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Cardiovagal Tone: A Predictor of Heart Rate Adjusted Augmentation Index in Men but Not in Women

Open Journal of Molecular and Integrative Physiology 2017年第3期7卷 41-51页

作者： Peter L. Latchman robert thiel Gregory Gates Weili Zhu robert Axtell Kenneth Gardner William Lunn Ronald DeMeersman Exercise Science Department Southern Connecticut State University New Haven CT USA Albert Einstein College of Medicine Yeshiva University Bronx NY USA Capital University of Physical Education and Sports Beijing China G.C. Foster College of Physical Education and Sports Spanish Town Jamaica Alfaisal University College of Medicine Riyadh KSA

Purpose: Aortic augmentation index (AIx) and cardiovagal tone (CVT) are indicators of cardiovascular health. Associations between these variables provide information about their roles in cardiovascular disease. However, evaluating these associations from a gender perspective and gaining an understanding of the relationship between cardiorespiratory fitness and AIx based on gender can provide additional information. Therefore, we examined the relationships between CVT, measured as the log transformed high-frequency power of R-R intervals from electrocardiogram measurements (lnHFR-R);cardiorespiratory fitness, measured as maximum oxygen consumption (VO2max);and AIx at a heart rate of 75 beats·min-1(AIx@75). We hypothesized that the relationships between CVT, cardiorespiratory fitness, and AIx@75 would differ based on gender. Methods: We examined the associations between lnHFR-R, VO2max, and AIx@75 in 41 women and 39 men. Power spectral density analysis of heart rate variability determined lnHFR-R, radial tonometry determined AIx@75 and the Bruce Treadmill Protocol determined VO2max. Results: In men, lnHFR-R positively correlated with and significantly predicted AIx@75 (P = 0.005) but not in women (P = 0.49). For every unit increase in lnHFR-R, there was a 4.6 unit increase in AIx@75 in men versus a 1.0 unit increase in women. There was a significant inverse relationship between VO2max and AIx@75, with VO2max being a significant predictor of AIx@75 in men (P = 0.01). For every unit increase in VO2max, there was a 0.60 unit decrease in AIx@75 in men versus a 0.2 unit decrease in women. Conclusions: The associations between CVT and AIx@75 and between cardiorespiratory fitness and AIx@75 differ by gender. CVT and cardiorespiratory fitness are significant predictors of AIx@75 in men but not in women.

关键词： Augmentation Index Heart Rate Variability Cardiorespiratory Fitness Cardiovascular Disease

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Spontaneous Baroreflex Sensitivity in Normotensive African-American Men

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Open Journal of Molecular and Integrative Physiology 2019年第1期9卷 1-10页

作者： Peter L. Latchman Gregory J. Gates robert thiel robert S. Axtell Weili Zhu Ally Morin-Viall Tianhong Yue Qin Yang Kenneth Gardner Ronald E. De Meersman Exercise Science Department Southern Connecticut State University New Haven CT USA Department of Pediatrics Albert Einstein College of Medicine Yeshiva University Bronx NY USA Capital University of Physical Education and Sports Beijing China G. C. Foster College of Physical Education and Sport Spanish Town Jamaica College of Medicine American University of Antigua Osbourn Antigua and Barbuda

Purpose: African-American men (AAM) have a greater risk of hypertension (HTN) than Caucasian men (CM). To reduce this risk, determining the differences in mechanisms involved in HTN and understanding the relationship between these mechanisms and factors affecting blood pressure (BP) in AAM and CM is necessary. One such mechanism is spontaneous baroreflex sensitivity (sBRS) and two factors are cardiorespiratory fitness (CRF) and arterial stiffness (AS). The aims of this study were to determine, firstly, whether there are differences in sBRS between young, normotensive AAM and CM, and secondly, to determine if CRF and AS are significant predictors of sBRS in young, normotensive AAM and CM. Methods: Twenty-three normotensive AAM and 36 CM were recruited from Southern Connecticut State University. Measures included anthropometric, sBRS (alpha-index), and CRF (maximal oxygen consumption [VO2max]), as well as AS (carotid-femoral pulse wave velocity [Cf-PWV]). Independent t-tests were used to determine differences between groups and multiple regression analysis was used to determine how much of the variation in sBRS was explained by CRF and AS. Results: The sBRS was significantly lower in AAM (10.3 ± 3.8 ms/mmHg) vs. CM (13.3 ± 5.7 ms/ mmHg), P = 0.03. CRF and AS were not significant predictors of sBRS in AAM (P = 0.25) and CM (P = 0.30). There was no relationship between, sBRS, CRF and AS;CRF was significantly reduced in AAM vs. CM (45.1 ± 6.3 vs. 52.1 ± 7.5 mL·kg?1·min?1, P ≤ 0.001). Conclusions: Young normotensive AAM demonstrated significantly lower sBRS vs. CM, irrespective of having fair CRF and normal BP. CRF and AS are not significant predictors of sBRS in young, normotensive AAM and CM. The attenuation in sBRS in AAM did not result in AAM having higher BP versus CM. This finding underscores the need for more detailed examination of the role of sBRS in the etiology of HTN in AAM.

关键词： African-American Men Spontaneous Baroreflex Sensitivity Cardiorespiratory Fitness Arterial Stiffness Hypertension

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CODE-EHR:临床研究中运用结构化电子医疗记录的最佳实践框架

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英国医学杂志中文版 2022年第12期25卷 721-729页

作者： Dipak Kotecha Folkert W Asselbergs Stephan Achenbach Stefan DAnker Dan Atars Colin Baigent Amitava Banerjee Birgit Beger Cunnar Brobert Barbara Casadei Cinzia Ceccarelli Martin R Cowie Filippo Crea Maureen Cronin Spiros Denaxas Andrea Derix Donna Fitzsimons Martin Fredriksson Chris PGale Georgios V Ckoutos Wim Goettsch Harry Hemingway Martin Ingvaris Adrian Jonas's robert Kazmierski Susanne Logstrup R Thomas Lumbers Thomas F Lischer Paul McGreavy leana L Pina Lothar Roesiga Carl Steinbeisser Mats Sundgren Benoit Tyl Chislaine van thiel Kees van Bochove Panos EVardas Tiago Villanueva Marilena Vrana Wim Weber Franz Weidinger Stephan Windecker Angela Wood Diederick E Grobbee 创新药物计划BigData@Heart联盟欧洲心脏病协会 CODE-EHR国际共识小组宋奇繁(译) 汪奕名(译) 不详重庆医药高等专科学校

改善患者生存质量是全球临床医学的发展目标,大数据是实现其发展的关键所在。技术进步使结构化电子医疗记录得以常规化,也可能会改善缺失重要临床证据的问题。虽然大数据及其相关分析在新冠大流行期间发挥了重要作用,但也存在严重的缺... 详细信息

改善患者生存质量是全球临床医学的发展目标,大数据是实现其发展的关键所在。技术进步使结构化电子医疗记录得以常规化,也可能会改善缺失重要临床证据的问题。虽然大数据及其相关分析在新冠大流行期间发挥了重要作用,但也存在严重的缺陷。证实、核验、数据隐私以及对科学研究社会责任的践行是一项重要挑战。欧洲心脏病协会和BigData@Heart联盟已经收集了包括患者代表、临床医生、科研人员、监管机构、期刊编辑和企业代表在内的多元化国际参与者,提出了CODE-EHR的最低标准框架。为改进研究设计、提高信息透明度提供方法手段,同时为实现医疗保健数据的稳健并能够有效运用制定了技术路线图。

关键词：大数据数据隐私 CODE 技术路线图科研人员信息透明度医疗保健最低标准

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成人原B急性淋巴细胞白血病的免疫表型、基因型和临床特征及其疗效:德国急性淋巴细胞白血病多中心研究(GMALL)03/87和04/89结果

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德国医学 2000年第1期17卷 19-22页

作者： W.DLudwig H.Rieder C.R.Bartram B.Heinze S.Schwartz W.Gassmann H.Lffler D.Hossfald G.Heil S.Handt A.Heyll H.Diedrich K.Fischer A.Weiss B.V.lkers ü.Aydermir C.Fonatsch N.Gkbuget E.thiel D.Hoelzer 祁明芳 Medizinische Fakultt Charité Humboldt-Universitt Robert-Rssle-KlinikBerlin Germany 广州暨南大学医学院第一附属医院

原 B 细胞白血病是 B 型急性淋巴细胞白血病(ALL)中最原始的一种亚型,在儿童和成人 ALL 中各占约5%和10%。其原始细胞免疫表型特点为CD19^+胞浆或表面 CD79a^+、CD22^+、CD24^+、CD10^-、胞浆IgM^-和表面 Ig^-。儿童原 B 细胞 ALL 常与... 详细信息

原 B 细胞白血病是 B 型急性淋巴细胞白血病(ALL)中最原始的一种亚型,在儿童和成人 ALL 中各占约5%和10%。其原始细胞免疫表型特点为CD19^+胞浆或表面 CD79a^+、CD22^+、CD24^+、CD10^-、胞浆IgM^-和表面 Ig^-。儿童原 B 细胞 ALL 常与患者年龄<1岁、高白细胞计数、肝脾明显肿大和中枢神经系统浸润等预后不佳的临床指标相关联。

关键词：急性白血病 B细胞 GMALL 基因型免疫表型

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