检索结果-南通市图书馆

Genetic assessment of inbred chicken lines indicates genomic signatures of resistance to Marek's disease

Journal of Animal Science and Biotechnology 2018年第4期9卷 803-812页

作者： lingyang Xu Yanghua He Yi Ding George E.liu Huanmin Zhang Hans H.Cheng robert l.taylor jr. Jiuzhou Song Department of Animal & Avian Sciences University of Maryland Animal Genomics and Improvement laboratory U.S. Department of Agriculture-Agricultural Research Services laboratory of Molecular Biology and Bovine Breeding Institute of Animal Science Chinese Academy of Agricultural Sciences United States Department of Agriculture-Agriculture Research Service (ARS) Avian Disease and Oncology Laboratory Animal and Nutritional Sciences Davis College of Agriculture West Virginia University

Background: Marek’s disease(MD) is a highly contagious pathogenic and oncogenic disease primarily affecting chickens. However, the mechanisms of genetic resistance for MD are complex and not fully understood. MD-resistant line 63and MD-susceptible line 72are two highly inbred progenitor lines of White leghorn. Recombinant Congenic Strains(RCS) were developed from these two lines, which show varied susceptibility to ***: We investigated genetic structure and genomic signatures across the genome, including the line 63and line72, six RCSs, and two reciprocally crossed flocks between the lines 63and 72(F1 63× 72and F1 72× 63) using Affymetrix~? Axiom~? HD 600 K genotyping array. We observed 18 chickens from RCS lines were specifically clustered into resistance sub-groups distributed around line 63. Additionally, homozygosity analysis was employed to explore potential genetic components related to MD resistance, while runs of homozygosity(ROH) are regions of the genome where the identical haplotypes are inherited from each parent. We found several genes including SIK, SOX1, lIG4, SIK1 and TNFSF13B were contained in ROH region identified in resistant group(line 63and RCS), and these genes have been reported that are contribute to immunology and survival. Based on FSTbased population differential analysis, we also identified important genes related to cell death and anti-apoptosis, including AKT1, API5, CDH13, CFDP and USP15,which could be involved in divergent selection during inbreeding ***: Our findings offer valuable insights for understanding the genetic mechanism of resistance to MD and the identified genes could be considered as candidate biomarkers in further evaluation.

关键词： Genetic structure Genomic signature Homozygosity Marek's disease Recombinant Congenic Strains(RCS)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Very weak solutions to the two-dimensional Monge-Ampére equation Dedicated to Professor Jean-Yves Chemin on the Occasion of His 60th Birthday

引用

Science China Mathematics 2019年第6期62卷 1041-1056页

作者： Wentao Cao lászló Székelyhidi jr. Institut für Mathematik Universit?t Leipzig

In this short note we revisit the convex integration approach to constructing very weak solutions to the 2D Monge-Ampére equation with H?lder-continuous ?rst derivatives of exponent β lewicka and Pakzad(2017) with a new diagonalization procedure which avoids the use of conformal coordinates, which was introduced by De lellis et al.(2018) for the isometric immersion problem.

关键词： Monge-Ampére equation convex integration weak solutions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Designing General Anesthetics That Have a Better Safety Profile

引用

Pharmacology & Pharmacy 2019年第10期10卷 407-415页

作者： robert B. Raffa Joseph V. Pergolizzi jr. robert taylor jr. Neumentum Inc.，Palo Alto CAUSA College of Pharmacy University of Arizona Tucson AZ USA Temple University School of Pharmacy Philadelphia PA USA NEMA Research Inc. Naples FL USA.

General anesthetics constitute some of the most important and widely-used therapeutic drugs in the pharmacotherapeutic armamentarium. They are routinely used effectively and with adequate precaution-safety throughout the world for a multitude of clinical applications, predominantly as adjunctive agents for surgical procedures. Nevertheless, they have potential adverse effects (such as a drop in blood pressure and the inhibition of steroid production), particularly in vulnerable populations such as the very young and the frail elderly. It would be desirable therefore to have alternative agents that are just as efficacious, but have a better safety profile in a broader spectrum of patients. Toward this end, an anesthetic based on a unique chemical core (viz., an N-arylpyrrole derivative) has been reported in preclinical models to produce anesthetic effects without hemodynamic suppression. This lead could pave the way for new general anesthetics that are safer and easier to use.

关键词： General Anesthetic Intravenous Drug Discovery GABAA Receptor Molecular Modeling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

THE GATE SQUAll lINE OF 9-10 AUGUST 1974

引用

Advances in Atmospheric Sciences 1987年第1期4卷 85-92页

作者：韦统健,robert A. Houze jr. Department of Atmospheric Sciences Nanjing University Nanjing Department of Atmospheric Sciences University of Washington Seattle WA 98195 U.S.A.

A tropical squall line that passed over the ship array of the Global Atmospheric Research Programme's Atlantic Tropical Experiment (GATE) on 9-10 August 1974 is analyzed. This squall line was similar to squall systems that passed over the GATE ship array on four other days. It began as a purely convective cloud line, then developed an associated stratiform cloud and precipitation area. The stratiform rain built up to a maximum amount over a period of 8 h, then gradually diminished over a 6 h period. This stratiform rain is estimated to have accounted for 32% of the squall system's total precipitation. As in other GATE squall lines, the upper-level cloud shield from which the stratiform rain fell, was advected slowly forward of the line during the system's lifetime, the leading line of convective clouds consisted of transient smaller-scale convective elements, which lent the line an irregular shape and pulsatory movement, and the stratiform portion of the system was characterized by the development of a

关键词： line THE GATE SQUAll lINE OF 9-10 AUGUST 1974 GMT lINE

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

“Atropisomeric” Drugs: Basic Concept and Example of Application to Drug Development

引用

Pharmacology & Pharmacy 2020年第1期11卷 1-8页

作者： robert B. Raffa Joseph V. Pergolizzi jr. robert taylor jr. Neumentum Inc. Palo Alto CA USA College of Pharmacy University of Arizona Tucson AZ USA School of Pharmacy Temple University Philadelphia PA USA NEMA Research Inc. Naples FL USA

Many therapeutic drugs are racemates;i.e. they are chiral molecules consisting of “left”- and “right-handed” enantiomers (stereoisomers that are mirror images of each other, and are non-superimposable). In some cases, both enantiomers of the drug contribute to some extent (or equally) to the therapeutic effect;in other cases they contribute not at all. The same is true for the adverse effects of racemate drugs: the adverse effects of a racemate drug can be greater-than, less-than, or equal to one or the other enantiomer. An unusual situation arises when a drug consists of “atropisomers”, stereoisomers arising because of hindered rotation about a single chemical bond. We summarize the concept of atropisomerism, and give examples.

关键词： Atropisomer Chirality Pharmacotherapy Drug Development NaV1.7 Inhibitor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The aggressive invasion of exotic reptiles in Florida with a focus on prominent species： A review

引用

Current Zoology 2011年第5期57卷 599-612页

作者： Richard ENGEMAN Elliott JACOBSON Michael l. AVERY Walter E. MESHAKA, jr. USDA/APHIS/Wildlife Services/National Wildlife Research Ctr 4101 LaPorte Ave. Fort Collins CO 80521-2154 USA College of Veterinary Medicine University of Florida Gainesville FL 32610 USA USDA/APHIS/Wildlife Services/National Wildlife Research Ctr 2820 East University Ave. Gainesville FL 32641 USA The State Museum of Pennsylvania 300 North Street Harrisburg Pennsylvania 17120 USA

Florida, along with Hawaii, has among the two worst invasive species problems in the USA, and the state is espe-cially susceptible to establishment by alien reptiles. Besides the large numbers of established non-native reptile species in Florida, many of these species present novel difficulties for management, or have other characteristics making effective management ex-tremely challenging. Moreover, initiation of management action requires more than recognition by experts that a potentially harmful species has become established. It also requires the political will along with concomitant resources and appropriate per-sonnel to develop effective methods and apply them. We review the situation in Florida, including assessment of risk for estab- lishment, and we use a subset of prominent species to illustrate in more detail the array of invasive reptile species circumstances in Florida, including routes of introduction, impacts, and potential and implemented management actions. These examples not only highlight the severity of the invasive reptile problems in the state, but they also show the diversity in resolve and response towards them and the motivating factors [Current Zoology 57 （5）： 599-612, 2011].

关键词： Argentine black and white tegus Biophysical ecology Burmese pythons Control Green and spiny-tailed iguanas,Invasive species Nile monitors Northern curlytail lizards

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Distribution Control Centers in the US and Europe:Commonalities,Differences,and lessons

引用

Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 259-268页

作者： Subramanian Vadari Izudin Dzafic Dan'l Koch Ryan Murphy Daniel Hayes jr. Tarik Donlagic Modem Grid Solutions New YorkUSA University of Sarajevo Faculty of Electrical EngineeringSarajevoBosnia and Herzegovina R.Murphy are with Puget Sound Energy BellevueUSA Commonwealth Edison ChicagoUSA Siemens AG ErlanglenGermany

The distribution control center(DCC)has evolved from a sideshow in the traditional distribution service center to a major centerpiece of the utility moving into the decentralized ***,this is the place where much of the action is happening due to new forms of energy that are coining into the distribution *** creates the flexibility of operation and in-creased complexity due to the need for increased coordination between the transmission control center and ***,the US and European utilities have adapted to this change in very different ***,we describe the research works done in a DCC and their evolutions from the perspectives of major US utilities,and those enhanced by the European perspective focusing on the coordination of distribution system operator and transmission system operator(DSO-TSO).We pres-ent the insights into the systems used in these control centers and the role of vendors in their *** this paper,we present the perspectives of challenges,operational capabilities,and the involvement of various parties who will be re-sponsible to make the transition *** differences are pointed out on how distribution operations are conducted between the US and Europe.

关键词： Distribution control center(DCC) power system operation distributed generation asset flexibility volt-var optimization and control.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of vertical position on trematode parasitism in larval anurans

引用

Current Zoology 2019年第6期65卷 657-664页

作者： Jacob R.JONES Camille l.STEENROD John A.MARINO jr. Biology Department Bradley UniversityPeoriaILUSA Department of Geography University of MarylandCollege ParkMDUSA

Spatial distributions of animals can affect interactions with their natural enemies,such as parasites,and thus have important implications for host-parasite *** spatial variation in infection risk has been explored in many systems at the landscape scale,less attention has been paid to spatial structure at smaller ***,we explore a hypothesized relationship between a common spatial variable,vertical position,and risk of parasite infection in a model aquatic system,larval frogs(Rana)and trematode(Digenea)*** position is relevant to this system given evidence that the densities of snail first intermediate hosts,tadpole second intermediate hosts,and trematode infective stages can vary with *** test the effects of depth on infection risk of larval frogs by trematodes,we performed two enclosure experiments,one in the laboratory and one in the field,in which larval frogs in cages just below the water surface or near the bottom of the water column were exposed to *** with near-surface cages,mean infection load(number of cysts)in tadpoles in near-bottom cages was 83%higher after 48-h exposures in the laboratory and 730%higher after 10-day exposures in the *** findings thus indicate that infection risk depends on depth,which may have adaptive significance,as tadpoles have previously been shown to change vertical position in response to parasite *** results motivate future work examining vertical variation in infection risk and may have broader implications for host-parasite dynamics and evolution of host and parasite behavior.

关键词： avoidance behavior cercariae Echinostomatidae host-parasite interactions Rana spatial structure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improved speciation of dissolved organic nitrogen in natural waters: amide hydrolysis with fluorescence derivatization

引用

Journal of Environmental Sciences 2008年第10期20卷 1273-1280页

作者： Ryan l.Fimmen Tamara D.Trouts Daniel D.Richter jr. Dharni Vasudevan School of Earth Sciences The Ohio State University 125 S.Oval MallColumbus OH 43210 USA.Nicholas School of the Environment and Earth Sciences Duke University Durham NC 27708 USA School of Earth Sciences The Ohio State University 125 S.Oval MallColumbus OH 43210 USA Nicholas School of the Environment and Earth Sciences Duke UniversityDurham NC 27708 USA. Nicholas School of the Environment and Earth Sciences Duke UniversityDurham NC 27708 USA.Department of Chemistry Bowdoin CollegeBrunswick ME 04011 USA

The objective of this study was to improve primary-amine nitrogen (1°-N) quantification in dissolved organic matter (DOM) originating from natural waters where inorganic forms of N, which may cause analytical interference, are commonly encountered. Efforts were targeted at elucidating organic-N structural criteria influencing the response of organic amines to known colorimetric and fluorescent reagents and exploring the use of divalent metal-assisted amide hydrolysis in combination with fluorescence analyse...

关键词： dissolved organic matter/nitrogen (DOM/DON) o-phthaldialdehyde fluorescamine ninhydrin amino acids amide hydrolysis peptides

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Twins Clock Paradox History and Perspectives

引用

Journal of Modern Physics 2014年第12期5卷 1062-1078页

作者： robert l. Shuler jr. NASA Johnson Space Center Houston TX USA

The twins or clock paradox has been a subject of lively discussion and occasional disagreement among both relativists and the public for over 100 years, and continues to attract physicists who write papers giving new analyses or defending old ones, even though many physicists now consider the matter only of educational interest. This paper investigates the number of papers, which is increasing, and trends in explanations, some of which are now targeted at professional physicists and other of which are targeted at optical or radar visualization rather than problem solving. Observations of students indicate that the latest techniques help but only somewhat. An analysis is made of 21 previous treatments appearing in the education related American Journal of Physics, Einstein’s discussions and several other pedagogical papers. A new memory aid for simultaneity transformation is given that puts it on a par with “time dilation” and “length contraction” for quick and easy problem visualization. The point of view of a trailing twin is introduced to show how simultaneity changes account for missing time in the turnaround. length contraction is treated on equal footing with time dilation, and Swann’s insight into clocks is extended to lengths. Treatments using the conventionality of simultaneity are seen as equivalent to choice of co-moving frames. Responses to difficult questions are suggested which avoid being dismissive, and engage students’ critical thinking.

关键词： Clock Paradox length Contraction Simultaneity Special Relativity Time Dilation Twins Paradox

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：