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Three-stage Transfer Learning with AlexNet50 for MRI Image Multi-Class Classification with Optimal Learning Rate

2004’中国棉业发展高峰论坛

作者： robert s.weil ⅱ 美国棉商协会

＜正＞尊敬的来宾、女士们、先生们: 很荣幸今天上午能够在这里向大家做这个演讲,演讲的题目是将中国市场完全纳入一个基于规则的体系中对国际棉花贸易具有重大意义。今天,我代表美国棉花发货人联合会——ACsA,来参加这个会议。美国棉...

＜正＞尊敬的来宾、女士们、先生们: 很荣幸今天上午能够在这里向大家做这个演讲,演讲的题目是将中国市场完全纳入一个基于规则的体系中对国际棉花贸易具有重大意义。今天,我代表美国棉花发货人联合会——ACsA,来参加这个会议。美国棉花发货人联合会是个有着80多年悠久历史的贸易协会,代表美国棉花贸易的非合作性领域。我们的会员包括美国主要的棉花商。其中部分会员公司的成立时间

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来源： cnki会议评论

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Computer Modeling in Engineering & sciences 2025年第1期142卷 155-183页

作者： suganya Athisayamani A.robert singh Gyanendra Prasad Joshi Woong Cho school of Computing Sastra Deemed to be UniversityThanjavur613401India Department of Computational Intelligence SRM Institute of Science and TechnologyKattankulathur603203India Department of AI and software Engineering Kangwon National UniversitySamcheok25913Republic of Korea Department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok25913Republic of Korea

In radiology,magnetic resonance imaging(MRI)is an essential diagnostic tool that provides detailed images of a patient’s anatomical and physiological *** is particularly effective for detecting soft tissue ***,radiologists manually interpret these images,which can be labor-intensive and time-consuming due to the vast amount of *** address this challenge,machine learning,and deep learning approaches can be utilized to improve the accuracy and efficiency of anomaly detection in MRI *** manuscript presents the use of the Deep AlexNet50 model for MRI classification with discriminative learning *** are three stages for learning;in the first stage,the whole dataset is used to learn the *** the second stage,some layers of AlexNet50 are frozen with an augmented dataset,and in the third stage,AlexNet50 with an augmented dataset with the augmented *** method used three publicly available MRI classification datasets:Harvard whole brain atlas(HWBA-dataset),the school of Biomedical Engineering of southern Medical University(sMU-dataset),and The National Institute of Neuroscience and Hospitals brain MRI dataset(NINs-dataset)for *** hyperparameter optimizers like Adam,stochastic gradient descent(sGD),Root mean square propagation(RMs prop),Adamax,and AdamW have been used to compare the performance of the learning ***-dataset registers maximum classification *** evaluated the performance of the proposed classification model using several quantitative metrics,achieving an average accuracy of 98%.

关键词： MRI tumors classification AlexNet50 transfer learning hyperparameter tuning optimizer

Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan Qi robert Chunhua Zhao Jiao Wang school of Life sciences Shanghai UniversityShanghaiChina school of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical sciences Chinese Academy of Medical sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi sun shiqian shen robert J.Thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

The state of the Integrative Medicine in the *** Western World

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Chinese Journal of Integrative Medicine 2011年第1期17卷 6-10页

作者： Andrew weil Director of Arizona Center for Integrative Medicine University of Arizona College of MedicineTucsonArizona85724USA

Introduction Andrew Thomas.weil （born June 8, 1942）, Lovell-Jones Professor of Integrative Rheumatology, Clinical Professor of Medicine, Professor of Public Health, is best known for establishing and popularizing the field of integrative medicine （IM）. He is the world leader of integrative medicine, founder and Program Director of the Arizona Center for Integrative Medicine, which was first established in 1994 at the University of Arizona.

关键词： In West The state of the Integrative Medicine in the U.s.and Western World

Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations

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Translational Neurodegeneration 2022年第1期11卷 514-531页

作者： Federico Rodriguez-Porcel Kathryn A.Wyman-Chick Carla Abdelnour Ruiz Jon B.Toledo Daniel Ferreira Prabitha Urwyler Rimona s.weil Joseph Kane Andrea Pilotto Arvid Rongve Bradley Boeve John-Paul Taylor Ian McKeith Dag Aarsland simon J.G.Lewis the Lewy Body Dementias Clinical Trials Workgroup from the Lewy Body Dementias Professional Interest Area-Alzheimer’s Association International society to Advance Alzheimer’s Research and Treatment(IsTAART) Department of Neurology Medical University of South Carolina208b Rutledge Av.CharlestonSC 29403USA Department of Neurology Center for Memory and AgingHealthPartnersSaint PaulMNUSA Autonomous University of Barcelona BarcelonaSpain Fixel Institute for Neurological Diseases University of FloridaGainesvilleFLUSA Division of Clinical Geriatrics Department of NeurobiologyCare Sciencesand SocietyCenter for Alzheimer’s ResearchKarolinska InstitutetStockholmSweden Department of Radiology Mayo ClinicRochesterMNUSA ARTORG Center for Biomedical Engineering Research University of BernBernSwitzerland Dementia Research Centre University College LondonLondonUK Centre for Public Health Queen’s UniversityBelfastUK Neurology Unit Department of Clinical and Experimental SciencesUniversity of BresciaBresciaItaly Department of Research and Innovation Helse FonnaHaugesund HospitalHaugesundNorway Institute of Clinical Medicine(K1) The University of Ber-genBergenNorway Department of Neurology Center for Sleep MedicineMayo ClinicRochesterMNUSA Translational and Clinical Research Institute Newcastle UniversityNewcastle upon TyneUK Department of Old Age Psychiatry Institute of Psychiatry Psychology and Neuroscience King’s College LondonLondonUK ForeFront Parkinson’s Disease Research Clinic Brain and Mind CentreSchool of Medical SciencesUniversity of Sydney100 Mallett StreetCamperdownNSW 2050Australia. 不详

The selection of appropriate outcome measures is fundamental to the design of any successful clinical trial. Although dementia with Lewy bodies (DLB) is one of the most common neurodegenerative conditions, assessment of therapeutic benefit in clinical trials often relies on tools developed for other conditions, such as Alzheimer’s or Parkinson’s disease. These may not be sufficiently valid or sensitive to treatment changes in DLB, decreasing their utility. In this review, we discuss the limitations and strengths of selected available tools used to measure DLB-associated outcomes in clinical trials and highlight the potential roles for more specific objective measures. We emphasize that the existing outcome measures require validation in the DLB population and that DLB-specific outcomes need to be developed. Finally, we highlight how the selection of outcome measures may vary between symptomatic and disease-modifying therapy trials.

关键词： Dementia with Lewy bodies Clinical trials Outcomes Measurement properties

Representations of and translation between common fractions and decimal fractions

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Chinese science Bulletin 2013年第36期58卷 4630-4640页

作者： WANG YunQi sIEGLER robert s school of International studies Zhejiang University Department of Psychology Carnegie Mellon University Department of Psychology and Behavioral science Zhejiang University The siegler Center for Innovative Learning (sCIL) Beijing Normal University

Recent years have seen a boom in research on the magnitude representations of common fractions and decimal ***,previous studies generally only explored the magnitude representations of these two types of fractions in *** present study,using a pretest-training-posttest design,examined and compared the magnitude representations of both types of fractions,and more importantly examined their relations to fraction translation and overall mathematical *** results showed that(1)accurate magnitude representations developed more often for decimal fractions than for common fractions;(2)individual differences in fraction magnitude representations predicted individual differences in fraction translation performance above and beyond initial knowledge of fraction translation;(3)mere exposure to visual representations of fractions on number lines improved children’s mental representations of fraction magnitudes more than exposure to visual representations of fractions on circles or reading a textbook section on *** present findings suggest that,like whole numbers,both types of fractions are organized on a mental number line,which appears to provide a central conceptual structure for organizing a wide range of numerical *** implications of the findings are discussed.

关键词：分数小数陈述个体差异数学能力概念结构预测试幅度

High-nickel insects and nickel hyperaccumulator plants： A review

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Insect science 2009年第1期16卷 19-31页

作者： robert s. Boyd Department of Biological sciences 101 Life Sciences Building Auburn University Alabama 36849-5407 USA

Insects can vary greatly in whole-body elemental concentrations. Recent investigations of insects associated with Ni hyperaccumulator plants have identified insects with relatively elevated whole-body Ni levels. Evaluation of the limited data available indicates that a whole-body Ni concentration of 500μg Ni/g is exceptional： I propose that an insect species with a mean value of 500μg Ni/g or greater, in either larval/nymphal or adult stages, be considered a ＂high-Ni insect＂. Using the 500μg Ni/g criterion, 15 species ofhigh-Ni insects have been identified to date from studies in Mpumalanga （south Africa）, New Caledonia and California （UsA）. The highest mean Ni concentration reported is 3 500 μg Ni/g for nymphs of a south African stenoscepa species （Orthoptera： Pyrgomorphidae）. The majority of high-Ni insects （66%） are heteropteran herbivores. studies of high-Ni insect host preference indicate they are monophagous （or nearly so） on a particular Ni hyperaccumulator plant species. Much of the Ni in bodies of these insects is in their guts （up to 66%-75%）, but elevated levels have also been found in Malpighian tubules, suggesting efficient elimination as one strategy for dealing with a high-Ni diet. Tissue levels of Ni are generally much lower than gut concentrations, but up to 1200μg Ni/g has been reported from exuviae, suggesting that molting may be another pathway of Ni elimination. One ecological function of the high Ni concentration of these insects may be to defend them against natural enemies, but to date only one experimental test has supported this ＂elemental defense＂ hypothesis. Community-level studies indicate that high-Ni insects mobilize Ni into food webs but that bioaccumulation of Ni does not occur at either plant-herbivore or herbivorepredator steps. Unsurprisingly, Ni bioaccumulation indices are greater for high-Ni insects compared to other insect species that feed on Ni hyperaccumulator plants. There is some evidence of Ni mobilization into food webs

关键词： bioaccumulation elemental defense heavy metals herbivore defense,hyperaccumulation metal tolerance nickel

Lygus hesperus （Heteroptera： Miridae） tolerates high concentrations of dietary nickel

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Insect science 2007年第3期14卷 201-205页

作者： robert s. BOYD Department of Biological sciences Auburn University Alabama USA

Nickel hyperaccumulator plants contain unusually elevated levels of Ni （〉 1 000 μg Ni/g）. some insect herbivores, including Lygus hesperus （Western tarnished plant bug）, have been observed feeding on the California Ni hyperaccumulator streptanthus polygaloides. This bug may be able to utilize s. polygaloides as a host either through its feeding behavior or by physiological tolerance of Ni. This experiment determined the Ni tolerance of L hesperus by offering insects artificial diet amended with 0, 0.4, 1, 2, 4.5, 10, 20 and 40 mmol Ni/L and recording survival. survival varied due to Ni concentration, with diets containing 10 mmol Ni/L and greater resulting in significantly lower survival compared to the control （0 mmol Ni/L） treatment. Insects tolerated diet containing as much as 4.5 mmol Ni/L, a relatively elevated Ni concentration. I conclude that L hesperus can feed on s. polygaloides because it is Ni-tolerant, probably due to physiological mechanisms that provide it with resistance to plant chemical defenses including elemental defenses such as hyperaccumulated Ni.

关键词： elemental defense heavy metals herbivore defense hyperaccumulation metal tolerance nickel