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变异组分析揭示番茄的育种历史

变异组分析揭示番茄的育种历史

未治疗的多形性胶质母细胞瘤:在质子MR波谱分析中对侧大脑半球的肌醇及谷氨酰胺水平增加

中国园艺学会2014年学术年会

作者：林涛祝光涛张俊红徐向阳余庆辉郑峥张忠华伦尧尧李帅王孝宣黄泽军李君明张春芝王涛涛张余洋王傲雪张艳聪林魁李传友熊国胜薛勇彪 Andrea Mazzucato Mathilde Causse Zhangjun Fei james j.Giovannoni Roger T.Chetelat Dani Zamir Thomas Stdler 李景富叶志彪杜永臣黄三文中国农业科学院蔬菜花卉研究所中国农业科学院农业基因组研究所华中农业大学东北农业大学新疆农业科学院园艺研究所北京师范大学中国科学院遗传发育研究所中国科学院北京基因组所 Department of Agriculture ForestsNatureand Energy(DAFNE)University of TusciaVia San Camillo de Lellis sncViterbo01100Italy Institut National de la Recherche Agronomique(INRA) Unite de Genetique et Amelioration des Fruits et LegumesDomaine Saint-MauriceMontfavet CedexF-84143France Boyce Thompson Institute for Plant Research U.S.Department of Agriculture(USDA) Robert W.Holley Centre for Agriculture and HealthIthacaCornell UniversityNew York14853USA C.M.Rick Tomato Genetics Resource Center Department of Plant SciencesUniversity of CaliforniaDavisCalifornia95616USA robert H.Smith of Plant Sciences and Genetics Faculty of AgricultureThe Hebrew University of JerusalemRehovot76100Israel Plant Ecological Genetics Institute of Integrative BiologyETH ZurichZurich CH-8092Switzerland

植物基因组的变化能够充分体现人类对其驯化的历史过程。番茄是植物生物学和果实发育研究的重要模式物种之一,但是人类长期驯化对番茄基因组的影响仍是未知的。本研究通过对收集于世界各地360份番茄变异组的深入分析,鉴定了1160多万个S... 详细信息

植物基因组的变化能够充分体现人类对其驯化的历史过程。番茄是植物生物学和果实发育研究的重要模式物种之一,但是人类长期驯化对番茄基因组的影响仍是未知的。本研究通过对收集于世界各地360份番茄变异组的深入分析,鉴定了1160多万个SNPs变异位点,获得了该作物最全面的遗传变异图谱。基于番茄系统发生树的构建和群体结构分析,发现番茄群体分为3个亚群,即醋栗番茄、樱桃番茄和普通栽培番茄,提出了醋栗番茄经过樱桃番茄最终驯化为大果栽培番茄的两步驯化(Domestication and Improvement)理论。通过番茄遗传多样性分析,发现了5个单果质量QTL属于驯化阶段选择基因,1 3个单果质量QTL属于改良阶段选择基因。通过加工番茄和鲜食番茄的群体分化分析,发现了含有控制可溶性固形物和果实硬度的QTLs位点。利用全基因组关联分析(GWAS),鉴定了控制番茄果皮颜色的关键变异位点,为番茄品质育种提供了基因组数据支撑。现代育种中野生抗病基因被广泛应用到栽培番茄中,研究发现R基因的利用导致了大片段的外源渗入(例如:Tm-2,Chr.9,≈50 Mb),导致了严重的连锁累赘。全面分析了番茄的群体结构、遗传多样性、基因组进化历程和群体分化等最基本的生物学命题,提出栽培番茄是经过驯化和改良两个历史过程形成,为番茄生物学研究、基因克隆及遗传改良等提供理论指导。

关键词：番茄基因组驯化改良群体遗传

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国际医学放射学杂志 2010年第1期 84-84页

作者： K.Kallenberg H.C.Bock G.Helms K.jung A.Wrede j.H.Buhk 史晓喆 MR-Research in Neurology and Psychiatry University medicineGeorg-August-Universitat GottingenRobert-Koch-Strasse 4037099 GottingenGermany

目的通过对多形性胶质母细胞瘤(GBM)病人对侧大脑半球局部活体质子磁共振波谱(MRS)分析来检出脑组织代谢改变作为多形性胶质细胞瘤浸润的潜在标志。材料与方法本研究征得了伦理委员会的同意并取得了病人的知情同意书。对22例新近诊断并... 详细信息

目的通过对多形性胶质母细胞瘤(GBM)病人对侧大脑半球局部活体质子磁共振波谱(MRS)分析来检出脑组织代谢改变作为多形性胶质细胞瘤浸润的潜在标志。材料与方法本研究征得了伦理委员会的同意并取得了病人的知情同意书。对22例新近诊断并未经治疗的GBM病人采用3.0MR成像系统行体内单一体素

关键词：多形性胶质母细胞瘤大脑半球肌醇环己六醇对侧谷氨酰胺谷-NH2 MR 质子核子

急性心肌梗死后心脏MR评价对心肌收缩力恢复潜能的低估

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国际医学放射学杂志 2013年第4期 388-388页

作者： D.P. O'Regan B. Ariff A.j. Baksi F. Gordon G. Durighel S.A. Cook 毛子婧 robert Steiner MRI Unit MRC Clinical Sciences Centre Imperial College London Hammersmith Hospital CampusDu Cane Road London W12 0NN UK

目的研究旨在应用心脏MR(CMR)成像评估急性ST段抬高性心肌梗死(STEMI)后心肌存活力与并发的可逆性收缩功能障碍之间的关系。方法 34例急性STEMI病人,接受经皮冠状动脉介入治疗(PPCI)1～7d后行CMR检查,并于1年后随访。以T2加权成像评估... 详细信息

目的研究旨在应用心脏MR(CMR)成像评估急性ST段抬高性心肌梗死(STEMI)后心肌存活力与并发的可逆性收缩功能障碍之间的关系。方法 34例急性STEMI病人,接受经皮冠状动脉介入治疗(PPCI)1～7d后行CMR检查,并于1年后随访。以T2加权成像评估缺血风险区(AAR),对比剂延迟强化评估心肌坏死。通过磁化互补空间调制(CSPAMM)量化心肌收缩力。结果 PPCI术后短期内,心肌存活力指数低(<25%)或中等(26%～50%)的心肌缺血段的欧拉圆周(Ecc)收缩力[分别为(-9.1±0.6)%,P=0.033和(-11.8±1.3)%,P=0.003]比那些心肌存活指数高(51%～100%)的缺血段的收缩力[(-14.4±1.3)%]差。1年后随访的缺血心肌的平均收缩力较首次提高[(-16.2±0.5)%∶(-10.1±0.5)%,P<0.0001]。尽管存活力差的节段1年后仍有大部分功能受损,但其心肌收缩力仍有所改善[分别为(-9.1±0.6)%和(-15.3±0.6)%,P=0.033]。结论 PPCI术后,即使存活力低于25%,仍可观察到收缩力峰值的部分恢复。对比剂延迟强化(LGE)并不等同于不可逆的心肌损伤,血管重建后1周内的心肌存活力评估可能低估心功能恢复潜力。要点①MRI可以衡量心脏病发作后心肌受损程度。②最初表现为坏死的心肌有时可以部分恢复。③梗死边缘的强化可随时间的推移而消散。④应用MRI评估预防性心脏治疗时要注意其局限性。

关键词：心肌梗死心肌顿抑心肌缺血 MRI 计算机辅助X线影像判读

肝细胞肝癌的化疗栓塞:对172例病人的各种综合影像和生存期的分析

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国际医学放射学杂志 2010年第4期 390-390页

作者： R.j.Lewandowski M.F.Mulcahy L.M.Kulik A.Riaz R.K.Ryu T.B.Baker 庞国栋 Dept of Radiology Section of Interventional RadiologyRobert H.Lurie Comprehensive Cancer CtrNorthwestern Memorial Hosp676 N St Clair StSuite 800ChicagoIL 60611USA

目的肝细胞肝癌化疗栓塞后,分析相关的影像和长期生存结果之间的关系。材料与方法该172例肝细胞肝癌病人化疗栓塞的研究经过机构审查委员会的批准,符合HIPAA要求。获得早

关键词：肝细胞肝癌化疗栓塞病人生存期

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欧洲中央银行（ECB）

城市环境设计 2020年第4期 162-173页

作者：沃尔夫·狄·普瑞克斯 Magdalena Baczkowska Markus Baumann Michael Beckert johannes Behrens Hilde Benda Marcelo Bernardi Nico Boyer jan Brosch Timo Carl Anna Rita Cedroni jasmin Dieterle Sabrina Dlugosch jan Ruben Fischer Brigitte Fuchs Sergio Gonzales Gesine G?rlich Martin Gruber Guthu Hallstein Sebastian Haffner Simone Hainz Sascha Hempel Rob Henderson Emanuele Iacono Martin jelinek Rashmi Krishna jois Ivana jug Frank Pascal Kaul Matt Kirkham Daniela Kr?hnert Bernward Krone Christian Labud Anke Lammert Monika Lyzyczka Steven M Christian Maeder Dimitra Mamou Ariane Marx Christoph Maurer Matthias Niemeyer Martin Oberascher Ross Olson Renate Ott Gerhard Pfeiler Ellen Pietrzyk james Pike robert Pippan jakob Przybylo Anna Ptaszynska Stephanie Rathgeber Carmen Renz Salome Reves Donna Riedel Akvile Rimantaite Pete Rose Penelope Rüttimann Stefan Rutzinger Oliver Sachse Kristina Schinegger Benjamin Schmidt Marita Schnepper Thomas Siegl Ebru Simsek-Lenk Denise Sokolowski Augustin Solorzano Anja Sorger Andrea St?llenwerk Ernst Stockinger Crystal K.H Tang jürgen Tiltmann Markus Tritthart josef Tr?ster Günther Weber Andreas Weissenbach Clemens Werb judith Werkh?user Markus Wings Eva Wolf Barbara Zeleny Thomas Zengger Zeyneb Badur Fabien Barthelemey Oliver Cassik Alejandro Corena Alexander Daxb?ck Mario Dign?ss Helmut Fr?tscher Annegret Haider Christian Halm Gregor Kassl Gernot K?fer Alexander Laber Anita Lischka Rangel Malinov Oliver Martinz Philipp Munz Barbara Roller Nicole Rumpler Wolfgang Ruthensteiner Stefan Salchinger Stefan Schadenb?ck Thomas Schwed Hannes Schwed Eckart Schwerdtfeger Sylvia Spernbauer Christoph Treberspurg johannes Weigl Paul Raftery European Central Bank/robertMetsch Markus Pillhofer

项目大事记/CHRONOLOGY竞赛/Competition:第一阶段/Phase 1:2003;第二阶段/Phase 2:2003-2004;修改阶段/Revision Phase:2004;优化阶段/Optimization Phase:2005规划设计起始时间/Start of Planning:2005前期工程/Preliminary Site Works:2008主体施工/Main Construction Works:2010竣工/Completion:2014项目参数/PROjECT DATA用地面积/Site Area:120 000m2建筑毛面积/Gross Floor Area:185 000m2

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“伦理管理悖论”及其争论

Fungal diversity notes 603–708: taxonomic and phylogenetic notes on genera and species

伦理学 2008年第2期

作者：卢克·博凯特汉克·范卢克罗纳德·伯伦班姆 G.j.罗索夫罗伯特·爱林森卢克·博凯特

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Fungal Diversity 2017年第6期87卷 1-235页

作者： Kevin D.Hyde Chada Norphanphoun Vanessa P.Abreu Anna Bazzicalupo K.W.Thilini Chethana Marco Clericuzio Monika C.Dayarathne Asha j.Dissanayake Anusha H.Ekanayaka Mao-Qiang He Sinang Hongsanan Shi-Ke Huang Subashini C.jayasiri Ruvishika S.jayawardena Anuruddha Karunarathna Sirinapa Konta Ivana Kusan Hyun Lee junfu Li Chuan-Gen Lin Ning-Guo Liu Yong-Zhong Lu Zong-Long Luo Ishara S.Manawasinghe Ausana Mapook Rekhani H.Perera Rungtiwa Phookamsak Chayanard Phukhamsakda Igor Siedlecki Adriene Mayra Soares Danushka S.Tennakoon Qing Tian Saowaluck Tibpromma Dhanushka N.Wanasinghe Yuan-Pin Xiao jing Yang Xiang-Yu Zeng Faten A.Abdel-Aziz Wen-jing Li Indunil C.Senanayake Qiu-ju Shang Dinushani A.Daranagama Nimali Ide Silva Kasun M.Thambugala Mohamed A.Abdel-Wahab Ali H.Bahkali Mary L.Berbee Saranyaphat Boonmee D.jayarama Bhat Timur S.Bulgakov Bart Buyck Erio Camporesi Rafael F.Castaneda-Ruiz Putarak Chomnunti Minkwan Doilom Francesco Dovana Tatiana B.Gibertoni Margita jadan Rajesh jeewon E.B.Gareth jones ji-Chuan Kang Samantha C.Karunarathna Young Woon Lim jian-Kui Liu Zuo-Yi Liu Helio Longoni Plautz jr Saisamorn Lumyong Sajeewa S.N.Maharachchikumbura Neven Matocec Eric H.C.McKenzie Armin Mesic Daniel Miller julia Pawłowska Olinto L.Pereira Itthayakorn Promputtha Andrea I.Romero Leif Ryvarden Hong-Yan Su Satinee Suetrong Zdenko Tkalcec Alfredo Vizzini Ting-Chi Wen Komsit Wisitrassameewong Marta Wrzosek jian-Chu Xu Qi Zhao Rui-Lin Zhao Peter E.Mortimer Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand A.M.B Circolo Micologico“Giovanni Carini”C.P.314BresciaItaly A.M.B.Gruppo Micologico Forlivese“Antonio Cicognani”Via Roma 18Forlı`Italy Centre of Mountain Ecosystem Studies Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China College of Agriculture and Biological Sciences Dali UniversityDali 671003YunnanPeople’s Republic of China College of Life Sciences University of Chinese Academy of SciencesHuairou DistrictBeijing 100408China Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Botany University of British ColumbiaVancouverCanada Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityP.O.Box 34123 Al-KhodOman Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduit 80837Mauritius Department of Molecular Phylogenetics and Evolution Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsaw_Zwirki i Wigury 10102-089 WarsawPoland Departamento de Micologia Centro de BiocienciasUniversidade Federal de PernambucoAv.da Engenharia s/nRecifePernambuco 50760-600Brazil Dipartimento

This is the sixth in a series of papers where we bring collaborating mycologists together to produce a set of notes of several taxa of *** this study we introduce a new family Fuscostagonosporaceae in *** also introduce the new ascomycete genera Acericola,Castellaniomyces,Dictyosporina and Longitudinalis and new species Acericola italica,Alternariaster trigonosporus,Amarenomyces dactylidis,Angustimassarina coryli,Astrocystis bambusicola,Castellaniomyces rosae,Chaetothyrina artocarpi,Chlamydotubeufia krabiensis,Colletotrichum lauri,Collodiscula chiangraiensis,Curvularia palmicola,Cytospora mali-sylvestris,Dictyocheirospora cheirospora,Dictyosporina ferruginea,Dothiora coronillae,Dothiora spartii,Dyfrolomyces phetchaburiensis,Epicoccum cedri,Epicoccum pruni,Fasciatispora calami,Fuscostagonospora cytisi,Grandibotrys hyalinus,Hermatomyces nabanheensis,Hongkongmyces thailandica,Hysterium rhizophorae,jahnula guttulaspora,Kirschsteiniothelia rostrata,Koorchalomella salmonispora,Longitudinalis nabanheensis,Lophium zalerioides,Magnibotryascoma mali,Meliola clerodendri-infortunati,Microthyrium chinense,Neodidymelliopsis moricola,Neophaeocryptopus spartii,Nigrograna thymi,Ophiocordyceps cossidarum,Ophiocordyceps issidarum,Ophiosimulans plantaginis,Otidea pruinosa,Otidea stipitata,Paucispora kunmingense,Phaeoisaria microspora,Pleurothecium floriforme,Poaceascoma halophila,Periconia aquatica,Periconia submersa,Phaeosphaeria acaciae,Phaeopoacea muriformis,Pseudopithomyces kunmingnensis,Ramgea ozimecii,Sardiniella celtidis,Seimatosporium italicum,Setoseptoria scirpi,Torula gaodangensis and Vamsapriya *** also provide an amended account of Rhytidhysteron to include apothecial ascomata and a j?*** type species of Ascotrichella hawksworthii(Xylariales genera incertae sedis),Biciliopsis leptogiicola(Sordariomycetes genera incertae sedis),Brooksia tropicalis(Micropeltidaceae),Bryochiton monascus(Teratosphaeriaceae),Bryomyces scapaniae(Pseud

关键词： Ascomycota Basidiomycota Mucoromycota Phylogeny Taxonomy

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基于辣椒基因组测序探究辣味在种群中的进化

辣椒杂志 2014年第2期12卷 40-50页

作者： Seungill Kim Minkyu Park Seon-In Yeom Yong-Min Kim je Min Lee Hyun-Ah Lee Eunyoung Seo jaeyoung Choi Kyeongchae Cheong Ki-Tae Kim Kyongyong jung Gir-Won Lee Sang-Keun Oh Chungyun Bae Saet-Byul Kim Hye-Young Lee Shin-Young Kim Myung-Shin Kim Byoung-Cheorl Kang Yeong Deuk jo Hee-Bum Yang Hee-jin jeong Won-Hee Kang jin-Kyung Kwon Chanseok Shin jae Yun Lim june Hyun Park jin Hoe Huh june-Sik Kim Byung-Dong Kim Oded Cohen Ilan Paran Mi Chung Suh Saet Buyl Lee Yeon-Ki Kim Younhee Shin Seung-jae Noh junhyung Park Young Sam Seo Suk-Yoon Kwon Hyun A Kim jeong Mee Park Hyun-jin Kim Sang-Bong Choi Paul W Bosland Gregory Reeves Sung-Hwan jo Bong-Woo Lee Hyung-Taeg Cho Hee-Seung Choi Min-Soo Lee Yeisoo Yu Yang Do Choi Beom-Seok Park Allen van Deynze Hamid Ashrafi Theresa Hill Woo Taek Kim Hyun-Sook Pai Hee Kyung Ahn Inhwa Yeam james j Giovannoni jocelyn K C Rose Iben Sφrensen Sang-jik Lee Ryan W Kim Ik-Young Choi Beom-Soon Choi jong-Sung Lim Yong-Hwan Lee Doil Choi 刘峰张西露 Department of Plant Science Seoul National University Plant Genomics and Breeding Institute Seoul National University Department of Agricultural Biotechnology Seoul National University Department of Bioinformatics and Life Science Soongsil University Vegetable Breeding Research Center Seoul National University Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael. Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael Department of Bioenergy Science and Technology Chonnam National University Genomics Genetics Institute GreenGene BioTech Inc. Codes Division Insilicogen Inc. Ginseng Resources Research Laboratory Korea Ginseng Corporation Korea Research Institute of Bioscience and Biotechnology Division of Bioscience and Bioinformatics Myongji University Department of Plant and Environmental Sciences New Mexico State University Chile Pepper Institute New Mexico State University Seeders Inc. Department of Biological Sciences Seoul National University Arizona Genomics Institute University of Arizona Agricultural Genome Center National Academy of Agricultural Science Rural Development Administration Seed Biotechnology Center University of California Davis Davis California USA Department of Systems Biology Yonsei University Department of Horticulture and Breeding Andong National University US Department of Agriculture-Agricultural Research Service Robert W. Holley Center Ithaca New York USA Boyce Thompson Institute for Plant Research Cornell University Ithaca New York USA Department of Plant Biology Cornell University Ithaca New York USA Biotechnology Institute Nongwoo Bio Yeoju Korea Genome Center University of California Davis Davis California USA National Instrumentation Center for Environmental Management Seoul National University Seoul Korea 湖南省蔬菜研究所

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表... 详细信息

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表明辣椒基因组大小约为番茄的4倍,辣椒基因组上存在大量gypsy转座子和花椰菜病毒家族元件的积累。结合转录组综合分析认为,辣椒素合成酶基因表达模式的改变及新功能化是导致辣椒素生物合成的原因,研究还发现辣椒与番茄在乙烯合成及果实成熟调控方面存在明显不同的分子模式。辣椒参考基因组的发布为辣椒营养品质和药用价值的改善提供了重要平台。

关键词：基因组测序辣椒素参考基因 Capsicum 转座子辣椒果实分子模式生物合成基因表达模式基因组大小

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