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Randomized control trial of a culturally adapted behavioral activation therapy for muslim patients with depression in Pakistan

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世界精神病学杂志 2023年第8期13卷 551-562页

作者： Saima Dawood Ghazala mir robert m West Centre for Clinical Psychology University of the PunjabLahore Punjab 54590Pakistan Leeds Institute of Health Sciences School of MedicineThe University of LeedsLeeds LS29JTWest YorkshireEnglandUnited Kingdom

BACKGROUND Behavioral activation therapy(BA)is as effective as cognitive behavior therapy(CBT)in treating depression and can be delivered by practitioners with much less psychological training,making it particularly suitable for low resource *** that is culturally adapted for muslims(BA-m)is a culturally adapted form of BA that has been found acceptable and feasible for muslims with depression in the United Kingdom and Turkey;however,this is the first time that its efficacy has been determined through a definitive randomized controlled *** To compare the effectiveness of BA-m with CBT for muslim patients with depression in *** One hundred and eight patients were randomized 1:1 to treatment arms in a parallel-group randomized controlled trial in hospital or community sites in Lahore,*** followed self-referral or referrals from clinicians,consultants or relevant professionals at each *** measures were recorded by blinded assessors:The patient health questionnaire-9(PHQ-9);the BA for depression scale short form(BADS-SF);symptom checklist-revised and the World Health Organization Quality-of-Life Brief *** measures were recorded at baseline and post treatment;PHQ-9 and BADS-SF were also recorded at each session and at three month follow *** primary analysis was to regress the PHQ-9 score after therapy upon the PHQ-9 score before therapy(baseline)and the type of therapy given,that is,analysis of *** addition,analysis using PHQ-9 scores collected at each therapy session was employed in a 2-level regression *** Patients in the BA-m arm experienced greater improvement in PHQ-9 score of 1.95 units compared to the CBT arm after adjusting for baseline values(P=0.006)The key reason behind this improvement was that patients were retained in therapy longer under BA-m,in which patients were retained for an average 0.75 sessions more than CBT patients(P=0.013).Patients also showed significant differences

关键词： Culturally adapted therapy Behavioral activation Depression Pakistan muslim Randomized control trial

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Role of ion channels in gastrointestinal cancer

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World Journal of Gastroenterology 2019年第38期25卷 5732-5772页

作者： Kyle J Anderson robert T Cormier Patricia m Scott Department of Biomedical Sciences University of Minnesota Medical School

In their seminal papers Hanahan and Weinberg described oncogenic processes a normal cell undergoes to be transformed into a cancer *** functions of ion channels in the gastrointestinal(GI)tract influence a variety of cellular processes,many of which overlap with these hallmarks of *** this review we focus on the roles of the calcium(Ca^2+),sodium(Na^+),potassium(K^+),chloride(Cl^-)and zinc(Zn^2+)transporters in GI cancer,with a special emphasis on the roles of the KCNQ1 K+channel and CFTR Cl-channel in colorectal cancer(CRC).Ca^2+is a ubiquitous second messenger,serving as a signaling molecule for a variety of cellular processes such as control of the cell cycle,apoptosis,and *** members of the TRP superfamily,including TRPm8,TRPm7,TRPm6 and TRPm2,have been implicated in GI cancers,especially through overexpression in pancreatic adenocarcinomas and down-regulation in colon ***-gated sodium channels(VGSCs)are classically associated with the initiation and conduction of action potentials in electrically excitable cells such as neurons and muscle *** VGSC NaV1.5 is abundantly expressed in human colorectal CRC cell lines as well as being highly expressed in primary CRC *** have demonstrated that conductance through NaV1.5 contributes significantly to CRC cell invasiveness and cancer ***2+transporters of the ZIP/SLC39A and ZnT/SLC30A families are dysregulated in all major GI organ cancers,in particular,ZIP4 up-regulation in pancreatic cancer(PC).more than 70 K+channel genes,clustered in four families,are found expressed in the GI tract,where they regulate a range of cellular processes,including gastrin secretion in the stomach and anion secretion and fluid balance in the intestinal *** distinct types of K+channels are found dysregulated in the GI *** are hERG1 upregulation in PC,gastric cancer(GC)and CRC,leading to enhanced cancer angiogenesis and invasion,and KCNQ1 down-regulation in CR

关键词： Ion channels Gastrointestinal cancer Colorectal cancer Gastric cancer Pancreatic cancer Esophageal cancer Hepatocellular carcinoma Prognostic biomarker Novel therapies Clinical targets

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Geochronological constraints on the metamorphic sole of the Semail ophiolite in the United Arab Emirates

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Geoscience Frontiers 2016年第4期7卷 609-619页

作者： Nick m.W.roberts robert J.Thomas Joachim Jacobs NERC Isotope Geosciences Laboratory British Geological SurveyKeyworthNG12 5GGUK Council for Geoscience P.O.Box 572Bellville 7535South Africa University of Bergen.Department of Earth Science PB 78035020 BergenNorway Norwegian Polar Institute Fram Centre9296 TromsoNorway

The Semail ophiolite of Oman and the United Arab Emirates （UAE） provides the best preserved large slice of oceanic lithosphere exposed on the continental crust, and offers unique opportunities to study processes of ocean crust formation, subduction initiation and obduction. metamorphic rocks exposed in the eastern UAE have traditionally been interpreted as a metamorphic sole to the Semail ophiolite. However, there has been some debate over the possibility that the exposures contain components of older Arabian continental crust. To help answer this question, presented here are new zircon and futile U-Pb geochronological data from various units of the metamorphic rocks. Zircon was absent in most samples. Those that yielded zircon and futile provide dominant single age populations that are 95-93 ma, partially overlapping with the known age of oceanic crust formation （96.5-94.5 ma）, and partially overlapping with cooling ages of the metamorphic rocks （95 90 ma）. The data are interpreted as dating high-grade metamorphism during subduction burial of the sediments into hot mantle lithosphere, and rapid cooling during their subsequent exhumation. A few discordant zircon ages, interpreted as late Neoproterozoic and younger, represent minor detrital input from the continent. No evidence is found in favour of the existence of older Arabian continental crust within the metamorphic rocks of the UAE.

关键词： Semail ophiolite United Arab Emirates metamorphic sole U-Pb geochronology Zircon Rutile

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Fluorescence-guided hepatobiliary surgery with long and short wavelength fluorophores

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Hepatobiliary Surgery and Nutrition 2020年第5期9卷 615-639页

作者： Thinzar m.Lwin robert m.Hoffman michael Bouvet Department of Surgery University of California San DiegoSan DiegoCAUSA AntiCancer Inc.San DiegoCAUSA VA San Diego Healthcare System San DiegoCAUSA

Importance:Fluorescence-guided surgery(FGS)is a potentially powerful tool for hepatobiliary(HPB)*** high sensitivity of fluorescence navigation is especially useful in settings where tactile feedback is ***:The present narrative review evaluates literature on the use of FDA-approved fluorophores such as methylene blue(mB),5-aminolevulinic acid(5-ALA),and indocyanine green(ICG)for clinical intra-operative image-guidance during HPB *** Review:Approaches such as dosing,timing,imaging devices and comparative endpoints are *** feasibility and safety of fluorophores in visualizing the biliary tree,identify biliary leaks,outline anatomic hepatic segments,identify tumors,and evaluate perfusion and graft function in liver transplants are ***:Tumor-specific probes are a promising advancement in FGS with a greater degree of *** current status of tumor-specific probes being evaluated in clinical trials are *** and Relevance for Reviews:Relevant discussion of promising tumor-specific probes in pre-clinical development are ***-guidance in HPB surgery is relatively new,but current literature shows that the dyes are reliably able to outline desired structures with a variety of dosing,timing,and imaging devices to provide real-time intra-operative anatomic information to *** of tumor-specific probes will further advance the field of HPB surgery especially during oncologic resections.

关键词： Fluorescence-guided surgery(FGS) methylene blue(mB) 5-aminolevulinic acid(5-ALA) indocyanine green(ICG) hepatobiliary surgery(HPB surgery) tumor-specific probes near-infrared fluorescence(NIR fluorescence)

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Has Axial Spin Decline Affected Earth's Geologic and Tectonic History?

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Journal of Earth Science 2022年第5期33卷 1333-1336页

作者： Anne m.Hofmeister robert E.Criss Timothy m.Kusky Department of Earth and Planetary Science Washington UniversitySt.LouisMO63130USA State Key Laboratory for Geological Processes and mineral Resources Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan430074China Badong National Observatory and Research Station for Geohazards China University of GeosciencesWuhan430074China

0 INTRODUCTION Among the rocky planets,only Earth remains active 4.5 Ga after ***,only Earth has a chemically and structurally complex,bimodal surface with unequivocal horizontal *** unique plate motions are currently... 详细信息

关键词： Earth formation mantle

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Quo vadis carbocatalysis?

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Journal of Energy Chemistry 2021年第10期30卷 219-227,I0007页

作者： robert Schlögl max-Planck-Institut für Chemische Energiekonversion Stiftstr.34-3645470 Mülheim an der RuhrGermany Fritz-Haber Institut der max-Planck-Gesellschaft Faradayweg 4-614195 BerlinGermany

Prologue The rich scientific heritage of Dangsheng Su contains as substantial fraction his contributions to the field of catalysis with nanostructured carbon *** from microstructural analysis it became quickly clear that the richness of morphological and hence surface electronic variations in this class of materials should be suitable for the development of a science base for heterogeneous catalysis.

关键词： materials. catalysis. catalysis

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A micromechanical model for efective conductivity in granular electrode structures

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Acta mechanica Sinica 2013年第5期29卷 682-698页

作者： Julia Ott Benjamin Vlker Yixiang Gan robert m.mc meeking marc Kamlah Institute of Applied materials Karlsruhe Institute of Technology76131 Karlsruhe Germany Department of mechanical Engineering University of CaliforniaSanta BarbaraCA 93106 USA School of Civil Engineering The University of SydneyNSW 2006 Australia materials Department University of CaliforniaSanta BarbaraCA 93106 USA School of Engineering University of AberdeenKing’s CollegeAberdeenAB24 3UE Scotland UK INm-Leibniz Institute for New materials Campus D22 66123 Saarbrücken Germany

Optimization of composition and microstructure is important to enhance performance of solid oxide fuel cells （SOFC） and lithium-ion batteries （LIB）. For this, the porous electrode structures of both SOFC and LIB are modeled as a binary mixture of electronic and ionic conducting particles to estimate effective transport properties. Particle packings of 10000 spherical, binary sized and randomly positioned particles are created numerically and densified considering the different manufacturing processes in SOFC and LIB： the sintering of SOFC electrodes is approximated geometrically, whereas the calendering process and volume change due to intercalation in LIB are modeled physically by a discrete el- ement approach. A combination of a tracking algorithm and a resistor network approach is developed to predict the con- nectivity and effective conductivity for the various densified structures. For SOFC, a systematic study of the influence of morphology on connectivity and conductivity is performed on a large number of assemblies with different compositions and particle size ratios between 1 and 10. In comparison to percolation theory, an enlarged percolation area is found, es- pecially for large size ratios. It is shown that in contrast to former studies the percolation threshold correlates to varying coordination numbers. The effective conductivity shows not only an increase with volume fraction as expected but also with size ratio. For LIB, a general increase of conductivity during the intercalation process was observed in correlation with increasing contact forces. The positive influence of cal- endering on the percolation threshold and the effective conductivity of carbon black is shown. The anisotropy caused by the calendering process does not influence the carbon black phase.

关键词： Granular electrode structures Effective conductivity - Percolation

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Honey Dressing of Cutaneous Wounds on Limbs in the Traumatology Orthopaedics Department of Bouaké University Hospital

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Open Journal of Orthopedics 2024年第9期14卷 411-420页

作者： Achié Jean-Régis Akobe Aya Adélaide Natacha Kouassi Ibrahim Soumahoro Zolopégué marcel Soro Sedy Louess De Randolphe Akpro Bakary Traoré Almamy Kamate Axel Fabrice Essehin Yao Aboh Ganyn robert Arnaud Assere Lanciné Kaba Kouamé Innocent m’bra Loukou Blaise Yao Bada Justin Léopold Niaoré Sery Koffi Léopold Krah michel Kodo Orthopaedics-Traumatology Department of the University Hospital of Bouak Bouak Ivory Coast Plastic and Reconstructive Surgery Department of the University Hospital of Bouak Bouak Ivory Coast

The study evaluated the effectiveness of honey dressings in healing recent skin wounds with soft tissue loss on limbs. Conducted over a year with 60 patients, results showed a significant reduction in wound size and early healing, with complete recovery on average within 29 days. The study supports honey as a viable wound treatment.

关键词： Healing Honey Limbs Loss of Substances

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Semi-automated segmentation of magnetic resonance images for thigh skeletal muscle and fat using threshold technique after spinal cord injury

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Neural Regeneration Research 2018年第10期13卷 1787-1795页

作者： mina P.Ghatas robert m.Lester m.Rehan Khan Ashraf S.Gorgey Department of Spinal Cord Injury and Disorders Hunter Holmes McGuire VA Medical Center Department of Radiology Hunter Holmes McGuire VA Medical Center Department of Physical medicine and Rehabilitation Virginia Commonwealth University

magnetic resonance imaging is considered the ＂gold standard＂ technique for quantifying thigh muscle and fat cross-sectional area. We have developed a semi-automated technique to segment seven thigh compartments in persons with spinal cord injury. Thigh magnetic resonance images from 18 men（18–50 years old） with traumatic motor-complete spinal cord injury were analyzed in a blinded fashion using the threshold technique. The cross-sectional area values acquired by thresholding were compared to the manual tracing technique. The percentage errors for thigh circumference were（threshold： 170.71 ± 38.67; manual： 169.45 ± 38.27 cm2） 0.74%, subcutaneous adipose tissue（threshold： 65.99±30.79; manual： 62.68 ± 30.22） 5.2%, whole muscle（threshold： 98.18 ± 20.19; manual： 98.20 ± 20.08 cm2） 0.13%, femoral bone（threshold： 6.53 ± 1.09; manual： 6.53 ± 1.09 cm2） 0.64%, bone marrow fat（threshold： 3.12 ± 1.12; manual： 3.1 ± 1.11 cm2） 0.36%, knee extensor（threshold： 43.98 ± 7.66; manual： 44.61 ± 7.81 cm2） 1.78% and % intramuscular fat（threshold： 10.45 ± 4.29; manual： 10.92 ± 8.35%） 0.47%. Collectively, these results suggest that the threshold technique provided a robust accuracy in measuring the seven main thigh compartments, while greatly reducing the analysis time.

关键词： spinal cord injury magnetic resonance imaging semi-automated segmentation subcutaneous adipose tissue intramuscular fat

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Towards standardizing retinal optical coherence tomography angiography:a review

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Light(Science & Applications) 2022年第4期11卷 520-541页

作者： Danuta m.Sampson Adam m.Dubis Fred K.Chen robert J.Zawadzki David D.Sampson Surrey Biophotonics Centre for VisionSpeech and Signal Processing and School of Biosciences and MedicineThe University of SurreyGuildford GU27XHUK NIHR Biomedical Research Centre at moorflelds Eye Hospital NHS Trust and UCL Institute of Ophthalmology London EC1V 2PDUK. Centre for Ophthalmology and Visual Science(incorporating Lions Eye Institute) The University of Western AustraliaNedlandsWestern Australia 6009Australia. Department of Ophthalmology Royal Perth HospitalPerthWestern Australia 6000Australia. Ophthalmology Department of SurgeryUniversity of MelbourneMelbourneVictoria 3002Australia. Department of Ophthalmology&Vision Science University of California DavisSacramentoCA 95817USA. Surrey Biophotonics Advanced Technology InstituteSchool of Physics and School of Biosciences and MedicineUniversity of SurreyGuildfordSurrey GU27XHUK

The visualization and assessment of retinal microvasculature are important in the study,diagnosis,monitoring,and guidance of treatment of ocular and systemic *** the introduction of optical coherence tomography angiography(OCTA),it has become possible to visualize the retinal microvasculature volumetrically and without a contrast *** lab-based and commercial clinical instruments,imaging protocols and data analysis methods and metrics,have been applied,often inconsistently,resulting in a confusing picture that represents a major barrier to progress in applying OCTA to reduce the burden of *** data and software sharing,and cross-comparison and pooling of data from different studies are *** inabilities have impeded building the large databases of annotated OCTA images of healthy and diseased retinas that are necessary to study and define characteristics of specific *** paper addresses the steps needed to standardize OCTA imaging of the human retina to address these *** review of the OCTA literature,we identify issues and inconsistencies and propose minimum standards for imaging protocols,data analysis methods,metrics,reporting of findings,and clinical practice and,where this is not possible,we identify areas that require further *** hope that this paper will encourage the unification of imaging protocols in OCTA,promote transparency in the process of data collection,analysis,and reporting,and facilitate increasing the impact of OCTA on retinal healthcare delivery and life science investigations.

关键词： transparency steps inconsistent

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