检索结果-南通市图书馆

Current advances in xenotransplantation

Hepatobiliary & Pancreatic Diseases International 2005年第4期4卷 490-494页

作者： Ashley Cox robert zhong Departments of Surgery Pathologyand Microbiology and ImmunologyUniversity of Western OntarioLondonCanada

BACKGROUND: Transplantation of organs is a well-known and accepted life-saving procedure for end-stage kidney, liver, heart and lung diseases. The insufficient number of donor organs limits the application of this technique and leads to unnecessary loss of life. Experimental techniques such as xenotransplantation are extremely important to determine new methods of creating organ availability. DATA SOURCES; A literature search of Pubmed database was conducted and research articles reviewed. RESULTS: Xenotransplantation is a progressive field of research. Human complement regulatory protein ( hDAF) transgenic pigs and new immunosuppressive strategies that reduce xenoreactive αgal antibodies, have decreased rates of acute vascular rejection. Transplantation of α-1, 3-galac-tosyltransferase knock-out pig organs into baboons has resulted in the longest graft survival to date. Coagulation pathways have been identified as having a role in graft rejection. In vitro studies of porcine endogenous retroviruses (PERVs) show encouraging results that zoonosis will be less hindering to xenotransplantation than once thought. CONCLUSIONS: Several recent advances in xenotransplantation research have brought this technique closer to clinical application. The Ethics Committee of the International Xenotransplantation Association has made recommendations to ensure maintenance of ethical standards. Advancement will depend on the development of pig models, novel immunosuppressive strategies to target the innate immune system, and new ways to create donor specific tolerance. Prevention of rejection and transmission of infectious agents remain unresolved issues. In the future, it is feasible that xenotransplantation will be used to resolve this medical dilemma.

关键词： xenotransplantation pig transgenic cloning zoonosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Covalent triazine frameworks modified by ultrafine Pt nanoparticles for efficient photocatalytic hydrogen production

引用

Nano Research 2024年第6期17卷 4908-4915页

作者： Xu Han Xueying Ge Wen-Wen He Wangwang Shen Tao Zhou Jian-Sen Wang Rong-Lin zhong Abdullah MAl-Enizi Ayman Nafady Shengqian Ma School of Chemistry and Life Science Advanced Institute of Materials ScienceChangchun University of TechnologyChangchun 130012China Laboratory of Theoretical and Computational Chemistry Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun 130021China Department of Chemistry University of North Texas1508 W.Mulberry St.DentonTX 76201USA Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia

Pt nanoparticles(PtNPs)as active species have always been considered as one of the best semiconductor materials for photocatalytic hydrogen *** this study,a Schottky heterojunction has been successfully constructed by evenly loading ultrafine PtNPs onto a triazine-based covalent organic frameworks(COFs).This strategy maintained the high activity of these ultra-small PtNPs while maximizing the utilization of the Pt active *** fabricated PtNPs@covalent triazine-based framework-1(CTF-1)composite accomplished a significantly high rate of hydrogen evolution(20.0 mmol·g^(−1)·h^(−1),apparent quantum efficiency(AQE)=7.6%,atλ=450 nm)with 0.40 wt.%Pt loading,giving rise to a 44-fold-increase in the efficiency of the photocatalytic hydrogen production compared to the pristine *** calculations revealed that the strong electron transfer(Q(Pt)=−0.726 qe,in the analysis of Bader charge,Q(Pt)is the charge quantity transferred from Pt cluster to CTF-1,and qe is the unit of charge transfer quantity)between PtNPs and CTF-1 triggers a strong interaction,which makes PtNPs being firmly attached to the structure of CTF-1,thereby enabling high stability and excellent hydrogen production ***,the hydrogen binding free energy(ΔGH*)of PtNPs@CTF-1 is much lower than that of the unmodified CTF-1,leading to a much lower intermediate state and hence a significant improvement in photocatalytic *** overall findings of this work provide a new platform to incorporate metallic NPs into COFs for the design and fabrication of highly efficient photocatalysts.

关键词： Pt nanoparticles covalent triazine-based framework-1(CTF-1) photocatalysts hydrogen evolution reaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fjord-Type AIEgens Based on Inherent Through-Space Conjugation

引用

CCS Chemistry 2024年第7期6卷 1739-1747页

作者： Ye-Qiang Han Yuan Xie Jianyu Zhang Shiyu Tan Haoke Zhang Ben zhong Tang Jonathan L.Sessler Feihe Huang Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310058 Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058 Center for AIE Research College of Materials Science and EngineeringShenzhen UniversityShenzhen 518061 Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyKowloonHong Kong 999077 School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Guangzhou 518172 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224 Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001

Through-space conjugation(TSC)is a noncovalently electronic interaction that is emerging as a potential complement to through-bond conjugation(TBC)-based strategies for constructing luminescent ***,the design of efficient luminogens based on TSC is currently challenging due to a lack of established structure-property *** is particularly true in the case of luminogens displaying aggregation-induced emission(AIE)*** this work,three terphenyl derivatives were prepared,and their photophysical properties were systemically *** was found that relative to the corresponding m-and p-linked analogues,the electronic interaction of TBC is weakened while the strength of TSC is commensurately enhanced in the constitutional isomer containing an o-linked fjordtype *** this set of luminogens,the presence of a fjord-type arrangement promotes a transformation from aggregation-caused quenching to *** investigations involving congeneric quaterphenyl and pentphenyl isomers support the universality of the fjord-type unit as a framework for synthesizing AIE-active luminogens(AIEgens)with inherent *** work not only provides a novel set of AIEgens but also establishes the utility of TSC in controlling the photophysical properties of nonconventional and twisted luminogens.

关键词： fjord-type through-space conjugation through-bond conjugation aggregation-induced emission luminescence twisted conformation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

h DAF转基因猪在肝脏离体灌注实验中对超急性排斥反应的阻止作用

引用

中华器官移植杂志 2001年第4期22卷 227-229页

作者：余小舫杨洪吉 robert zhong 深圳市人民医院普外科 518020 加拿大西安大略大学伦敦健康中心实验外科部

目的　在离体肝脏灌注实验中 ,观察人衰变加速因子 (hDAF)转基因猪对肝脏超急性排斥反应的阻止作用。方法　全麻下分别分离出门静脉、肝上及肝下下腔静脉、腹主动脉 ,分别经腹主动脉和门静脉插管 ,用UW液对肝脏进行原位灌注 ,然后摘取... 详细信息

目的　在离体肝脏灌注实验中 ,观察人衰变加速因子 (hDAF)转基因猪对肝脏超急性排斥反应的阻止作用。方法　全麻下分别分离出门静脉、肝上及肝下下腔静脉、腹主动脉 ,分别经腹主动脉和门静脉插管 ,用UW液对肝脏进行原位灌注 ,然后摘取肝脏置于 4℃的冷容器中 ,冷缺血时间少于 1h ;灌注中 ,血液经肝下下腔静脉流出 ,循经膜氧和器—热交换器 ,然后经门静脉返回肝脏 ,血流速度 0 .75～ 1ml/克肝组织。共灌注 16只猪 ,将其分为猪血灌注猪肝脏组 (P P组 ,n =6)、人血灌注猪肝脏组 (H P组 ,n =5 )和人血灌注hDAF转基因猪肝脏组 (H hDAF组 ,n =5 )。结果　经组织学检查 ,P P组有正常的组织学结构 ;H P组显示有明显的血管内皮细胞的损害、出血、血小板及纤维蛋白的沉积 ;H hDAF组除 1例有轻度的血管内皮损害和出血外 ,其余为基本正常的组织学结构。H hDAF组在灌注过程中的胆汁产量、凝血功能及门脉压力的变化都明显好于H P组。结论　hDAF的转基因猪对肝脏的超急性排斥反应有明显的阻止作用 ,这为将来临床应用hDAF的转基因猪肝脏做体外灌注支持治疗提供了理论支持。

关键词：移植物排斥肝移植 hDAF转基因猪肝脏离体灌注超急性排斥反应实验研究

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Encapsulated Fe(IV)Molecular Complex for Photoacoustic Imaging

引用

CCS Chemistry 2024年第5期6卷 1184-1197页

作者： Ye Xu Chao Li zhong-Yu Yu Jiamin Wang Zhaoyang Liu Chao Jiang Zhen-Feng Chen Xiaoyu Wu Ming-Xing Li Hong Yang Zhao-Xi Wang Jonathan L.Sessler Department of Chemistry Center for Supramolecular Chemistry and CatalysisInnovative Drug Research CenterShanghai UniversityShanghai 200444 College of Chemistry and Materials Science Shanghai Key Laboratory of Rare Earth Functional MaterialsShanghai Frontiers Science Center of Biomimetic CatalysisShanghai Normal UniversityShanghai 200234 Sijing Community Health Service Center of Songjiang District Shanghai 201601 Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuilin 541004 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224

stable neutral Fe(IV)complex(Fe-HDCL),readily accessible on the g scale,was found to possess high water solubility and good stability(<5%degradation over 4 h upon photoirradiation).Fe-HDCL is green and absorbs light effectively in the visible region(500–800 nm)with aλmax at 650 nm(ɛ=7830 M^(−1)cm^(−1)).Fe-HDCL also exhibits photothermal(PT)behavior comparable to single-wall carbon nanotubes in the solid *** aqueous solution,high PT conversion(η=72.6%)is achieved,and a strong hyperthermia-based inhibition of cell growth is observed upon subjecting Fe-HDCL to near-infrared 730 nm laser *** biological studies in vitro and in vivo confirmed that Fe-HDCL is biocompatible,clears readily,and allows the visual detection of blood *** subjecting mice to intravenous injection at low doses(e.g.,50μmol·kg^(−1)),Fe-HDCL also permits the photoacoustic(PA)imaging of kidneys and the evaluation of renal fibrosis in mouse *** addition,Fe-HDCL allows PA-based imaging of brain tissues,presumably reflecting its ability to pass through the blood-brain *** thus propose that Fe-HDCL has a role to play as PT agent and as a photodiagnostic.

关键词： stable Fe(IV)complex blood-brain barrier molecular cage photoacoustic imaging renal fibrosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

论美育在儿童读物插图设计中的重要性

引用

包装工程 2024年第4期45卷 280-287页

作者：蒋苏平何忠北京工业大学艺术设计学院北京100124

目的儿童读物中的插图设计作为一种特殊的插画种类,可以将美育思想以生动有趣的叙事画面传递给儿童,丰富少儿认知,助其树立良好的情感态度与价值观,从而塑造完整的人格。近年来,由于国内儿童读物市场的崛起和教育界对儿童美育的重视,使... 详细信息

目的儿童读物中的插图设计作为一种特殊的插画种类,可以将美育思想以生动有趣的叙事画面传递给儿童,丰富少儿认知,助其树立良好的情感态度与价值观,从而塑造完整的人格。近年来,由于国内儿童读物市场的崛起和教育界对儿童美育的重视,使得美育观念在儿童读物插图设计中发挥着愈加重要的作用。文章从教育学、儿童审美心理学及设计学交叉学科的角度出发,探讨美育在儿童读物插图设计创意及表现中的重要性。方法通过跨学科研究法、文献研究法、案例分析法等研究方法,结合罗伯特·皮亚杰的认知发展阶段论和霍华德·加德纳儿童审美认知发展阶段论的横向对比分析,导出不同阶段儿童的插图偏好,在了解不同阶段儿童审美心理发展特征的基础上,探讨美育在儿童读物插图中的重要作用。结论希望美术创作者给予儿童审美教育以更多关注,正确引导儿童读物插图设计的方向,加强对儿童审美能力的培养,更好地从设计学领域出发,传递中国文化,讲好中国故事。

关键词：美育儿童读物插图设计创意表现

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

小鼠同种异位心脏移植模型中新型免疫抑制剂LF 15-0195与环胞霉素A相互作用的研究

引用

天津医科大学学报 2009年第4期15卷 671-674页

作者：周德俊 robert zhong 天津医科大学肿瘤医院内镜室天津300060 Department of Surgery The University of Western Ontario

目的:检测LF15-0195联合环胞霉素A(CsA)治疗的相互作用。方法:在C57BL/6对BALB/c小鼠同种异位心脏移植模型中检测:(1)剂量相关作用对移植物存活的影响。(2)对长期存活的小鼠进行供体和第三方皮肤移植物移植用以评价其免疫耐受的状态。(3... 详细信息

目的:检测LF15-0195联合环胞霉素A(CsA)治疗的相互作用。方法:在C57BL/6对BALB/c小鼠同种异位心脏移植模型中检测:(1)剂量相关作用对移植物存活的影响。(2)对长期存活的小鼠进行供体和第三方皮肤移植物移植用以评价其免疫耐受的状态。(3)LF联合应用CsA检测它们对移植物存活的相互作用。结果:单独应用高剂量LF(>2mg/kg)可以诱导特种供体的手术免疫耐受。同时应用高剂量CsA(15mg/kg)可以阻止由LF(2mg/kg)诱导的免疫耐受。相反,短期应用LF(1mg/kg)并联合应用低剂量CsA(5mg/kg)可成功诱导BALB/c小鼠心脏移植物长期存活(>100days)。结论:单独应用高剂量LF(>2mg/kg)可以诱导特种供体的手术免疫耐受。同时应用高剂量CsA可以阻止由LF诱导的免疫耐受,短期应用LF明显地减少了对CsA的需求量以防止免疫排斥。

关键词：免疫抑制剂免疫耐受同种异体移植物心脏移植小鼠

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A combinatorial indexing strategy for low-cost epigenomic profiling of plant single cells

引用

Plant Communications 2022年第4期3卷 72-82页

作者： Xiaoyu Tu Alexandre P.Marand robert J.Schmitz Silin zhong Joint Center for Single Cell Biology School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Collaborative Innovation Center of Agri-Seeds School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Department of Genetics University of GeorgiaAthensGA 30602USA State Key Laboratory of Agrobiotechnology School of Life SciencesThe Chinese University of Hong KongHong KongChina

Understanding how cis-regulatory elements facilitate gene expression is a key question in *** advances in single-cell genomics have led to the discovery of cell-specific chromatin landscapes that underlie transcription programs in animal ***,the high equipment and reagent costs of commercial systems limit their applications for many *** this study,we developed a combinatorial index and dual PCR barcode strategy to profile the Arabidopsis thaliana root single-cell epigenome without any specialized *** generated chromatin accessibility profiles for 13576 root nuclei with an average of 12784 unique Tn5 integrations per *** of the single-cell assay for transposaseaccessible chromatin sequencing and RNA sequencing data sets enabled the identification of 24 cell clusters with unique transcription,chromatin,and cis-regulatory *** with single-cell data generated using the commercial microfluidic platform from 10X Genomics revealed that this low-cost combinatorial index method is capable of unbiased identification of cell-type-specific chromatin *** anticipate that,by removing cost,instrumentation,and other technical obstacles,this method will be a valuable tool for routine investigation of single-cell epigenomes and provide new insights into plant growth and development and plant interactions with the environment.

关键词： combinatorial indexing single-cell ATAC-seq epigenome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hydrogel-based local drug delivery strategies for spinal cord repair

引用

Neural Regeneration Research 2021年第2期16卷 247-253页

作者： robert B.Shultz Yinghui zhong School of Biomedical Engineering Science and Health SystemsDrexel UniversityPhiladelphiaPAUSA Department of Neurosurgery University of PennsylvaniaPhiladelphiaPAUSA Department of Bioengineering University of PennsylvaniaPhiladelphiaPAUSA New Jersey Center for Biomaterials Rutgers–The State University of New JerseyPiscatawayNJUSA Center for Neurotrauma Neurodegeneration&RestorationCorporal Michael J.Crescenz Veterans Affairs Medical CenterPhiladelphiaPAUSA

Spinal cord injury results in significant loss of motor, sensory, and autonomic functions. Although a wide range of therapeutic agents have been shown to attenuate secondary injury or promote regeneration/repair in animal models of spinal cord injury, clinical translation of these strategies has been limited, in part due to difficulty in safely and effectively achieving therapeutic concentrations in the injured spinal cord tissue. Hydrogelbased drug delivery systems offer unique opportunities to locally deliver drugs to the injured spinal cord with sufficient dose and duration, while avoiding deleterious side effects associated with systemic drug administration. Such local drug delivery systems can be readily fabricated from biocompatible and biodegradable materials. In this review, hydrogel-based strategies for local drug delivery to the injured spinal cord are extensively reviewed, and recommendations are made for implementation.

关键词： drug carriers drug delivery hydrogels microparticles nanoparticles neurotrophic factors scaffolds spinal cord injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Minocycline targets multiple secondary injury mechanisms in traumatic spinal cord injury

引用

Neural Regeneration Research 2017年第5期12卷 702-713页

作者： robert B.Shultz Yinghui zhong School of Biomedical Engineering Science and Health Systems Drexel University Philadelphia PA USA

Minocycline hydrochloride（MH）, a semi-synthetic tetracycline derivative, is a clinically available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective activities. It has been shown to target multiple secondary injury mechanisms in spinal cord injury, via its anti-inflammatory, anti-oxidant, and anti-apoptotic properties. The secondary injury mechanisms that MH can potentially target include inflammation, free radicals and oxidative stress, glutamate excitotoxicity, calcium influx, mitochondrial dysfunction, ischemia, hemorrhage, and edema. This review discusses the potential mechanisms of the multifaceted actions of MH. Its anti-inflammatory and neuroprotective effects are partially achieved through conserved mechanisms such as modulation of p38 mitogen-activated protein kinase（MAPK） and phosphoinositide 3-kinase（PI3K）/Akt signaling pathways as well as inhibition of matrix metalloproteinases（MMPs）. Additionally, MH can directly inhibit calcium influx through the N-methyl-D-aspartate（NMDA） receptors, mitochondrial calcium uptake, poly（ADP-ribose） polymerase-1（PARP-1） enzymatic activity, and iron toxicity. It can also directly scavenge free radicals. Because it can target many secondary injury mechanisms, MH treatment holds great promise for reducing tissue damage and promoting functional recovery following spinal cord injury.

关键词： minocycline inflammation anti-oxidant neuroprotection oxidative stress glutamate exitotoxicity cytochrome c P38 MAPK PI3K/Akt calcium influx

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：