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The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan juan Alec C.Bancroft ji Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard juhoon Lee Sowmya Ramesh Aaron W.james David Hudson Kevin N.Dalby Lin Xu robert j.Tower Benjamin Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

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Confirmation of a Sub-Saturn-size Transiting Exoplanet Orbiting a G Dwarf:TOI-1194 b and a Very Low Mass Companion Star: TOI-1251 B from TESS

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Research in Astronomy and Astrophysics 2024年第3期24卷 129-143页

作者： jia-Qi Wang Xiao-jun jiang jie Zheng Hanna Kellermann Arno Riffeser Liang Wang Karen A.collins Allyson Bieryla Lars A.Buchhave Steve B.Howell Elise Furlan Eric Girardin joao Gregorio Eric jensen Felipe Murgas Mesut Yilmaz Sam Quinn Xing Gao Ruo-Yu Zhou Frank Grupp Hui-juan Wang CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy Of SciencesBeijing 10010China University of Chinese Academy of Sciences Beijing 100049China University Observatory Munich Scheinertrsse 1.D-81679 MunichGemany Max Planck Institute for Extraterrestrial Physics Giessenbachstr.1D-85748 GarchingGermany National Astronomical Observatories/Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing210042China CAS Key Laboratory of Astronomical Optics&Technology Nanjing Institute of Astronomical Optics&TechnologyNanjing 210042China Center for Astrophysics Harvard&Smithsonian60 Garden Street.CambridgeMA 02138USA National Space Institute Technical University of DenmarkElektrovejDK-2800 KgsLyngbyDenmark NASA Ames Research Center Moffett FieldCA 94035USA NASA Exoplanet Science Institute Caltech/IPACMail Code 100-221200 E.California Blvd.PasadenaCA91125USA Grand Pra Observatory Switzerland Department of Physics Washington UniversitySt.LouisMO 63130.USA Department of Physics and Astronomy Swarthmore CollegeSwarthmorePA 19081USA Instituto de Astrofísica de Canarias(IAC) E-38205 La Laguna.TenerifeSpain Departamento de Astrofísica Universidad de La LagunaSpain Dept.of Astronomy and Space Sciences Ankara UniversityTandogan 06100AnkaraTurkey Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Urumqi No.1 Senior High School Urumqi 830002China Lijiang Gemini Observatory Lijiang 674199China

We report the confirmation of a sub-Saturn-size exoplanet,TOI-1194 b,with a mass of about 0.456+0.055-0.051M_(j),and a very low mass companion star with a mass of about 96.5±1.5 Mj,TOI-1251 *** candidates provided by the Transiting Exoplanet Survey Satellite(TESS)are suitable for further follow-up observations by ground-based telescopes with small and medium *** analysis is performed based on data from several telescopes worldwide,including telescopes in the Sino-German multiband photometric campaign,which aimed at confirming TESS Objects of Interest(TOIs)using ground-based small-aperture and medium-aperture telescopes,especially for long-period ***-1194 b is confirmed based on the consistent periodic transit depths from the multiband photometric *** measure an orbital period of 2.310644±0.000001 days,the radius is 0.767+0.045-0.041Rj and the amplitude of the RV curve is 69.4_(-7.3)^(+7.9)m s^(-1).TOI-1251 B is confirmed based on the multiband photometric and high-resolution spectroscopic data,whose orbital period is 5.963054+0.000002-0.000001days,radius is 0.947+0.035-0.033 R_(j) and amplitude of the RV curve is 9849_(-40)^(+42)ms^(-1).

关键词： planets and satellites fundamental parameters-planets and satellites gaseous planets-stars fundamental parameters-stars low-mass-methods data analysis-techniques photometric-techniques spectroscopic

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改善聚酯织物的舒适性

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印染 1989年第5期15卷 62-63页

作者： S.Haig Zeronian Martha j.collins 王秀玲

普通聚酯的很多性能,如强力、耐磨、回弹性和尺寸稳定性均能满足各种最终用途的需要。但它也有不足之处,如疏水性和亲油性,它会集结静电,并且难以除去油污渍。在感觉方面聚酯织物则不如天然纤维织物舒适。消费者评论合成纤维的主要局限... 详细信息

普通聚酯的很多性能,如强力、耐磨、回弹性和尺寸稳定性均能满足各种最终用途的需要。但它也有不足之处,如疏水性和亲油性,它会集结静电,并且难以除去油污渍。在感觉方面聚酯织物则不如天然纤维织物舒适。消费者评论合成纤维的主要局限性是:不自然的手感,令人不悦的热的感觉,织物与皮肤接触时的冷湿感、缺乏吸湿性、异样的皮肤接触感及与静电相关的问题。很多年来进行了许多研究和开发工作以改善这些性能。本文主要述及舒适性。对于舒适性难以下定义和用数量表示。任何对服装舒适性的分析,必须考虑到物理、心理、生理方面。控制舒适性的重要因素是通过织物传递热量、湿气和空气。主观组成部分,如尺寸、合身性、柔软性、手感和静电发生也应考虑在内。需要穿着试验和实验室测试。服装舒适性是个复杂的和引起争论的问题。它已被广泛地评论并作为讨论的主题。服装舒适性可通过各种技术得到改善,包括服装设计、织物结构、纱线结构、纤维变性、各种类别纤维的混纺和有关这方面的专题整理。纤维变性可以通过化学方法完成,或通过纺丝工艺以完成变化,如改变纤维横截面。这些方法可以各别使用或结合使用。以下部分应用专门整理和化学变性评论了某些用于改善聚酯舒适性的工艺。应强调的是。

关键词：聚酯织物舒适性整理

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Optical simulation of external quantum efficiency spectra of CuIn_(1-x)Ga_xSe_2 solar cells from spectroscopic ellipsometry inputs

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journal of Energy Chemistry 2018年第4期27卷 1151-1169页

作者： Abdel-Rahman A.Ibdah Prakash Koirala Puruswottam Aryal Puja Pradhan Michael j.Heben Nikolas j.Podraza Sylvain Marsillac robert W.collins Department of Physics & Astronomy and Center for Photovoltaics Innovation & Commercialization University of Toledo Virginia Institute of Photovoltaics Old Dominion University

Applications of in-situ and ex-situ spectroscopic ellipsometry （SE） are presented for the development of parametric expressions that define the real and imaginary parts （ε1, ε2） of the complex dielectric function spectra of thin film solar cell components. These spectra can then be utilized to analyze the structure of complete thin film solar cells. Optical and structural/compositional models of complete solar cells developed through least squares regression analysis of the SE data acquired for the complete cells enable simulations of external quantum efficiency （EQE） without the need for variable parameters. Such simulations can be compared directly with EQE measurements. From these comparisons, it becomes possible to understand in detail the origins of optical and electronic gains and losses in thin film photovoltaics （PC） technologies and, as a result, the underlying performance limitations. In fact, optical losses that occur when above-bandgap photons are not absorbed in the active layers can be distinguished from electronic losses when electron-hole pairs generated in the active layers are not collected. This overall methodology has been applied to copper indium-gallium diselenide （Culn1-xGaxSe2; CIGS） solar cells, a key commercialized thin film PV technology. CIGS solar cells with both standard thickness （〉2 μm） and thin （〈1 μm） absorber layers are studied by applying SE to obtain inputs for EQE simulations and enabling comparisons of simulated and measured EQE spectra. SE data analysis is challenging for CIGS material components and solar cells because of the need to develop an appropriate （ε1, ε2） database for the CIGS alloys and to extract absorber layer Ga profiles for accurate structural/compositional models. For cells with standard thickness absorbers, excellent agreement is found between the simulated and measured EQE, the latter under the assumption of 100% collection from the active layers, which include the CIGS bulk and CIGS/CdS heterojunction inter

关键词： Solar cells Thin-film Ellipsometry Spectroscopic Culn1-xGaxSe2(CIGS) Optical properties Quantum efficiency External Simulation Solar-cell

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我还有很多

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跨世纪(时文博览) 2006年第2期 28-29页

作者： MICHAL j.collins

我的承诺我的病人,有一个人永远无法忘怀:莎拉·贝德森。我是在骨科肿瘤部遇上她的。莎拉当时才十八岁,貌美如花,但生命危在旦夕,骨盆左侧长了个骨骼肉瘤,情况并不乐观。比尔·柯莱默是主治医师。我们得告诉莎拉:她要活下去的唯一办法,... 详细信息

我的承诺我的病人,有一个人永远无法忘怀:莎拉·贝德森。我是在骨科肿瘤部遇上她的。莎拉当时才十八岁,貌美如花,但生命危在旦夕,骨盆左侧长了个骨骼肉瘤,情况并不乐观。比尔·柯莱默是主治医师。我们得告诉莎拉:她要活下去的唯一办法,是动大手术,切除左腿以及部分骨盆。

关键词：莎拉护士安妮骨盆手术室开刀房莱默医师麻醉师

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Association between Exposure to Metals during Pregnancy,Childhood Gut Microbiome,and Risk of Intestinal Inflammation in Late Childhood

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Environment & Health 2024年第10期2卷 739-749页

作者： Vishal Midya Manasi Agrawal jamil M.Lane Chris Gennings Leonid Tarassishin Libni A.Torres-Olascoaga joseph Eggers jill K.Gregory Mellissa Picker Inga Peter jeremiah j.Faith Manish Arora Martha M.Tellez-Rojo robert O.Wright jean-Frederic Colombel Shoshannah Eggers Department of Environmental Medicine and Climate Science Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Division of Gastroenterology Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Center for Molecular Prediction of Inflammatory Bowel Disease(PREDICT) Department of Clinical MedicineAalborg UniversityCopenhagen 9220Denmark Department of Genetics and Genomic Sciences Icahn School of MedicineNew York 10029-6574New YorkUnited States Center for Research on Nutrition and Health National Institute of Public HealthCuernavaca 62508Mexico Department of Immunology and Immunotherapy Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Department of Epidemiology University of Iowa College of Public HealthIowa City 52242 IowaUnited States Instructional Technology Group Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States

Alterations to the gut microbiome and exposure to metals during pregnancy have been suggested to impact inflammatory bowel ***,how prenatal exposure to metals eventually results in long-term effects on the gut microbiome,leading to subclinical intestinal inflammation,particularly during late childhood,has not been *** is also unknown whether such an interactive effect drives a specific subgroup of children toward elevated susceptibility to intestinal *** used an amalgamation of machine-learning techniques with a regression-based framework to explore if children with distinct sets of gut microbes and certain patterns of exposure to metals during pregnancy(metal−microbial clique signature)had a higher likelihood of intestinal inflammation,measured based on fecal calprotectin(FC)in late *** obtained samples from a well-characterized longitudinal birth cohort from Mexico City(n=108),*** the second and third trimesters of pregnancy,11 metals were measured in whole *** microbial abundances and FC were measured in stool samples from children 9−11 years of *** FC was defined as having FC above 100μg/g of *** identified subgroups of children in whom microbial and metal−microbial clique signatures were associated with elevated FC(false discovery rate(FDR)<0.05).In particular,we found two metal−microbial clique signatures significantly associated with elevated FC:(1)low cesium(Cs)and copper(Cu)in the third trimester and low relative abundance of Eubacterium ventriosum(OR[95%CI]:10.27[3.57,29.52],FDR<0.001)and(2)low Cu in the third trimester and high relative abundances of Roseburia inulinivorans and Ruminococcus torques(OR[95%CI]:7.21[1.81,28.77],FDR<0.05).This exploratory study demonstrates that children with specific gut microbes and specific exposure patterns to metals during pregnancy may have higher fecal calprotectin levels in late childhood,denoting an elevated risk of intestinal inflammation.

关键词： exposome metals machine learning microbiome environmental epidemiology intestinal inflammation

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采用状态检测系统改进重复使用火箭发动机的操作效率

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导弹与航天运载技术 1988年第9期 28-32页

作者： j.collins 王维彬

通过采用直接现场状态检测系统,可使重复使用的火箭发动机飞行任务的准备工作得到重大改进,并且可安全可靠地减少地面维修时间和费用。这些系统可在不分解发动机和手头上只有很少或几乎没有手册性的数据可供分析的情况下,通过采用一些... 详细信息

通过采用直接现场状态检测系统,可使重复使用的火箭发动机飞行任务的准备工作得到重大改进,并且可安全可靠地减少地面维修时间和费用。这些系统可在不分解发动机和手头上只有很少或几乎没有手册性的数据可供分析的情况下,通过采用一些新技术,对与发动机正常工作有关的元件进行连续的观测,直接测出这些关键元件的磨损情况。这些直接测量技术,可在有关元件的磨损还没影响整个发动机的性能以前,就及早地预报它们的损耗情况。将它们与发动机状态检测系统的计算机组合后,这些关键元件的测量结果为我们提供了一个不断更新的数据库,从而可为我们预测发动机是否可参与飞行提供依据,并可提前告诉我们是否需要提前维修。

关键词：发动机回收地面维修

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在融合的VPN方案中实现报告和控制功能

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网络电信 2006年第11期8卷 21-24页

作者： j.collins K.Frank

企业接受托管式通信业务的前提是运营商在他们提供的VPN网络业务中实现新的、离级的报告和控制功链。

关键词：控制功能 VPN 网络业务通信业务运营商

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微波辅助有机合成——应用于药物开发

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生命科学仪器 2003年第6期1卷 48-50页

作者： Michael j.collins 刘威志 Analytical & Life Sclence System Association

多年来,药物开发的瓶颈一直是在合成这个步骤上,其原因在于用以驱使合成反应的方式一直是传统的热力加热。而最新技术的开发让微波成为加热反应更有效的方法。那些本需要几小时,甚至几天才能完成的合成反应现在只需几分钟,因而让有机化... 详细信息

多年来,药物开发的瓶颈一直是在合成这个步骤上,其原因在于用以驱使合成反应的方式一直是传统的热力加热。而最新技术的开发让微波成为加热反应更有效的方法。那些本需要几小时,甚至几天才能完成的合成反应现在只需几分钟,因而让有机化学家们有更多的时间用以分析和优化他们的反应,使他们更有创造性。微波合成包括很多有优点,例如反应速率的提升,产率的提高和“更干净”的化学。由CEM所开发的新型微波环形单膜腔把所有传统合成设备的优点以及微波瞬间加热的能力结合于一个简洁但具有强大作用的仪器上。Abbott实验室(芝加哥、伊利诺斯)使用此仪器执行了针对药物开发的合成反应。化学家们发现环形单膜腔辅助有机合成的好处是在传统方法和从前的微波方法上的大量改良。

关键词：微波辅助化学有机合成化学药物开发微波加热

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The Orosirian(1800–2050 Ma)plate tectonic episode:Key for reconstructing the Proterozoic tectonic record

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Geoscience Frontiers 2023年第3期14卷 1-9页

作者： robert j.Stern Geosciences Dept. U Texas at DallasRichardsonTX 75083-0688United States

Eight lines of evidence indicate that the Orosirian Period in mid-Paleoproterozoic time was characterized by plate tectonics:ophiolites,low T/P metamorphism including eclogites,passive margin formation,tall mountains,paleomagnetic constraints,ore deposits,abundant S-type granites,and seismic images of paleo-subduction *** plate tectonic episode occurred about 1 billion years earlier than the present plate tectonic episode began in Neoproterozoic *** two plate tectonic episodes bracket the‘Boring Billion’,which may have been a protracted single lid tectonic episode that began when the supercontinent Nuna or Columbia *** of multiple lines of evidence for Orosirian plate tectonics demonstrates that Earth’s tectonic style can be reconstructed with some confidence back to at least Early Paleoproterozoic time,and thus the absence of compelling evidence for Mesoproterozoic plate tectonics is not obvious due to poor preservation.A tectono-magmatic lull2.3 Ga suggests an earlier episode of single lid *** for two episodes of plate tectonics and two episodes of single lid tectonics indicates that Earth switched between single lid and plate tectonics multiple times during the last 2.4 Ga.

关键词： Plate tectonics Single lid tectonics Urey ratio Paleoproterozoic

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