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Effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease:Clinical implications

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World Journal of Gastroenterology 2024年第27期30卷 3264-3267页

作者： Giovanna McGinty robert Przemioslo Department of Gastroenterology North Bristol TrustSouthmead HospitalBristol BS105NBUnited Kingdom Department of Gastroenterology and Hepatology North Bristol TrustSouthmead HospitalBristol BS105NBUnited Kingdom

In this editorial,we comment on the article by Chen et al recently published in *** focus the debate on whether reducing the upper limit of normal of alanine aminotransferase(ALT)would effectively identify cases of fibrosis in metabolic-dysfunction associated fatty liver disease(MAFLD).This is important given the increasing prevalence of MAFLD and obesity ***,a suitable screening test to identify patients in the general population does not exist and most patients are screened after the finding of an abnormal *** authors of this paper challenge the idea of what a normal ALT is and whether that threshold should be lowered,particularly as their study found that 83.12%of their study population with a diagnosis of MAFLD had a normal *** main advantages of screening would be to identify patients and provide intervention early,the mainstay of this being changing modifiable risk factors and monitoring for liver ***,there is not enough suitable therapeutic options available as of yet although this is likely to change in the coming years with more targets for therapy being *** is one example of this which has demonstrated benefit with an acceptable side effect profile for those patients with MAFLD and obesity,although studies have not yet shown a significant improvement in fibrosis *** would also require a huge amount of resource if a reduced ALT level alone was used as criteria;it is more likely that current scoring systems such as fibrosis-4 may be amended to represent this additional ***,there is not a good argument to recommend wide-spread screening with a reduced ALT level as this is unlikely to be *** is compounded by the fact that there is a significant heterogeneity in what is considered a normal ALT between *** studies previously have suggested a more pragmatic approach in screening those over the age of 60,this is likely to change with the increasing inc

关键词： Alanine aminotransferase Metabolic-dysfunction associated fatty liver disease Metabolic syndrome Fibrosis Cirrhosis Semaglutide

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Glycolysis and glucose metabolism as a target for bioenergetic and neuronal protection in glaucoma

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Neural Regeneration Research 2024年第8期19卷 1637-1638页

作者： Pete A.Williams robert J.Casson Department of Clinical Neuroscience Division of Eye and VisionSt.Erik Eye HospitalKarolinska InstitutetStockholmSweden Ophthalmic Research Laboratories Discipline of Ophthalmology and Visual SciencesUniversity of AdelaideAdelaideAustralia

Vision is arguably our most valued sense,yet approximately 340 million people globally suffer blindness or moderate visual impairment,highlighting the need to further develop and advance treatments for ophthalmic *** refers to a group of ocular disorders united by a clinically characteristic optic neuropathy with associated retinal ganglion cell loss.

关键词： metabolism glaucoma globally

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Utility and Application of a Versatile Analytical Method for MMF Calculation in AC Machines

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CES Transactions on Electrical Machines and Systems 2024年第1期8卷 22-31页

作者： Ze-Zheng Wu robert Nilssen Jian-Xin Shen IEEE the College of Electrical Engineering Zhejiang UniversityHangzhou 310027China the Department of Electric Energy Norwegian University of Science and TechnologyTrondheimNorwayand also affiliated with the College of Electrical EngineeringZhejiang UniversityHangzhou 310027China

A versatile analytical method(VAM) for calculating the harmonic components of the magnetomotive force(MMF) generated by diverse armature windings in AC machines has been proposed, and the versatility of this method has been established in early literature. However, its practical applications and significance in advancing the analysis of AC machines need further elaboration. This paper aims to complement VAM by augmenting its theory, offering additional insights into its conclusions, as well as demonstrating its utility in assessing armature windings and its application of calculating torque for permanent magnet synchronous machines(PMSM). This work contributes to advancing the analysis of AC machines and underscores the potential for improved design and performance optimization.

关键词： AC machine Analytical method Harmonic analysis MMF Magnetic field Torque calculation

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Science and reflections: With some thoughts to young applied scientists and engineers

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Earthquake Science 2024年第5期37卷 459-493页

作者： robert L Nowack Department of Earth Atmospheric and Planetary SciencesPurdue UniversityWest LafayetteIN47906USA

I provide some science and reflections from my experiences working in geophysics,along with connections to computational and data sciences,including recent developments in machine learning.I highlight several individuals and groups who have influenced me,both through direct collaborations as well as from ideas and insights that I have learned *** my reflections are rooted in geophysics,they should also be relevant to other computational scientific and engineering fields.I also provide some thoughts for young,applied scientists and engineers.

关键词： geophysics computational and data science applied science and engineering

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Coupled Inversion of Pressure and Tiltmeter Data for Mapping Hydraulic Fracture Geometry

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Acta Mechanica Solida Sinica 2024年第3期37卷 396-405页

作者： Zuorong Chen Xiaofang Jiang Zhejun Pan robert G.Jeffrey National Key Laboratory of Continental Shale Oil Northeast Petroleum UniversityDaqing163318China SCT Operation Pty.Ltd. PO Box 824WollongongNSW2520Australia

Pressure and tilt data are jointly inverted to simultaneously map the orientation and dimensions of a hydraulic *** deformation induced by a fracture under internal pressure is modeled using the distributed dislocation *** planar fracture is represented by four quarter ellipses,joined at the center and sharing *** configuration provides a straightforward model for characterizing asymmetric fracture *** inverse problem of mapping the fracture geometry is formulated using the Bayesian probabilistic method,combining the a priori information on the fracture model with updated information from pressure and tilt *** the nonlinear inverse problem is achieved by pseudo-randomly sampling the posterior probability distribution through the Markov chain Monte Carlo *** resulting posterior probability distribution is then explored to assess uncertainty,resolution,and correlation between model *** experiments are conducted to verify the accuracy and validity of the proposed analysis method in mapping the fracture geometry using synthetic pressure and tilt data.

关键词： Hydraulic fracture mapping Coupled inversion Tilt Treating pressure

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An explainable AI framework for robust and transparent data-driven wind turbine power curve models

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Energy and AI 2024年第1期15卷 312-327页

作者： Simon Letzgus Klaus-robert Müller Machine Learning Group Technische Universitβe BerlinStraβe des 17.Juni 135Berlin10623Germany Berlin Institute for the Foundations of Learning and Data Berlin10587Germany Department of Artificial Intelligence Korea UniversitySeoul136-713South Korea Max Planck Institute for Informatics Saarbrücken66123Germany

In recent years,increasingly complex machine learning methods have become state-of-the-art in modelling wind turbine power curves based on operational *** these methods often exhibit superior performance on test sets,they face criticism due to a perceived lack of transparency and concerns about their robustness in dynamic,non-stationary environments encountered by wind *** this work,we address these issues and present a framework that leverages explainable artificial intelligence methods to gain systematic insights into data-driven power curve *** its core,we propose a metric to quantify how well a learned model strategy aligns with the underlying physical principles of the *** novel tool enables model validation beyond the conventional error metrics in an automated *** demonstrate,for instance,its capacity as an indicator for model generalization even when limited data is ***,it facilitates understanding how decisions made during the machine learning development process,such as data selection,pre-processing,or training parameters,affect learned *** a result,we obtain physically more reasonable models,a prerequisite not only for robustness but also for meaningful insights into turbine operation by domain *** latter,we illustrate in the context of wind turbine performance *** summary,the framework aims to guide researchers and practitioners alike toward a more informed selection and utilization of data-driven wind turbine power curve models.

关键词： Explainable AI(XAI) Machine learning Wind energy Wind turbine power curve SCADA Condition monitoring

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Actuating droplets with electrowetting: Force and dynamics

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Droplet 2024年第2期3卷 113-124页

作者： robert Hennig Vito Cacucciolo Herbert Shea Soft Transducers Laboratory(LMTS) Ecole Polytechnique Fédérale de Lausanne(EPFL)NeuchatelSwitzerland Politecnico di Bari BariItaly

Electrowetting on dielectric(EWOD)allows rapid movement of liquid droplets on a smooth surface,with applications ranging from lab-on-chip devices to *** in-plane force on a droplet is a key indicator of EWOD *** force has been extensively modeled but few direct experimental measurements are *** study the EWOD force on a droplet using two setups that allow,for the first time,the simultaneous measurement of force and contact angle,while imaging the droplet shape at 6000 frames/*** several liquids and surfaces,we observe that the force saturates at a voltage of approximately 150 *** of voltages of up 2 kV,that is,10 times higher than is typical,does not significantly increase forces beyond the saturation ***,we observe that the transient dynamics,localized at the front contact line,do not show saturation with *** the higher voltages,the initial front contact line speed continues to increase,the front contact angle temporarily becomes near zero,creating a thin liquid film,and capillary waves form at the liquid–air *** the localized EWOD forces at the contact line exceed the capillary forces,projectile droplets *** surface tension allows for higher droplet forces,which we demonstrate with mercury.

关键词： capillary forces dynamics

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Does MgSO_(4) protect the preterm brain?Dissecting its role in the pathophysiology of hypoxic ischemic encephalopathy

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Neural Regeneration Research 2024年第9期19卷 1861-1862页

作者： robert Galinsky Laura Bennet Alistair J.Gunn The Ritchie Centre Hudson Institute of Medical ResearchMelbourneVICAustralia Department of Obstetrics and Gynaecology Monash UniversityMelbourneVICAustralia Department of Physiology The University of AucklandAucklandNew Zealand

Mitigating preterm encephalopathy continues to be one of the greatest challenges in perinatal *** encephalopathy is associated with high mortality,serious morbidity,and significant socio-economic impacts on the individuals,their families,and public health sectors and welfare systems that last a *** cost of disability associated with preterm brain injury continues to *** of this injury,and disability,would significantly reduce this socioeconomic burden.

关键词： encephalopathy mortality hypoxic

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Role of practice standardization in outcome optimization for CDH

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World Journal of Pediatric Surgery 2024年第2期7卷 110-118页

作者： Alexandra Dimmer robert Baird Pramod Puligandla Harvey E.Beardmore Division of Pediatric Surgery Department of Pediatric SurgeryMontreal Children's HospitalMontrealQuebecCanada Division of Pediatric General and Thoracic Surgery British Columbia Children's HospitalVancouverBritish ColumbiaCanada Harvey E.Beardmore Department of Pediatric Surgery McGill UniversityMontrealQuebecCanada

Standardization of care seeks to improve patient outcomes and healthcare delivery by reducing unwanted variations in care as well as promoting the efficient and effective use of healthcare *** are many types of standardization,with clinical practice guidelines(CPGs),based on a stringent assessment of evidence and expert consensus,being the hallmark of high-quality *** article outlines the history of CPGs,their benefits and shortcomings,with a specific focus on standardization efforts as it relates to congenital diaphragmatic hernia management.

关键词： congenital clinical shortcomings

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Earliest megafossils of scandent calamoid palms from the Deccan Intertrappean Beds of Central India and their paleobiogeographic implications

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Journal of Palaeogeography 2024年第3期13卷 509-527页

作者： Sanchita Kumar Kaustav Roy robert A.Spicer Mahasin Ali Khan Palaeobotany and Palynology Laboratory Department of BotanySidho-Kanho-Birsha UniversityRanchi RoadPurulia-723104India CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303Yunnan ProvinceChina School of Environment Earth and Ecosystem SciencesThe Open UniversityMilton KeynesMK76AAUK State Key Laboratory of Tibetan Plateau Earth System Resources and Environment(TPESRE)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

Two well-preserved petrified palm stems from the latest Maastrichtian(Late Cretaceous) to earliest Danian(Early Paleocene) sediments of the Deccan Intertrappean Beds of Madhya Pradesh, Central India are described. Their significant anatomical characteristics include a Calamus-type general stem pattern,the presence of well-preserved fibrovascular bundles(fvbs) with two wide metaxylem vessel elements(230 μm-250 μm) and one phloem strand, uniform density of fvbs, lack of continuity between protoxylem and metaxylem vessel elements, and an absence of centrifugal differentiation of sclerenchymatous fibrous *** features reveal a close resemblance to those of extant genera of scandent Calamoideae. The permineralized stems are described as a new species namely, Palmoxylon calamoides Kumar, Roy et Khan sp. *** fossils represent the oldest reliable fossil records of this family, supporting their Gondwanan origin, their importance in tracing their migration pathways from India to Europe and other continents after the docking of the Indian subcontinent with Eurasia during the Paleocene, and an “Out-of-India” dispersal hypothesis. Today the subfamily Calamoideae is disjunctly occurred in Africa, Asia, Australia, Europe, and South America, but the poor deep-time fossil record of this subfamily with a small number of Cenozoic fossils makes hypotheses concerning its origin and dispersal difficult to evaluate. The present study has significant implications for the origin and migration of this subfamily and the paleoclimate.

关键词： Scandent Calamoideae Stem anatomy K-Pg Paleobiogeography Paleoclimate Central India

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