检索结果-南通市图书馆

Optimizing laser coupling,matter heating,and particle acceleration from solids using multiplexed ultraintense lasers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Matter and Radiation at Extremes 2024年第4期9卷 16-28页

作者： Weipeng Yao Motoaki Nakatsutsumi Sébastien Buffechoux Patrizio Antici Marco Borghesi Andrea Ciardi Sophia N.Chen Emmanuel d’Humières Laurent Gremillet robert Heathcote Vojtech Horny Paul McKenna Mark N.Quinn Lorenzo Romagnani Ryan Royle Gianluca Sarri Yasuhiko Sentoku Hans-Peter Schlenvoigt Toma Toncian Olivier Tresca Laura Vassura Oswald willi Julien Fuchs LULI-CNRS CEASorbonne UniversitéEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance Sorbonne Université Observatoire de ParisUniversité PSLCNRSLERMAF-75005 ParisFrance INRS-EMT 1650 BoulLionel-BouletVarennesQuebec J3X 1S2Canada Center for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastBelfast BT71NNUnited Kingdom “Horia Hulubei”National Institute for Physics and Nuclear Engineering 30 Reactorului StreetRO-077125 Bucharest-MagureleRomania University of Bordeaux Centre Lasers Intenses et ApplicationsCNRSCEAUMR 5107F-33405 TalenceFrance CEA DAMDIFF-91297 ArpajonFrance Université Paris-Saclay CEALMCE91680 Bruyères-le-ChatelFrance Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUnited Kingdom SUPA Department of PhysicsUniversity of StrathclydeGlasgow G40NGUnited Kingdom Department of Physics University of NevadaRenoNevada 89557USA Institute of Laser Engineering Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan Institut fur Laser und Plasmaphysik Heinrich Heine Universitat DusseldorfDusseldorfGermany

Realizing the full potential of ultrahigh-intensity lasers for particle and radiation generation will require multi-beam arrangements due to technology ***,we investigate how to optimize their coupling with solid ***,we show that overlapping two intense lasers in a mirror-like configuration onto a solid with a large preplasma can greatly improve the generation of hot electrons at the target front and ion acceleration at the target *** underlying mechanisms are analyzed through multidimensional particle-in-cell simulations,revealing that the self-induced magnetic fields driven by the two laser beams at the target front are susceptible to reconnection,which is one possible mechanism to boost electron *** addition,the resistive magnetic field generated during the transport of the hot electrons in the target bulk tends to improve their *** simulations also indicate that such effects can be further enhanced by overlapping more than two laser beams.

关键词： laser acceleration particle

Flexible, diamond-based microelectrodes fabricated using the diamond growth side for neural sensing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2020年第1期6卷 742-753页

作者： Bin Fan Cory A.Rusinek Cort H.Thompson Monica Setien Yue Guo robert Rechenberg Yan Gong Arthur J.Weber Michael F.becker Erin Purcell Wen Li Department of Electrical and Computer Engineering Michigan State UniversityEast LansingMIUSA Fraunhofer USA Center for Coatings and Diamond Technologies East LansingMIUSA Department of Biomedical Engineering Michigan State UniversityEast LansingMIUSA Department of Physiology Michigan State UniversityEast LansingMIUSA

Diamond possesses many favorable properties for biochemical sensors,including biocompatibility,chemical inertness,resistance to biofouling,an extremely wide potential window,and low double-layer *** hardness of diamond,however,has hindered its applications in neural implants due to the mechanical property mismatch between diamond and soft nervous ***,we present a flexible,diamond-based microelectrode probe consisting of multichannel boron-doped polycrystalline diamond(BDD)microelectrodes on a soft Parylene C *** developed and optimized a wafer-scale fabrication approach that allows the use of the growth side of the BDD thin film as the sensing *** to the nucleation surface,the BDD growth side exhibited a rougher morphology,a higher sp^(3) content,a wider water potential window,and a lower background *** dopamine(DA)sensing capability of the BDD growth surface electrodes was validated in a 1.0 mM DA solution,which shows better sensitivity and stability than the BDD nucleation surface *** results of these comparative studies suggest that using the BDD growth surface for making implantable microelectrodes has significant advantages in terms of the sensitivity,selectivity,and stability of a neural ***,we validated the functionality of the BDD growth side electrodes for neural recordings both in vitro and in *** biocompatibility of the microcrystalline diamond film was also assessed in vitro using rat cortical neuron cultures.

关键词： neural film diamond

Effects of Flicker in a Distribution Grid with High PV Penetration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy and Power Engineering 2014年第12期8卷 2001-2011页

作者： Andreas Spring Georg Wirth Gerd becker robert Pardatscher Rolf Witzmann Department of Electrical Engineering University of Applied Sciences Munich Munich 80335 Germany Department of Electrical Engineering and Information Technology Technische Universitat Miinchen Munich 80333 Germany

The quantity of installed PV （photovoltaic） systems in the German distribution grid is still increasing. In some areas, the installed PV capacity exceeds 5 kW per HC （house connection）. Therefore, the load flow changes its characteristics and leads to new requirements for the grid. In some areas, the power feedback is higher than the delivery and the installed PV capacity becomes the decisive factor for grid planning. This paper discusses the impact of PV systems on the flicker level. The focus hereby is on the correlation among the flicker level, the grid voltage and the meteorological parameters. Different approaches to investigate if there is an influence of PV systems on the maximum flicker are taken into account. Furthermore, an investigation if the normative limit is exceeded will be shown.

关键词： Grid integration stability PV.

Predictive value of Ki67 and p53 in locally advanced rectal cancer:Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第7期14卷 1060-1066页

作者： Christiane Jakob Torsten Liersch Wolfdietrich Meyer Heinz becker Gustavo B Baretton Daniela E Aust Institute for Pathology University of TechnologyFetscherstr. 74D-01307 DresdenGermany Department of General Visceral and Transplantation SurgeryUniversity Medical Center of GttingenRobert-Koch-Str. 40D-37075 GttingenGermany

AIM: To investigate the predictive value of Ki67 and p53 and their correlation with thymidylate synthase (TS) gene expression in a rectal cancer patient cohort treated according to a standardized recommended neoadjuvant treatment ***: Formalin fixed, paraffin embedded pre-therapeutical tumor biopsies (n = 22) and post-therapeutical resection specimens (n = 40) from patients with rectal adenocarcinoma (clinical UICC stage Ⅱ/Ⅲ) receiving standardized neoadjuvant 5-fluorouracil (5-FU) based chemoradiotherapy were studied for Ki67 and p53 expression by immunohistochemistry and correlated with TS mRNA expression by quantitative TaqMan real-time PCR after laser microdissection. The results were compared with histopathological tumor regression according to a standardized semiquantitative score grading ***: Responders (patients with high tumor regression) showed a significantly lower Ki67 expression than non-responders in the pre-therapeutical tumor biopsies (81.2% vs 16.7%; P < 0.05) as well as in the post-therapeutical resection specimens (75.8% vs 14.3%; P < 0.01). High TS mRNA expression was significantly correlated with a high Ki67 index and low TS mRNA expression was significantly correlated with a low Ki67 index in the pre-therapeutical tumor biopsies (corr. coef. = 0.46; P < 0.01) as well as in the post-therapeutical resection specimens (corr. coef. = 0.40; P < 0.05). No significant association was found between p53 and TS mRNA expression or tumor ***: Ki67 has, like TS, predictive value in rectal cancer patients after neoadjuvant 5-FU based chemoradiotherapy. The close correlation between Ki67 and TS indicates that TS is involved in active cell cycle processes.

关键词： p53 Ki67 Neoadjuvant treatment Rectal cancer Thymidylate synthase

Systematic Cross-biospecimen Evaluation of DNA Extraction Kits for Long-and Short-read Multi-metagenomic Sequencing Studies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2022年第2期20卷 405-417页

作者： Jacqueline Rehner Georges Pierre Schmartz Laura Groeger Jan Dastbaz Nicole Ludwig Matthias Hannig Stefan Rupf Berthold Seitz Elias Flockerzi Tim Berger Matthias Christian Reichert Marcin Krawczyk Eckart Meese Christian Herr robert Bals Soren L.becker Andreas Keller Rolf Muller The IMAGINE Consortium Institute of Medical Microbiology and Hygiene Saarland UniversityD-66421 HomburgGermany Clinical Bioinformatics Saarland UniversityD-66123 SaarbruckenGermany Department of Human Genetics Saarland UniversityD-66421 HomburgGermany Helmholtz Institute for Pharmaceutical Research Saarland D-66123 SaarbruckenGermany Clinic of Operative Dentistry Periodontology and Preventive DentistrySaarland UniversityD-66421 HomburgGermany Department of Ophthalmology Saarland University Medical CenterD-66421 HomburgGermany Department of Medicine Ⅱ Saarland University Medical CenterD-66421 HomburgGermany Department of Internal Medicine V–Pulmonology AllergologyIntensive Care MedicineSaarland UniversityD-66421 HomburgGermany

High-quality DNA extraction is a crucial step in metagenomic *** by different isolation kits impairs the comparison across datasets.A trending topic is,however,the analysis of multiple metagenomes from the same patients to draw a holistic picture of microbiota associated with *** thus collected bile,stool,saliva,plaque,sputum,and conjunctival swab samples and performed DNA extraction with three commercial *** each combination of the specimen type and DNA extraction kit,20-gigabase(Gb)metagenomic data were generated using short-read *** profiles of the specimen types showed close proximity to each other,we observed notable differences in the alpha diversity and composition of the microbiota depending on the DNA extraction *** kit outperformed all selected kits on every *** reached consistently good results using the Qiagen QiAamp DNA Microbiome *** on the specimen,our data indicate that over 10 Gb of sequencing data are required to achieve sufficient resolution,but DNA-based identification is superior to identification by mass ***,longread nanopore sequencing confirmed the results(correlation coefficient>0.98).Our results thus suggest using a strategy with only one kit for studies aiming for a direct comparison of multiple microbiotas from the same patients.

关键词： Whole-genome analysis Comparative genomics Short-read sequencing Long-read sequencing DNA extraction Metagenomics

在线全文

学校读者我要写书评

暂无评论

数学经济学的研究动态

世界科学 1991年第1期 12-14页

作者： robert becker 李绍煌

美国数学协会编撰并出版了《数学的研究动态》,其中第25卷为《数学经济学的研究动态》,由斯坦利·罗伊特(Stanley Roiter)主编.美国印度安纳大学经济系的罗伯特·贝克尔根据该卷的内容综述成本文.

关键词：经济学家期望加法拉斯沃尔存在性罗伊特斯坦利需求函数参预者数学研究动态

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

巨大嵌壁胆囊结石的超声波碎石疗法

放射学实践 1991年第1期6卷 26-29页

作者： Christoph D.becker robert G.Gibney J.Stephen Fache V.Allen Rowley M.G.McLoughlin Burhenne H.Joachim 武卫国胡仁昭 Departments of Radiology and Urology University of British Columbia and Vancouver General Hospital Canada 同济医科大学附属同济医院

当急性胆囊炎患者手术危险性较大或解剖关系不清楚时,可以用胆囊造瘘术代替胆囊切除术,胆囊结石的取出或通过外科手术,或者以后在X线监视下由放射科医生完成,后者使急性炎症期的手术创伤降至最小。我院对36例手术高危的且伴有多种并发... 详细信息

当急性胆囊炎患者手术危险性较大或解剖关系不清楚时,可以用胆囊造瘘术代替胆囊切除术,胆囊结石的取出或通过外科手术,或者以后在X线监视下由放射科医生完成,后者使急性炎症期的手术创伤降至最小。我院对36例手术高危的且伴有多种并发症的老年患者进行了此种卓有成效的治疗。尽管放射科医生用或不伴用机械碎石法在多数病例可取出结石碎片,但是对特别巨大的嵌壁结石的取出还存在着技术上的困难。下面报道的三例此类胆囊结石均采用超声波碎石法成功取出结石。

关键词：胆结石超声波碎石

Lack of correlation between rejection of tumor cells co-expresssing interleukin-2 and B7.1 and vaccine efficiency

在线全文

学校读者我要写书评

暂无评论

中国实验血液学杂志 1997年第3期5卷 315-316页

作者： G.Richter S.Cayeux C.becker C.Beck A.Aicher B.Drken T.Blankenstein Max-Delbrck-Center for Molecular Medicine Robert-Rssle-Strasse 1013122 BerlinRobert-Rssle KlinikFreie Universitt BerlinLindenberger Weg 8013125 BerlinGernmanyMax-Delbrck-Center for Molecular MedicineRobert-Rssle-Strasse 1013122 BerlinMax-Delbrck-Center for Molecular MedicineRobert-Rssle-Strasse 1013122 BerlinMax-Delbrck-Center for Molecular MedicineRobert-Rssle-Strasse 1013122 BerlinRobert-Rssle KlinikFreie Universitt BerlinLindenberger Weg 8013125 BerlinGernmanyMax-Delbrck-Center for Molecular MedicineRobert-Rssle-Strasse 1013122 Berlin

Gene modification of tumor cells to express a varietyof cytokines such as IL-2 or the co-stimulatory moleculeB7. 1 led to increased immunogenicity and reducedtumorigenicity of tumors has several models and thisprocess involves T cells. We have previously reporteddecreased tumorigenicity of the murine plasmacytomaJ558L (MHC class Ⅰ^+ and class Ⅱ^-) expressing IL-2 orB7. l. When systemic immunity was analyzed,

关键词： rejection interleukin vaccine immunity expressing cytokines immunized comparable nude alone

在线全文

学校读者我要写书评

暂无评论

工业革命:过去与未来

东岳论丛 2006年第1期27卷 5-12页

作者： robert E.Lucas.Jr. 李志宏山东大学

通过全球经济增长的跨世纪比较,作者洞察出18世纪末开始的工业革命之后的经济增长与先前经济增长之根本不同在于工业世界是以人口总量相对于产出总量的增长率呈现稳定下降态势和广大普通民众生活水准的普遍提高为典型特征。进一步的分... 详细信息

通过全球经济增长的跨世纪比较,作者洞察出18世纪末开始的工业革命之后的经济增长与先前经济增长之根本不同在于工业世界是以人口总量相对于产出总量的增长率呈现稳定下降态势和广大普通民众生活水准的普遍提高为典型特征。进一步的分析表明,以马尔萨斯(Malthus)的人口理论为代表的传统经济增长理论可以成功解释传统农业社会里各国人均收入大致相等且基本上不随时间的变化而改变,而以贝克尔(becker)的人力资本积累理论为代表的现代经济增长理论则可以成功解释现代工业社会中全球人均收入的持续大幅度成长、跨国人均收入的巨大不平等和人均收入跨国分布的动态变化。最后,作者指出随着仍然处在进行中的工业革命向全球各个角落扩散,世界人均收入整体上将不断提高,而解决全球低收入人群生活水准的最佳途径是不断地增加世界产出总量,而非重新分配现有的世界总产出。

关键词：传统农业社会工业革命现代工业社会古典增长理论现代增长理论