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Genetic assessment of inbred chicken lines indicates genomic signatures of resistance to Marek's disease

Journal of Animal Science and Biotechnology 2018年第4期9卷 803-812页

作者： lingyang Xu Yanghua He Yi Ding George E.liu Huanmin Zhang Hans H.Cheng robert l.taylor Jr. Jiuzhou Song Department of Animal & Avian Sciences University of Maryland Animal Genomics and Improvement laboratory U.S. Department of Agriculture-Agricultural Research Services laboratory of Molecular Biology and Bovine Breeding Institute of Animal Science Chinese Academy of Agricultural Sciences United States Department of Agriculture-Agriculture Research Service (ARS) Avian Disease and Oncology Laboratory Animal and Nutritional Sciences Davis College of Agriculture West Virginia University

Background: Marek’s disease(MD) is a highly contagious pathogenic and oncogenic disease primarily affecting chickens. However, the mechanisms of genetic resistance for MD are complex and not fully understood. MD-resistant line 63and MD-susceptible line 72are two highly inbred progenitor lines of White leghorn. Recombinant Congenic Strains(RCS) were developed from these two lines, which show varied susceptibility to ***: We investigated genetic structure and genomic signatures across the genome, including the line 63and line72, six RCSs, and two reciprocally crossed flocks between the lines 63and 72(F1 63× 72and F1 72× 63) using Affymetrix~? Axiom~? HD 600 K genotyping array. We observed 18 chickens from RCS lines were specifically clustered into resistance sub-groups distributed around line 63. Additionally, homozygosity analysis was employed to explore potential genetic components related to MD resistance, while runs of homozygosity(ROH) are regions of the genome where the identical haplotypes are inherited from each parent. We found several genes including SIK, SOX1, lIG4, SIK1 and TNFSF13B were contained in ROH region identified in resistant group(line 63and RCS), and these genes have been reported that are contribute to immunology and survival. Based on FSTbased population differential analysis, we also identified important genes related to cell death and anti-apoptosis, including AKT1, API5, CDH13, CFDP and USP15,which could be involved in divergent selection during inbreeding ***: Our findings offer valuable insights for understanding the genetic mechanism of resistance to MD and the identified genes could be considered as candidate biomarkers in further evaluation.

关键词： Genetic structure Genomic signature Homozygosity Marek's disease Recombinant Congenic Strains(RCS)

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肥育牛藻菌病

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动物医学进展 1980年第1期 28-29页

作者： robert l.taylor 王恒史学增

藻菌病是一个含义广泛的术语,是以描述人和动物由藻菌纲中的几属真菌所引起的真菌病。其临床表现因病原体不同而异。感染严重的动物最常见的疾病是牛真菌性流产、肺或淋巴结的肉芽肿及瘤胃或肠溃疡。胃肠道藻菌病的临床表现于1951年西... 详细信息

藻菌病是一个含义广泛的术语,是以描述人和动物由藻菌纲中的几属真菌所引起的真菌病。其临床表现因病原体不同而异。感染严重的动物最常见的疾病是牛真菌性流产、肺或淋巴结的肉芽肿及瘤胃或肠溃疡。胃肠道藻菌病的临床表现于1951年西班牙一研究人员首次提出,并对一头公牛真胃中生成的溃疡加以描述。后来对在绵羊、山羊、猿、俄卡皮(非洲小长颈鹿)、

关键词：藻菌病瘤胃酸中毒粘膜下层

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Impact of carbon-based nutrient enhancement on biofiltration performance for drinking water treatment

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Journal of Environmental Sciences 2019年第8期31卷 124-131页

作者： Yu Zhao liz taylor-Edmonds robert C.Andrews Department of Civil and Mineral Engineering University of Toronto

Incorporation of a carbon-based nutrient enhancementstrategy for drinking water biofiltration is an attractive option, especially for source waters which contain recalcitrant organics. This study compared biofilters that were operated in parallel and individually enhanced with amino acids(including alanine, phenylalanine, and tryptophan), inulin, and sucrose to increase biomass concentration and promote biodegradation of dissolved organic carbon(DOC) in the source water, including disinfection by-product(DBP) precursors. Biomass activity was characterized by measuring adenosine tri-phosphate(ATP), dissolved oxygen(DO) consumption, and through the use of laccase and esterase enzyme assays. Performance was evaluated in terms of headloss,turbidity, p H, DOC, UV254, and DBP formation potential(DBP FP). The introduction of carbonbased nutrients significantly increased biomass activity, where ATP values peaked at 976 ng/g of filter media, 853 ng/g, and 513 ng/g for amino acids, inulin, and sucrose-spiked biofilters,respectively, while a non-spiked control only reached 104 ng/g. DO utilization by the enhanced biofilters was significantly higher than the control, with a strong correlation between ATP and DO uptake observed for all filters(R^2> 0.74). laccase and esterase enzyme activities of enhanced biofilters were also elevated(p > 0.05), suggesting greater biodegradation potential. Operational parameters such as headloss development and turbidity control were not impaired by carbon supplementation strategies or an increase in biomass concentration and activity. However, the enhancement strategy did not provide improvement in terms of source water carbon removal(DOC and UV254) or DBP FP when treated filters were compared to a control.

关键词： Biological filtration Carbon enhancement Biomass Disinfection by-products Dissolved organic carbon

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Rapid micro-immunohistochemistry

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Microsystems & Nanoengineering 2020年第1期6卷 285-294页

作者： robert D.lovchik David taylor Govind Kaigala IBM Research Europe Saeumerstrasse 48803 RueschlikonSwitzerland Present address:Eidgenossische Technische Hochschule Zurich Department of Mechanical and Process EngineeringSonneggstrasse 38092 ZurichSwitzerland

We present a new and versatile implementation of rapid and localized immunohistochemical staining of tissue ***(IHC)comprises a sequence of specific biochemical reactions and allows the detection of specific proteins in tissue *** the rapid implementation of IHC,we fabricated horizontally oriented microfluidic probes(MFPs)with functionally designed apertures to enable square and circular footprints,which we employ to locally expose a tissue to time-optimized sequences of different *** show that the two main incubation steps of IHC protocols can be performed on MDAMB468-1510A cell block sections in less than 30 min,compared to incubation times of an hour or more in standard *** analysis on the timescale of tens of minutes could potentially be applied during surgery,enabling clinicians to react in more dynamically and ***,this rapid IHC implementation along with conservative tissue usage has strong potential for the implementation of multiplexed assays,allowing the exploration of optimal assay conditions with a small amount of tissue to ensure high-quality staining results for the remainder of the sample.

关键词： versatile steps sections

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Nanofluid-based optical filter optimization for PV/T systems

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light(Science & Applications) 2012年第1期1卷 24-30页

作者： robert A taylor Todd Otanicar Gary Rosengarten University of New South Wales SydneyNSWAustralia University of Tulsa TulsaOKUSA RMIT University MelbourneVic.Australia

Optical filters are essential in a wide range of applications,including optical communications,electronics,lighting,optical sensors and *** article presents recent work which indicates that optical filters can be created from specialized nanoparticle ***,this article describes a theoretical optimization process for designing nanofluid-based filters for hybrid solar photovoltaic/thermal(PV/T)*** particular application is suitable because nanofluids can be utilized as both volumetric solar absorbers and flowing heat transfer *** nanofluid filters described in this work compare favorably with conventional optical filters for five photovoltaic(PV)cell alternatives:InGaP,CdTe,InGaAs,Si,and *** study demonstrates that nanofluids make efficient,compact and potentially low-cost,spectrally selective optical filters.

关键词： Hybrid nanofluid optical filter photovoltaic solar energy solar thermal

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Optical shaping of the polarization anisotropy in a laterally coupled quantum dot dimer

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light(Science & Applications) 2020年第1期9卷 1047-1056页

作者： Heedae Kim Kwangseuk Kyhm robert A.taylor Jong Su Kim Jin Dong Song Sungkyun Park School of Physics Northeast Normal University130024 ChangchunChina Clarendon laboratory Department of PhysicsUniversity of OxfordOxford OX13PUUK Department of Opto-mechatronics Pusan Nat’l UniversityBusan 609-735Republic of Korea Department of Physics Yeungnam UniversityGyeongsan 712-749Republic of Korea Nano-Photonics Research Center KISTSeoul 136-791Republic of Korea Department of Physics Pusan Nat’l UniversityBusan 609-735Republic of Korea

We find that the emission from laterally coupled quantum dots is strongly polarized along the coupled direction[110],and its polarization anisotropy can be shaped by changing the orientation of the polarized *** the nonresonant excitation is linearly polarized perpendicular to the coupled direction[110],excitons(X_(1) and X_(2))and local biexcitons(X_(1)X_(1) and X_(2)X_(2))from the two separate quantum dots(QD_(1) and QD_(2))show emission anisotropy with a small degree of polarization(10%).On the other hand,when the excitation polarization is parallel to the coupled direction [110],the polarization anisotropy of excitons,local biexcitons,and coupled biexcitons(X_(1)X_(2))is enhanced with a degree of polarization of 74%.We also observed a consistent anisotropy in the time-resolved *** decay rate of the polarized photoluminescence intensity along the coupled direction is relatively high,but the anisotropic decay rate can be modified by changing the orientation of the polarized *** energy difference is also observed between the polarized emission spectra parallel and perpendicular to the coupled direction,and it increases by up to three times by changing the excitation polarization orientation from [110] to [110].These results suggest that the dipole-dipole interaction across the two separate quantum dots is mediated and that the anisotropic wavefunctions of the excitons and biexcitons are shaped by the excitation polarization.

关键词： anisotropy quantum polarized

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SO(n)-Invariant Special lagrangian Submanifolds of C^(n+1) with Fixed loci

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Chinese Annals of Mathematics,Series B 2006年第1期27卷 95-112页

作者： robert l. BRYANT Dedicated to the memory of Shiing-Shen Chern

let SO（n） act in the standard way on C^n and extend this action in the usual way to C^n＋l = C＋ C^n. It is shown that a nonsingular special lagrangian submanifold l→∪ C^n＋l that is invariant under this SO（n）-action intersects the fixed C→∪ C^n＋1 in a nonsingular real-analytic arc A （which may be empty）. If n 〉 2, then A has no compact component. Conversely, an embedded, noncompact nonsingular real-analytic arc A→∪ C lies in an embedded nonsingular special lagrangian submanifold that is SO（n）-invariant. The same existence result holds for compact A if n =2. nonsingular SO（n）-invariant special lagrangian nonsingular SO（n）-invariant special lagrangian extensions in some open neighborhood of A. If A is connected, there exist n distinct extensions of A such that any embedded extension of A agrees with one of these n The method employed is an analysis of a singular nonlinear PDE and ultimately calls on the work of Gerard and Tahara to prove the existence of the extension.

关键词： Calibrations Special lagrangian submanifolds

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Utility of current thrombophilia screening in young patients with stroke and TIA

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Stroke & Vascular Neurology 2018年第4期3卷 231-236页

作者： Vafa Alakbarzade Alice taylor Marie Scully robert Simister Arvind Chandratheva Hyper-acute Stroke Unit University College London Hospitals NHS Foundation TrustLondonUK Department of Haematology University College London Hospitals NHS Foundation TrustLondonUK

Introduction Approximately 40%of strokes in young adults are *** diagnostic yield of thrombophilia screening remains *** aimed to determine utility of current thrombophilia testing for young patients with stroke and transient ischaemic attack(TIA).Methods We present a retrospective review of all patients with stroke and TIA≤60 years presenting to University College london Hospital stroke unit and daily TIA clinic from 1 January 2015 to 1 August *** clinical records and thrombophilia tests,including factor V leiden(FVl),prothrombin G20210A mutation(PGM),antiphospholipid antibody(APA),and protein S,C and antithrombin(AT)levels,were *** The mean age of 628 patients with stroke and TIA was 49.1 years(SD 9.2).Thrombophilia testing was performed in 360(57%)patients,including 171 with stroke and 189 with *** tests were found in 50(14%)patients,of whom 24 patients werelts were found in 36(10%)with acute ischaemic stroke,4(1%)with haemorrhagic stroke and 10(3%)with *** patients(4%)had homozygous/heterozygous FVl or PGM,and 27(7.5%)had positive APA(anticardiolipin antibody,anti-β2 glycoprotein antibody or lupus anticoagulant).Of 27(7.5%)patients with protein C,S or AT deficiency,10(2.8%)had primary deficiency,presumed hereditary with other secondary causes excluded.9%of patients with protein C,S or AT and 27%with APA were followed by confirmatory *** Thrombophilia testing was positive in only 14%of cases *** mutations and protein C,S or AT abnormalities were found rarely and were very uncommon in patients with ***-up of abnormal results was generally poor for all groups,which further limited the impact of the thrombophilia testing policy.

关键词： patients testing TIA

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Boundary element method (BEM) applied to the rough surface contact vs. BEM in computational mechanics

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Friction 2019年第4期7卷 359-371页

作者： Yang XU robert l.JACKSON Mechanical Engineering Department Auburn University

In the numerical study of rough surfaces in contact problem, the flexible body beneath the roughness is commonly assumed as a half-space or a half-plane. The surface displacement on the boundary, the displacement components and state of stress inside the half-space can be determined through the convolution of the traction and the corresponding influence function in a closed-form. The influence function is often represented by the Boussinesq-Cerruti solution and the Flamant solution for three-dimensional elasticity and plane strain/stress, respectively. In this study, we rigorously show that any numerical model using the above mentioned half-space solution is a special form of the boundary element method(BEM). The boundary integral equations(BIEs) in the BEM is simplified to the Flamant solution when the domain is strictly a half-plane for the plane strain/stress condition. Similarly, the BIE is degraded to the Boussinesq-Cerruti solution if the domain is strictly a half-space. Therefore, the numerical models utilizing these closed-form influence functions are the special BEM where the domain is a half-space(or a half-plane). This analytical work sheds some light on how to accurately simulate the non-half-space contact problem using the BEM.

关键词： boundary element method rough surface contact half-space half-plane Flamant solution Boussinesq-Cerruti solution

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Assessment of portable FTIR and Raman spectroscopy for the detection of 2,3-dimethyl-2,3-dinitrobutane(DMDNB)in plastic explosives

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Defence Technology（防务技术） 2024年第4期34卷 11-18页

作者： Jacky Cailes robert Dunsmore Kathryn l.linge ChemCentre PO Box 1250PerthAustralia

The Marplex Convention was established to prevent the manufacture of unmarked plastic explosives and stipulates that a volatile detection agent must be added at the time of ***,to-date,laboratory testing remains the internationally accepted practice for identifying and quantifying the taggants stipulated in the *** this project,portable FTIR and Raman instruments were tested for their ability to detect 2,3-dimethyl-2,3-dinitrobutane(DMDNB),the chemical marker incorporated in plastic explosives that are manufactured within *** both FTIR and Raman instruments detected solid DMDNB(98%purity),field analysis of plastic explosives at an Australian Defence establishment showed that both FTIR and Raman spectra were matched the relevant explosive(RDX or PETN),rather than the DMDNB *** all three plastic explosives tested,the concentration of DMDNB was measured by SPME-GC-MS to be between 1.8 and 2%,greater than the minimum 1%concentration stipulated by the Marplex *** testing with a plastic explosive analogue confirmed that the minor absorption peaks that would characterize low concentrations of DMDNB were masked by absorption bands from other compounds within the ***,while both FTIR and Raman spectroscopy are suitable for detection of plastic explosives,neither rely on the presence of DMDNB for *** is likely that similar results would be found for other taggants stipulated by the Marplex Convention,given they are also present in concentrations less than 1%.

关键词： Explosive ICAO taggants 2,3-Dimethyl-2,3-dinitrobutane(DMDNB) Fourier transform infrared(FTIR) Raman

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