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A model and Treatment for Autism at the Convergence of Chinese medicine and Western Science:First 130 Cases

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Chinese Journal of Integrative medicine 2011年第6期17卷 421-429页

作者： Louisa m.T.Silva mark Schalock robert Ayres Teaching Research Institute Western Oregon University

Objective：To present a model for autism showing that impairment of sensory and self-regulation is the core deficit that underlies delays in social/language skills and abnormal behavior in autism;and to demonstrate the efficacy of a treatment for autism based on Chinese ***：Children with autism under 6 years of age were assigned to treatment or wait-list conditions.A total of 130 children were treated and the results compared with 45 wait-list *** is a tuina methodology directed at sensory impairment——Kai Qiao *** treatment was a five-month protocol that was implemented daily by trained parents via trained support *** effects of treatment on the main symptoms,autistic behavior,social/ language delay,sensory and self-regulatory impairment,as well as on parenting stress,were observed and ***：The treatment had a large effect size（P0.0001） on measures of sensory and self-regulation. The evaluations done by pre-school teachers demonstrated improvement in the measures of autism（P0.003）, and were confirmed by evaluations done by parents（P0.0001）.There was a large decrease（P0.0001） in parenting ***：Sensory and self-regulatory impairment is a main factor in the development and severity of *** of young children with autism with Kai Qiao Tuina resulted in a decrease in sensory and self-regulatory impairment and a reduction in severity of measures of autism.

关键词： Kai Qiao Tuina Qigong sensory training autism treatment for children sensory impairment abnormal sensory responses autism early intervention for autism

Role of ion channels in gastrointestinal cancer

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World Journal of Gastroenterology 2019年第38期25卷 5732-5772页

作者： Kyle J Anderson robert T Cormier Patricia m Scott Department of Biomedical Sciences University of Minnesota Medical School

In their seminal papers Hanahan and Weinberg described oncogenic processes a normal cell undergoes to be transformed into a cancer *** functions of ion channels in the gastrointestinal(GI)tract influence a variety of cellular processes,many of which overlap with these hallmarks of *** this review we focus on the roles of the calcium(Ca^2+),sodium(Na^+),potassium(K^+),chloride(Cl^-)and zinc(Zn^2+)transporters in GI cancer,with a special emphasis on the roles of the KCNQ1 K+channel and CFTR Cl-channel in colorectal cancer(CRC).Ca^2+is a ubiquitous second messenger,serving as a signaling molecule for a variety of cellular processes such as control of the cell cycle,apoptosis,and *** members of the TRP superfamily,including TRPm8,TRPm7,TRPm6 and TRPm2,have been implicated in GI cancers,especially through overexpression in pancreatic adenocarcinomas and down-regulation in colon ***-gated sodium channels(VGSCs)are classically associated with the initiation and conduction of action potentials in electrically excitable cells such as neurons and muscle *** VGSC NaV1.5 is abundantly expressed in human colorectal CRC cell lines as well as being highly expressed in primary CRC *** have demonstrated that conductance through NaV1.5 contributes significantly to CRC cell invasiveness and cancer ***2+transporters of the ZIP/SLC39A and ZnT/SLC30A families are dysregulated in all major GI organ cancers,in particular,ZIP4 up-regulation in pancreatic cancer(PC).more than 70 K+channel genes,clustered in four families,are found expressed in the GI tract,where they regulate a range of cellular processes,including gastrin secretion in the stomach and anion secretion and fluid balance in the intestinal *** distinct types of K+channels are found dysregulated in the GI *** are hERG1 upregulation in PC,gastric cancer(GC)and CRC,leading to enhanced cancer angiogenesis and invasion,and KCNQ1 down-regulation in CR

关键词： Ion channels Gastrointestinal cancer Colorectal cancer Gastric cancer Pancreatic cancer Esophageal cancer Hepatocellular carcinoma Prognostic biomarker Novel therapies Clinical targets

Fluorescence-guided hepatobiliary surgery with long and short wavelength fluorophores

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Hepatobiliary Surgery and Nutrition 2020年第5期9卷 615-639页

作者： Thinzar m.Lwin robert m.Hoffman michael Bouvet Department of Surgery University of California San DiegoSan DiegoCAUSA AntiCancer Inc.San DiegoCAUSA VA San Diego Healthcare System San DiegoCAUSA

Importance:Fluorescence-guided surgery(FGS)is a potentially powerful tool for hepatobiliary(HPB)*** high sensitivity of fluorescence navigation is especially useful in settings where tactile feedback is ***:The present narrative review evaluates literature on the use of FDA-approved fluorophores such as methylene blue(mB),5-aminolevulinic acid(5-ALA),and indocyanine green(ICG)for clinical intra-operative image-guidance during HPB *** Review:Approaches such as dosing,timing,imaging devices and comparative endpoints are *** feasibility and safety of fluorophores in visualizing the biliary tree,identify biliary leaks,outline anatomic hepatic segments,identify tumors,and evaluate perfusion and graft function in liver transplants are ***:Tumor-specific probes are a promising advancement in FGS with a greater degree of *** current status of tumor-specific probes being evaluated in clinical trials are *** and Relevance for Reviews:Relevant discussion of promising tumor-specific probes in pre-clinical development are ***-guidance in HPB surgery is relatively new,but current literature shows that the dyes are reliably able to outline desired structures with a variety of dosing,timing,and imaging devices to provide real-time intra-operative anatomic information to *** of tumor-specific probes will further advance the field of HPB surgery especially during oncologic resections.

关键词： Fluorescence-guided surgery(FGS) methylene blue(mB) 5-aminolevulinic acid(5-ALA) indocyanine green(ICG) hepatobiliary surgery(HPB surgery) tumor-specific probes near-infrared fluorescence(NIR fluorescence)

Has Axial Spin Decline Affected Earth's Geologic and Tectonic History?

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Journal of Earth Science 2022年第5期33卷 1333-1336页

作者： Anne m.Hofmeister robert E.Criss Timothy m.Kusky Department of Earth and Planetary Science Washington UniversitySt.LouisMO63130USA State Key Laboratory for Geological Processes and mineral Resources Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan430074China Badong National Observatory and Research Station for Geohazards China University of GeosciencesWuhan430074China

0 INTRODUCTION Among the rocky planets,only Earth remains active 4.5 Ga after ***,only Earth has a chemically and structurally complex,bimodal surface with unequivocal horizontal *** unique plate motions are currently... 详细信息

关键词： Earth formation mantle

Quo vadis carbocatalysis?

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Journal of Energy Chemistry 2021年第10期30卷 219-227,I0007页

作者： robert Schlögl max-Planck-Institut für Chemische Energiekonversion Stiftstr.34-3645470 Mülheim an der RuhrGermany Fritz-Haber Institut der max-Planck-Gesellschaft Faradayweg 4-614195 BerlinGermany

Prologue The rich scientific heritage of Dangsheng Su contains as substantial fraction his contributions to the field of catalysis with nanostructured carbon *** from microstructural analysis it became quickly clear that the richness of morphological and hence surface electronic variations in this class of materials should be suitable for the development of a science base for heterogeneous catalysis.

关键词： materials. catalysis. catalysis

A micromechanical model for efective conductivity in granular electrode structures

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Acta mechanica Sinica 2013年第5期29卷 682-698页

作者： Julia Ott Benjamin Vlker Yixiang Gan robert m.mc meeking marc Kamlah Institute of Applied materials Karlsruhe Institute of Technology76131 Karlsruhe Germany Department of mechanical Engineering University of CaliforniaSanta BarbaraCA 93106 USA School of Civil Engineering The University of SydneyNSW 2006 Australia materials Department University of CaliforniaSanta BarbaraCA 93106 USA School of Engineering University of AberdeenKing’s CollegeAberdeenAB24 3UE Scotland UK INm-Leibniz Institute for New materials Campus D22 66123 Saarbrücken Germany

Optimization of composition and microstructure is important to enhance performance of solid oxide fuel cells （SOFC） and lithium-ion batteries （LIB）. For this, the porous electrode structures of both SOFC and LIB are modeled as a binary mixture of electronic and ionic conducting particles to estimate effective transport properties. Particle packings of 10000 spherical, binary sized and randomly positioned particles are created numerically and densified considering the different manufacturing processes in SOFC and LIB： the sintering of SOFC electrodes is approximated geometrically, whereas the calendering process and volume change due to intercalation in LIB are modeled physically by a discrete el- ement approach. A combination of a tracking algorithm and a resistor network approach is developed to predict the con- nectivity and effective conductivity for the various densified structures. For SOFC, a systematic study of the influence of morphology on connectivity and conductivity is performed on a large number of assemblies with different compositions and particle size ratios between 1 and 10. In comparison to percolation theory, an enlarged percolation area is found, es- pecially for large size ratios. It is shown that in contrast to former studies the percolation threshold correlates to varying coordination numbers. The effective conductivity shows not only an increase with volume fraction as expected but also with size ratio. For LIB, a general increase of conductivity during the intercalation process was observed in correlation with increasing contact forces. The positive influence of cal- endering on the percolation threshold and the effective conductivity of carbon black is shown. The anisotropy caused by the calendering process does not influence the carbon black phase.

关键词： Granular electrode structures Effective conductivity - Percolation

Honey Dressing of Cutaneous Wounds on Limbs in the Traumatology Orthopaedics Department of Bouaké University Hospital

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Open Journal of Orthopedics 2024年第9期14卷 411-420页

作者： Achié Jean-Régis Akobe Aya Adélaide Natacha Kouassi Ibrahim Soumahoro Zolopégué marcel Soro Sedy Louess De Randolphe Akpro Bakary Traoré Almamy Kamate Axel Fabrice Essehin Yao Aboh Ganyn robert Arnaud Assere Lanciné Kaba Kouamé Innocent m’bra Loukou Blaise Yao Bada Justin Léopold Niaoré Sery Koffi Léopold Krah michel Kodo Orthopaedics-Traumatology Department of the University Hospital of Bouak Bouak Ivory Coast Plastic and Reconstructive Surgery Department of the University Hospital of Bouak Bouak Ivory Coast

The study evaluated the effectiveness of honey dressings in healing recent skin wounds with soft tissue loss on limbs. Conducted over a year with 60 patients, results showed a significant reduction in wound size and early healing, with complete recovery on average within 29 days. The study supports honey as a viable wound treatment.

关键词： Healing Honey Limbs Loss of Substances

Semi-automated segmentation of magnetic resonance images for thigh skeletal muscle and fat using threshold technique after spinal cord injury

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Neural Regeneration Research 2018年第10期13卷 1787-1795页

作者： mina P.Ghatas robert m.Lester m.Rehan Khan Ashraf S.Gorgey Department of Spinal Cord Injury and Disorders Hunter Holmes McGuire VA Medical Center Department of Radiology Hunter Holmes McGuire VA Medical Center Department of Physical medicine and Rehabilitation Virginia Commonwealth University

magnetic resonance imaging is considered the ＂gold standard＂ technique for quantifying thigh muscle and fat cross-sectional area. We have developed a semi-automated technique to segment seven thigh compartments in persons with spinal cord injury. Thigh magnetic resonance images from 18 men（18–50 years old） with traumatic motor-complete spinal cord injury were analyzed in a blinded fashion using the threshold technique. The cross-sectional area values acquired by thresholding were compared to the manual tracing technique. The percentage errors for thigh circumference were（threshold： 170.71 ± 38.67; manual： 169.45 ± 38.27 cm2） 0.74%, subcutaneous adipose tissue（threshold： 65.99±30.79; manual： 62.68 ± 30.22） 5.2%, whole muscle（threshold： 98.18 ± 20.19; manual： 98.20 ± 20.08 cm2） 0.13%, femoral bone（threshold： 6.53 ± 1.09; manual： 6.53 ± 1.09 cm2） 0.64%, bone marrow fat（threshold： 3.12 ± 1.12; manual： 3.1 ± 1.11 cm2） 0.36%, knee extensor（threshold： 43.98 ± 7.66; manual： 44.61 ± 7.81 cm2） 1.78% and % intramuscular fat（threshold： 10.45 ± 4.29; manual： 10.92 ± 8.35%） 0.47%. Collectively, these results suggest that the threshold technique provided a robust accuracy in measuring the seven main thigh compartments, while greatly reducing the analysis time.

关键词： spinal cord injury magnetic resonance imaging semi-automated segmentation subcutaneous adipose tissue intramuscular fat

Chemistry-led investigations into the mode of action of NAmPT activators,resulting in the discovery of non-pyridyl class NAmPT activators

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Acta Pharmaceutica Sinica B 2023年第2期13卷 709-721页

作者： Siyuan Tang miguel Garzon Sanz Oliver Smith Andreas Krämer Daniel Egbase Paul W.Caton Stefan knapp Sam Butterworth Division of Pharmacy and Optometry School of Health SciencesManchester Academic Health Sciences CentreUniversity of ManchesterManchester M139PLUK Structural Genomics Consortium(SGC) 60438 Frankfurt Am MainGermany Buchmann Institute for Life Sciences(BmLS) 60438 Frankfurt Am MainGermany Institut für Pharmazeutische Chemie Goethe University60438 Frankfurt Am MainGermany Frankfurt Cancer Institute(FCI) 60596 Frankfurt Am MainGermany Department of Diabetes School of Cardiovascular and Metabolic Medicine&SciencesFaculty of Life Sciences&MedicineKing's College LondonLondon SE11ULUK

The cofactor nicotinamide adenine dinucleotide(NAD+)plays a key role in a wide range of physiological processes and maintaining or enhancing NAD+levels is an established approach to enhancing healthy ***,several classes of nicotinamide phosphoribosyl transferase(NAmPT)activators have been shown to increase NAD+levels in vitro and in vivo and to demonstrate beneficial effects in animal *** best validated of these compounds are structurally related to known urea-type NAmPT inhibitors,however the basis for the switch from inhibitory activity to activation is not well *** we report an evaluation of the structure activity relationships of NAmPT activators by designing,synthesising and testing compounds from other NAmPT ligand chemotypes and mimetics of putative phosphoribosylated adducts of known *** results of these studies led us to hypothesise that these activators act via a through-water interaction in the NAmPT active site,resulting in the design of the first known urea-class NAmPT activator that does not utilise a pyridine-like warhead,which shows similar or greater activity as a NAmPT activator in biochemical and cellular assays relative to known analogues.

关键词： Nicotinamide phosphoribosyl transferase activator Healthy aging Drug discovery Bioisosteres medicinal chemistry