检索结果-南通市图书馆

Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure

引用

World Journal of Hepatology 2019年第1期11卷 65-73页

作者： Brianna J Shinn Aaron martin robert m coben mitchell I Conn Jorge Prieto Howard Kroop Anthony J Dimarino Hie-Won Hann Division of Gastroenterology and Hepatology Department of Medicine Thomas Jefferson University Hospital

Hepatitis B virus(HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma(HCC). During the last two decades, with the use of currently available anti-HBV therapies(lamivudine, entecavir and tenofovir disoproxil fumatate), there has been a decrease in the incidence of HBVassociated HCC(HBV-HCC). Furthermore, several studies have demonstrated a reduction in recurrent or new HCC development after initial HCC tumor ablation. However, during an observation period spanning 10 to 20 years, several case reports have demonstrated the development of new, subsequent new and recurrent HCC even in patients with undetectable serum HBV DNA. The persistent risk for HCC is attributed to the presence of covalently closed circular DNA(cccDNA) in the hepatocyte nucleus which continues to work as a template for HBV replication. While a functional cure(loss of hepatitis B surface antigen and undetectable viral DNA) can be attained with nucleos(t)ide analogues, these therapies do not eliminate cccDNA. Of utmost importance is successful eradication of the transcriptionally active HBV cccDNA from hepatocyte nuclei which would be considered a complete cure. The unpredictable nature of HCC development in patients with chronic HBV infection shows the need for a complete cure. Continued support and encouragement for research efforts aimed at developing curative therapies is imperative. The aims of this minireview are to highlight these observations and emphasize the need for a cure for HBV.

关键词： Hepatitis B Hepatocellular carcinoma Antiviral therapy Persistent Risk for hepatocellular carcinoma Tumor ablation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

引用

Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen robert J.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

On-line non-intrusive particle size measurement of pulverised fuel through digital imaging

引用

仪器仪表学报 2007年第11期28卷 1942-1946页

作者： Carter robert m Department of Electronics University of Kent

This paper presents the basic principles of particle size measurement and latest industrial results recorded using an innovative optical instrumentation system designed to measure the size distribution of particles in a pneumatic *** system is non-intrusive and cost-effective.A low-cost CCD camera is used to capture images of the particulate flow field,which is illuminated by a low-cost pulsed laser sheet *** particle size distribution is then determined by processing the particle images through the use of novel processing *** results obtained in the past on a small scale particle flow test rig have demonstrated that the system is capable of measuring the size distribution of pneumatically conveyed particles with an accuracy of a few *** the present paper results obtained when testing the system at a 4 mW industrial test facility are *** are made with both off-line reference data achieved through sieving and on-line laser diffraction data recorded using an intrusive,extractive,malvern Instruments *** general there is good agreement between results when considering the characteristics and limitations of the individual *** novel imaging system shows itself to be rugged,practical and useful under genuine industrial conditions.

关键词：粒子测量方法数字成像数码

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Universal correlations in percolation

引用

Frontiers of physics 2020年第4期15卷 1-3页

作者： robert m.Zif Center for the Study of Compler Systems and Department of Chemical Engineering University of MichiganAnn ArborMI 48109-2800USA

Percolation is the process where connections from link to link in random systems leads to clustering and long-range connectivity.A standard model of percolation is a reg-ular lattice,with the links being nearest-neighbor bonds that are randomly occupied(bond percolation),or all links exist and random sites(vertices)are occupied(site per-colation).At a critical occupancy fraction Pe of sites or bonds,the mean cluster size in an infinite system first becomes infinite,and many properties become universal for a given *** characteristics of the uni-versal behavior has been the focus of much research for decades[1-5].

关键词： bonds percolation infinite

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thiolsulfonate functionalized polystyrene resin:Preparation and application in the isolation and identification of electrophilic mutagens

引用

Journal of Environmental Sciences 2007年第12期19卷 1520-1527页

作者： Wu El robert m. Carlson Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Department of Chemistry University of Minnesota-Duluth Duluth MN 55812 USA

A new approach for isolation and identification of elecrtophilic mutagens from complex matrix was developed. Thiosulforfic anion was immobilized onto polystyrene beads and used as separation media. Potassium polystyryl-thiosulfonate, prepared from polystyryl- sulfonyl chloride and KHS, was observed to selectively react with model electrophilic mutagens such as alkyl halides, ct-chloroketones and α-chloroesters to produce polystyryl-thiosulfonlc esters. After separation from other nonreactive organic compounds, the beads then reacted with ethanethiol to produce unsymmetrical ethyl disulfides which are easily detected by GC/mS. For one mutagenic compound, only one unsymmetrical disulfide was found to contain its structure part. Thus, the structure of the parent mutagens could be deduced from that of the unsymmetrical disulfides. The degree of functionalization of the potassium polystyryl-thiosulfonate resin was 1.11 mmol/g. Its reactivity was discussed and its recycling method was reported here.

关键词： functionalized polystyrene potassium polystyryl-thiosulfonate unsymmetrical ethyl disulfides electrophilic mutagens

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in local ablation of malignant liver lesions

引用

World Journal of Gastroenterology 2016年第15期22卷 3885-3891页

作者： robert m Eisele Department of General Visceral Vascular and Pediatric Surgery Medical Faculty of the University of Saarland

Local ablation of liver tumors matured during the recent years and is now proven to be an effective tool in the treatment of malignant liver lesions. Advances focus on the improvement of local tumor control by technical innovations, individual selection of imaging modalities, more accurate needle placement and the free choice of access to the liver. Considering data found in the current literature for conventional local ablative treatment strategies, virtually no single technology is able to demonstrate an unequivocal superiority. Hints at better performance of microwave compared to radiofrequency ablation regarding local tumor control, duration of the procedure and potentially achievable larger size of ablation areas favour the comparably more recent treatment modality; image fusion enables more patients to undergo ultrasound guided local ablation; magnetic resonance guidance may improve primary success rates in selected patients; navigation and robotics accelerate the needle placement and reduces deviation of needle positions; laparoscopic thermoablation results in larger ablation areas and therefore hypothetically better local tumor control under acceptable complication rates, but seems to be limited to patients with no, mild or moderate adhesions following earlier surgical procedures. Apart from that, most techniques appear technically feasible, albeit demanding. Which technology will in the long run become accepted, is subject to future work.

关键词： Local ablation Liver microwave ablation Hepatocellular carcinoma Colorectal liver metastases Navigation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Junction Point Elimination based Tamil Handwritten Character Recognition:An Experimental Analysis

引用

Journal of Systems Science and Systems Engineering 2020年第1期29卷 100-123页

作者： m.Antony robert Raj S.Abirami Department of Information Science and Technology Anna UniversityChennai 600025

Optical Character Recognition is the mechanical or electronic conversion of images of typed,handwritten or printed text into machine-encoded text for online reading and *** this OCR technique,Tamil handwritten character recognition is one of the most needed and challengeable subjects of *** encounter between selection and extraction of proper features eliminates the issues faced by the Tamil handwritten *** character and the writers complexities are the major difficulties and challenges faced by this recognition ***,the character complexity can be overcome by any pre-extraction or selection process,wherein,structured or statistical pre-extraction algorithm can be designed,discovering the essential features,in the case of writer *** challenges of Tamil handwritten characters are structure over looping;unnecessary character portion;structure discontinuations and so *** character portions in this research are chosen by implementing a new algorithm called the Junction Point Elimination(JPE)after conscientious analysis done on the existing algorithms like Zoning,Zoning and Junction Point(ZJP)and the Junction Point (JP) based feature pre-extraction *** novelty behind this work is introducing an algorithm in order to truncate the problem in the existing feature selection and preextraction *** feature extraction and classification algorithm are chosen and applied on the features extracted by JPE to test whether the same can be reached in successful *** final analysis and experiments shows that the JPE is better than the others.

关键词： Junction point elimination chain code zoning prism tree quad tree support vector machine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recovery of spermatogenesis following testosterone replacement therapy or anabolic-androgenic steroid use

引用

Asian Journal of Andrology 2016年第3期18卷 373-380,I0007页

作者： J Abram mcBride robert m Coward Department of Urology University of North Carolina School of Medicine Chapel Hill NC 27599-7235 USA.

The use of testosterone replacement therapy （TRT） for hypogonadism continues to rise, particularly in younger men who may wish to remain fertile. Concurrently, awareness of a more pervasive use of anabolic-androgenic steroids （AAS） within the general population has been appreciated. Both TRT and AAS can suppress the hypothalamic-pituitary-gonadal （HPG） axis resulting in diminution of spermatogenesis. Therefore, it is important that clinicians recognize previous TRT or AAS use in patients presenting for infertility treatment. Cessation of TRT or AAS use may result in spontaneous recovery of normal spermatogenesis in a reasonable number of patients if allowed sufficient time for recovery. However, some patients may not recover normal spermatogenesis or tolerate waiting for spontaneous recovery. In such cases, clinicians must be aware of the pathophysiologic derangements of the HPG axis related to TRT or AAS use and the pharmacologic agents available to reverse them. The available agents include injectable gonadotropins, selective estrogen receptor modulators, and aromatase inhibitors, but their off-label use is poorly described in the literature, potentially creating a knowledge gap for the clinician. Reviewing their use clinically for the treatment of hypogonadotropic hypogonadism and other HPG axis abnormalities can familiarize the clinician with the manner in which they can be used to recover spermatogenesis after TRT or AAS use.

关键词： anabolic steroids hypogonadism infertility spermatogenesis testosterone testosterone replacement therapy vasectomy reversal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessment of mercury(II) bioavailability using a bioluminescent bacterial biosensor: Practical and theoretical challenges

引用

Journal of Environmental Sciences 2010年第8期22卷 1137-1143页

作者： Paulo R G Barrocas William m Landing robert J m Hudson Department of Sanitation and Environmental Health National School of Public Health Oswaldo Cruz Foundation Department of Oceanography Florida State University. Tallahassee Department of Natural Resources and Environmental Sciences University of Illinois

Critical methodological challenges in the microbial biosensor approach to assessing Hg（II） bioavailability were evaluated from the perspective of analytical chemists. The main challenge stems from the fact that the chemical speciation of Hg（II） in natural waters exerts a major control on its bioavailability, yet its natural complexation equilibria are extensively altered during conventional bioassays. New data, obtained using a bioluminescent Hg（II）-biosensor, that illustrate these challenges are presented and potential solutions proposed.

关键词： mercury bioavailability biosensor chemical speciation bioluminescent

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of three-dimensional fluorescence analysis methods for predicting formation of trihalomethanes and haloacetic acids

引用

Journal of Environmental Sciences 2015年第1期27卷 159-167页

作者： Nicolás m.Peleato robert C.Andrews Department of Civil Engineering University of Toronto

This work investigated the application of several fluorescence excitation–emission matrix analysis methods as natural organic matter（NOm） indicators for use in predicting the formation of trihalomethanes（THms） and haloacetic acids（HAAs）. Waters from four different sources（two rivers and two lakes） were subjected to jar testing followed by 24 hr disinfection by-product formation tests using chlorine. NOm was quantified using three common measures： dissolved organic carbon, ultraviolet absorbance at 254 nm, and specific ultraviolet absorbance as well as by principal component analysis, peak picking,and parallel factor analysis of fluorescence spectra. Based on multi-linear modeling of THms and HAAs, principle component（PC） scores resulted in the lowest mean squared prediction error of cross-folded test sets（THms： 43.7（μg/L）^2, HAAs： 233.3（μg/L）^2）. Inclusion of principle components representative of protein-like material significantly decreased prediction error for both THms and HAAs. Parallel factor analysis did not identify a protein-like component and resulted in prediction errors similar to traditional NOm surrogates as well as fluorescence peak picking. These results support the value of fluorescence excitation–emission matrix–principal component analysis as a suitable NOm indicator in predicting the formation of THms and HAAs for the water sources studied.

关键词： Natural organic matter Fluorescence Principal component analysis PARAFAC Disinfection byproducts Drinking water

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：