检索结果-南通市图书馆

Development of a classification system based on corneal biomechanical properties using artificial intelligence predicting keratoconus severity

引用

Eye and Vision 2021年第3期8卷 203-213页

作者： robert Herber Lutz E.pillunat Frederik Raiskup Department of Ophthalmology University Hospital Carl Gustav CarusUniversitätsklinikum Carl Gustav Carus an der Technischen Universität DresdenFetscherstraße 74TU 01307 DresdenGermany

Background:To investigate machine-learning(ML)algorithms to differentiate corneal biomechanical properties between different topographical stages of keratoconus(KC)by dynamic Scheimpflug tonometry(CST,Corvis ST,Oculus,Wetzlar,Germany).In the following,ML models were used to predict the severity in a training and validation ***:Three hundred and eighteen keratoconic and one hundred sixteen healthy eyes were included in this monocentric and cross-sectional pilot *** corneal response(DCR)and corneal thickness related(pachymetric)parameters from CST were chosen by appropriated selection techniques to develop a ML *** stage of KC was determined by the topographical keratoconus classification system(TKC,pentacam,Oculus).patients who were classified as TKC 1,TKC 2 and TKC 3 were assigned to subgroup mild,moderate,and advanced *** patients were classified as TKC 1-2,TKC 2-3 or TKC 3-4,they were assigned to subgroups according to the normative range of further corneal indices(index of surface variance,keratoconus index and minimum radius).patients classified as TKC 4 were not included in this study due to the limited amount of *** discriminant analysis(LDA)and random forest(RF)algorithms were used to develop the classification *** were divided into training(70%of cases)and validation(30%of cases)***:LDA model predicted healthy,mild,moderate,and advanced KC eyes with a sensitivity(S_(n))/specificity(S_(p))of 82%/97%,73%/81%,62%/83%and 68%/95%from a validation dataset,*** the RF model,a S_(n)/S_(p) of 91%/94%,80%/90%,63%/87%,72%/95%could be reached for predicting healthy,mild,moderate,and advanced KC eyes,*** overall accuracy of LDA and RF was 71%and 78%,*** accuracy for KC detection including all subgroups of KC severity was 93%in both ***:The RF model showed good accuracy in predicting healthy eyes and various stages of *** accuracy was superior with respec

关键词： Artificial intelligence Corneal biomechanics Corvis ST Grading Keratoconus Machine learning

来源：

维普期刊数据库

维普期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Distinct risk factors for early and late blood transfusion following pancreaticoduodenectomy

引用

Hepatobiliary & pancreatic Diseases International 2018年第4期17卷 349-357页

作者： Sukhchain S.Bansal James Hodson Khalid Khalil Bobby Dasari Ravi Marudanayagam robert p.Sutcliffe John Isaac Keith J.roberts Department of Hepatobiliary pancreatic Surgery Queen Elizabeth Hospital BirminghamUniversity Hospitals Birmingham Institute of Translational Medicine Queen Elizabeth Hospital BirminghamUniversity Hospitals Birmingham

Background: The International Study Group of pancreatic Surgery(ISGpS) has defined two periods of postpancreatectomy hemorrhage, early(24 h). A previously published Blood Usage Risk Score(BURS) aimed to predict early and late blood transfusion. The primary aim of this study was to define risk factors for early and late blood transfusion after pancreaticoduodenectomy. Secondary aims were to assess the predictive accuracy of the ***: In this retrospective observational study, multivariable analyses were used to identify independent risk factors for both early and late blood transfusion. The predictive ability of the BURS was then assessed using a receiver operating characteristic(ROC) curve ***: Among 628 patients, 99(15.8%) and 144(22.9%) received early and late blood transfusion, respectively. Risk factors for blood transfusion differed between early and late periods. preoperative anemia and venous resection were associated with early blood transfusion whilst Whipple’s resection(as opposed to pylorus preserving pancreaticoduodenectomy), lack of biliary stent and a narrow pancreatic duct were predictors of late blood transfusion. The BURS was significantly predictive of early blood transfusion,albeit with a modest degree of accuracy(AUROC: 0.700, p p = 0.360). Late blood transfusion was independently associated with increasing severity of postoperative pancreatic fistula(pOpF)(OR: 1.85, 3.18 and 9.97 for biochemical, types B and C pOpF,respectively, relative to no pOpF).Conclusions: Two largely different sets of variables are related to early and late blood transfusion following pancreaticoduodenectomy. The BURS was significantly associated with early, albeit with modest predictive accuracy, but not late blood transfusion. An understanding of pOpF risk allows assessment of the need for late blood transfusion.

关键词： pancreatic cancer Blood transfusion pancreaticoduodenectomy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modules and Structure presheaves for Arbitary Rings

引用

数学进展 1991年第1期 15-23页

作者： robert Wisbauer University of Dusseldorf West Germany

Basic techniques in the classical theory of commutative associative rings A with unity are:(i) The homological characterization of A in the category of A-modules. (ii) The rings of quotients of prime or semjprime rings A,(iii) The localization Ap at a prime ideal p and the structure sheaf on the prime spectrum of A. All these parts of structure theory are closely related to each other in this *** technique (i) was successfully applied to non-commutative rings, the parts (ii) and (iii) do not allow a satisfying extension to this more general situation. Moreover, in the special cases which admit corresponding constructions, the interplay between the different points usually gets *** the cateaory of left A-modules by a suitable subcategory σ[A] of bimodules over an arbitary (non-associative) ring A a natural extension of all three techniques under consideration which preserves relationships known from the classical situation is obtainedpart (i) and (ii) of the resulting theory can be fou

关键词： pr Modules and Structure presheaves for Arbitary Rings

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Current strategies for reproductive management of gilts and sows in North America

引用

Journal of Animal Science and Biotechnology 2015年第2期6卷 191-204页

作者： robert R Kraeling Stephen K Webel L&R Research Associates JBS United Animal Health

Many advances in genetic selection, nutrition, housing and disease control have been incorporated into modern pork production since the 1950s resulting in highly prolific females and practices and technologies, which significantly increased efficiency of reproduction in the breeding herd. The objective of this manuscript is to review the literature and current industry practices employed for reproductive management. In particular the authors focus on assisted reproduction technologies and their application for enhanced productivity. Modern maternal line genotypes have lower appetites and exceptional lean growth potential compared to females of 20 yr ago. Thus, nutrient requirements and management techniques and technologies, which affect gilt development and sow longevity, require continuous updating. Failure to detect estrus accurately has the greatest impact on farrowing rate and litter size. Yet, even accurate estrus detection will not compensate for the variability in the interval between onset of estrus and actual time of ovulation. However, administration of GnRH analogs in weaned sows and in gilts after withdrawal of altrenogest do overcome this variability and thereby synchronize ovulation, which makes fixed-time AI practical. Seasonal infertility, mediated by temperature and photoperiod, is a persistent problem. Training workers in the art of stockmanship is of increasing importance as consumers become more interested in humane animal care. Altrenogest, is used to synchronize the estrous cycle of gilts, to prolong gestation for 2-3 d to synchronize farrowing and to postpone post-weaning estrus. p.G. 600~ is used for induction of estrus in pre-pubertal gilts and as a treatment to overcome seasonal anestrous. Sperm cell numbers/dose of semen is significantly less for post cervical AI than for cervical AI. Real-time ultrasonography is used to determine pregnancy during wk 3-5. pGF2a effectively induces farrowing when administered within two d of normal gestati

关键词： Gilts Management Nutrition Reproductive technology Sows

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cenozoic topography,monsoons and biodiversity conservation within the Tibetan Region:An evolving story

引用

plant Diversity 2020年第4期42卷 229-254页

作者： robert A.Spicer Alexander Farnsworth Tao Su CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesXishuangbanna 666303China School of Environmental Earth and Ecosystem SciencesThe Open UniversityWalton HallMilton KeynesMK76AAUK School of Geographical Sciences University of BristolBristolBS81SSUK

The biodiversity of the Himalaya,Hengduan Mountains and Tibet,here collectively termed the Tibetan Region,is exceptional in a global *** contextualize and understand the origins of this biotic richness,and its conservation value,we examine recent fossil finds and review progress in understanding the orogeny of the Tibetan *** examine the deep-time origins of monsoons affecting Asia,climate variation over different timescales,and the establishment of environmental niche heterogeneity linked to topographic *** origins of the modern biodiversity were established in the Eocene,concurrent with the formation of pronounced topographic relief across the Tibetan ***(>4 km)mountains to the north and south of what is now the Tibetan plateau bounded a paleogene central lowland(pical vegetation influenced by an intensifying *** mid Miocene times,before the Himalaya reached their current elevation,sediment infilling and compressional tectonics raised the floor of the central valley to above 3000 m,but central Tibet was still moist enough,and low enough,to host a warm temperate angiosperm-dominated *** 15 Ma,global cooling,the further rise of central Tibet,and the rain shadow cast by the growing Himalaya,progressively led to more open,herb-rich vegetation as the modern high plateau formed with its cool,dry *** the moist monsoonal Hengduan Mountains,high and spatially extensive since the Eocene but subsequently deeply dissected by river incision,Neogene cooling depressed the tree line,compressed altitudinal zonation,and created strong environmental *** served as a cradle for the then newly-evolving alpine biota and favoured diversity within more thermophilic vegetation at lower *** diversity has survived through a combination of minimal Quaternary glaciation,and complex relief-related environmental niche *** great antiquity and diversity of the Tibetan Regi

关键词： Tibet Himalaya Hengduan Mountains Landscape Fossils Conservation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Associations between concussion and risk of diagnosis of psychological and neurological disorders:a retrospective population-based cohort study

引用

Family Medicine and Community Health 2020年第3期8卷 27-35页

作者： Marc p Morissette Heather J prior robert B Tate John Wade Jeff R S Leiter pan Am Clinic Foundation WinnipegManitobaCanada Applied Health Sciences Faculty of Graduate StudiesUniversity of ManitobaWinnipegManitobaCanada Manitoba Centre for Health policy Rady Faculty of Health SciencesUniversity of ManitobaWinnipegManitobaCanada Community Health Sciences Rady Faculty of Health SciencesUniversity of ManitobaWinnipegManitobaCanada Rady Faculty of Health Sciences University of ManitobaWinnipegManitobaCanada Faculty of Kinesiology and Recreation Management University of ManitobaWinnipegManitobaCanada

Objective To investigate associations between concussion and the risk of follow-up diagnoses of attention-deficit hyperactivity disorder(ADHD),mood and anxiety disorders(MADs),dementia and parkinson’s *** A retrospective population-based cohort *** Administrative health data for the province of Manitoba between 1990-1991 and *** A total of 47483 individuals were diagnosed with a concussion using International Classification of Diseases(ICD)codes(ICD-9-CM:850;ICD-10-CA:S06.0).All concussed subjects were matched with healthy controls at a 3:1 ratio based on age,sex and geographical *** between concussion and conditions of interest diagnosed later in life were assessed using a stratified Cox proportional hazards regression model,with adjustments for socioeconomic status and pre-existing medical *** 28021 men(mean age±SD,25±18 years)and 19462 women(30±21 years)were included in the concussion group,while 81871 men(25±18 years)and 57159 women(30±21 years)were included in the matched control *** was associated with adjusted hazard ratios of 1.39(95%CI 1.32 to 1.46,ppppparkinson’s *** Concussion was associated with an increased risk of diagnosis for all four conditions of interest later in life.

关键词： diagnosis disorders matched

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interstate Comparison of Soil Remediation Standards among Six Mid-Atlantic States, USA

引用

Journal of Environmental protection 2014年第10期5卷 811-818页

作者： robert p. Blauvelt Mathew Sweet GEI Consultants Montclair New Jersey USA

To address and help mitigate potential public health and ecological impacts associated with contaminated soil, most state environmental agencies have promulgated cleanup standards or action level criteria that are based broadly on US Environmental protection Agency risk assessment methodologies. These standards or criteria often are assembled into easy-to-use look-up tables that allow responsible parties (Rps) to determine quickly the extent of remediation that could be required simply by comparing site investigation data to the listed cleanup goal or standard. This paper compares and contrasts soil remediation standards and criteria for 20 common soil pollutants taken from state environmental agency look-up tables for five Middle Atlantic States: New York, Connecticut, New Jersey, Delaware, pennsylvania, and Maryland. We examine the differences between numeric remedial goals for these pollutants and propose a relative rank for each state based on the overall degree of soil cleanup standard or criterion stringency. In order to identify and rank the stringency of the residential cleanup goals or standards published by the six Mid-Atlantic States, a three-step process was used that included compiling in one data set, the numerical (mg/kg), residential or unrestricted use look-up values published by state for each of the 20 contaminants;organizing and grouping those values in numerical sequence into one of three categories ranging from lowest (Most Restrictive) to highest (Least Restrictive);and then ranking each state by the number of first place finishes in each stringency category: Most Restrictive, Moderately Restrictive, and Least Restrictive. The socioeconomic consequences of these ranks were examined relative to their effects on gross state product, unemployment, and health.

关键词： Regulatory Standards Soil Remediation Look-Up Tables Ranking Socioeconomic Consequences

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Telaprevir/boceprevir era: From bench to bed and back

引用

World Journal of Gastroenterology 2012年第43期18卷 6183-6188页

作者： Maikel p peppelenbosch Harry LA Janssen robert J de Knegt Department of Gastroenterology and Hepatology Erasmus MC-University Medical Center 3015 CE Rotterdam The Netherlands

Hepatitis C virus (HCV) infects approximately 200 million people worldwide. Interferon-based therapies have dominated over the past two decades. However, the overall response rates remain suboptimal. Thanks to the tremendous effort from both academia and industry, two serine protease inhibitors telaprevir and boceprevir for treating chronic hepatitis C have finally reached the clinic. Although these compounds are only approved for combination use with interferon and ribavirin in genotype 1 HCV infected chronic patients, the management of HCV patients however is now evolving incredibly. Here, we overviewed a series of landmark studies, regarding the clinical development of telaprevir and boceprevir. We discussed the mechanism-of-action of telaprevir/boceprevir and their potential application in HCV-positive liver transplantation patients. We further emphasized some emerging concerns with perspective of further development in this field.

关键词： Telaprevir Boceprevir Mechanism-of-action Clinical efficacy Liver transplantation patient Interferon Ribavirin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gastroenterostoma after Billroth antrectomy as a premalignant condition

引用

World Journal of Gastroenterology 2012年第25期18卷 3201-3206页

作者： robert Sitarz Ryszard Maciejewski Wojciech p polkowski G Johan A Offerhaus Department of pathology University Medical CentreUtrecht3584 CX UtrechtThe Netherlands Department of Human Anatomy Medical University of Lublin20-950 LublinPoland Department of Surgical Oncology Medical University of Lublin20-081 LublinPoland Department of pathology Academic Medical Centre 1105 AZ Amsterdam The Netherlands

Gastric stump carcinoma （GSC） following remote gastric surgery is widely recognized as a separate entity within the group of various types of gastric cancer. Gastrecto- my is a well established risk factor for the development of GSC at a long time after the initial surgery. Both exo- as well as endogenous factors appear to be involved in the etiopathogenesis of GSC, such as achlorhydria, hypergastrinemia and biliary reflux, Epstein-Barr virus and Helicobacter pylori infection, atrophic gastritis, and also some polymorphisms in interleukin-l~ and maybe cyclo-oxygenase-2. This review summarizes the litera- ture of GSC, with special reference to reliable early di- agnostics. In particular, dysplasia can be considered as a dependable morphological marker. Therefore, close endoscopic surveillance with multiple biopsies of the gastroenterostomy is recommended. Screening start- ing at 15 years after the initial ulcer surgery can detect tumors at a curable stage. This approach can be ofspecial interest in Eastern European countries, where surgery for benign gastroduodenal ulcers has remained a practice for a much longer time than in Western Eu- rope, and therefore GSC is found with higher frequency.

关键词： Gastric stump cancer Gastrectomy Riskfactors Endoscopic surveillance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

心脏象一个轮子

引用

国外医学（生物医学工程分册） 1991年第4期14卷 199-201页

作者： robert p 宗伟

一个心脏电活动的相对简单的模型,可以有助于解释突然冠心病死亡的原因当大学篮球明星。Gathers在一次比赛中倒下并在两小时后死去,人们震惊地意识到,心肌梗塞甚至会发生于处于很好状况下的青年人和运动员。在报刊上心肌梗塞被报道得不... 详细信息

一个心脏电活动的相对简单的模型,可以有助于解释突然冠心病死亡的原因当大学篮球明星。Gathers在一次比赛中倒下并在两小时后死去,人们震惊地意识到,心肌梗塞甚至会发生于处于很好状况下的青年人和运动员。在报刊上心肌梗塞被报道得不象艾滋病或癌症那样多,但是它在这个国家中导致死亡的人数——每年多于50万美国人。许多这种死亡。是由受损伤的心脏中电活动的紊乱而引起的。这些电活动紊乱引起心脏不规划地跳动或心室纤颤。

关键词：心脏电信号

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：