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年轻患者视网膜前膜的自发分离:个案观察及文献回顾

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 36-36页

作者： Meyer C.h. Rodrigues E.B. Mennel S. 秦雪娇 Department of Ophthalm ology Philipps University Marburg Robert-Koch-Strasse 4 35037 Marburg Germany

Background: Idiopathic epiretinal membranes (ERM) grow on the surface of the i nternal limiting membrane (ILM) and are a very uncommon condition in young subje cts. Methods: We report six young subjects withERM and describe the spontaneous separation of the membranes. The functional and anatomical recovery was assessed by Snellen visual acuity, Amsler grid and funduscopy. Selected cases were addit ionally assessed by optical coherence tomography (OCT). Results: All subjects in itially claimed a sudden, unilateral, reduction in visual acuity (VA) with sever e distortion at the age of 15-30 years. No ocular trauma or disease was ascerta ined in any case. Initial fundus examination demonstrated a gray-whitish ERM wi th translucent stress lines over the macula. Visual recovery occurred in all cas es after resolution of the ERM. Sequential OCT demonstrated the successive peeli ng of an ERM accompanied by normalization of foveal thickness. Conclusions: Youn g subjects should b e counseled about the favorable prognosis for maintaining go od vision and possible spontaneous membrane separation. Conservative observation is advocated if the visual disturbance is located temporally, as functional rec overy and spontaneous membrane separation may occur. When the contracting forces of the immature ERM are stronger than its adhesions to the retina, the membrane may separate spontaneously.

关键词：视网膜前膜文献回顾眼底检查视网膜内界膜眼底镜检查视物变形眼部外伤复位情况牵张评价功能

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早期发病的多发性硬化症患者CSF的特征

世界核心医学期刊文摘（神经病学分册） 2005年第4期1卷 48-48页

作者： PohlD. Rostasy K. Reiber h. hanefeld F. 张玉龙 Dept. of Pediat. and Pediat. Neurol. Georg- August- University Goettingen Robert- Koch- Stras- se 40 37075 Goettingen Germany Dr

The authors studied CSF characteristics in 136 patients with multiple sclerosis (MS) with a disease onset before age 16. In the initial diagnostic lumbar puncture, CSF- pleocytosis was observed in 66% , blood- CSF barrier dysfunction in 13% , and oligoclonal IgG in 92% of the early- onset MS (EOMS) patients. CSF oligoclonal IgG supports the early diagnosis of MS in childhood with a sensitivity similar to adult- onset MS.

关键词：多发性硬化症 CSF 血-脑脊液屏障 IgG 早期诊断

患家族性腺瘤性息肉病的同胞10岁前和13岁前的结肠直肠癌2例

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世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 50-50页

作者： Jerkic S. Rosewich h. Scharf J.-G. J. Grtner 虎小毅 Dept. Paediatr. Paediatr. Neurol. Georg August University Faculty of Medicine Robert-Koch-Strasse 40 37075 Gttingen Germany

Familial adenomatous polyposis (FAP) is an autosomal dominant disorder that ch aracteristically presents with colon cancer in early adult life. We describe a P akistani FAP family in which two sons had an unusually early manifestation of co lorectal cancer. The index patient presented at 11 years of age with abdominal p ain, rectal bleeding and iron deficiency anaemia. Colonoscopy showed that the co lon was carpeted with a myriad of polyps. Oesophago-gastric and duodenal endosc opy revealed that polyps had also developed in the duodenum. Multiple biopsies i ndicated neoplastic lesions. The patient underwent a proctocolectomy and endosco pic duodenal mucosectomy. The diagnosis of an adenocarcinoma of the colon and fu rther adenomatous polyps with low-grade and high-grade dysplasia was confirmed by histology. Family screening including a blood test for anaemia and bowel exa mination revealed that his 12-year-old brother was also affected. Conclusion: Children with familial adenomatous polyposis are at risk for colon cancer and em phasise the need for early tumour recognition. Gastrointestinal symptoms in chil dren should be thoroughly evaluated and standard screening for colonic polyposis should be performed in all individuals with a positive family history and/or kn own mutations in cancer-associated genes, particularly in children who are unde r 10 years of age.

关键词：结肠直肠癌结肠切除术结肠腺癌腺瘤性息肉结肠癌内窥镜检成年早期贫血状况肠道症状早期肿瘤

在局部进展性头颈癌的辅助放疗和化疗中,高级别急性器官毒性作用作为阳性预后因素

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国际医学放射学杂志 2011年第3期 280-280页

作者： h.A.Wolff B.Daldrup K.Jung T.Overbeck S.hennies C.Matthias 焦慧 Departments of Radiotherapy and Radiooncology Universittsmedizin GttingenGermany Robert-Koch-Strasse 4037075 GttingenGermany

目的探讨在患局部进展性头颈鳞状细胞癌(hNSCC)病人的辅助放疗和化疗中高级别的急性器官毒性作用与治疗效果存在的联系。材料与方法本项回顾性研究

关键词：毒性作用病人辅助放疗预后因素进展性器官

Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C haussen Muhammad M Qureshi hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia hammami Anna M Cervantes-Arslanian hormuzdiyar h Dasenbrock huynh Le Vu Viet Quy Nguyen Steven hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram huded Nobuyuki Ohara Daisuke Watanabe Dong hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-hoffmann roberto Crosa Markus Möhlenbruch Simon Nagel hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man hong robert Fahed Gregory Walker Eiji hagashi Steve M Cordina hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura roberta Novakovic Jun Deguchi Yuri Sugiura hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAh)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAh,aneurysmal SAh,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAh hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAh hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,ph 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAh hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,phospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAh admissions in this *** There was a relative decrease in the volume of SAh hospitalisations,aneurysmal SAh hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAh are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid

种族与心衰患者的肾脏损害:黑人和白人患者的死亡率

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世界核心医学期刊文摘（心脏病学分册） 2005年第9期1卷 45-45页

作者： Smith G.L. Shlipak M.G. havranek E.P. h.M. Krumholz 黎一兵 Dr. robert Wood Johnson Clin. S. Yale University School of Medicine Sterling Hall of Medicine(SHM) 333 Cedar St New Haven CT 06520 United States

Background -Renal impairment is an emerging prognostic indicator in heart failure(hF) patients. Despite known racial differences in the progression of both hF and renal disease, it is unclear whether the prognosis for renal impairment in hF patients differs by race. We sought to determine in hF patients the 1-year mortality risks associated with elevated creatinine and impaired estimated glomerular filtration rate(eGFR) and to quantify racial differences in mortality. Methods and Results -We retrospectively evaluated the National heart Care Project nationally representative cohort of 53 640 Medicare patients hospitalized with hF. Among 5669 black patients, mean creatinine was 1.6±0.9mg/dL, and 54%had an eGFR ≤60, compared with creatinine 1.5±0.7 mg/dL and 68%eGFR ≤60 in 47 971 white patients. higher creatinine predicted increased mortality risk, although the magnitude of risk differed by race(interaction P=0.0001). Every increase in creatinine of 0.5 mg/dL was associated with a >10%increased risk in adjusted mortality for blacks, compared with >15%increased risk in whites(interaction P=0.0001), with the most striking racial disparities at the highest levels of renal impairment. Depressed eGFR showed similar racial differences(interaction P=0.0001). Conclusions -Impaired renal function predicts increased mortality in elderly hF patients, although risks are more pronounced in whites. Distinct morbidity and mortality burdens in black versus white patients underscore the importance of improving patient risk-stratification, defining optimal therapies, and exploring physiological underpinnings of racial differences.

关键词：种族差异心脏护理预后指标死亡风险肌酐水平估算值肾功能受损生理学基础肾小球滤过率回顾性评价

卒中一级预防指南美国心脏协会／美国卒中协会对医疗专业人员的声明

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国际脑血管病杂志 2015年第7期23卷 403-439页

作者： James F. Meschia Cheryl Bushnell Bernadette Boden-Albala Lynne T. Braun Dawn M. Bravata Seemant Chaturvedi Mark A. Creager robert h. Eckel Mitchell S.V. Elkind Myriam Fornage Larry B Goldstein Steven M. Greenberg Susanna E. horvath Costantino Iadecola Edward C. Jauch Wesley S. Moore John A. Wilson 李迪高一鹭陈政弘霍晓川孙海欣孙冬玲茹小娟江滨代表美国心脏协会卒中委员会、心血管和卒中护理委员会、临床心脏病学委员会、功能基因组学和生物转化委员会以及高血压委员会北京市神经外科研究所首都医科大学首都医科大学附属北京天坛医院临床流行病学北京市重点实验室 100050

这份更新版指南旨在为既往无卒中或短暂性脑缺血发作史的人群提供适时的综合性卒中预防循证建议，包括危险因素控制、头颈部动脉粥样硬化性疾病的干预方法以及预防血栓形成和血栓栓塞性卒中的抗栓治疗。此外，本指南还提供了针对遗传和... 详细信息

这份更新版指南旨在为既往无卒中或短暂性脑缺血发作史的人群提供适时的综合性卒中预防循证建议，包括危险因素控制、头颈部动脉粥样硬化性疾病的干预方法以及预防血栓形成和血栓栓塞性卒中的抗栓治疗。此外，本指南还提供了针对遗传和药理学检测以及在其他特殊情况下（包括镰状细胞疾病和卵圆孔未闭）进行卒中预防的建议。

关键词： AhA/ASA科学声明 AF 糖尿病高脂血症高血压颅内动脉瘤缺血预防与控制吸烟卒中

128层螺旋CT对脑胶质瘤容积灌注扫描的可行性研究

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国际医学放射学杂志 2011年第6期 597-597页

作者： A.Xyda U.haberland E.Klotz h.C.Bock K.Jung M.Knauth 朱叶青 Department of Neuroradiology Georg-August UniversityUniversity Hospital of GoettingenRobert-Koch Str.4037075 GoettingenGermany

目的确定128层涵盖肿瘤范围的容积灌注CT(VPCT)对脑胶质瘤术前评估的可行性及有效性。方法利用VPCT对46例胶质瘤病人(25例男性,21例女性,平均年龄52.8岁)进行评估。2名阅片医生独立进行VPCT数据的分析,在肿瘤周围勾画感兴趣容积(VOI)以... 详细信息

目的确定128层涵盖肿瘤范围的容积灌注CT(VPCT)对脑胶质瘤术前评估的可行性及有效性。方法利用VPCT对46例胶质瘤病人(25例男性,21例女性,平均年龄52.8岁)进行评估。2名阅片医生独立进行VPCT数据的分析,在肿瘤周围勾画感兴趣容积(VOI)以自动计算肿瘤的脑

关键词：锥体束CT 脑肿瘤胶质瘤可行性研究

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宝马世界

城市环境设计 2020年第4期126卷 134-149页

作者：沃尔夫·狄·普瑞克斯 Paul Kath Tom Wiscombe Waltraut hoheneder Mona Marbach hans Aescht Beatrix Basting Guy Bebiè Chris Beccone Johannes Behrens Marcelo Bernardi Pawel Bodzak Verena Boyer Antja Bulthaup Claudia Buhmann Timo Carl Jan Chaldil Ing Tse Chen Tadeusz Chimiak Andrea Christmann Patrick Erhardt Stephan Exsternbrink Wolfgang Fiel Benedikt Frass helmut Fr?tscher Volker Gessendorfer Andrea Graser Lukas haller Markus henning Armin hess Jens hoff Tamas horvath robert huebser Astrid Jagersberger Marin Jurycz Gregor Kassl Areta Keller Markus Klausecker Tobias Klein Martin Konrad Quirin Krumbholz Caroline Kufferath Marion Lattenmayer Stefan Laub Wolfgang Leitgeb Andreas Mieling Karin Miesenberger Dennis Milam Elke Müller henrike Münker Claudia Nehammer Martin Oberascher Alexander Ott Stefan Pfefferle Florian Pfeifer Markus Pillhofer Ekkehard Rehfeld Goswin Rothenthal Wolfgang Ruthensteiner Jasmin Sauerbier Florian Schafschetzy Kristina Schinegger Karolin Schmidbaur Patrick Schneider Katharina Schneider hubert Schoba Angus Schoenberger Andrea Sch?ning Anja Sorger Gernot Stangl Mark Steinmetz Sigrid Steinwender Martina Tippelskirch Dionicio Valdez Pascal Vauclair Akvile Rimantaite Andreas Weissenbach heribert Wolfmayer Irina Zahler 2007 Ari Marcopoulos Gerald Zugmann hélène Binet Duccio Malagamba Marcus Buck Christian Richters Richard Walch

项目大事记/ChRONOLOGY竞赛（一等奖）/Competition（1st Prize）:2001规划设计起始时间/Start of Planning:11/2001施工起始时间/Start of Construction:08/2003投入使用/Opening:20/10/2007-21/10/2007项目参数/PROJECT DATA用地面积/Site Area:约25 000m2/Approx. 25 000m2建筑毛面积/Gross Floor Area:约73 000m2（除坡道）=100%/Approx.73 000m2（excluding ramps）=100%地上建筑毛面积/Gross Floor Area above ground:约28 500m2=40%/Approx.28 500m2=40%地下建筑毛面积/Gross Floor Area underground:约44 500m2=60%/Approx.44 500m2=60%

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