University52074 Aachen Wenzhou Institute University of Chinese Academy of Sciences325001 Wenzhou

Ultrasound(US)activation of mechanophores in polymers that initiates cascade chemical reactions is a promising strategy for on-demand molecule ***,the typical US frequency used for mechanochemistry is around 20 kHz,producing inertial cavitation that exceeds the tolerance threshold of biological ***,high-intensity focused US(HIFU)as a mechanical stimulus is introduced to drive the activation of disulfide mechanophores in hyperbranched star polymers(HBSPs)and microgels(mGLs).The mechanism of molecular release is attributed to the thiol-disulfide exchange reaction and subsequent intramolecular *** reveal that HBSPs and mGLs effectively transduce HIFU as mechanical input to chemical output,demonstrated by the quantification of the release of fluorescent umbelliferone(UmB).moreover,an in vitro study of drug release is carried out using camptothecin as the model drug,which is covalently loaded in mGLs,demonstrating the potential of our system for controlled drug delivery to cancer cells.

关键词： mechanophores polymer mechanochemistry polymeric nanostructures ultrasound drug release sonopharmacology

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