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Acta Mechanica Solida Sinica 2024年第3期37卷 396-405页

作者： Zuorong Chen Xiaofang Jiang Zhejun Pan robert g.Jeffrey National Key Laboratory of Continental Shale Oil Northeast Petroleum UniversityDaqing163318China SCT Operation Pty.Ltd. PO Box 824WollongongNSW2520Australia

Pressure and tilt data are jointly inverted to simultaneously map the orientation and dimensions of a hydraulic *** deformation induced by a fracture under internal pressure is modeled using the distributed dislocation *** planar fracture is represented by four quarter ellipses,joined at the center and sharing *** configuration provides a straightforward model for characterizing asymmetric fracture *** inverse problem of mapping the fracture geometry is formulated using the Bayesian probabilistic method,combining the a priori information on the fracture model with updated information from pressure and tilt *** the nonlinear inverse problem is achieved by pseudo-randomly sampling the posterior probability distribution through the Markov chain Monte Carlo *** resulting posterior probability distribution is then explored to assess uncertainty,resolution,and correlation between model *** experiments are conducted to verify the accuracy and validity of the proposed analysis method in mapping the fracture geometry using synthetic pressure and tilt data.

关键词： Hydraulic fracture mapping Coupled inversion Tilt Treating pressure

Hydrodynamic function and spring constant calibration of FluidFM micropipette cantilevers

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Microsystems & Nanoengineering 2024年第1期10卷 277-286页

作者： Attila Bonyár Ágoston g.Nagy Hans gunstheimer gotthold Fläschner robert Horvath Department of Electronics Technology Faculty of Electrical Engineering and InformaticsBudapest University of Technology and EconomicsBudapestHungary Nanobiosensorics Laboratory Institute of Technical Physics and Materials ScienceCentre for Energy ResearchHUN-RENBudapestHungary Nanosurf Ag Gräubernstrasse 12CH-4410 LiestalSwitzerland

Fluidic force microscopy(FluidFM)fuses the force sensitivity of atomic force microscopy with the manipulation capabilities of microfluidics by using microfabricated cantilevers with embedded fluidic *** innovation initiated new research and development directions in biology,biophysics,and material *** acquire reliable and reproducible data,the calibration of the force sensor is ***,the hollow FluidFM cantilevers contain a row of parallel pillars inside a rectangular *** precise spring constant calibration of the internally structured cantilever is far from trivial,and existing methods generally assume simplifications that are not applicable to these special types of *** addition,the Sader method,which is currently implemented by the FluidFM community,relies on the precise measurement of the quality factor,which renders the calibration of the spring constant sensitive to *** this study,the hydrodynamic function of these special types of hollow cantilevers was experimentally determined with different *** on the hydrodynamic function,a novel spring constant calibration method was adapted,which relied only on the two resonance frequencies of the cantilever,measured in air and in a *** on these results,our proposed method can be successfully used for the reliable,noise-free calibration of hollow FluidFM cantilevers.

关键词： spring cantilever function

Predicting the coefficient of friction in a sliding contact by applying machine learning to acoustic emission data

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Friction 2024年第6期12卷 1299-1321页

作者： robert gUTIERREZ Tianshi FANg robert MAINWARINg Tom REDDYHOFF Tribology group Department of Mechanical EngineeringImperial College LondonExhibition RoadLondon SW72AZUK Shell global Solutions(US)Inc.Shell Technology Center Houston 3333 Highway 6 SouthHoustonTX 77082USA Shell International Petroleum Company Limited Shell CentreYork RoadLondon SE17NAUK

It is increasingly important to monitor sliding interfaces within machines,since this is where both energy is lost,and failures *** emission(AE)techniques offer a way to monitor contacts remotely without requiring transparent or electrically conductive ***,acoustic data from sliding contacts is notoriously complex and difficult to ***,we simultaneously measure coefficient of friction(with a conventional force transducer)and acoustic emission(with a piezoelectric sensor and high acquisition rate digitizer)produced by a steel‒steel rubbing *** data is then used to train machine learning(ML)algorithms(e.g.,gaussian process regression(gPR)and support vector machine(SVM))to correlated acoustic emission with *** training requires the dense AE data to first be reduced in size and a range of processing techniques are assessed for this(e.g.,down-sampling,averaging,fast Fourier transforms(FFTs),histograms).Next,fresh,unseen AE data is given to the trained model and the resulting friction predictions are compared with the directly measured *** is excellent agreement between the measured and predicted friction when the gPR model is used on AE histogram data,with root mean square(RMS)errors as low as 0.03 and Pearson correlation coefficients reaching ***,predictions remain accurate despite changes in test conditions such as normal load,reciprocating frequency,and stroke *** paves the way for remote,acoustic measurements of friction in inaccessible locations within machinery to increase mechanical efficiency and avoid costly failure/needless maintenance.

关键词： acoustic emission condition monitoring friction machine learning gaussian process regression support vector machine

A general mirror equivalence theorem for coset vertex operator algebras

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Science China Mathematics 2024年第10期67卷 2237-2282页

作者： robert McRae Yau Mathematical Sciences Center Tsinghua University

We prove a general mirror duality theorem for a subalgebra U of a simple conformal vertex algebra A and its commutant V=ComA（U）.Specifically,we assume that ■ as a U■V-module,where the U-modules Uiare simple and distinct and are objects of a semisimple braided ribbon category of Umodules,and the V-modules Viare semisimple and contained in a（not necessarily rigid） braided tensor category of *** also assume U=ComA（V）.Under these conditions,we construct a braid-reversed tensor equivalence τ:uA→vA,where uAis the semisimple category of U-modules with simple objects Ui,i∈I,and vAis the category of V-modules whose objects are finite direct sums of *** particular,the V-modules Viare simple and distinct,and vAis a rigid tensor *** an application,we find a rigid semisimple tensor subcategory of modules for the Virasoro algebra at central charge 13+6p+6p-1,p∈Z≥2, which is braided tensor equivalent to an abelian 3-cocycle twist of the category of finite-dimensional ***,the Virasoro vertex operator algebra at central charge 13+6p+6p-1is the PSL2（C）-fixed-point subalgebra of a simple conformal vertex algebra w（-p）,analogous to the realization of the Virasoro vertex operator algebra at central charge 13-6p-6p-1as the PSL2（C）-fixed-point subalgebra of the triplet algebra W（p）.

关键词： vertex operator algebras coset conformal field theory braid-reversed tensor equivalence Virasoro algebra

Necrotic enteritis and antibiotic-free production of broiler chickens:Challenges in testing and using alternative products

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Animal Nutrition 2024年第01期16卷 288-298页

作者： robert J.Moore School of Science RMIT University

The global trend towards raising broiler chickens without the use of in-feed antibiotics(IFAs) means that there is an ongoing need to develop alternative treatments capable of delivering the benefits that IFAs previously provided. IFAs supported the productivity performance of chickens and played a key role in maintaining their health. Necrotic enteritis(NE) is an important disease of broilers that affects health,productivity, and welfare, and was previously well controlled by IFAs. However, with the reduction in IFA use, NE is resurgent in some countries. Vaccines and various feed additives, including pre-, pro-, and postbiotics, phytobiotics, fatty acids, and phage therapies have been introduced as alternative methods of NE control. While some of these feed additives have specific activity against the NE pathogen, Clostridium perfringens, most have the more general goal of reinforcing gut health. Extensive reviews of the effects of many of these feed additives on gut health have been published recently. Hence, rather than cover previously well reviewed areas of research this review focuses on the challenges and pitfalls in undertaking experimental assessment of alternative NE treatments and translating laboratory research to real world commercial production settings. The review is based on the author's particular experience,reading, thoughts, and analysis of the available information and inevitably presents a particular understanding that is likely to be at odds with others thinking on these issues. It is put forward to stimulate thinking and discussion on the issues covered.

关键词： Necrotic enteritis Clostridium perfringens Vaccines Feed additive Farm management

A detailed rock density model of the Hong Kong territories

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geodesy and geodynamics 2024年第1期15卷 75-81页

作者： Albertini Nsiah Ababio robert Tenzer Department of Land Surveying and geo-Informatics Hong Kong Polytechnic UniversityHong KongChina

We used the geological map and published rock density measurements to compile the digital rock density model for the Hong Kong *** then estimated the average density for the whole *** to our result,the rock density values in Hong Kong vary from 2101 to 2681 kg·m^(-3).These density values are typically smaller than the average density of 2670 kg·m^(-3),often adopted to represent the average density of the upper continental crust in physical geodesy and gravimetric geophysics *** finding reflects that the geological configuration in Hong Kong is mainly formed by light volcanic formations and lava flows with overlying sedimentary deposits at many locations,while the percentage of heavier metamorphic rocks is very low(less than 1%).This product will improve the accuracy of a detailed geoid model and orthometric heights.

关键词： Density model Rock types gravimetric modeling Hong Kong

The concept of gene therapy for glaucoma:the dream that has not come true yet

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Neural Regeneration Research 2024年第1期19卷 92-99页

作者： robert Sulak Xiaonan Liu Adrian Smedowski Department of Physiology Faculty of Medical Sciences in KatowiceMedical University of Silesia in KatowiceKatowicePoland Institute of Biotechnology HiLIFEUniversity of HelsinkiHelsinkiFinland glaucoTech Co. KatowicePoland

gene therapies,despite of being a relatively new therapeutic approach,have a potential to become an important alternative to current treatment strategies in *** glaucoma is not considered a single gene disease,the identified goals of gene therapy would be rather to provide neuroprotection of retinal ganglion cells,especially,in intraocular-pressure-independent *** most commonly reported type of vector for gene delivery in glaucoma studies is adeno-associated virus serotype 2 that has a high tro pism to retinal ganglion cells,res ulting in long-term expression and low immunogenic *** gene thera py studies recruit inducible and genetic animal models of optic neuropathy,like DBA/2J mice model of high-tension glaucoma and the optic nerve *** gene therapy-based neuroprotection of retinal ganglion cells is targeting specific genes translating to growth factors(i.e.,brain derived neurotrophic factor,and its receptor TrkB),regulation of apoptosis and neurodegeneration(i.e.,Bcl-xl,Xiap,FAS system,nicotinamide mononucleotide adenylyl transferase 2,Digit3 and Sarm1),immunomodulation(i.e.,Crry,C3 complement),modulation of neuroinflammation(i.e.,e rythropoietin),reduction of excitotoxicity(i.e.,Com KIlα)and transcription regulation(i.e.,Max,Nrf2).On the other hand,some of gene therapy studies focus on lowering intra ocular pressure,by impacting genes involved in both,decreasing aqueous humor production(i.e.,aquaporin 1),and increasing outflow facility(i.e.,COX2,prostaglandin F2a receptor,RhoA/RhoA kinase signaling pathway,MMP1,Myocilin).The goal of this review is to summarize the current stateof-art and the direction of development of gene therapy strategies for glaucomatous neuropathy.

关键词： adeno-associated virus gene editing gene therapy glaucoma IOP lowering IOP-independent mechanisms neuroprotection optic nerve optic neuropathy retinal ganglion cells

Assessment of portable FTIR and Raman spectroscopy for the detection of 2,3-dimethyl-2,3-dinitrobutane(DMDNB)in plastic explosives

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Defence Technology（防务技术） 2024年第4期34卷 11-18页

作者： Jacky Cailes robert Dunsmore Kathryn L.Linge ChemCentre PO Box 1250PerthAustralia

The Marplex Convention was established to prevent the manufacture of unmarked plastic explosives and stipulates that a volatile detection agent must be added at the time of ***,to-date,laboratory testing remains the internationally accepted practice for identifying and quantifying the taggants stipulated in the *** this project,portable FTIR and Raman instruments were tested for their ability to detect 2,3-dimethyl-2,3-dinitrobutane(DMDNB),the chemical marker incorporated in plastic explosives that are manufactured within *** both FTIR and Raman instruments detected solid DMDNB(98%purity),field analysis of plastic explosives at an Australian Defence establishment showed that both FTIR and Raman spectra were matched the relevant explosive(RDX or PETN),rather than the DMDNB *** all three plastic explosives tested,the concentration of DMDNB was measured by SPME-gC-MS to be between 1.8 and 2%,greater than the minimum 1%concentration stipulated by the Marplex *** testing with a plastic explosive analogue confirmed that the minor absorption peaks that would characterize low concentrations of DMDNB were masked by absorption bands from other compounds within the ***,while both FTIR and Raman spectroscopy are suitable for detection of plastic explosives,neither rely on the presence of DMDNB for *** is likely that similar results would be found for other taggants stipulated by the Marplex Convention,given they are also present in concentrations less than 1%.

关键词： Explosive ICAO taggants 2,3-Dimethyl-2,3-dinitrobutane(DMDNB) Fourier transform infrared(FTIR) Raman

Optimization of product characteristics of porous carbon agglomerates using a design of experiments in fluidized bed agglomeration

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Particuology 2024年第6期89卷 258-269页

作者： Martin Oelofse robert Rack Marcelle Hilden Peter Langguth Department of Pharmaceutical Technology and Biopharmaceutics Johannes Gutenberg UniversityMainzGermany Carbon Advanced Solutions gmbH HeuchelheimGermany

Spraying parameters during particle agglomeration processes can affect the agglomeration kinetics and particle *** study was conducted to better understand the influence of the spraying parameters in a fluidized bed wet agglomeration process,and the influence on the stability characteristics of carbon tablets.A formulation based on fine carbon and peroxide powder,as well as carboxymethyl cellulose as a binder,was used to produce agglomerates in a first production *** in a second production step carbon tablets with a high porosity were molded for the customer goods *** optimization of the compressive strength of these carbon tablets was the goal of the *** agglomerates were produced with a laboratory scale granulator called“ProCell”and were compressed with a five-cavity mechanical *** screening of the agglomeration process parameters and their influence on the agglomerates quality,as well as the performance characteristics of the carbon tablets,were investigated using a multilevel factorial *** experimental runs were done by varying atomized air pressure and feed rate of the *** was determined by the design *** findings of the statistical trials showed that low atomized air pressure and a low feed rate lead to a higher tablet compressive strength.

关键词： Wet agglomeration Fluidized bed Design of experiments Carbon agglomerates and tablets