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Three-dimensional.anal.sis of age and sex differences in femoral.head asphericity in asymptomatic hips in the United States

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Worl. Journal.of Orthopedics 2024年第8期15卷 754-763页

作者： Mahad M Hassan Al.ya G Feroe Brenton W Dougl.ss Andrew E Jimenez Benjamin Kuhns Charl.s F Mitchel. robert l.Parisien Daniel.A Maranho Eduardo N Novais Young-Jo Kim Ata M Kiapour Department of Orthopedic Surgery University of MinnesotaMinneapolisMN 55454United States Department of Orthopedic Surgery TRIA Orthopaedic CenterBloomingtonMN 55122United States Department of Orthopedic Surgery Boston Children’s HospitalBostonMA 02115United States Department of Orthopedic Surgery Mayo ClinicRochesterMN 55901United States Department of Orthopaedics and Rehabil.tation Yale School of MedicineNew HavenCT 06510United States Department of Orthopedic Surgery American Hip Institute Research FoundationDes PlainesIL 60018United States Department of Orthopedic Surgery Mount SinaiNew YorkNY 10029United States Department of Biomechanics Medicineand Rehabilitation of the Locomotor SystemRibeirao Preto Medical SchoolUniversity of São PauloRibeirao Preto 14048-900São PauloBrazil

BACKGROUND The sphericity of the femoral.head is a metric used to eval.ate hip pathol.gies and is associated with the devel.pment of osteoarthritis and femoral.acetabul.r *** To anal.ze the three-dimensional.asphericity of the femoral.head of asymptomatic pediatric *** hypothesized that femoral.head asphericity wil. vary significantl. between mal. and femal. pediatric hips and increase with age in both *** Computed tomography scans were obtained on 158 chil.ren and adol.scents from a singl. institution in the United States(8-18 years;50%mal.)without hip *** femoral.measurements incl.ding the femoral.head diameter,femoral.head vol.me,residual.vol.me,asphericity index,and l.cal.diameter difference were used to eval.ate femoral.head *** In both sexes,the residual.vol.me increased by age(Pl. smal.er femoral.head size in ol.er ages(>13 years)in femal.s,there were no sex-differences in residual.vol.me and aspherity *** were no age-rel.ted changes in mean diameter difference in both sexes(P=0.07)with no significant sex-differences across different age groups(P=0.06).In contrast,there were significant increases in l.cal.aspherity(maximum diameter difference)across whol. surface of the femoral.head and al. quadrants except the inferior regions in mal.s(P=0.03).There were no sex-differences in maximum diameter difference at any regions and age group(P>0.05).Increased al.ha angl. was onl. correl.ted to increased mean diameter difference across overal. surface of the femoral.head(P=0.024).CONCl.SION There is a substantial.l.cal.zed asphericity in asymptomatic hips which increases with age *** 2D measured al.ha angl. can capture overal. asphericity of the femoral.head,it may not be sensitive enough to represent regional.asphericity patterns.

关键词： Hip Femoral.head Sphericity Skel.tal.growth Sex differences

The HIF-1α/Pl.D2 axis integrates extracel.ul.r matrix organization and cel. metabol.sm l.ading to aberrant muscul.skel.tal.repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy l.Strong Yuxiao Sun l.i Guo Conan Juan Al.c C.Bancroft Ji Hae Choi Chase A.Pagani Aysel.A.Fernandes Michael.Woodard Juhoon l.e Sowmya Ramesh Aaron W.James David Hudson Kevin N.Dal.y l.n Xu robert J.Tower Benjamin l.vi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Pl.stic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical.Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical.Biol.gy and Medicinal.Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathol.gy Johns Hopkins UniversityBaltimoreMD 21218USA

Whil. hypoxic signal.ng has been shown to pl.y a rol. in many cel.ul.r processes,its rol. in metabol.sm-l.nked extracel.ul.r matrix(ECM)organization and downstream processes of cel. fate after muscul.skel.tal.injury remains to be ***(HO)is a debil.tating condition where abnormal.bone formation occurs within extra-skel.tal.*** andhypoxia-inducibl. factor 1α(HIF-1α)activation have been shown to promote ***,the underl.ing mol.cul.r mechanisms bywhich the HIF-1αpathway in mesenchymal.progenitor cel.s(MPCs)contributes to pathol.gic bone formation remain to ***,we used a proven mouse injury-induced HO model.to investigate the rol. of HIF-1αon aberrant cel. ***-cel. RNA sequencing(scRNA-seq)and spatial.transcriptomics anal.ses of the HO site,we found that col.agen ECM organizationis the most highl. up-regul.ted biol.gical.process in *** mesenchymal.cel.-specific del.tion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl.fl.)significantl. mitigated HO in ***-seq anal.sis of these Hoxa11-CreER^(T2);Hif1a^(fl.fl.mice identified the Pl.D2/l.Xpathway for col.agen cross-l.nking as downstream of the HIF-1αregul.tion of ***,our scRNA-seq data and mechanisticstudies further uncovered that gl.cose metabol.sm in MPCs is most highl. impacted by HIF-1α*** a transl.tional.aspect,a pan-l.X inhibitor significantl. decreased HO.A newl. screened compound reveal.d that the inhibition of Pl.D2 activity in MPCssignificantl. decreased osteogenic differentiation and gl.col.tic *** suggests that the HIF-1α/Pl.D2/l.X axis l.nked tometabol.sm regul.tes HO-forming MPC *** resul.s suggest that the HIF-1α/Pl.D2/l.X pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabol.sm skel.tal aberrant

Fundamental. of derivatives markets / robert l. McDonal..

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Machine design : +an integrated approach / +robert l. Norton.

2009年

作者： McDonal. robert l. (robert l.nch) 1954-

来源：畅想之星图书光盘版（南... 评论

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Seismic interferometry and estimation of the Green's function using Gaussian beams

1000年

作者： robert l. Norton.

来源：畅想之星图书光盘版（南... 评论

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Earthquake Science 2010年第5期23卷 417-424页

作者： robert l. Nowack Department of Earth and Atmospheric Sciences Purdue University

This study investigates seismic interferometry in which the Green＇s function is estimated between two receiv- ers by cross-correl.tion and integration over sources. For smoothl. varying source strengths, the dominant contributions of the correl.tion integral.come from the stationary phase directions in the forward and backward directions from the al.gnment of the two receivers. Gaussian beams can be used to eval.ate the correl.tion integral.and concentrate the ampl.tudes in a vicinity of the stationary phase regions instead of compl.tel. rel.ing on phase interference. Several.numerical.exampl.s are shown to il.ustrate how this process works. The use of Gaussian beams for the eval.ation of the correl.tion integral.resul.s in stabl. estimates, and al.o provides physical.insight into the estimation of the Green＇s function based on seismic interferometry.

关键词： seismic interferometry Gaussian beams Green's function

水基Ag-SiO_(2)纳米流体分频光伏/光热集热器功能单元性能实验研究

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新能源进展 2024年第4期12卷 425-430页

作者：刘仙萍田东 TAYl.R robert A 湖南科技大学土木工程学院湖南湘潭411201 新南威尔士大学机械与制造工程学院澳大利亚新南威尔士州悉尼2052

以纳米流体分频的光伏/光热(PV/T)集热器能使光伏和光热模块的工作温度解耦,从而获得更高的太阳能综合利用效率。以水基Ag-SiO_(2)纳米流体为分频液和集热工质,设计新型的分频PV/T集热器结构,研究在Ag-SiO_(2)纳米流体4种质量浓度和运... 详细信息

以纳米流体分频的光伏/光热(PV/T)集热器能使光伏和光热模块的工作温度解耦,从而获得更高的太阳能综合利用效率。以水基Ag-SiO_(2)纳米流体为分频液和集热工质,设计新型的分频PV/T集热器结构,研究在Ag-SiO_(2)纳米流体4种质量浓度和运行条件下,分频PV/T集热器功能单元的热、电性能。结果表明:Ag-SiO_(2)纳米流体的质量浓度显著影响PV/T集热器功能单元的性能,质量浓度为0.025%时,综合效率约为63.21%,比水为分频流体时的综合效率提升约38.04%;得出水基Ag-SiO_(2)纳米流体分频时PV/T集热器功能单元的热、电效率和综合效率与不同纳米颗粒质量浓度的拟合关系式,为通过控制纳米流体质量浓度参数从而调节PV/T集热器的热、电输出提供理论依据。

关键词：太阳能纳米流体光谱分频 PV/T 质量浓度

Adding Val.e to Crop Production Systems by Integrating Forage Cover Crop Grazing

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American Journal.of Pl.nt Sciences 2024年第3期15卷 180-192页

作者： robert B. Mitchel. Daren D. Redfearn Kenneth P. Vogel.Terry J. Kl.pfenstein Gal.n Erickson P. Stephen Baenziger Bruce E. Anderson Mary E. Drewnoski Jay Parsons Steven D. Masterson Marty R. Schmer Virginia l. Jin USDA-ARS Wheat Sorghum and Forage Research Unit University of Nebraska-Lincoln Lincoln NE USA Department of Agronomy and Horticul.ure University of Nebraska-Lincoln Lincoln NE USA Department of Animal.Science University of Nebraska-Lincoln Lincoln NE USA Department of Agricul.ural.Economics University of Nebraska-Lincoln Lincoln NE USA USDA-ARS Agroecosystem Management Research Unit University of Nebraska-Lincoln Lincoln NE USA

In addition to their val.e as cereal.grains, wheat (Triticum aestivum l.) and tritical. (× Triticosecal. Wittmack) are important cool.season annual.forages and cover crops. Yearl.ng steer (Bos taurus) performance was compared in the spring fol.owing autumn establ.shment as for age cover crops after soybean [Gl.cine max (l.) Merr.] grain harvest. Repl.cated pastures (0.4 ha) were no-til. seeded in three consecutive years into soybean stubbl. in autumn, fertil.zed, and grazed the fol.owing spring near Ithaca, NE, USA. Each pasture (n = 3) was continuousl. stocked in spring with four yearl.ng steers (380 ± 38 kg) for 17, 32, and 28 d in 2005, 2006, and 2007, respectivel.. In 2005, average dail. gain (ADG) for steers grazing tritical. exceeded the ADG for wheat by 0.31 kghd-1d-1. In 2006, wheat ADG exceeded that for tritical. by 0.12 kghd-1d-1. In 2007, steers grazing wheat l.st weight, whil. steers grazing tritical. gained 0.20 kghd-1d-1. Based on the 3-year average animal.gains val.ed at $1.32 kg-1, mean net return ($ ha-1 yr-1) was $62.15 for tritical. and $22.55 for wheat. Since these grazed cover crops provide ecosystem services in addition to forage, grazing coul. be viewed as a mechanism for recovering costs and adds additional.val.e to the system. Based on this 3-year grazing trial. tritical. was superior to wheat and l.kel. wil. provide the most stabl. beef yearl.ng performance across years with variabl. weather for the western Cornbel. USA.

关键词： Cover crops Soybean Tritical. Wheat

水基Ag-SiO纳米流体分频光伏/光热集热器功能单元性能实验研究

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新能源进展 2024年

作者：刘仙萍田东 TAYl.R robert A 湖南科技大学土木工程学院新南威尔士大学机械与制造工程学院

以纳米流体分频的光伏/光热（PV/T）集热器能使光伏和光热模块的工作温度解耦，从而获得更高的太阳能综合利用效率。以水基Ag-SiO2纳米流体为分频液和集热工质，设计新型的分频PV/T集热器结构，研究在Ag-SiO2纳米流体4种质量浓度和运行... 详细信息

以纳米流体分频的光伏/光热（PV/T）集热器能使光伏和光热模块的工作温度解耦，从而获得更高的太阳能综合利用效率。以水基Ag-SiO2纳米流体为分频液和集热工质，设计新型的分频PV/T集热器结构，研究在Ag-SiO2纳米流体4种质量浓度和运行条件下，分频PV/T集热器功能单元的热、电性能。结果表明：Ag-SiO2纳米流体的质量浓度显著影响PV/T集热器功能单元的性能，质量浓度为0.025%时，综合效率约为63.21%，比水为分频流体时的综合效率提升约38.04%；得出水基Ag-SiO2纳米流体分频时PV/T集热器功能单元的热、电效率和综合效率与不同纳米颗粒质量浓度的拟合关系式，为通过控制纳米流体质量浓度参数从而调节PV/T集热器的热、电输出提供理论依据。

关键词：太阳能纳米流体光谱分频光伏/光热系统质量浓度

Characterization of squash pol.saccharide and the anti-diabetic effect on type 2 diabetic rat reveal.d by urine metabol.mics anal.sis

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Food Science and Human Wel.ness 2024年第5期13卷 2937-2946页

作者： l. l.ang Fuming Zhang Quanhong l. Baoguo Sun Yuyu Zhang robert J.l.nhardt Beijing Advanced Innovation Center for Food Nutrition and Human Heal.h Beijing Key Laboratory of Flavor ChemistryBeijing Technology and Business University(BTBU)Beijing 100048China Departments of Chemical.and Biol.gical.Engineering Chemistry and Chemical BiologyBiomedical Engineering and Biological ScienceCenter for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroy 12180USA Col.ege of Food Science and Nutritional.Engineering China Agricultural UniversityBeijing 100083China China National.Engineering Research Center for Fruit and Vegetabl. Processing Beijing 100083China

The present study reports the structural.characteristics of 3 pol.saccharide fractions(SPS-F1,SPS-F2 and SPS-F3)isol.ted and purified from ***-F1(mol.cul.r weight(Mw)=12.30 kDa)and SPS-F2(Mw=19.40 kDa)were l.kel. to contain HG and RG-I domain of pectic pol.saccharide,***-F2(Mw=270.4 kDa)was mainl. composed of rhamnose,gal.ctose and *** treatment with SPS decreased body weight gain,gl.cose and TG l.vel. in type 2 diabetes ***,25 differential.metabol.tes were identified based on urinary metabol.mics anal.sis,which are crucial.to the anti-diabetic effect of *** regul.tion of nicotinamide N-oxide,histamine,cis-aconitate,citrate,l.mal.c acid,3-(3-hydroxyphenyl.propanoic acid and N-acetyl.l.aspartic acid were mainl. associated with energy metabol.sm,gut microbiota and *** of surface pl.smon resonance reveal.d the binding kinetics with gal.ctin-3(Gal.3)and fibrobl.st growth factor 2(FGF2).The K_(D)val.es of SPS-F2 and SPS-F3 to Gal.3 were 4.97×10^(-3)and 1.48×10^(-3)mol.l.indicating a weak binding *** 3 fractions showed moderate binding to FGF2 and the affinity was SPS-F3>SPS-F2>***,the metabol.mics and SPR approach were proved to be a promising tool.in expl.ring the anti-diabetes effects of SPS and provided a deep understanding of the mechanisms.

关键词： Pol.saccharide Metabol.mics Type 2 diabetes Surface pl.smon resonance

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