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AIpL1突变患者先天性Leber黑蒙表现型

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美国医学会眼科杂志（中文版） 2005年第2期17卷 119-120页

作者： Sharola Dharmaraj Ban p. Leroy Melanie M. Sohocki robert K. Koenekoop Isabelle perrault Khalid Anwar Shagufta Khaliq R. Summathi Devi David G. Birch Elaine De pool Natalio Izquierdo Lionel Van Maldergem Mohammad Ismail Annette M. payne Graham E. Holder Shomi S. Bhattacharya Alan C. Bird Josseline Kaplan Irene H. Maumenee 刘欣怡（译）

目的：叙述26例先证者中芳香族羟基碳氢化合物受体蛋白样1蛋白质（AIpL1）突变的先天性Leber黑蒙（LCA）的表现型，并比较其他LCA相关性基因的表现型。叙述杂合子携带者的视网膜电图（ERG）。

关键词： Leber黑蒙表现型先天性突变患者碳氢化合物相关性基因视网膜电图受体蛋白蛋白质

脂肪乳剂、肾上腺素及脂肪乳剂复合肾上腺素对布比卡因诱导离体大鼠心脏停搏的复苏作用比较

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麻醉与镇痛 2013年第5期9卷 67-75页

作者： Le Liu, MD Yun Xia, MD, phD Ying Chen, MD Quanguang Wang, MD Tong Shi, MD Fangyan Wang, phD robert H. Small, MD Xuzhong Xu, MD 诸琳婕(译) 肖洁(校) 王祥瑞(校) Department of Anesthesiology First Affiliated Hospital of Wenzhou Medical College Zheiiang China Department of Anesthesiology Ohio State University Medical Center Columbus Ohio Department of Anesthesiology Longyan No. 1 Hospital affiliated with Fujian Medical University Fujian China Department of pathophysiology Wenzhou Medical College Zhejiang China 不详

背景目前对于脂肪乳剂复合肾上腺素治疗布比卡因的心脏毒性是否优于单纯脂肪乳剂或肾上腺素尚不清楚。我们比较了在治疗布比卡因引起的离体大鼠心脏停搏中脂肪乳剂、肾上腺素及复合物的作用。同时也测定了脂肪乳剂、肾上腺素及其复合物... 详细信息

背景目前对于脂肪乳剂复合肾上腺素治疗布比卡因的心脏毒性是否优于单纯脂肪乳剂或肾上腺素尚不清楚。我们比较了在治疗布比卡因引起的离体大鼠心脏停搏中脂肪乳剂、肾上腺素及复合物的作用。同时也测定了脂肪乳剂、肾上腺素及其复合物对布比卡因在心脏组织中浓度的影响。方法从Sprague—Dawley雄性大鼠游离出心脏并进行再灌注建立Langendofrr离体心脏灌注模型。以100μmol／L布比卡因诱导心脏停搏后继续灌注3分钟。脂肪乳剂组含2％脂肪乳剂复合30μmol／L布比卡因；肾上腺素组含0．15μg／ml肾上腺素复合30μmol／L布比卡因；脂肪乳剂复合肾上腺素组含2％脂肪乳剂复合0．15μg／ml肾上腺素及30μmol／L布比卡因；单独以30μmol／L布比卡因灌注为对照组。心脏复跳的定义为有自主规则的心律，恢复后心率血压乘积（***，Rpp）值〉基础值的10％且持续1分钟以上。我们比较每组100μmol／L布比卡因输注结束至心脏复跳的时间。复跳后对心功能变化继续观察40分钟。4组中能复跳的心脏于试验末截取心尖心肌采用高效液相色谱法测定心肌组织中布比卡因的浓度。结果脂肪乳剂组和复合组的心脏复跳时间（Trecovery）显著短于肾上腺素组和对照组（p〈0．001），肾上腺素组的T短于对照组（p〈0．）。心脏复跳后分钟内4组平均值从高到低依次排序为复合组〉脂肪乳剂组、肾上腺素组〉对照组（p〈0．01）。心脏复跳过程中Rpp的最大值（Rppmaximum）、Rppmaximum与基础值之比（Rppmaximum／Rppbaselinc）从最高到最低的依次排序为复合组〉脂肪乳剂组、肾上腺素组〉对照组（p〈0．01）。Rppmaximum 、Rppmaximum／Rppbaseline在脂肪乳剂组和肾上腺素组之间无显著差异。肾上腺素组和对照组中的心肌组织中布比卡因的浓度高于脂肪乳剂组和复合组（p〈0．001）。结论脂肪乳剂复合肾上腺素治疗布比卡因诱导的离体大鼠心脏停搏，较单纯使用脂肪乳剂或肾上腺素能更好地改善复苏后的心脏功能。

关键词：肾上腺素能脂肪乳剂布比卡因心脏停搏离体大鼠复合物复苏后心脏灌注模型

Nature：死亡的肿瘤细胞释放出胞内钾离子来阻断免疫系统

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现代生物医学进展 2016年第31期16卷 I0002-I0002页

作者： robert Eil, Suman K. Vodnala, David Clever, Christopher A. Klebanoff, Madhusudhanan Sukumar, Jenny H. pan, Douglas C. palmer, Alena Gros, Tori N. Yamamoto, Shashank J. patel, Geoffrey C. Guittard, Zhiya Yu, David S. Schrump, W. Marston Linehan, Nicholas p. Restifo Christopher A. Klebanoff Valentina Carbonaro, Klaus Okkenhaug, Rahul Roychoudhuri National Cancer Institute National Institutes of Health (NIH) Bethesda Maryland 20892 USA Center for Cell Engineering and Department of Medicine Memorial Sloan Kettering Cancer Center New York New York 10065 USA Laboratory of Lymphocyte Signalling and Development The Babraham Institute Cambridge CB22 3AT UK

在一项新的研究中。来自美国国家癌症研究所和英国巴布拉汉研究所的研究人员发现当肿瘤组织死亡时从它当中泄露出来的一种无机离子起着阻止抗肿瘤免疫细胞发挥功能的作用。这一发现为开发调动免疫系统抵抗癌症的疗法提供一种新的方法。... 详细信息

在一项新的研究中。来自美国国家癌症研究所和英国巴布拉汉研究所的研究人员发现当肿瘤组织死亡时从它当中泄露出来的一种无机离子起着阻止抗肿瘤免疫细胞发挥功能的作用。这一发现为开发调动免疫系统抵抗癌症的疗法提供一种新的方法。相关研究结果在线发表在Nature期刊上。

关键词：免疫系统肿瘤细胞死亡钾离子免疫细胞无机离子肿瘤组织研究人员

重度颅脑损伤后不同营养支持途径合理性的临床评价

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中国临床营养杂志 2000年第1期8卷 14-17页

作者：张建军宣宏飞顾水均谢仁龙张俊来谊浙江萧山第一人民医院神经外科 311200 浙江萧山第一人民医院pN配制室 311200

目的评价重度颅脑损伤后早期不同营养支持途径的合理性及临床意义。方法将GCS≤8分的重度颅脑损伤患者随机分成A组（肠外、肠内序贯营养支持组）、B组（单纯肠外营养组，pN）、C组（单纯肠内营养组，EN），每组28例。伤后48～72小时给... 详细信息

目的评价重度颅脑损伤后早期不同营养支持途径的合理性及临床意义。方法将GCS≤8分的重度颅脑损伤患者随机分成A组（肠外、肠内序贯营养支持组）、B组（单纯肠外营养组，pN）、C组（单纯肠内营养组，EN），每组28例。伤后48～72小时给予不同的营养支持，观察各组营养状态的变化及早、晚期并发症的发生率和预后。结果伤后1周时，A、B组血清总蛋白、白蛋白、血红蛋白等指标优于C组，早期并发症少于C组（p＜0．05）。2周时三组上述指标虽略有高低，统计学差异无显著性（p＞0．05），但B、C组的并发症高于A组（p＜0．05）。按GCS预后评定A组预后优于B、C两组（p＜0．05），死亡率A组最低。结论重度颅脑损伤后早期肠外、一周后过渡至肠内营养支持是较为合理的营养支持途径。

关键词：营养支持途径颅脑损伤后合理性重度临床评价颅脑损伤患者序贯营养支持肠内营养支持晚期并发症血清总蛋白早期并发症统计学差异临床意义肠外营养营养状态血红蛋白 GCS C组预后发生率白蛋白显著性死亡率

尼泊尔农村地区孕期妇女补充维生素A对青春期前儿童肺功能的影响:一项随机、双盲、安慰剂对照的队列研究

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营养健康新观察 2009年第3期 44-44页

作者： William Checkly Keith p West robert Wise Matthew R Baldwin Steven C LeClerq Lee Wu parul Christian Joanne Tielsch Subaran Khatry Alfred Sommer 张喆庆 Instructor Division of Pulmonary and Critical Care School of MedicineThe Johns Hopkins University

Survey of damaging pests and preliminary assessment of forest health risks to the long term success of pinus radiata introduction in Sichuan, southwest China

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Journal of Forestry Research 2008年第2期19卷 85-100页

作者：李荣伟肖育贵周建华吴宗兴阎红黄泉刘千里四川省林业科学研究院四川省成都市610081 中国林业科学研究院北京100091 阿坝州科学技术研究院四川省汶川县623000

pinus radiata was introduced to the summer rainfall environments of Sichuan province, China in the 1990s as a part of an afforestation pmgram for soil and water conservation in the arid and semi-arid river valley area of Aba prefecture. Within this region a total area of 26 000 ha have been identified through climate matching as suitable and a further 63 000 ha potentially suitable for environmental plantings of p. radiata. The plantations are being established in widely separated small patches on steep and degraded slopes along the dry river valley The newly introduced p. radiata are exposed to two kinds of forest health risks： they may be attacked by （a） indigenous pathogens and pests against which they may not possess any resistance or （b） by inadvertently introduced foreign pests or pathogens. This paper presents a survey of the potential damaging pests and a preliminary assessment of forest health risks facing the p. radiata plantations over a much longer timeframe than the initial phase of introduction and early plantation establishment. An empirical appmach was adopted to evaluate forest health risks by a combination of literature review, examination of historical records of pest and disease outbreaks in the surrounding conifemus forests, field surveys and inspections, specimen collection and identification, and most importantly, expert analysis of the likelihood of attack by specific pests and pathogens and the subsequent impact of such attacks. The assessment identified some specific forest health risks to the long-term success of p. radiata introduction in this area. These risks are closely associated with the indigenous pests and pathogens of the two native pine species, p. tabulaeformis and p. armondii since these pests and pathogens are considered more likely to establish on p. radiata over time. Exotic pests and pathogens are of a quarantine concern at present. Based on the results of assessment, recommendations are pmvided to improve forest vigour and

关键词： pinus radiata species introduction dry river valley forest health risks

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肛裂临床诊治指南（第三次修订）

中华胃肠外科杂志 2013年第7期16卷 689-690页

作者： Farshid Araghizadeh ~ Robin Boushey Sridhar Chalasani George Chang robert Cima Gary Dunn Daniel Feingold philip Fleshner Daniel Geisler Jill Genua Sharon Gregorcyk Daniel Herzig Andreas Kaiser Ravin Kumar David Larson Steven Mills John Monson p. Terry phang Feza Remzi David Rivadeneira Howard Ross peter Senatore Elin Sigurdson Thomas Stahl Scott Steele Scott Strong Charles Tement Judith Trudel Madhulika Varnna Martin Weiser 丁义江(译) 皇甫少华(译) 丁曙晴(译) 美国结直肠外科医师协会不详

“美国结直肠外科医师协会（American Societyof ColonandRectal ***）”（协会）致力于推进结直肠和肛门疾病的相关理论以及预防和诊疗水平的提高，给患者提供优质的医疗服务。“标准委员会”由协会中在结直肠外科方面有显著专长的成... 详细信息

“美国结直肠外科医师协会（American Societyof ColonandRectal ***）”（协会）致力于推进结直肠和肛门疾病的相关理论以及预防和诊疗水平的提高，给患者提供优质的医疗服务。“标准委员会”由协会中在结直肠外科方面有显著专长的成员组成。该委员会的建立是为了引领国际结直肠和肛门疾病诊治的发展，以建立具有循证医学证据的临床诊疗指南。指南是涵盖性的，非指令性的，目的是为临床决策提供信息，而非具体的治疗方法。指南适用于所有相关的医护人员以及希望得到相应指南中疾病的相关诊治信息的患者。

关键词：诊治指南临床决策结直肠外科修订肛裂医师协会肛门疾病循证医学证据

Limitations of multimodality imaging in the diagnosis of pannus formation in prosthetic aortic valve and review of the literature

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World Journal of Cardiology 2015年第4期7卷 224-229页

作者： Juan Bautista Soumoulou Tomás Francisco Cianciulli Andrea Zappi Alberto Cozzarin María Cristina Saccheri Jorge Alberto Lax robert Guidoin Ze Zhang Department of Cardiology Hospital "Dr.Cosme Argerich"Ciudad Autónoma de Buenos Aires C1155 AHDArgentina Researcher of the Ministry of Health Government of the City of Buenos Aires Department of pathology Hospital "Dr.Cosme Argerich"Ciudad Autónoma de Buenos Aires C1155AHDArgentina Department of Surgery and Radiology Laval University and Québec Biomaterials InstituteCHUQQuebec G1K 7P4Canada

pannus formation is a rare complication and occurs almost exclusively in mechanical prosthetic *** consists of fibrous tissue that covers the surface of the prosthesis either concentrically or eccentrically,resulting in valve *** pathophysiology seems to be associated to a chronic inflammatory process that explains the late and insidious clinical *** diagnosis should be considered in patients with high transvalvular gradients on transthoracic echo,and workup should be completed with fluoroscopy and transesophageal *** is always surgical and recurrence is *** present a case of pannus formation in a prosthetic aortic valve and a review of the literature regarding this disorder.

关键词： pannus formation prosthetic aortic valve Fluoroscopy Transthoracic echocardiography Transesophageal echocardiography

The Role of Synthetic Biology in Atmospheric Greenhouse Gas Reduction: prospects and Challenges

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BioDesign Research 2020年第1期2020卷 1-8页

作者： Charles DeLisi Aristides patrinos Michael MacCracken Dan Drell George Annas Adam Arkin George Church robert Cook-Deegan Henry Jacoby Mary Lidstrom Jerry Melillo Ron Milo Keith paustian John Reilly Richard J.roberts Daniel Segrè Susan Solomon Dominic Woolf Stan D.Wullschleger Xiaohan Yang Department of Biomedical Engineering and program in Bioinformatics College of EngineeringBoston UniversityBoston MA 02215USA The NOVIM Group Kohn HallUC Santa BarbaraCA 93106USA Climate Institute WashingtonDCUSA Department of Energy WashingtonDCUSA Center for Health Law Ethics&Human Rights at the Boston University School of Public HealthSchool of MedicineBoston UniversityUSA Department of Bioengineering University of CaliforniaBerkeley CAUSA Department of Genetics Harvard Medical SchoolCambridge MAUSA School for the Future of Innovation in Society Arizona State UniversityBarrett&O’Connor Washington Center1800 I StreetNWWashingtonDC 20006USA Sloan School of Management MITCambridge MAUSA Department of Chemical Engineering University of WashingtonSeattle WashingtonUSA The Ecosystems Center of the Marine Biological Laboratory in Woods Hole MAUSA Department of plant and Environmental Sciences Weizmann Institute of ScienceRehovotIsrael Department of Soil and Crop Sciences Colorado State UniversityFort Collins CO 80523USA MIT Joint program on the Science and policy of Global Change MITCambridge MAUSA New England Biolabs Beverly MAUSA Department of Biology and program in Bioinformatics Boston UniversityBoston MA 02215USA Department of Earth Atmospheric and Planetary SciencesMITCambridge MAUSA Soil and Crop Sciences Section School of Integrated Plant SciencesCornell UniversityIthaca NYUSA Environmental Sciences Division Oak Ridge National LaboratoryOak Ridge TNUSA Biosciences Division Oak Ridge National LaboratoryOak RidgeTNUSA

The long atmospheric residence time of CO2 creates an urgent need to add atmospheric carbon drawdown to CO2 regulatory *** and systems biology(SSB),which enables manipulation of cellular phenotypes,offers a powerful approach to amplifying and adding new possibilities to current land management practices aimed at reducing atmospheric *** participants(in attendance:Christina Agapakis,George Annas,Adam Arkin,George Church,robert Cook-Deegan,Charles DeLisi,Dan Drell,Sheldon Glashow,Steve Hamburg,Henry Jacoby,Henry Kelly,Mark Kon,Todd Kuiken,Mary Lidstrom,Mike MacCracken,June Medford,Jerry Melillo,Ron Milo,pilar Ossorio,Ari patrinos,Keith paustian,Kristala Jones prather,Kent Redford,David Resnik,John Reilly,Richard ***,Daniel Segre,Susan Solomon,Elizabeth Strychalski,Chris Voigt,Dominic Woolf,Stan Wullschleger,and Xiaohan Yang)identified a range of possibilities by which SSB might help reduce greenhouse gas concentrations and which might also contribute to environmental sustainability and *** include,among other possibilities,engineering plants to convert CO2 produced by respiration into a stable carbonate,designing plants with an increased root-to-shoot ratio,and creating plants with the ability to self-fertilize.A number of serious ecological and societal challenges must,however,be confronted and resolved before any such application can be fully assessed,realized,and deployed.

关键词： Synthetic roberts enable