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现代生物医学进展 2017年第6期17卷 I0003-I0003页

作者： Itay Tirosh, Andrew S. Venteicher, Christine Hebert, Leah E. Escalante, Keren Yizhak, j.nathan M. Fisher, Christopher Rodman, Mariella G. Filbin, Cyril Neftel, j.ckson Nyman, Benj.min Izar, j.shua M. Francis, Kenneth j. Livak, Dave Gennert, Rahul Satij., Todd R. Golub, Miguel N. Rivera, Gad Getz, Orit Rozenblatt-Rosen, Bradley E. Bernstein, Aviv Regev Mario L. Suv agrave Andrew S. Venteicher, Christine Hebert, Leah E. Escalante, Keren Yizhak, Mariella G. Filbin, Cyril Neftel, Niyati Desai, Christina C. Luo, Aanand A. Patel, Maristela L. Onozato, Nicolo Riggi, Ravindra Mylvaganam, A. j.hn Iafrate, Matthew P. Frosch, Miguel N. Rivera, Gad Getz, Bradley E. Bernstein, David N. Louis Mario L. Suv agrave Andrew S. Venteicher, Anoop P. Patel, Brian V. Nahed, William T. Curry, robert L. Martuza Daniel P. Cahill Christopher Mount Michelle Monj. Mariella G. Filbin Todd R. Golub j.shua M. Francis Todd R. Golub Aviv Regev Broad Institute of Harvard and MIT Cambridge Massachusetts 02142 USA Department of Pathology and Center for Cancer Research Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Department of Neurosurgery Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Departments of Neurology Neurosurgery Pediatrics and Pathology Stanford University School of Medicine Stanford California 94305 USA Department of Pediatric Oncology Dana-Farber Cancer Institute and Children’s Hospital Cancer Center Boston Massachusetts 02215 USA Department of Medical Oncology Dana-Farber Cancer Institute Boston Massachusetts 02215 USA Howard Hughes Medical Institute Koch Institute Department of Biology MIT Cambridge Massachusetts 02139 USA

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研... 详细信息

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研究刊登于Nature杂志上。同时研究者还首次在人类脑瘤样本中鉴别出了癌症干细胞及其分化的后代细胞。

关键词：干细胞单细胞分析癌症脑瘤神经胶质瘤键角利用研究人员

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对比增强磁共振血管成像在严重颈动脉狭窄中的诊断准确性:不同影像技术的Meta回归分析

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国际医学放射学杂志 2009年第6期 596-596页

作者： j.Menke 黄莉 Department of Diagnostic Radiology University HospitalRobert-Koch-Strasse 4037075 GoettingenGermany

对比增强磁共振血管成像（CE-MRA）现在已经成为一种评价严重颈动脉狭窄的成熟的、无创的影像学方法[按北美症状性颈动脉内膜切除试验（NASCET）标准符合率达70%;9%]。然而,CE-MRA不是一个标准化的技术,它又包括了不同的共存的技术。本

关键词：对比增强颈动脉狭窄磁共振诊断准确性血管成像影像技术回归分析多元分析 Meta

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传统时间设定团注的磁共振颈动脉血管成像:临床观察及对比剂动力学傅里叶数字模型

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国际医学放射学杂志 2010年第1期 91-91页

作者： j.Menke 徐霁 Department of Diagnostic Radiology University HospitalRobert-Koch-Strasse 4037075 GoettingenGermany

本文分析时间设定团注的MR颈动脉血管成像(MRA)图像质量和对比剂动力学的关系,以傅里叶数字模型解释其结果。对100例易患颈动脉狭窄的病人用时间设定团注技术行对比剂增强的颈动脉MRA检查。颈动脉MRA开始扫描的时间设定在相对较早期,未... 详细信息

本文分析时间设定团注的MR颈动脉血管成像(MRA)图像质量和对比剂动力学的关系,以傅里叶数字模型解释其结果。对100例易患颈动脉狭窄的病人用时间设定团注技术行对比剂增强的颈动脉MRA检查。颈动脉MRA开始扫描的时间设定在相对较早期,未算入对比剂注射的时间。为便于说明,建立不同开始时

关键词：团注颈动脉时间设定对比剂血管成像傅里叶动力学

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Successful treatment of cervical esophageal leakage by endoscopic-vacuum assisted closure therapy

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World j.urnal of Gastrointestinal Endoscopy 2013年第7期5卷 340-345页

作者： Henrike Lenzen Ahmed A Negm Thomas j.Erichsen Michael P Manns j.chen Wedemeyer Tim O Lankisch Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School30625 Hannover Germany Department of Internal Medicine Robert Koch Hospital Gehrden30989 Gehrden Germany

AIM: To evaluate the efficacy and safety of endoscopic-vacuum assisted closure (E-VAC) therapy in the treatment of cervical esophageal leakage. METHODS: Between May and November 2012, three male patients who developed post-operative cervical esophageal leakage were treated with E-VAC therapy. One patient had undergone surgical excision of a pharyngo-cervical liposarcoma with partial esophageal resection, and the other two patients had received surgical treatment for symptomatic Zenker's diverticulum. Following endoscopic verification of the leakage, a trimmed polyurethane sponge was fixed to the distal end of a nasogastric silicone tube and endoscopically positioned into the wound cavity, and with decreasing cavity size the sponge was positioned intraluminally to cover the leak. Continuous suction was applied, and the vacuum drainage system was changed twice a ***: The initial E-VAC placement was technically successful for all three patients, and complete closure of the esophageal leak was achieved without any procedure-related complications. In all three patients, the insufficiencies were located either above or slightly below the upper esophageal sphincter. The median duration of the E-VAC drainage was 29 d (range: 19-49 d), with a median of seven sponge exchanges (range: 5-12 sponge exchanges). In addition, the E-VAC therapy reduced inflammatory markers to within normal range for all three patients. Two of the patients were immediately fitted with a percutaneous enteral gastric feeding tube with j.j.nal extension, and the third patient received parenteral feeding. All three patients showed normal swallow function and no evidence of stricture after completion of the E-VAC therapy. CONCLUSION: E-VAC therapy for cervical esophageal leakage was well tolerated by patients. This safe and effective procedure may significantly reduce morbidity and mortality following cervical esophageal leakage.

关键词： Endoscopic-vacuum assisted closure therapy Vacuum therapy Negative pressure wound therapy Cervical esophageal leakage Anastomotic leakage

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多层CT对急性肠缺血的诊断准确性:系统回顾和荟萃分析

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国际医学放射学杂志 2010年第5期 471-471页

作者： j.Menke 陈柱 Department of Diagnostic Radiology University HospitalRobert-Koch-Strasse 40

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Towards an open grapevine information system

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Horticulture Research 2016年第1期3卷 43-50页

作者： A-F Adam-Blondon M Alaux C Pommier D Cantu Z-M Cheng GR Cramer C Davies S Delrot L Deluc G Di Gaspero j.Grimplet A Fennell j. Londo P Kersey F Mattivi S Naithani P Neveu M Nikolski M Pezzotti BI Reisch R Töpfer MA Vivier D Ware H Quesneville URGI UR1164 INRAUniversitéParis-SaclayVersailles78026France Department of Viticulture and Enology University of CaliforniaDavis95616CAUSA Department of Plant Sciences University of TennesseeKnoxville37996TNUSA Department of Biochemistry and Molecular Biology University of NevadaReno89557NVUSA CSIRO Agriculture and Food Waite CampusWIC West BuildingPMB2Glen OsmondSouth Australia5064Australia Universitéde Bordeaux ISVVEGFVUMR 1287Villenave d’OrnonF-33140France Department of Botany and Plant Pathology Oregon State UniversityCorvallis97331ORUSA Istituto di Genomica Applicata Udine33100Italy Instituto de Ciencias de la Vid y del Vino(CSIC Universidad de La RiojaGobierno de La Rioja)Logroño26006Spain Plant Science Department South Dakota State UniversityBioSNTRBrookings57007SDUSA United States Department of Agriculture-Agricultural Research Service-Grape Genetics Research Unit Geneva14456NYUSA European Molecular Biology Laboratory The European Bioinformatics InstituteWellcome Trust Genome CampusHinxtonCB101SDCambridgeUK Dipartimento QualitàAlimentare e Nutrizione Centro Ricerca ed Innovazione Fondazione Edmund MachVia E.Mach 1San Michele all'Adige38010Italia UMR Mistea INRAMontpellier34060France University of Bordeaux CBiBBordeaux33000France University of Bordeaux CNRS/LaBRITalence33405France Department of Biotechnology Universitàdegli Studi di VeronaVerona37134Italy Horticulture Section School of Integrative Plant ScienceCornell UniversityGeneva14456NYUSA j.I Institute for Grapevine Breeding Geilweilerhof Siebeldingen76833Germany Department of Viticulture and Oenology Institute for Wine BiotechnologyStellenbosch UniversityStellenbosch7602MatielandSouth Africa Cold Spring Harbor Laboratory Cold Spring Harbor11724NYUSA US Department of Agriculture-Agricultural Research Service NEA Robert W.Holley Center for Agriculture and HealthCornell UniversityIthaca14853NYUSA

Viticulture,like other fields of agriculture,is currently facing important challenges that will be addressed only through sustained,dedicated and coordinated *** the methods used in biology have evolved tremendously in recent years and now involve the routine production of large data sets of varied nature,in many domains of study,including grapevine research,there is a need to improve the findability,accessibility,interoperability and reusability(FAIR-ness)of these *** the heterogeneous nature of the data produced,the transnational nature of the scientific community and the experience gained elsewhere,we have formed an open working group,in the framework of the International Grapevine Genome Program(***),to construct a coordinated federation of information systems holding grapevine data distributed around the world,providing an integrated set of interfaces supporting advanced data modeling,rich semantic integration and the next generation of data mining *** achieve this goal,it will be critical to develop,implement and adopt appropriate standards for data annotation and *** development of this system,the GrapeIS,linking genotypes to phenotypes,and scientific research to agronomical and oeneological data,should provide new insights into grape biology,and allow the development of new varieties to meet the challenges of biotic and abiotic stress,environmental change,and consumer demand.

关键词： system gained sustained

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Search for the doubly heavy baryons Ω^(0)_(bc) and E^(0)_(bc) decaying to Λ^(+)_(c)π^(-) and E^(+)_(c)π^(-)

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Chinese Physics C 2021年第9期45卷 10-21页

作者： R.Aaij.C.Abelian Beteta T.Ackernley B.Adeva M.Adinolfi H.Afshamia C.A.Aidala S.Aiola Z.Aj.ltouni S.Aka j.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelie S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer j.j.Back P.Baladron Rodriguez V.Balagura W.Baldini j.Baptista Leite R.j.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov j.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Beminghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin j.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bitadze A.Bizzeti M.Bj.rn M.P.Blago T.Blake F.Blanc S.Blusk D.Bobulska j.A.Boelhauve O.Boente Garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato j.T.Borsuk S.A.Bouchiba T.j.V.Bowcock A.Boyer C.Bozzi M j.Bradley S.Braun A.Brea Rodriguez M.Brodski j.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Bursche A.Butkevich j.S.Butter j.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Camiti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani j.Cerasoli A.j.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Baraj.s M.Chefdeville C.Chen S.Chen A.Chernov V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.E.L.Clarke M.Clemencic H.V.Cliff j.Closier j.L.Cobbledick V.Coco j.A.B.Coelho j.Cogan E.Cogneras L.Coj.cariu P.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier D.C.Craik j.Crkovska M.Cruz Torres R.Currie C.L.Da Silva E.Dall'Occo j.Dalseno C.D'Ambrosi Centro Brasileiro de Pesquisas Fisicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de j.neiro(UFRj. Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina Institute of High Energy Physics(IHEP) BeijingChina School of Physics State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijingChina University ofChinese Academy of Sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Savoie Mont Blanc CNRSIN2P3-LAPPAnnecyFrance Universite Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Universite Paris-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHE Sorbonne UniversiteParis Diderot Sorbonne Paris CiteCNRS/FN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kemphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universita degli Studi di Padova Universita e INFNPadovaPadovaItaly INFN Sezione di Pisa PisaItaly INFN Sezione di Roma La Sapienza RomaItaly INFN Sezione di Roma Tor Vergata RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and VU University Amsterdam AmsterdamNetherlands AGH-University of Science and Technology Faculty of Physics and Applied Computer ScienceKr

The first search for the doubly heavyΩ^(0)_(bc)baryon and a search for the E^(0)_(bc)baryon are performed using pp collision data collected via the LHCb experiment from 2016 to 2018 at a centre-of-mass energy of 13 TeV,corresponding to an integrated luminosity of 5.2 fb^(-1).The baryons are reconstructed via their decays to Λ^(+)_(c)π^(-)and E^(+)_(c)π^(-).No significant excess is fbund for invariant masses between 6700 and 7300 MeV/c^(2),in a rapidity range from 2.0 to 4.5 and a transverse momentum range from 2 to 20 MeV/*** limits are set on the ratio of the Ω^(0)_(bc)and E^(0)_(bc)production cross-section times the branching fraction to Λ^(+)_(c)π^(-)(E^(+)_(c)π^(-))relative to that of the Λ^(0)_(b)(E^(0)_(b))baryon,for different lifetime hypotheses,at 95%confidence *** upper limits range from 0.5 x 10^(-4)to 2.5 x 10^(-4)for theΩ^(0)_(bc)→Λ^(+)_(c)π^(-)(E^(0)_(bc)→Λ^(+)_(c)π^(-))decay,and from 1.4x 10^(-3)to 6.9 x 10^(-3)for theΩ^(0)_(bc)→E^(+)_(c)π^(-)(E^(0)_(bc)→E^(+)_(c)π^(-))decay,depending on the considered mass and lifetime of theΩ^(0)_(bc)(E^(0)_(bc))baryon.

关键词： B physics quarkonium spectroscopy heavy quark production

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放射性肝段切除术:早期肝癌的潜在性根治疗法

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国际医学放射学杂志 2018年第4期 485-485页

作者： R.j.Lewandowski A.Gabr N.Abouchaleh R.Ali A.A.Asadi R.A.Mora 朱静 Department of Radiology Section of Interventional RadiologyNorthwestern Memorial HospitalRobert H. Lurie Comprehensive Cancer Center

目的探究早期肝细胞癌(HCC)放射性肝段切除术(RS)的远期疗效。针对直径不超过5 cm的孤立性HCC且欲保留肝功能的病人,比较RS的远期疗效与根治疗法疗效是否存在差异。材料与方法回顾性纳入2003年—2016年期间的孤立性HCC病人(年龄22～96岁... 详细信息

目的探究早期肝细胞癌(HCC)放射性肝段切除术(RS)的远期疗效。针对直径不超过5 cm的孤立性HCC且欲保留肝功能的病人,比较RS的远期疗效与根治疗法疗效是否存在差异。材料与方法回顾性纳入2003年—2016年期间的孤立性HCC病人(年龄22～96岁,中位年龄71岁)。病人肿瘤大小均不超过5 cm,且进行RS(剂量为190 Gy)治疗,而未进行经皮消融治疗。排除后续接受治疗性肝移植的病人以消除影响生存的混杂因素,最终纳入70例病人。根据欧洲肝脏研究协会(EASL)与世界卫生组织(WHO)的指南,使用Kaplan Meier法评估病人经RS治疗后的进展时间和总生存期中位数。结果 70例病人经RS治疗随访长达14年以上。其中63例(90%)经EASL标准评价,有41例(59%)显示完全缓解。50例(71%)经WHO标准评价,有11例(16%)取得完全缓解。采用EASL和WHO标准,6个月的反应率分别为86%和49%。中位进展时间为2.4年(95%CI:2.1～5.7),72%的病人在5年内没有靶病变进展。总生存期中位数为6.7年(95%CI:3.1～6.7);1、3、5年的生存率分别为98%、66%和57%。1、3、5年总生存率分别为100%、82%和75%。直径不超过3 cm的肿瘤(n=45)病人总生存率显著大于3 cm以上的肿瘤病人(P=0.026)。结论在早期原发性肝细胞癌肝功能保留的病人中,RS治疗在肿瘤反应率、肿瘤控制和生存率与根治性治疗具有可比性。

关键词：肝段切除术肝功能远期疗效 RS 放射性 HCC 进展时间

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Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fuj.naka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby j.hn Emma Griffin j.hn Thornton j.se Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal j.bbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj.Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-j.hani Sunil A Sheth Victor S Lopez Rivera j.mes E Siegler Achmad Fidaus Sani Aj.t S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Aj.y K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brij.sh P Mehta Naoto Kimura Mamoru Murakami j.n Soo Lee j. Man Hong robert Fahed Gregory Walker Eij. Hagashi Steve M Cordina Hong Gee Roh Ken Wong j.an F Arenillas Mario Martinez-Galdamez j.rdi Blasco Alej.ndro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon j.hn Alex Brehm Marios Psychogios William j.Mack Matthew Tenser Tatemi Todaka Miki Fuj.mura roberta Novakovic j.n Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters j.hnny Wong Mohamed Teleb j.remy Payne Hiroki Fukuda Kosuke Miyake j.nsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s obj.ctive was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid

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去甲肾上腺素激活星形胶质细胞内核膜上的β1-肾上腺素能受体

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神经损伤与功能重建 2022年第7期17卷 434-434页

作者： Kelsey C Benton Daniel S Wheeler Beliz Kurtoglu Mahshid Bagher Zadeh Ansari Daniel P Cibich Dante A Gonzalez Matthew R Herbst Saema Khursheed Rachel C Knorr Doug Lobner j.nree G Maglasang Kayla E Rohr Analisa Taylor robert C Twining Paul j.itt Paul j.Gasser 杜一星(编译) Department of Biomedical Sciences Marquette UniversityMilwaukeeWisconsinUSA 不详

去甲肾上腺素对星形胶质细胞的代谢、神经保护和免疫调节功能有强大的影响。直到最近,去甲肾上腺素的所有作用尚被认为是由仅存在于细胞质膜的受体介导的。然而,最近对心肌细胞的研究已经确定定位于细胞内膜(包括高尔基体和内核膜)的肾... 详细信息

去甲肾上腺素对星形胶质细胞的代谢、神经保护和免疫调节功能有强大的影响。直到最近,去甲肾上腺素的所有作用尚被认为是由仅存在于细胞质膜的受体介导的。然而,最近对心肌细胞的研究已经确定定位于细胞内膜(包括高尔基体和内核膜)的肾上腺素能受体,并表明去甲肾上腺素可以通过转运蛋白介导的摄取而作用于这些受体。我们最近发现了一种高容量去甲肾上腺素转运蛋白有机阳离子转运蛋白3(OCT3)。该转运蛋白密集定位于星形胶质细胞的外核膜,这表明肾上腺素能信号传导也可能发生在这些细胞的内核膜上。本研究证实:使用免疫荧光和蛋白质印迹技术显示β1-肾上腺素受体定位于星形胶质细胞内核膜;关键的肾上腺素能信号通路组分存在于星形胶质细胞核中;且OCT3和其他儿茶酚胺转运蛋白于星形胶质细胞质膜和核膜均表达。为了测试核膜β1-肾上腺素能受体的功能,我们使用荧光生物传感器实时监测星形胶质细胞核中的蛋白激酶A(PKA)活性。用去甲肾上腺素处理星形胶质细胞会导致核区室中PKA活性的快速增加。用儿茶酚胺摄取抑制剂预处理星形胶质细胞可阻断去甲肾上腺素诱导的核PKA活性的快速增加。这些研究首次记录了任何中枢神经系统细胞核膜上的功能性肾上腺素能受体,揭示了去甲肾上腺素可能直接影响核过程的新机制。这种机制可能与先前描述的去甲肾上腺素的神经保护、代谢和免疫调节作用有关。

关键词： G蛋白偶联受体肾上腺素受体单胺转运体去甲肾上腺素细胞核蛋白激酶A 亚细胞定位

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