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Outcomes of central hepatectomy versus extended hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2019年第3期18卷 249-254页

作者： Jenny Chan Luke Bradshaw Nezor Houli Laurence Weinberg Marcos V Perini Michael Fink Vijayaragavan Muralidharan Graham Starkey robert jones Bao Zhong Wang Christopher Christophi Mehrdad Nikfarjam Department of Surgery University of Melbourne Austin Health Heidelberg Melbourne Victoria Australia Department of Surgery University of Melbourne Northern Health Epping Victoria Australia Department of Anaesthesia University of Melbourne Austin Health Heidelberg Melbourne Victoria Australia

Background: Central hepatectomy(CH) is more difficult than extended hepatectomy(EH) and is associated with greater morbidity. In this modern era of liver management with aims to prevent posthepatectomy liver failure(PHLF), there is a need to assess outcomes of CH as a parenchyma-sparing procedure for centrally located liver tumors. Methods: A total of 178 major liver resections performed by specialist surgeons from two Australian tertiary institutions between June 2009 and March 2017 were reviewed. Eleven patients had CH and 24 had EH over this study period. Indications and perioperative outcomes were compared between the groups. Results: The main indication for performing CH was colorectal liver metastases. There was no perioperative mortality in the CH group and four(16.7%) in the EH group( P = 0.285). No group differences were found in median operative time [CH vs. EH: 450 min(290–840) vs. 523 min(310–860), P = 0.328], intraoperative blood loss [850 mL(40 0–150 0) vs. 650 mL(10 0–20 0 0), P = 0.746] or patients requiring intraoperative blood transfusion [1(9.1%) vs. 7(30.4%), P = 0.227]. There was a trend towards fewer hepatectomyspecific complications in the CH group [3(27.3%) vs. 13(54.2%), P = 0.167], including PHLF(CH vs. EH: 0 vs. 29.2%, P = 0.072). Median length of stay was similar between groups [CH vs. EH: 9 days(5–23) vs. 12 days(4–85), P = 0.244]. Conclusions: CH has equivalent postoperative outcomes to EH. There is a trend towards fewer hepatectomy-specific complications, including PHLF. In appropriate patients, CH may be considered as a safe parenchyma-sparing alternative to EH.

关键词： Central hepatectomy Mesohepatectomy Central bisectionectomy Central bisegmentectomy Extended hepatectomy

Mechanisms underlying the vasoconstrictor actions of prostaglandins E

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Acta Pharmacologica Sinica 1999年第7期 90-90页

作者： robert L jones China Chinese University of Hong Kong. Shatin Department of Pharmacology

AIM: To investigate the cellular,mechanisms wherebyprostaglandin E2and other EP3-receptor agonists (eg Sulprostone )contract vascular smooth muscle. METHODS: Isometrictension was recorded from ring preparations of guinea pig *** renal artery and human intrapulmonary artery in the presenceof indomethacin 1 μmol·L-1. RESULTS: On all threeprepartions the maximal contractile response to sulprostone (EC50)=10-25 nmol·L-1) was less (40％. 7％.60％ ) than thatof U-46619 (TP agonist) or phenylephrine. Contractions werealmost abolished by removal of Ca2+from the bathing f1uid and byCd2+(500 μmol·L-1). but were usually unaffected by L-typeCa2+channel blockers and by PKC inhibitors (calphostin C.

关键词： Pr Mechanisms underlying the vasoconstrictor actions of prostaglandins E

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龙卷预报参数——螺旋度的试验结果

气象科技 1993年第1期21卷 40-45页

作者： robert Davies-jones Donald Burgess Michael Foster 李术华美国国家强风暴实验室美国国家气象局预报台

1 引言垂直风切变是预报龙卷的一个重要参数,在某些情况下与风暴运动同等重要。然而直到最近才认识到有利于中尺度气旋及相伴龙卷发展的高空风分布特征。大多数中尺度气旋（中尺度反气旋）生成于相对于风暴（s-r）的低空环境风很强(≥10... 详细信息

1 引言垂直风切变是预报龙卷的一个重要参数,在某些情况下与风暴运动同等重要。然而直到最近才认识到有利于中尺度气旋及相伴龙卷发展的高空风分布特征。大多数中尺度气旋（中尺度反气旋）生成于相对于风暴（s-r）的低空环境风很强(≥10ms-1)

关键词：龙卷预报参数螺旋度试验

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如何给人留下积极的第一印象

科技英语学习 2009年第5期 31-35页

作者： robert jones 张成伟

从演讲家那儿学习出场和闲聊的艺术，即使你自认为你不行，这些专家发誓说你可以。

关键词：第一印象闲聊自信语言艺术

A Polymer Coated Cicaprost-Eluting Stent Increases Neointima Formation and Impairs Vessel Function in the Rabbit Iliac Artery

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Pharmacology & Pharmacy 2016年第6期7卷 226-235页

作者： Christopher McCormick robert L. jones Roger M. Wadsworth Alexander B. Mullen Simon Kennedy Biomedical Engineering Department University of Strathclyde Glasgow UK Strathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyde Glasgow UK Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UK

Drug-eluting stents have been successful in reducing in-stent restenosis but are not suitable for all lesion types and have been implicated in causing late stent thrombosis due to incomplete regeneration of the endothelial cell layer. In this study we implanted stents coated with cicaprost, a prostacyclin analogue with a long plasma half-life and antiproliferative effects on vascular smooth muscle cells, into the iliac arteries of rabbits. At 28-day follow-up we compared neointima formation within the stented vessels and vascular function in adjacent vessels, to assess if cicaprost could reduce restenosis without impairing vessel function. Arteries implanted with cicaprost eluting stents had significantly more neointima compared to bare metal stents. In adjacent segments of artery, endothelium-dependent relaxation was impaired by the cicaprost-eluting stent but vasodilation to an endothelium-independent vasodilator was maintained. We conclude that the presence of the polymer and sub-optimal release of cicaprost from the stent may be responsible for the increased neointma and impaired functional recovery of the endothelium observed. Further experiments should be aimed at optimising release of cicaprost and exploring different stent polymer coatings.

关键词： Cicaprost Neointima Iliac Artery Endothelium Drug-Eluting Stent

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空间站推进:路易斯研究中心的高级研制计划

控制工程 1986年第3期 77-82页

作者： robert E.jones 张舜英

空间站付诸实际使用之前,必须解决很多技术问题。已经确认了一个用于初期工作能力(IOC)空间站的标准结构。这个标准结构将采用肼推力器作为推进系统。这个高级研制计划是发展空间站总体计划的一个组成部分。这个计划的目的是要为最初的... 详细信息

空间站付诸实际使用之前,必须解决很多技术问题。已经确认了一个用于初期工作能力(IOC)空间站的标准结构。这个标准结构将采用肼推力器作为推进系统。这个高级研制计划是发展空间站总体计划的一个组成部分。这个计划的目的是要为最初的空间站和发展后的空间站提供先进的技术方案,该方案在性能、成本及实用性方面将为系统提供最优的功能特性。本文介绍该研制计划中的辅助推进系统。

关键词：空间站收集器航天站推进剂推力器推进系统研制计划路易斯

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动物权利是社会正义问题——对动物的压迫

牡丹 2018年第21期 78-80页

作者：张学嵘 robert C jones 天津外国语大学欧美哲学研究所

与其他社会正义运动一样,当代动物解放运动的重点是消除制度和系统的统治与压迫。笔者认为,那些致力于社会正义——减少暴力、剥削、统治、客观化和压迫的人,同样有义务考虑所有有感知生物的利益,而不仅仅是人类的利益。一、正义、统治... 详细信息

与其他社会正义运动一样,当代动物解放运动的重点是消除制度和系统的统治与压迫。笔者认为,那些致力于社会正义——减少暴力、剥削、统治、客观化和压迫的人,同样有义务考虑所有有感知生物的利益,而不仅仅是人类的利益。一、正义、统治和压迫公平地说,在很大程度上,动物伦理学家本质上所做的就是建议人们不要不公正地行事。然而,当

关键词：动物权利物种主义种族主义社会正义优势物种

Epidemiology and outcomes of acute liver failure in Australia

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World Journal of Hepatology 2019年第7期11卷 586-595页

作者： Penelope Hey Timothy P Hanrahan Marie Sinclair Adam G Testro Peter W Angus Adam Peterson Stephen Warrillow Rinaldo Bellomo Marcos V Perini Graham Starkey robert M jones Michael Fink Tess McClure Paul Gow Liver Transplant Unit Austin HealthHeidelberg 3084Australia The University of Melbourne Melbourne 3052Australia Department of Intensive Care Austin HeathMelbourne 3084Australia Department of Surgery Austin HealthMelbourne 3084Australia

BACKGROUND Acute liver failure (ALF) is a life-threatening syndrome with varying aetiologies requiring complex care and multidisciplinary management. Its changing incidence, aetiology and outcomes over the last 16 years in the Australian context remain uncertain. AIM To describe the changing incidence, aetiology and outcomes of ALF in South Eastern Australia. METHODS The database of the Victorian Liver Transplant Unit was interrogated to identify all cases of ALF in adults (> 16 years) in adults hospitalised between January 2002 and December 2017. Overall, 169 patients meeting criteria for ALF were identified. Demographics, aetiology of ALF, rates of transplantation and outcomes were collected for all patients. Transplant free survival and overall survival (OS) were assessed based on survival to discharge from hospital. Results were compared to data from a historical cohort from the same unit from 1988- 2001. RESULTS Paracetamol was the most common aetiology of acute liver failure, accounting for 50% of cases, with an increased incidence compared with the historical cohort (P = 0.046). Viral hepatitis and non-paracetamol drug or toxin induced liver injury accounted for 15% and 10% of cases respectively. Transplant free survival (TFS) improved significantly compared to the historical cohort (52% vs 38%, P = 0.032). TFS was highest in paracetamol toxicity with spontaneous recovery in 72% of cases compared to 31% of non-paracetamol ALF (P < 0.001). Fifty-nine patients were waitlisted for emergency liver transplantation. Nine of these died while waiting for an organ to become available. Forty-two patients (25%) underwent emergency liver transplantation with a 1, 3 and 5 year survival of 81%, 78% and 72% respectively. CONCLUSION Paracetamol toxicity is the most common aetiology of ALF in South-Eastern Australia with a rising incidence over 30 years. TFS has improved, however it remains low in non-paracetamol ALF.

关键词： Liver failure Acute Paracetamol Australia Victoria Liver transplant

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提高低热值燃料发电效率的设计创新

通用机械 2012年第4期 24-27页

作者： robert M.jones Joel Hall GE能源集团

发电项目中使用的工业废气被认为是低热值的燃料,难以高效地转化为电能。GE废热发电技术,使用新型高效的燃机发电方式取代锅炉发电,在武汉钢铁公司,并将在鞍山钢铁公司和邯郸钢铁公司得以应用,将高炉煤气转化为清洁能源。这一技术克服... 详细信息

发电项目中使用的工业废气被认为是低热值的燃料,难以高效地转化为电能。GE废热发电技术,使用新型高效的燃机发电方式取代锅炉发电,在武汉钢铁公司,并将在鞍山钢铁公司和邯郸钢铁公司得以应用,将高炉煤气转化为清洁能源。这一技术克服了传统难题,将废气进行压缩,使其能够驱动重型燃气轮机。

关键词：燃气轮机循环发电余热回收压缩机低热值