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作者： (美)帕克

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Depression and Brain-derived Neurotrophic Factor Levels in Alzheimer's Disease

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Neuroscience & Medicine 2011年第1期2卷 43-47页

作者： James R. Hall Sid E. O'Bryant Leigh Johnson robert C. Barber 不详

Background: Depression is often viewed as a risk factor for the development of Alzheimer's disease (AD), however little is known regarding the underlying biological mechanisms linking these two diseases. Brain-derived neurotrophic factor (BDNF) has been linked to both cognitive impairment and depression in past research;however few studies have ex-amined this relation in a sample of Alzheimer's patients. The present study sought to address this gap in the literature by examining the relation between serum BDNF levels and depression assessed by the Geriatric Depression Scale (GDS) in a group of patients diagnosed with probable Alzheimer's disease. Methods: Participants included 169 individuals diagnosed with Probable AD enrolled in the TARC Longitudinal Research Cohort with available BDNF levels and GDS scores. The participants were divided into Depressed (N = 20) and Not Depressed (N = 149) based on GDS scores. Re-sults: BDNF levels significantly predicted level (High vs. Low) of depression (β = 0.066, SE = 0.031, p = 0.034). BDNF levels for the Depressed group were significantly higher than those observed in the Not Depressed group (p. > 0.036). Conclusions: These findings suggest that an upregulation of BDNF possibly exists among depressed AD patients as a response to the chronic inflammatory processes that occur in depression. This upregulation of BDNF appears to persist at least into early stages of Alzheimer's.

关键词： Alzheimer's Disease Depression BDNF Depression Severity

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牛奶可乐经济学

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作者： (美)罗伯特·弗兰克(robert H.Frank)

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Elastic and Rheological Property Measurements at High Pressure and Temperature Using Ultrasonic Data Transfer Function Method

Elastic and Rheological Property Measurements at High Pressu...

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18th International Conference on High Pressure Science and Technology

作者： Baosheng Li Jennifer Kung robert C.Liebermann Donald J.Weidner Mineral Physics Institute State University of New York at Stony Brook Stony Brook NY 11794 USA Mineral Physics Institute State University of New York at Stony Brook Stony Brook NY 11794 USA Mineral Physics Institute State University of New York at Stony Brook Stony Brook NY 11794 USA Mineral Physics Institute State University of New York at Stony Brook Stony Brook NY 11794 USA

＜正＞ Elastic and rheological properties of Earth minerals at high pressure and temperature are crucial for the understanding of the composition, structure and the dynamics of the Earth’s interior. Recently, we have developed the techniques to measure sound velocity to 8GPa and 1500K using ultrasonic interferemetry and in-situ synchrotron X-ray diffraction in a DIA-type, cubic anvil high pressure apparatus （SAM85） installed at beamline X17B at NSLS in Brookhaven National Laboratory. In these experiments, a piezoelectric transducer is mounted onto a non-stressed surface at the back of the WC anvil to transmit and receive acoustic signals from buffer rod and sample enclosed in Boron epoxy pressure medium. Conventional methods, such as pulse echo overlap and phase comparison, involve sending rf pulse as input signals and recording the in-phase and out-of-phase interference between the buffer rod and sample echoes for travel time measurements. In this case, data collection over a frequency range of 30 MHz takes several minutes which is not satisfactory for capturing the information related to the time dependent processes, such as strain relaxation at high pressure and temperature and phase transformations. In this study, we have implemented a new ultrasonic method for travel time measurements by recording the data transfer function in a a few seconds. Instead of rf pulse, a waveform of sine function （sin（x）/x） with a center frequency of the transducer resonance frequency is sent to excite the piezoelectric transducer. Figure la is an input sine signal with center frequency 50 MHz from 25 to 75 MHz. Its amplitude in the frequency domain is shown in Fig. Ib. The amplitude of the signal sent to the buffer rod and sample will be modulated by the transducer response in the corresponding frequency range. The data transfer function, i.e., the response from the buffer rod and sample along the wave propagation path is then recorded. Figure 2 is the recorded data transfe

关键词： Elasticity Synchrotron High Pressrue

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A Surviving Patient with Record High Creatinine

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Open Journal of Nephrology 2013年第4期3卷 217-219页

作者： Andrew C. Storm Naing L. Htike David A. Cohen robert L. Benz Department of Internal Medicine Lankenau Medical Center Wynnewood USA Department of Internal Medicine The Johns Hopkins Hospital Baltimore USA Department of Nephrology Lankenau Medical Center Wynnewood USA Division Chief of Nephrology Lankenau Medical Center and Main Line Health and Lankenau Institute for Medical Research Wynnewood USA

Creatinine is a product of muscle protein breakdown cleared by the kidneys at a constant rate. The glomerular filtration rate is estimated based on serum creatinine. There is no definitive level of serum creatinine which is itself incompatible with human survival. We present the highest serum creatinine associated with survival based on a thorough review of the literature. A 34-year-old male patient with baseline serum creatinine of 1.2 mg/dl presented our emergency department with a six week history of new onset of uremic symptoms. His past medical history was unremarkable. On exam, he was in no distress. His BMI was 28. His exam was significant only for elevated blood pressure and asterixis. His peak serum creatinine was 53.9 mg/dl. The patient subsequently required maintenance hemodialysis and later changed to long-term peritoneal dialysis. To our knowledge, based on a thorough review of the literature using PubMed, Cochrane Database and the United States Renal Data System (USRDS), this is the highest level of serum creatinine ever reported. We conclude that serum creatinine itself is non-lethal. It is more likely that other electrolyte and retained metabolic abnormalities of renal failure frequently cause symptoms or death before creatinine toxicity, if such a level exists, creatinine has reached.

关键词： Survival Outcome Uremia Mortality Creatinine

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α-Catenin Inactivation Disrupts Expression of Intercalated Disc Protein and Alters Physiological Function in HL-1 Cells

α-Catenin Inactivation Disrupts Expression of Intercalated ...

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第六届海南省生命科学联合学术会议

作者： Shigan Fu Junli Guo Xuezhi Cui Brenda Su robert M.Hamilton Department of Physiology Cardiovascular Disease Research InstituteHainan Medical College

α-Catenin is a key cell adhesion protein that is thought to indispensably link the cadherin-based adhesion complex to the actin cytoskeleton.α-catenin appears to play a central role in cell-cell contact *** dilated cardiomyopathy,interaction with adherens junction protein,biochemical,structural and live-cell imaging studies ofα-catenin are observed in cardiomyocytes and tissues in vivo or in vitro,its physiological function and relationships with expression of intercalated disc proteins in HL-1 cell line remain *** objective of this study was to assess the expression and/or localization of intercalated disks proteins,and communication and electric conduction of gap junction inα-catenin knockout HL-1 ***-1 mouse myocyte cells were transfected withα-catenin siRNA and negative contorl(NC)*** of intercalated disks proteins was characterized by immunoblotting and Immuno-fluorescence microscopy inα-catenin siRNA and NC siRNA transfected HL-1 *** of cells was counted after trypsinization using a *** or necrotic of HL-1 cells were determined with annexin-V-Fluos staining assay ***-cardiomyocyte coupling was determined by Lucifer yellow(LY)dye *** conduction of gap junctions were studied by microelectrode arrays(MEA).With the concetration ofα-catenin siRNA gradually increase,anti-α-catenin antibody expression in HL-1 cell line was reduced gradually and showed significant dose-dependence decreasing *** of HL-1 cells were reduced at 96h and 120h inα-catenin transfected HL-1cells,even decreased to 50%compared with none siRNA group and NC ***,apoptosis or necrosis of HL-1 cardiomyocytes were exhibited at 48h and 72h inα-catenin transfected HL-1cells,and showed early than reduction of number of *** levels of other adherens junctionβ-catenin,γ-catenin),gap junction(Cx43)and ZO-1 proteins were significantly decrease at 96h inα-catenin siRNA trans

关键词： small interfering RNA a-catenin apoptosis proliferation cell communication intercalated disc protein HL-1 cell line

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采用SilviScan-3TM研究木材性质的方法及其在气候变化研究中的应用

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气候变化研究进展 2012年第2期08卷 124-130页

作者：徐金梅吕建雄鲍甫成肖军 robert Evans 黄荣凤徐明中国林业科学研究院木材工业研究所国家林业局木材科学与技术重点实验室北京100091 国家林业局亚太森林网络管理中心北京100013 CSIRO Materials Science and Engineering Clayton South Australia 北京市朝阳区产品质量监督检验所北京100124

系统介绍了利用SilviScan-3TM测量细胞结构、术材密度、微纤丝角和划分年轮界线的方法,并以祁连山青海云杉为例,分析青海云杉6个术材性质参数(年轮细胞直径、年轮细胞壁厚、年轮宽度、年轮密度、年轮微纤丝角、年轮弹性模量)与气候因子... 详细信息

系统介绍了利用SilviScan-3TM测量细胞结构、术材密度、微纤丝角和划分年轮界线的方法,并以祁连山青海云杉为例,分析青海云杉6个术材性质参数(年轮细胞直径、年轮细胞壁厚、年轮宽度、年轮密度、年轮微纤丝角、年轮弹性模量)与气候因子的关系,以期为利用多个树轮参数研究气候提供参考.结果表明:6个木材性质参数与月平均气温和月降水量都有显著相关的月份,但显著相关的时间段不同,并且微纤丝角和细胞结构参数中包含的气候信息强于常用的年轮宽度和年轮密度.SilviScan-3TM测量木材性质参数的优越性体现在:测量精度高、速度快,能在同一个试样上测量多个参数并能精确定年.

关键词： SilviScan-3TM 木材性质参数气温降水气候重建

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Would ivermectin for malaria control be beneficial in onchocerciasis-endemic regions?

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Infectious Diseases of Poverty 2019年第4期8卷 108-108页

作者： Joseph Nelson Siewe Fodjo Marina Kugler An Hotterbeekx Adam Hendy Jean-Pierre Van Geertruyden robert Colebunders Global Health Institute University of AntwerpKinsbergen centrumDoornstraat 3312610 AntwerpBelgium 不详

Background:There is accumulating evidence supporting the use of ivermectin as a malaria control *** findings from the repeat ivermectin mass drug administrations for control of malaria trial demonstrated a reduced incidence of malaria in villages which received repeated ivermectin mass drug administration(MDA;six doses)compared to those who had only one round of *** other studies investigating the benefits of ivermectin for malaria purposes are ongoing/*** text:While ivermectin MDA offers promising perspectives in the fight against malaria,we highlight the added benefits and anticipated challenges of conducting future studies in onchocerciasis-endemic regions,which are confronted with a substantial disease burden including onchocerciasis-associated *** the frequency of ivermectin MDA in such places may reduce the burden of both malaria and onchocerciasis,and allow for more entomological investigations on both the Anopheles mosquitoes and the ***,acceptability and feasibility studies are needed to assess the endorsement by the local populations,as well as the programmatic feasibility of implementing ivermectin MDA several times a ***:Onchocerciasis-endemic sites would doubly benefit from ivermectin MDA interventions,as these will alleviate onchocerciasis-associated morbidity and mortality,while potentially curbing malaria *** onchocerciasis programs and other relevant stakeholders in the malaria/ivermectin research agenda would foster the implementation of pluri-annual MDA in target communities.

关键词： Malaria Ivermectin Onchocerciasis Mass drug administration Vector control

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數位訊號處理

數位訊號處理

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2008年

作者： robert J.Schilling Sandra L. Harris

来源：畅想之星图书光盘版（南... 评论

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猪的非常规饲料原料(一)

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中国畜牧杂志 2009年第6期45卷 36-40页

作者：武书庚 robert O.Myer Joel H.Brendemhl 中国农业科学院饲料研究所北京100081

猪饲料一般由谷物和油籽粕组成，但猪能利用多种饲料原料，包括食品加工、配菜和服务业的副（共）产品或可食废弃物，如谷物加工、酿造和蒸馏、烘焙、水果和蔬菜加工、肉蛋奶加工、海产品加工、精细食品制造业、食品零售等。猪饲料不常... 详细信息

猪饲料一般由谷物和油籽粕组成，但猪能利用多种饲料原料，包括食品加工、配菜和服务业的副（共）产品或可食废弃物，如谷物加工、酿造和蒸馏、烘焙、水果和蔬菜加工、肉蛋奶加工、海产品加工、精细食品制造业、食品零售等。猪饲料不常用的原料还包括在低价格、过剩或传统原料不足时使用的原料，及传统饲料不足而能经济替代的当地丰富的原料。

关键词：非常规饲料原料猪饲料海产品加工食品加工谷物加工食品制造业蔬菜加工废弃物

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