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Role of the complement cascade in cerebral aneurysm formation,growth,and rupture

Neuroimmunology and Neuroinflammation 2015年第1期2卷 93-101页

作者： Blake E.S.Taylor Geoff Appelboom robert zilinyi Ariana Goodman David Chapel Melissa LoPresti Edward Sander Connolly Jr. Department of Neurosurgery Cerebrovascular LabColumbia University Medical CenterNew YorkNY 100027USA Department of Neurosurgery Columbia UniversityNew YorkNY 100027USA College of Physicians and Surgeons Columbia UniversityNew YorkNY 100027USA Department of Pathology and Cell Biology Columbia UniversityNew YorkNY 100027USA New York University School of Medicine New YorkNY 100027USA Neuro-intensive Care Unit Columbia University Medical CenterNew YorkNY 100027USA

Rupture of intracranial aneurysms is the most common cause of nontraumatic subarachnoid hemorrhage,but the intricate neuroinflammatory processes which contribute to aneurysm pathophysiology are not well‑*** evidence has implicated the complement cascade in the progression of aneurysms from their formation to *** this article,we identify and review studies that have sought to determine the role of the complement system in the aneurysm *** studies were generally conducted by immunhistological analyses on aneurysm tissue collected intraoperatively,and multiple components of the complement cascade and its modulators were identified in specific regions of the aneurysm *** results of the studies suggest that the complement cascade is locally upregulated and disinhibited in the perianeurysmal environment,and that it contributes to chronic as well as acute immunological damage to the aneurysm *** the future,understanding the mechanisms at work in complement‑mediated damage is necessary to leading the development of novel therapies.

关键词： Aneurysm complement neuroinflammation rupture subarachnoid hemorrhage

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