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Proximal gastric response to small intestinal nutrients is abnormal in mechanically ventilated critically ill patients

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World Journal of Gastroenterology 2006年第27期12卷 4383-4388页

作者： Nam Q Nguyen robert J Fraser Marianne Chapman Laura K Bryant Richard h holloway Rosalie Vozzo Christine Feinle-Bisset Department of Gastroenterology Hepatology and General MedicineRoyal Adelaide HospitalSouth Australia University Department of Medicine University of AdelaideSouth Australia Department of Intensive Care Royal Adelaide HospitalSouth Australia Department of Gastroenterology Hepatology and General MedicineRoyal Adelaide HospitalSouth Australia Department of GastroenterologyUniversity of AdelaideSouth Australia

AIM： To determine the response of the proxima stomach to small intestinal nutrients in critically ill patients. METhODS： Proximal gastric motility was measured in 13 critically ill patients （49.3 ± 4.7 years） and 12 healthy volunteers （27.7 ± 2.9 years） using a barostat technique. Recordings were performed at baseline, during a 60-rain intra-duodenal infusion of Ensure^R （2 kcal/min）, and for 2 h following the infusion. Minimum distending pressure （MDP）, intra-bag volume and fundic wave activity were determined. RESULTS： The MDP was higher in patients （11.7 ± 1.1 vs 7.8 ± 0.7 mmhg; P 〈 0.01）. Baseline intrabag volumes were similar in the 2 groups. In healthy subjects, a ‘bimodal＇ proximal gastric volume response was observed. In patients, the initial increase in proximal gastric volume was small and delayed, but eventually reached a maximal volume similar to that of healthy subjects. In healthy subjects, the proximal gastric volume rapidly returned to baseline level after nutrient infusion （median 18 min）. In contrast, the recovery of volume to baseline was delayed in critically ill patients （median 106 min）. In 6 patients, the volume had not returned to baseline level 2 hours after nutrient infusion. In patients, fundic volume waves were less frequent （P 〈 0.05） and had lower amplitude （P 〈 0.001）, compared to healthy subjects. CONCLUSION： In critical illness, proximal gastric motor responses to small intestinal nutrient stimulation are abnormal.

关键词： Proximal gastric response Small intestinal nutrient Critical illness

多工件族无缓冲混合Flow Shop问题的模型和算法构建

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系统工程理论与实践 2013年第8期33卷 2116-2124页

作者：张煜李文锋 robert h.Storer 严新平武汉理工大学物流工程学院武汉430063 里海大学工业与系统工程系伯利恒18015 武汉理工大学智能运输系统研究中心武汉430063

旨在研究并解决一类从集装箱混合装卸作业环境中提取的多工件族无缓冲混合Flow Shop问题.针对该问题的多工件族、无缓冲、部分专用机、与机器和顺序相关的准备时间和作业时间等特点,构建了问题的混合整数线性规划模型.鉴于问题的NP-har... 详细信息

旨在研究并解决一类从集装箱混合装卸作业环境中提取的多工件族无缓冲混合Flow Shop问题.针对该问题的多工件族、无缓冲、部分专用机、与机器和顺序相关的准备时间和作业时间等特点,构建了问题的混合整数线性规划模型.鉴于问题的NP-hard特性,构造型的启发式算法被构建,核心思想是基于提出的机器库存和配额等概念,动态构建含有三元副的调度列表,三元副表示与其一一对应的工件在3阶混合Flow Shop中的加工轨迹.通过仿真实验、下界分析,发现算法能获得好的近优解和低的计算成本.更为重要的是.算法尤其适合解决大规模的实际问题.

关键词：混合流水车间工件族混合整数线性规划启发式算法调度

Granular titanite from the Roter Kamm crater in Namibia:Product of regional metamorphism,not meteorite impact

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Geoscience Frontiers 2022年第3期13卷 156-163页

作者： Aaron J.Cavosie Christopher J.Spencer Noreen Evans Kai Rankenburg robert J.Thomas Paul h.Macey Space Science and Technology Centre and The Institute for Geoscience Research School of Earth and Planetary ScienceCurtin UniversityPerthWA 6102Australia Dept.of Geological Sciences and Geological Engineering Queen’s UniversityOntarioCanada John de Laeter Centre Curtin UniversityPerthWA 6102Australia Council for Geoscience BellvilleWestern CapeSouth Africa

Accessory minerals with so-called granular texture have risen in importance as geochronological tools for U-Pb dating of meteorite impact events. Grain-scale recrystallization, typically triggered by a combination of high-strain deformation and post-impact heating, can create a polycrystalline microstructure consisting of neoblasts that expel radiogenic Pb, which are thus ideal for isotopic dating. While granular domains in zircon and monazite from shocked rocks have been demonstrated to preserve impact ages,few U-Pb dating studies have been conducted on granular microstructures in titanite(CaTiSiO;). here we report the occurrence of granular-textured titanite from ~2020 Ma granite basement rock exposed in the rim of the 4–5 Ma Roter Kamm impact structure in Namibia. Orientation mapping reveals two microstructurally distinct titanite populations: one consisting of strained/deformed grains, and the other consisting of grains that comprise aggregates of strain-free neoblasts. In situ U-Pb geochronology on 37 grains shows that most grains from both titanite populations yield indistinguishable U-Pb dates of ca.1025 Ma, consistent with the observed microstructures forming during the Mesoproterozoic Namaqua Orogeny. Only four grains preserved older age domains, recording ca. 1875 Ma Paleoproterozoic metamorphism. Two significant observations emerge:(1) none of the analyzed titanite grains yield the 2020 Ma igneous crystallization age previously established from zircon in the same sample, and(2) no age-resetting was detected that could be attributed to the 4 to 5 Ma Roter Kamm impact *** the similarity of the neoblastic microstructure to minerals from other sites with an established impact provenance, the granular texture and near-complete Pb-loss in titanite from Roter Kamm granite instead records a Paleo-to Mesoproterozoic polymetamorphic history, rather than Miocene age shockrelated processes. These results highlight the critical importance of grain-scale cont

关键词： Namibia Roter Kamm Titanite EBSD Geochronology

No difference in mortality among ALPPS,two-staged hepatectomy,and portal vein embolization/ligation:A systematic review by updated traditional and network meta-analyses

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hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 411-419页

作者： Paschalis Gavriilidis robert P Sutcliffe Keith J roberts Madhava Pai Duncan Spalding Nagy habib Long R Jiao Mikael h Sodergren Department of hepatopanceaticobiliary Surgery Imperial College Healthcare NHS TrustHammersmith HospitalLondon W120HSUK Department of hepato-Pancreato-Biliary and Liver Transplant Surgery Queen Elizabeth University Hospitals Birmingham NHS Foundation TrustBirmingham B152THUK

Background:There is an ongoing debate on the feasibility,safety,and oncological efficacy of the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)*** aim of this study was to compare ALPPS,two-staged hepatectomy(TSh),and portal vein embolization(PVE)/ligation(PVL)using updated traditional meta-analysis and network meta-analysis(NMA).Data sources:Electronic databases were used in a systematic literature *** traditional metaanalysis and NMA were performed and *** and major morbidity were selected as primary ***:Nineteen studies including 1200 patients were selected from the pool of 436 *** these patients,315(31%)and 702(69%)underwent ALPPS and portal vein occlusion(PVO),*** mortality based on updated traditional meta-analysis,subgroup analysis of the randomized controlled trials(RCTs),and both Bayesian and frequentist NMA did not demonstrate significant differences between the ALPPS cohort and the PVE,PVL,and TSh ***,analysis of RCTs did not demonstrate significant differences of major morbidity between the ALPPS and PVO *** ALPPS cohort demonstrated significantly more favorable outcomes in hypertrophy parameters,time to operation,definitive hepatectomy,and R0 margins rates compared with the PVO *** contrast,1-year disease-free survival was significantly higher in the PVO cohort compared to the ALPPS ***:This study is the first to use updated traditional meta-analysis and both Bayesian and frequentist NMA and demonstrated no significant differences in 90-day mortality between the ALPPS and other hepatic hypertrophy ***,two high quality RCTs including 147 patients demonstrated no significant differences in major morbidity between the ALPPS and PVO cohorts.

关键词： ALPPS hepatectomy Portal vein embolization Portal vein ligation Network meta-analysis

Effect of replacement of soybean oil by hermetia illucens fat on performance,digestibility,cecal microbiome,liver transcriptome and liver and plasma lipidomes of broilers

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1466-1484页

作者： Lea Schäfer Sarah M.Grundmann Garima Maheshwari Marcus höring Gerhard Liebisch Erika Most Klaus Eder robert Ringseis Institute of Animal Nutrition and Nutrition Physiology Justus Liebig University GiessenHeinrich-Buff-Ring 26-3235392 GiessenGermany Institute of Nutritional and Food Sciences Molecular Food TechnologyUniversity of BonnFriedrich-Hirzebruch-Allee 753115 BonnGermany Institute of Clinical Chemistry and Laboratory Medicine University Hospital of RegensburgFranz-Josef-Strauss-Allee 1193053 RegensburgGermany.

Background In contrast to protein-rich insect meal,the feed potential of insect fat is generally less explored and knowledge about the suitability of insect fat as a fat source specifically in broiler diets is still *** view of this,the present study aimed to comprehensively investigate the effect of partial(50%) and complete replacement of soybean oil with insect fat from hermetia illucens(hI) larvae in broiler diets on performance,fat digestibility,cecal microbiome,liver transcriptome and liver and plasma ***,100 male,1-day-old Cobb 500 broilers were randomly assigned to three groups and fed three different diets with either 0(group hI-0,n cens(hI) larvae fat for 35 d.= 30),2.5%(group hI-2.5,n %(hI-5.0,n = 35) or 5.0= 35) hermetia illuResults Body weight gain,final body weight,feed intake,and feed:gain ratio during the whole period and apparent ileal digestibility coefficient for ether extract were not different between *** microbial diversity did not differ between groups and taxonomic analysis revealed differences in the abundance of only four low-abundance bacterial taxa among groups;the abundances of phylum Actinobacteriota,class Coriobacteriia,order Coriobacteriales and family Eggerthellaceae were lower in group hI-5.0 compared to group hI-2.5(P hort-chain fatty acids in the cecal digesta were not different between the three *** transcriptomics revealed a total of 55 and 25 transcripts to be differentially expressed between groups hI-5.0 ***-0 and groups hI-2.5 ***-0,respectively(P he concentrations of most lipid classes,with the exception of phosphatidylethanolamine,phosphatidylglycerol and lysophosphatidylcholine in the liver and cholesterylester and ceramide in plasma(P he sum of all lipid classes were not different between *** Partial and complete replacement of soybean oil with hI larvae fat in broiler diets had no effect on gro

关键词： Broilers Cecal microbiota hermetia illucens Insect fat Liver lipidome Medium-chain fatty acids

Reactivation of latent tuberculosis with TNF inhibitors: critical role of the beta 2 chain of the IL-12 receptor

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Cellular & Molecular Immunology 2021年第7期18卷 1644-1651页

作者： Marie robert Pierre Miossec Department of Clinical Immunology and Rheumatology and immunogenomics and inflammation research unitUniversity of LyonHôpital Edouard HerriotLyonFrance

Tumor necrosis factor(TNF)inhibitors have improved a lot the treatment of numerous diseases,with the well-known example of rheumatoid arthritis(RA).In the early 2000s,postmarketing data quickly revealed an alarming number of severe tuberculosis(TB)under such *** findings were consistent with previous results in mice where TNF is essential for lymph node formation and granuloma *** effects of TNF inhibition on RA synovium structure are very similar to those on granuloma,with changes in cellular interactions,cytokine,and chemokine *** addition to the role of TNF in granuloma,the interleukin(IL)-12/interferon(IFN)-γpathway is required for an efficient host defense against *** and secondary immunodeficiencies affecting this pathway lead to severe bacillus Calmette-Guérin(BCG)reaction or full *** chronic inflammation as in RA induces a systemic Th1 defect that predisposes to TB through specific downregulation of the IL-12Rß2 *** TNF inhibitors are initiated,this transiently increases this risk of TB,through effects on cellular interactions in a latent TB *** a later stage,when a better control disease activity is obtained,the risk of TB is reduced but not *** the clear benefit from TNF inhibition,latent TB infection screening at baseline is essential for an optimal safety.

关键词： tuberculosis TNF inhibition rheumatoid arthritis cytokines

Reheating and entropy perturbations in fibre inflation

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Chinese Physics C 2020年第1期44卷 136-148页

作者： Bao-Min Gu robert Brandenberger Department of Physics Nanchang UniversityNanchang 330031China Center for Relativistic Astrophysics and high Energy Physics Nanchang UniversityNanchang 330031China Department of Physics McGill UniversityMontr′ealQCH3A 2T8Canada

We study reheating in some one and two field realizations of fibre *** find that reheating begins with a phase of preheating in which long wavelength fluctuation modes are *** two field models there is a danger that the parametric amplification of infrared fluctuations in the second scalar field-associated with an entropy mode-might induce an instability of the curvature *** show that,at least in the models we consider,the entropy mode has a sufficiently large mass to prevent this ***,from the point of view of reheating the models we consider are well-behaved.

关键词： inflation preheating perturbations

Targeting the insulin-like growth factor-1 receptor in MTAP-deficient renal cell carcinoma

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Signal Transduction and Targeted Therapy 2019年第1期4卷 625-635页

作者： Jihao Xu Wen-hsin Chang Lon Wolf R.Fong robert h.Weiss Sung-Liang Yu Ching-hsien Chen Division of Nephrology Department of Internal MedicineUniversity of California DavisDavisCAUSA Institute of Molecular Medicine National Taiwan University College of MedicineTaipeiTaiwan Department of Experimental Therapeutics Division of Cancer MedicineThe University of Texas MD Anderson Cancer CenterHoustonTXUSA Medical Service Department of Veterans’Affairs Northern California Health Care System CenterSacramentoCAUSA Comprehensive Cancer Center University of California DavisSacramentoCAUSA Department of Clinical Laboratory Sciences and Medical Biotechnology National Taiwan University College of MedicineTaipeiTaiwan

Renal cell carcinoma(RCC)has emerged as a metabolic disease characterized by dysregulated expression of metabolic *** with metastatic RCC have an unusually poor prognosis and near-universal resistance to all current *** improve RCC treatment and the survival rate of patients with RCC,there is an urgent need to reveal the mechanisms by which metabolic reprogramming regulates aberrant signaling and oncogenic *** an integrated analysis of RCC metabolic pathways,we showed that methylthioadenosine phosphorylase(MTAP)and its substrate methylthioadenosine(MTA)are dysregulated in aggressive RCC.A decrease in MTAP expression was observed in RCC tissues and correlated with higher tumor grade and shorter overall *** manipulation of MTAP demonstrated that MTAP expression inhibits the epithelial-mesenchymal transition,invasion and migration of RCC ***,we found a decrease in the protein methylation level with a concomitant increase in tyrosine phosphorylation after MTAP knockout.A phospho-kinase array screen identified the type 1 insulin-like growth factor-1 receptor(IGF1R)as the candidate with the highest upregulation in tyrosine phosphorylation in response to MTAP *** further demonstrated that IGF1R phosphorylation acts upstream of Src and STAT3 signaling in MTAP-knockout RCC ***1R suppression by a selective inhibitor of IGF1R,linsitinib,impaired the cell migration and invasion capability of MTAP-deleted ***,an increase in linsitinib-mediated cytotoxicity occurred in RCC cells with MTAP *** data suggest that IGF1R signaling is a driver pathway that contributes to the aggressive nature of MTAP-deleted RCC.

关键词： invasion impaired deleted

Polyaniline Nanofiber Composites with Amines:Novel Materials for Phosgene Detection

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Nano Research 2009年第2期2卷 135-142页

作者： Shabnam Virji robert Kojima Jesse D.Fowler Joey G.Villanueva Richard B.Kaner Bruce h.Weiller Materials Processing and Evaluation Department Space Materials LaboratoryThe Aerospace CorporationP.O.Box 92957/M2-248Los AngelesCA 90009USA Department of Chemistry&Biochemistry and California NanoSystems Institute University of CaliforniaLos AngelesLos AngelesCA 90095-1569USA

Several orders of magnitude of change in resistance are observed upon chemical doping and dedoping of the conducting polymer *** large conductivity range can be utilized to make sensitive chemical ***,in its nanofiber form,has even greater sensing capabilities due to the small fiber diameters,high surface area,and porous nanofiber network that enhances gas diffusion into the *** nanofibers have been synthesized using a rapid mixing method and dispersed in water allowing them to be easily modified with water soluble agents,making new composite *** nanofiber composite materials can be used to enhance detection of analytes that unmodified polyaniline would not otherwise be able to *** detection mechanism involves the reaction of an additive with the analyte to generate a strong acid that is easily detected by polyaniline,resulting in orders of magnitude changes in *** reaction of the additive alone with the analyte produces no electrical response,*** this paper,an array of amine-polyaniline nanofiber composite materials is investigated for the detection of phosgene *** influence of environmental conditions such as humidity and temperature are examined and a detection mechanism is presented.

关键词： Polyaniline nanofibers conducting polymer amines chemical sensor phosgene