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Angiographic evaluation and management of acute gastrointestinal hemorrhage

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World Journal of Gastroenterology 2012年第11期18卷 1191-1201页

作者： T gregory walker Gloria M Salazar Arthur C Waltman Division of Vascular Imaging and Intervention Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States

Although most cases of acute nonvariceal gastrointestinal hemorrhage either spontaneously resolve or respond to medical management or endoscopic treatment,there are still a significant number of patients who require emergency angiography and transcatheter *** with noninvasive imaging such as nuclear scintigraphy or computed tomography may localize the bleeding source and/or confirm active hemorrhage prior to *** angiographic evaluation should begin with selective catheterization of the artery supplying the most likely site of bleeding,as determined by the available clinical,endoscopic and imaging *** a hemorrhage source is identified,superselective catheterization followed by transcatheter microcoil embolization is usually the most effective means of successfully controlling hemorrhage while minimizing potential *** is now wellrecognized as a viable and safe alternative to emergency *** selected situations transcatheter intra-arterial infusion of vasopressin may also be useful in controlling acute gastrointestinal *** must be aware of the various side effects and potential complications associated with this treatment,however,and recognize the high re-bleeding *** this article we review the current role of angiography,transcatheter arterial embolization and infusion therapy in the evaluation and management of nonvariceal gastrointestinal hemorrhage.

关键词： Angiodysplasia Aneurysm Digital subtrac-tion angiography Contrast media Hemorrhage Radio-nuclide angiography Therapeutic embolization

Fine-tuning the response of growth cones to guidance cues: a perspective on the role of microRNAs

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Neural Regeneration Research 2019年第10期14卷 1719-1720页

作者： Sarah E.walker Gaynor E.Spencer robert L.Carlone Department of Biological Sciences Brock University

In the development and regeneration of the nervous system, neurons face the complex task of establishing and/or repairing neuronal connections and contacts. The formation of these neuronal circuits is largely coordinated by tightly regulated temporal and spatial changes in mRNA translation, which enables incredibly precise control over protein expression and localization (Jung and Holt, 2011). Local mRNA translation in specific cellular compartments appears to play a role in many processes that are important to nervous system development and regeneration, including: cell survival, migration, growth cone guidance, and synaptogenesis (Jung and Holt, 2011).

关键词： In the development nervous system synaptogenesis

First-line endoscopic treatment with over-the-scope clips significantly improves the primary failure and rebleeding rates in high-risk gastrointestinal bleeding: A single-center experience with 100 cases

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World Journal of Gastroenterology 2016年第41期22卷 9162-9171页

作者： Hans-Jürgen Richter-Schrag Torben Glatz Christine walker Andreas Fischer robert Thimme Center of Interdisciplinary Gastrointestinal Endoscopy Department of Medicine II Medical Center-University of Freiburg Faculty of Medicine University of Freiburg Department of General and Visceral Surgery Medical Center-University of Freiburg Faculty of Medicine University of Freiburg

AIM To evaluate rebleeding, primary failure(PF) and mortality of patients in whom over-the-scope clips(OTSCs) were used as first-line and second-line endoscopic treatment(FLET, SLET) of upper and lower gastrointestinal bleeding(UGIB, LGIB).METHODS A retrospective analysis of a prospectively collected database identified all patients with UGIB and LGIB in a tertiary endoscopic referral center of the University of Freiburg, Germany, from 04-2012 to 05-2016(n= 93) who underwent FLET and SLET with OTSCs. The complete Rockall risk scores were calculated from patients with UGIB. The scores were categorized as < or ≥ 7 and were compared with the original Rockall data. Differences between FLET and SLET were calculated. Univariate and multivariate analysis were performed to evaluate the factors that influenced rebleeding after OTSC *** Primary hemostasis and clinical success of bleeding lesions(without rebleeding) was achieved in 88/100(88%) and 78/100(78%), respectively. PF was significantly lower when OTSCs were applied as FLET compared to SLET(4.9% vs 23%, P = 0.008). In multivariate analysis, patients who had OTSC placement as SLET had a significantly higher rebleeding risk compared to those who had FLET(OR 5.3; P = 0.008). Patients with Rockall risk scores ≥ 7 had a significantly higher in-hospital mortality compared to those with scores < 7(35% vs 10%, P = 0.034). No significant differences were observed in patients with scores < or ≥ 7 in rebleeding and rebleeding-associated *** Our data show for the first time that FLET with OTSC might be the best predictor to successfully prevent rebleeding of gastrointestinal bleeding compared to SLET. The type of treatment determines the success of primary hemostasis or primary failure.

关键词： Gastrointestinal bleeding Rockall risk score Over-the-scope clip First-line endoscopic treatment Second-line endoscopic treatment

The diagnostic and prognostic utility of the dual-task tandem gait test for pediatric concussion

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Journal of Sport and Health Science 2021年第2期10卷 131-137页

作者： Katie A.Van Deventer Corrine N.Seehusen gregory A.walker Julie C.Wilson David R.Howell University of Colorado School of Medicine AuroraCO 80045USA Sports Medicine Center Children’s Hospital ColoradoAuroraCO 80045USA Department of Orthopedics University of Colorado School of MedicineAuroraCO 80045USA Department of Pediatrics University of Colorado School of MedicineAuroraCO 80045USA

Background:The tandem gait test has gained interest recently for assessment of concussion *** purpose of our study was to determine the prognostic and diagnostic use of the single-and dual-task tandem gait test,alongside other clinical measures,within 10 days of pediatric ***:We assessed 126 patients post-concussion(6.3§2.3 days post-injury,mean§SD)at a pediatric sports medicine clinic and compared them to 58 healthy controls(age:15.6§1.3 years;43%female).We also compared the 31 patients with concussion who developed persistent post-concussion symptoms(PPCS)(age=14.9§2.0 years;48%female)to the 81 patients with concussion who did not develop PPCS following the initial assessment(age:14.1§3.0 years;41%female).All subjects completed a test battery,and concussion patients were monitored until they experienced concussion-symptom *** test battery included tandem gait(single-task,dual-task(performing tandem gait while concurrently completing a cognitive test)conditions),modified Balance Error Scoring System(mBESS),and concussion symptom assessment(Health and Behavior Inventory).We defined PPCS as symptom resolution time>28 days post-concussion for the concussion *** outcomes included tandem gait time(single-and dual-task),dual-task cognitive accuracy,mBESS errors(single/double/tandem stances),and symptom ***:The concussion group completed the single-task(mean difference=9.1 s,95%confidential interval(95%CI):6.1-12.1)and dual-task(mean difference=12.7 s,95%CI:8.716.8)tandem gait test more slowly than the control *** to those who recovered within 28 days of concussion,the PPCS group had slower dual-task tandem gait test times(mean difference=7.9 s,95%CI:2.0-13.9),made more tandem-stance mBESS errors(mean difference=1.3 errors,95%CI:0.2-2.3),and reported more severe symptoms(mean difference=26.6 Health and Behavior Inventory rating,95%CI:21.1-32.6).Conclusion:Worse dual-task tandem gait test time and mB

关键词： Adolescent Balance Mild traumatic brain injury Postural stability Prognosis

COVID-19:Still a Matter of Life and Death

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China Today 2023年第1期72卷 48-50页

作者： robert walker China Academy of Social Management/School of Sociology Beijing Normal University Royal Society of Arts and the Academy of Social Sciences in the U.K

China has begun the transition from pandemic to an endemic phase with announcements of a reduction in COVID-test checks, the possibility of isolating at home, and priority vaccination of the elderly. A total of 6.7 million people in 224 countries and jurisdictions have died from COVID-19. Many more will have perished without being diagnosed and others because they were denied treatment for other illnesses in over-crowded hospitals. Altogather, 653 million cases have been confirmed.

关键词： Still treatment fir

Open to Chinese Democracy

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China Today 2024年第3期73卷 46-48页

作者： robert walker Beijing Normal University

The National People’s Congress meets every year for about a week in *** there is much more to China’s *** 2,977 elected deputies will be attending the second plenary meeting of the 14th National People’s Congress at the Great Hall of the People in Beijing in early ***,the world’s largest legislative body,is the most striking manifestation of China’s governance system,whole-process people’s *** outsiders,the gathering seems symbolic and ***,the deliberation undertaken by the unpaid deputies in the week that they are together is merely the most visible element in a complex consultative system of government.

关键词： gathering striking system

From Disaster to No Disaster

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China Today 2024年第12期73卷 52-55页

作者： robert walker Green Templeton College University of Oxford Jingshi Academy at Beijing Normal University Royal Society of Arts and the Academy of Social Sciences in the U.K.

Mitigation requires public participation in monitoring and warning,but this works only in a well-ordered *** world is discharging greenhouse gas emissions at the fastest rate in *** is increasing global temperatures a... 详细信息

关键词： becoming creating participation

Learning from Each Other’s Culture

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China Today 2024年第10期73卷 54-56页

作者： robert walker Green Templeton College University of Oxford

Successful collaboration across cultures requires understanding,acceptance and *** is as true for governments as it is for *** our world almost broken apart by the forces of geopolitical self-interest,cross-cultural understanding is the glue needed to hold it *** means recognizing the fact that as people and nations,we are all the same but different.

关键词： Other get acceptance

Common Prosperity:Turning Dreams Into Reality

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Beijing Review 2023年第19期66卷 20-21页

作者： robert walker School of Sociology under Beijing Normal University Green Templeton College Universit

On September 25, 1953, when China’s intention of achieving common prosperity was first announced in the country’s largest-circulated newspaper People’s Daily, it must have seemed like an impossible dream. A census conducted earlier that year reported a total population on the Chinese mainland of 582.6million, with 87 percent residing in the rural areas. A similar proportion of the population at the time was extremely poor and the literacy rate was just over 20 percent.

关键词： mainland dream population