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Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan Qi robert chunhua zhao Jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

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Mesenchymal stem cells and immune disorders: from basic science to clinical transition

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Frontiers of Medicine 2019年第2期13卷 138-151页

作者： Shihua Wang Rongjia Zhu Hongling Li Jing Li Qin Han robert chunhua zhao Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegePeking Union Medical College HospitalCenter of Excellence in Tissue EngineeringChinese Academy of Medical SciencesBeijing 100005China

As a promising candidate seed cell type in regenerative medicine, mesenchymal stem cells (MSCs) have attracted considerable attention. The unique capacity of MSCs to exert a regulatory effect on immunity in an autologous/allergenic manner makes them an attractive therapeutic cell type for immune disorders. In this review, we discussed the current knowledge of and advances in MSCs, including its basic biological properties, i.e., multilineage differentiation, secretome, and immunomodulation. Specifically, on the basis of our previous work, we proposed three new concepts of MSCs, i.e.,“subtotipotent stem cell” hypothesis, MSC system, and “Yin and Yang” balance of MSC regulation, which may bring new insights into our understanding of MSCs. Furthermore, we analyzed data from the Clinical Trials database (http://***) on registered clinical trials using MSCs to treat a variety of immune diseases, such as graft-versus-host disease, systemic lupus erythematosus, and multiple sclerosis. In addition, we highlighted MSC clinical trials in China and discussed the challenges and future directions in the field of MSC clinical application.

关键词： mesenchymal stem cell clinical transition immune disorders

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Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src

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Signal Transduction and Targeted Therapy 2021年第11期6卷 3318-3332页

作者： Xian Xiao Meiqian Xu Hongliang Yu Liping Wang Xiaoxia Li Janusz Rak Shihua Wang robert chunhua zhao Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical CollegeBeijingChina Department of Genetics and Cell Biology Basic medical collegeQingdao University308 Ningxia Road266071QingdaoChina Research Institute of the McGill University Health Centre Glen SiteMcGill UniversityMontrealQCH4A 3J1Canada Department of Cell Biology School of Life SciencesShanghai University200444ShanghaiChina

Senescent endothelial cells (ECs) could impair the integrity of the blood vessel endothelium, leading to vascular aging and a series of diseases, such as atherosclerosis, diabetes. Preventing or mitigating EC senescence might serve as a promising therapeutic paradigm for these diseases. Recent studies showed that small extracellular vesicles (sEV) have the potential to transfer bioactive molecules into recipient cells and induce phenotypic changes. Since mesenchymal stem cells (MSCs) have long been postulated as an important source cell in regenerative medicine, herein we investigated the role and mechanism of MSC-derived sEV (MSC-sEV) on EC senescence. In vitro results showed that MSC-sEV reduced senescent biomarkers, decreased senescence-associated secretory phenotype (SASP), rescued angiogenesis, migration and other dysfunctions in senescent EC induced by oxidative stress. In the In vivo natural aging and type-2 diabetes mouse wound-healing models (both of which have senescent ECs), MSC-sEV promoted wound closure and new blood vessel formation. Mechanically, miRNA microarray showed that miR-146a was highly expressed in MSC-sEV and also upregulated in EC after MSC-sEV treatment. miR-146a inhibitors abolished the stimulatory effects of MSC-sEV on senescence. Moreover, we found miR-146a could suppress Src phosphorylation and downstream targets VE-cadherin and Caveolin-1. Collectively, our data indicate that MSC-sEV mitigated endothelial cell senescence and stimulate angiogenesis through miR-146a/Src.

关键词： miR wound healing

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A novel Trmt5-deficient zebrafish model with spontaneous inflammatory bowel disease-like phenotype

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Signal Transduction and Targeted Therapy 2023年第3期8卷 928-931页

作者： Qiong zhao Hui Chang Jing Zheng Ping Li Lidan Ye Ruolang Pan Di Li Jian-Zhong Shao robert chunhua zhao Ye Chen Department of Genetics and Department of Genetic and Metabolic DiseaseThe Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China College of Life Sciences Key Laboratory for Cell and Gene Engineering of Zhejiang ProvinceZhejiang UniversityHangzhou 310052China Zhejiang Provincial Key Laboratory of Genetic and Developmental Disorders Institute of GeneticsZhejiang UniversityHangzhou 310052China Key Laboratory for Food Microbial Technology of Zhejiang Province Zhejiang Gongshang UniversityHangzhouChina Institute of Bioengineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Zhejiang Provincial Key Laboratory of Cell‐Based Drug and Applied Technology Development Institute for Cell‐Based Drug Development of Zhejiang ProvinceHangzhouChina

Dear Editor,Inflammatory bowel disease(IBD),a complex syndrome characterized by chronic inflammation of the gastrointestinal tract,is considered a global health problem,especially prevalent in western developed countries and with accelerating incidence in the developing world over the last decade.1 To date,the primary etiology of IBD remains elusive.

关键词： inflammation bowel gastrointestinal

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Nonmyeloablative haploidentical transplantation with intra-bone marrow injection of mesenchymal stem cells for high-risk acute leukemia:successful engraftment and mild GVHD

Nonmyeloablative haploidentical transplantation with intra-b...

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第12届全国实验血液学会议

作者： robert chunhua zhao Institute of Basic Medical Sciences ＆ School of Basic Medicine Center of Excellence in Tissue EngineeringChinese Academy of Medical Sciences ＆ Peking Union Medical College

＜正＞Thirty-three cases of high risk acute leukemia patients who needed HSCT but lacked HLA identical donors were received nonmyeloablative haploidentical peripheral blood stem cell transplantation combined with bone marrow-mesenchymal stem cells（MSCs） by intra-bone marrow *** were no MSC infusion-related adverse *** patients achieved

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Promoting oral mucosal wound healing using a DCS-RuB_(2)A_(2) hydrogel based on a photoreactive antibacterial and sustained release of BMSCs

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Bioactive Materials 2023年第5期23卷 53-68页

作者： Wenxin Qi Naijun Dong Lingling Wu Xueqi Zhang He Li Hao Wu Natalie Ward Jian Yu He Liu Jiao Wang Xiaoyong Deng robert chunhua zhao School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Beijing University of Chemical Technology BeijingChina Banner Ocotillo Medical Center 1405 S Alma School RdChandlerAZ85286USA Division of Endodontics Department of Oral Biological and Medical SciencesFaculty of DentistryUniversity of British ColumbiaVancouverV6T 1Z3Canada The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory for Oral Biomedicine Ministry of Education School and Hospital of StomatologyWuhan UniversityWuhan430079China School of Environmental and Chemical Engineering Shanghai UniversityShanghaiPR China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical CollegeBeijingChina Centre of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy(BZ0381) BeijingChina

The high occurrence rate and difficulties in symptom control are listed as the major problems of oral mucosal disease by medical *** the development of oral mucosal lesions,the oral microenvironment changes,immunity declines,and continuous bacterial stimulation causes wound *** antibacterial drugs are ineffective for oral mucosal *** overcome this problem,a light-responsive antibacterial hydrogel containing sustained-release BMSCs was inspired by the trauma environment in the oral cavity,which is different from that on the body surface since it mostly remains under dark *** the absence of light,the hydrogel seals the wound to form a barrier,exerts a natural bacteriostatic effect,and prevents invasion by foreign ***,mesenchymal stem cells are presented,and the released growth factors and other substances have excellent anti-inflammatory and angiogenic effects,which result in rapid repair of the damaged *** light conditions,after photo-induced shedding of the hydrogel,RuB_(2)A exerts an antibacterial effect accompanied by degradation of the *** in a rat oral mucosal repair model demonstrate that DCS-RuB_(2)A_(2)-BMSCs could rapidly repair the oral mucosa within 4 *** data provide ideas for further analysis of the intrinsic molecular mechanisms and signaling *** together,our results suggest that this light-responsive antibacterial hydrogel loaded with BMSCs can be used for rapid wound repair and may advance the development of therapeutic strategies for the treatment of clinical oral mucosal defects.

关键词： Oral mucosa Light-responsive Hydrogel DCS BMSCs

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Correction to:Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src

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Signal Transduction and Targeted Therapy 2022年第8期7卷 3139-3142页

作者： Xian Xiao Meiqian Xu Hongliang Yu Liping Wang Xiaoxia Li Janusz Rak Shihua Wang robert chunhua zhao Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Beijing China Department of Cell Biology School of Life Sciences Shanghai University 200444 Shanghai China Department of Genetics and Cell Biology Basic medical college Qingdao University 308 Ningxia Road 266071 Qingdao China Research Institute of the McGill University Health Centre Glen Site McGill University Montreal QC H4A 3J1 Canada

In the process of collating the raw data,the authors noticed several inadvertent mistakes occurred in Fig.1b,Fig.2d,f,l,and Supplementary Fig.1b that need to be corrected after online publication of the *** correct data are provided as *** key findings of the article are not affected by these *** original article has been corrected.

关键词： correction finding corrected

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Exploring the feasibility of prestressed anchor cables as an alternative to temporary support in the excavation of super-large-span tunnel

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Railway Engineering Science 2024年第3期32卷 344-360页

作者： Shunhua Zhou Yuyin Jin Zhiyao Tian chunhua Zou Heming zhao Zengrun Miao Shanghai Key Laboratory of Rail Infrastructure Durability and System Safety Tongji UniversityShanghai 201804China Key Laboratory of Road and Traffic Engineering of the Ministry of Education Tongji UniversityShanghai 201804China China Railway Construction Corporation Limited Beijing 100855China The 2nd Engineering Co. Ltd.of China Railway Construction Bridge Engineering Bureau GroupShenzhen 518083China China Railway Construction Bridge Engineering Bureau Group Co. LtdTianjin 300300China

Excavating super-large-span tunnels in soft rock masses presents significant *** ensure safety,the sequential excavation method is commonly *** utilizes internal temporary supports to spatially partition the tunnel face and divide the excavation into multiple ***,these internal supports generally impose spatial constraints,limiting the use of large-scale excavation equipment and reducing construction *** address this constraint,this study adopts the“Shed-frame”principle to explore the feasibility of an innovative support system,which aims to replace internal supports with prestressed anchor cables and thus provide a more spacious working space with fewer internal *** evaluate its effectiveness,a field case involving the excavation of a 24-m span tunnel in soft rock is presented,and an analysis of extensive field data is conducted to study the deformation characteristics of the surrounding rock and the mechanical behavior of the support *** results revealed that prestressed anchor cables integrated the initial support with the shed,creating an effective“shed-frame”system,which successively maintained tunnel deformation and frame stress levels within safe regulatory ***,the prestressed anchor cables bolstered the surrounding rock effectively and reduced the excavation-induced disturbance zone *** summary,the proposed support system balances construction efficiency and *** field experiences may offer valuable insights into the popularization and further development of prestressed anchor cable support systems.

关键词： Super-large-span tunnel Construction safety Sequential excavation method Shed-frame principle Prestressed anchor cables

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Access to advanced sodium-ion batteries by presodiation:Principles and applications

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Journal of Energy Chemistry 2024年第5期92卷 162-175页

作者： Shihao Zhang Ruoyu Cao Xiangjun Pu Along zhao Weihua Chen chunhua Song Yongjin Fang Yuliang Cao College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power SourcesWuhan UniversityWuhan 430072HubeiChina College of Chemistry&Green Catalysis Center Zhengzhou UniversityZhengzhou 450001HenanChina Shenzhen Janaenergy techonulogy Co. Ltd.Shenzhen 518000GuangdongChina School of Chemistry and Chemical Engineering Jiangsu University of TechnologyChangzhou 213001JiangsuChina Zonergy Corporation NO.68 Fucang RoadYantan DistrictZigong 643030SichuanChina

Sodium-ion batteries(SIBs)are expected to offer affordability and high energy density for large-scale energy storage ***,the commercial application of SIBs is hurdled by low initial coulombic efficiency(ICE),continuous Na loss during long-term operation,and low sodium-content of cathode *** this scenario,presodiation strategy by introducing an external sodium reservoir has been rationally proposed,which could supplement additional sodium ions into the system and thereby markedly improve both the cycling performance and energy density of *** this review,the significance of presodiation is initially introduced,followed by comprehensive interpretation on technological properties,underlying principles,and associated approaches,as well as our perspectives on present inferiorities and future research ***,this contribution outlines a distinct pathway towards the presodiation methodology,of significance but still in its nascent phase,which may inspire the targeted guidelines to explore new chemistry in this field.

关键词： Presodiation Increased coulombic efficiency High reversible capacity Sodium ion batteries

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Sca-1+Lin-CD117-mesenchymal stem/stromal cells induce the generation of novel IRF8-controlled regulatory dendritic cells through Notch-RBP-J signaling

Sca-1+Lin-CD117-mesenchymal stem/stromal cells induce the ge...

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中国解剖学会2015年年会

作者： Xingxia Liu Shaoda Ren Chaozhuo Ge Kai Cheng Martin Zenke Armand Keating robert chunhua zhao Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College

＜正＞Mesenchymal stem/stromal cells（MSCs）can influence the destiny of hematopoietic stem/progenitor cells（HSCs）,and exert broadly immunomodulatory effects on immune ***,how MSCs regulate the differentiation of regulatory dendritic cells（regDCs）from HSCs remains incompletely *** showed that mouse bone marrow（BM）-derived Sca-l+Lin-CD117-MSCs

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