检索结果-南通市图书馆

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen robert J.Thomas m.Brandon Westover Can Zhang department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(Ad) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of Ad is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and m.d.rate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel e.Ocasio Rivera dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge d.miranda department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor m.d.lator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a m.d.rate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain eAAT-1/GLAST eAAT-2/GLT-1 glutamate transporters selective estrogen receptor m.d.lator sexual dimorphism spinal cord injury trauma

ANemIA ANd BLOOd BOOSTING

在线全文

学校读者我要写书评

暂无评论

中国运动医学杂志 2002年第5期21卷 537-543页

作者： e.Randy eichner,m.d. department of m.d.cine University of Oklahoma Health Sciences Center Oklahoma City department of m.d.cine University of Oklahoma Health Sciences Center Oklahoma City Oklahoma Oklahoma

electrical and band-gap properties of amorphous zinc-indium-tin oxide thin films

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Progress in Natural Science:materials International 2012年第1期22卷 1-6页

作者： d.B. Buchholz d.e. Proffit m.d. Wisser T.O. mason R.P.H. Chang department of materials Science and engineering Northwestern University 2220 Campus Drive Cook Hall Room 2013 Evanston IL 60208 USA

Zinc-indium-tin oxide (ZITO) films were grown by pulsed-laser deposition. Three different material compositions were investigated: ZITO-30, ZITO-50 and ZITO-70 in which 30%, 50% and 70%, respectively, of the indium in the In 2 O 3 structure was replaced by substitution with zinc and tin in equal molar proportions (co-substitution): In 2 2x Zn x Sn x O 3 , where x 0.3, 0.5, 0.7. All ZITO films grown at room temperature were amorphous. The first evidence of crystallinity was observed at higher deposition-temperature as the degree of co-substitution was increased. A decrease in mobility and conductivity was also observed as the degree of co-substitution was increased. The highest mobility for ZITO-30 and ZITO-50 was observed at deposition temperatures just prior to crystallization. The effect of deposition temperature on carrier concentration was minor compared to the effect of oxygen partial pressure during deposition.

关键词： Transparent conducting oxide Semiconductor Oxide Amorphous deposition temperature

Hepatitis B and C infection and liver disease trends among human immunodeficiency virus-infected individuals

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第14期17卷 1807-1816页

作者： Susan e Buskin elizabeth A Barash John d Scott david m Aboulafia robert W Wood Public Health-Seattle and King County WA 98104United States University of Washington SeattleWA 98195United States Harborview m.d.cal Center SeattleWA 98104United States Virginia mason m.d.cal Center SeattleWA 98101United States

AIm:To examine trends in and correlates of liver disease and viral hepatitis in an human immunodeficiency virus (HIV)-infected cohort. meTHOdS:The multi-site adult/adolescent spectrum of HIV-related diseases (ASd) followed 29 490 HIVinfected individuals receiving m.d.cal care in 11 U.S. metropolitan areas for an average of 2.4 years,and a total of 69 487 person-years,between 1998 and 2004. ASd collected data on the presentation,treatment,and outcomes of HIV,including liver disease,hepatitis screening,and hepatitis diagnoses. ReSULTS:Incident liver disease,chronic hepatitis B virus (HBV),and hepatitis C virus (HCV) were diagnosed in 0.9,1.8,and 4.7 per 100 person-years. HBV and HCV screening increased from fewer than 20% to over 60% during this period of observation (P deaths occurred in 57% of those diagnosed with liver disease relative to 15% overall (P erall 10% of deaths occurred among individuals with a diagnosis of liver disease. despite care guidelines promoting screening and vaccination for HBV and screening for HCV,screening and vaccination were not universally conducted or,if conducted,not documented. CONCLUSION:due to high rates of incident liver disease,viral hepatitis screening,vaccination,and treatment among HIV-infected individuals should be a priority.

关键词： Human immunodeficiency virus Hepatitis B Hepatitis C Liver disease

evaluation of the Heat,entropy,and Rotational Changes Produced by Gravitational Segregation during Core Formation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of earth Science 2015年第1期26卷 124-133页

作者： Anne m.Hofmeister robert e.Criss department of earth and Planetary Sciences Washington University

Core formation by gravitational segregation allegedly released sufficient interior heat to melt the earth. Analysis of the energetics, which compare gravitational potential energy （Ug） of a fictitious, homogeneous reference state to earth＇s current layered configuration, needs updating to correct errors and omissions, and to accomm.d.te recent findings：（1） An erroneous positive sign was used for Ug while maintaining the reference value of 0 at infinity, which results in an incorrect sign fur AUg, which is crucial in determining whether a process is endothermic or exothermic. （2） The value of Ug for earth＇s initial state is uncertain. （3） Recent meteorite evidence indicates that core formation began before the earth was full-sized, which severely limits AUg. （4） Inhomogeneous accretion additionally reduced AUg. （5） The potentially large effect of differential rotation between the core and the mantle was not accounted for. （6） entropy changes associated with creating order were neglected. Accordingly, we revise values of Ug, evaluate uncertainties, and show that AUg was converted substantially to eonfigurational energy （TAS）. These considerations limit the large sources of primordial heat to impacts and radioactivity. Although these processes may play a role in core formation, their energies are independent of gravitational segregation, which produces order and rotational energy, not internal heat. Instead, gravitational segregation promotes planetary cooling mainly because it segregates lithophilic radioactive elements upward, increasing surface heat flux while shortening the distance over which radiogenic heat diffuses outwards.

关键词： core formation primordial heat configurational energy therm.d.namics rotational energy.

Uptake and Clearance of diazinon in different Tissues of the european eel (Anguilla anguilla L.)

在线全文

学校读者我要写书评

暂无评论

Biom.d.cal and environmental Sciences 1994年第1期7卷 41-49页

作者： e. SANCHO m.d. FeRRANdO m. GAmON ANd e. ANdReU-mOLINeR( department of Animal Phvsiology, Faculty of Biological Sciences, Universityof Valencia, dr- moliner SO, Burjasot H46100, Valencia , Spain, AgrarianLaboratoFy, Conselleria de Agricultura, Generalit department of Animal Physiology Faculty of Biological Sciences University of Valencia Spain.

Acute toxicity cffeets of diazinon on european cel (Anguilla anguilla ) was cxamined using short -term exposures in static conditions . The LC50 values were 0. 16. 0, 11, 0.09 and0.08 mg/l al 24. 48. 72 and 96 h exposure . respeclivcly. In additio the cels were exposedio 0.042 mg/ l of diazinon and bioaccumulation and clearance processcs of this insccticidein liver, muscle and gill tissties were studred . Bioconcentration factor (BCF ) of diazinonovcr 96 h cxposure Period was 1850 in livcr, 875 in gill and 775 in musele tissuc. diazinoncliminalion from the sclccled lissucs was rapid. The excretion ratc constants of thisinsccticidc werc 0.108 h : for Iivcr, 0.055 h for gill and 0.016 h for muscle. diazinonhalf-lives werc calculatcd as 16.6, 33.2 and 27 h tbr liver, musele and gill , *** showed rclativcly short half lives in eel tissues.

关键词： Anguilla anguilla L

efficient approaches of determining the motion of a spherical particle in a swirling fluid flow using weighted residual methods

在线全文

学校读者我要写书评

暂无评论

Particuology 2015年第6期13卷 68-74页

作者： Seiyed e. Ghasemi m. Vatani d.d. Ganji Young Researchers and elite Club Qaemshahr Branch Islamic Azad University Qaemshahr lran department of mechanical engineering Babol University of Technology Babol lran

The motion of a spherical particle released in a swirling fluid flow is studied employing the least-squares method and method of moments. The governing equations are obtained and solved employing the two methods. The accuracy of the results is examined against the results of a fourth-order Runge-Kutta numer- ical method. The effects of various parameters, namely the initial radius, initial radial velocity, initial angular velocity, and drag-to-inertia ratio, on the non-dimensional velocity profiles and particle position distribution are considered. The results show that the radial velocity increases over time while the angular velocity decreases, and that an increase in the initial radial velocity increases the particle radial distance and angular velocity but decreases the radial velocity profile.

关键词： Spherical particle Swirling flow Radial velocity Angular velocity Least-squares method method of moments

Stability of Two Conservative,High-Order Fluid-Fluid Coupling methods

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Applied mathematics and mechanics 2019年第6期11卷 1287-1338页

作者： Jeffrey m.Connors robert d.dolan University of Connecticut Department of MathematicsStorrsCT 06269USA

This paper investigates two methods of coupling fluids across an interface,motivated by air-sea interaction in application *** method is for sequential configurations,where the air code m.d.le in invoked over some time interval prior to the sea *** other method is for concurrent setups,in which the air and sea m.d.les run in *** focus is the temporal representation of air-sea *** methods we study conserve moments of the fluxes,with an arbitrary order of accuracy possible in *** step sizes are allowed for the two fluid *** a posteriori stability indicator is defined,which can be computed efficiently on-the-fly over each coupling *** a m.d.l of two coupled fluids with natural heat convection,using finite elements in space,we prove the sufficiency of our stability *** certain conditions,we also prove that stability can be enforced by iteration when the coupling interval is small *** particular,for solutions in a certain class,we show that the step size scaling is no worse than O(h)in three dimensions of space,where Oh is a mesh *** is a sharper result than what has been shown previously for related algorithms with finite element *** examples illustrate the behavior of the algorithms under a wide variety of configurations.

关键词： Air-sea atmosphere-ocean fluid-fluid partitioned time stepping conservative coupling