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Characteristics of Anthropogenic Sulfate and Carbonaceous Aerosols over east Asia: Regional Modeling and Observation

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Advances in Atmospheric Sciences 2008年第6期25卷 946-959页

作者： Yan HUANG William L. CHAMeIDeS Qian TAN robert e. DICKINSON School of earth and Atmospheric Sciences Georgia Institute of Technology Atlanta GA 30332 Nicholas School of the environment and earth Sciences Duke University Durham NC 27708 Goddard earth Sciences and Technology Center University of Maryland Baltimore MD 21228

The authors present spatial and temporal characteristics of anthropogenic sulfate and carbonaceous aerosols over east Asia using a 3-D coupled regional climate-chemistry-aerosol model, and compare the simulation with the limited aerosol observations over the region. The aerosol module consists of SO2, SO4^2-, hydrophobic and hydrophilic black carbon （BC） and organic carbon compounds （OC）, including emission, advections, dry and wet deposition, and chemical production and conversion. The simulated patterns of SO2 are closely tied to its emission rate, with sharp gradients between the highly polluted regions and more rural areas. Chemical conversion （especially in the aqueous phase） and dry deposition remove 60% and 30% of the total SO2 emission, respectively. The SO4^2- shows less horizontal gradient and seasonality than SO2, with wet deposition （60%） and export （27%） being two major sinks. Carbonaceous aerosols are spatially smoother than sulfur species. The aging process transforms more than 80% of hydrophobic BC and OC to hydrophilic components, which are removed by wet deposition （60%） and export （30%）. The simulated spatial and seasonal SO4^2-, BC and OC aerosol concentrations and total aerosol optical depth are generally consistent with the observations in rural areas over east Asia, with lower bias in simulated OC aerosols, likely due to the underestimation of anthropogenic OC emissions and missing treatment of secondary organic carbon. The results suggest that our model is a useful tool for characterizing the anthropogenic aerosol cycle and for assessing its potential climatic and environmental effects in future studies.

关键词： regional climate modeling anthropogenic emission sulfate aerosol black carbon and organic carbon east Asia

Is there consensus regarding surgical treatment of bone sarcomas?

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World Journal of Orthopedics 2018年第9期9卷 173-179页

作者： Thomas Baad-Hansen Sarah Stammose Freund Bodil hammer Bech Johnny Keller Department of Orthopaedic Oncology Aarhus University Hospital Department of Public Health Aarhus University

AIM To perform an Internet based survey on the surgical management of bone sarcomas in the lower extremity amongst sarcoma surgeons. MeTHODS All orthopedic surgical members of the Scandinavian Sarcoma Group were invited to participate in an online questionnaire. The questionnaire consisted of a clinical case involving resection of a malignant bone tumor. Several questions were asked, subdivided into categories. Among these, surgical/technical considerations, e.g., choice of implant; choice of antibiotics, dosage, and duration of treatment, choice of antithrombotic drug, initial start-up, dosage, and duration were *** In terms of choice of implant fixation, the majority of surgeons preferred an uncemented prosthesis in younger patients until the age of 50. All participants administer intravenous prophylactic antibiotics for endoprosthetic reconstructive surgery. First choice of antibiotics was cephalosporin. Less common used was glycopeptide, penicillin, or a combination. Duration of prophylactic antibiotics ranged from less than one day to more than four days. All participants used low molecular weight heparins as antithrombotic prophylaxis and 55% of the participants answered that initial treatment was started preoperatively, 3% perioperatively and 42% postoperatively. Duration of the antithrombotic treatment ranged from five days to more than twenty-eight *** The use of resection prosthesis in the treatment of bone sarcomas is a well-established procedure. However, therse is a significant discrepancy in the surgical treatment algorithm between the sarcoma centers. Still the treatment is mainly based on best clinical practice,due to the lack of evidence-based medicine in the surgical management of bone sarcomas.

关键词： Sarcoma Reconstruction Megaprosthesis Antibiotics Antithrombotic prophylaxis

Biological Markers on Human Pregnancy

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Biomedical and environmental Sciences 1991年第1期4卷 56-58页

作者： robert e.CANFIeLD JOHN F.O'CONNOR Departments of Medicine Pathology Columbia University College of Physicians and Surgeons New York New York 10032

This article reviews a selected set of recently described pregnancy-associated proteins which possess potential for both signaling pregnancy onset and monitoring its course. These molecules are compared and contrasted with human chorionic gonadotropin, the first pregnancy-associated protein to be discovered, and the standard biomarker of pregnancy to which all others must still be referenced. Recent advances in hCG research have focused on the structural determination and diagnostic significance of the subunits and fragments of the hCG molecule, particularly in urine. An outline of the potential utility of this approach is also presented.

关键词： Biological Markers on Human Pregnancy

Reconciling Local and Global Agendas in Sustainable Development: Participatory Research with Indigenous Andean Communities

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Journal of Mountain Science 2006年第4期3卷 334-346页

作者： robert e. Rhoades Virginia Nazarea University of Georgia USA Professor of Anthropology University of Georgia USA

This paper discusses participatory research in the Andes and presents a case study in Cotacachi, ecuador, where sustainability scientists and indigenous people seek common ground in their respective but drastically different research and social agendas. Participatory research based on Andean experiences pre-dated and inspired much of the later international movement in agriculture, health, and conservation. Andean communities have a long history in demanding that outsiders address the needs of the community as a condition for carrying out scientific or applied activities. What an Andean community, however, sees as relevant may or may not be within the rubric of ‘participatory research’ as it is practiced throughout much of the world. In fact, overzealous participatory researchers are just as bothersome as their predecessors bearing long questionnaires. More important to Andean people is an equitable relationship with researchers and developers in which exchanges of value are made. A distinction between ‘enriching’ and ‘extractive’ research is drawn. In the case of the SANReM project in Cotacachi, ecuador, scientists carried out enriching research activities of interest to local people as a wayto generate social capital for conducting basic research which does not have an obvious, immediate local benefit. The requested research did not have a conventional participatory methodology but provided valuable products (educational opportunity, germplasm, community visualization tools, and information) to the indigenous community in exchange for time and resources to conduct research on more basic natural resource questions. We argue that in the Andean context the key to reconciling the needs of scientists and of local needs is seeking new forms of equitable collaboration which reach beyond the present and now somewhat tired discourse of ‘participation’.

关键词： Andes indigenous peoples participatory research sustainability

SARS-COV-2 infection(coronavirus disease 2019)for the gastrointestinal consultant

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World Journal of Gastroenterology 2020年第14期26卷 1546-1553页

作者： Kaveh Hajifathalian Srihari Mahadev robert e Schwartz Shawn Shah Kartik Sampath Felice Schnoll-Sussman robert S Brown Jr David Carr-Locke David e Cohen Reem Z Sharaiha Division of Gastroenterology and Hepatology Weill Cornell MedicineNew York-Presbyterian HospitalNew YorkNY 10021United States

The current pandemic due to the severe acute respiratory syndrome coronavirus 2 has caused an extreme burden for health care systems globally,and the number of cases is expected to continue to increase,at least in the immediate *** virus is estimated to have infected more than 1.5 million *** available reports suggest that gastrointestinal(GI)involvement in coronavirus disease 2019(COVID-19)is common and in some cases the GI symptoms may precede the respiratory *** addition to direct effects of severe acute respiratory syndrome coronavirus 2,the infected patients remain at risk for the complications commonly managed by gastroenterology and hepatology *** most commonly reported GI manifestation of COVID-19 is diarrhea,which is reported in a third to up to more than half of the *** to moderate elevation of the liver enzymes are also common,although no case of acute liver failure has been reported so *** of the medications used for treatment of COVID-19 can also be associated with GI symptoms or liver injury and can be included in the differential diagnosis in these *** the diagnosis of the infection is currently based on RNA analysis in respiratory samples,the available literature on fecal shedding of this virus suggests that fecal RNA testing might prove to be a useful diagnostic *** is reasonable to delay all non-urgent endoscopic procedures during the peak of the pandemic and use additional protective equipment such as N95 respirators during endoscopy while most patients can be considered high risk for having been exposed to the virus.

关键词： SARS-CoV-2 COVID-19 Gastroenterology Hepatology Liver

Generation and Propagation of an Urban Flash Flood and Our Collective Responsibilities

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Journal of earth Science 2022年第6期33卷 1624-1628页

作者： robert e.Criss eric M.Stein David L.Nelson Department of earth and Planetary Sciences Washington UniversitySt.LouisMO 63130USA 7427 Chamberlain Ave. University CitySt.LouisMO 63130USA 470 Columbia Circle PasadenaCA 91105USA

0 INTRODUCTION Destructive flash flooding is a growing global problem,with dangers being particularly acute in densely populated urban areas. The intensity of rainfall events is increasing, creating high runoff rates ... 详细信息

关键词： Flash flash Generation

Has Axial Spin Decline Affected earth's Geologic and Tectonic History?

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Journal of earth Science 2022年第5期33卷 1333-1336页

作者： Anne M.Hofmeister robert e.Criss Timothy M.Kusky Department of earth and Planetary Science Washington UniversitySt.LouisMO63130USA State Key Laboratory for Geological Processes and Mineral Resources Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan430074China Badong National Observatory and Research Station for Geohazards China University of GeosciencesWuhan430074China

0 INTRODUCTION Among the rocky planets,only earth remains active 4.5 Ga after ***,only earth has a chemically and structurally complex,bimodal surface with unequivocal horizontal *** unique plate motions are currently... 详细信息

关键词： earth formation mantle

Method for rapid on-site identification of VOCs

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Journal of environmental Sciences 2009年第7期21卷 1005-1008页

作者： Justin D Fair William F Bailey robert A Felty Amy e Gifford Benjamin Shultes Leslie H Volles Department of Chemistry University of Connecticut Storrs Connecticut 06269-3060 USA. INFICON Inc. 2 Technology Place East Syracuse New York 13057 USA

Rapid on-site identification of volatile organic compounds （VOCs） in ambient air is an important first step in remediation efforts. This study describes modification of a commercially available, portable GC/MS system and development of an analysis protocol for rapid （〈 3 min） sampling and identification of VOCs typically found at contaminated sites at the low ppbv level.

关键词： field analysis gas chromatograph mass spectrometer toxic industrial chemicals thermal desorption

Association between exposure to Metals during Pregnancy,Childhood Gut Microbiome,and Risk of Intestinal Inflammation in Late Childhood

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environment & Health 2024年第10期2卷 739-749页

作者： Vishal Midya Manasi Agrawal Jamil M.Lane Chris Gennings Leonid Tarassishin Libni A.Torres-Olascoaga Joseph eggers Jill K.Gregory Mellissa Picker Inga Peter Jeremiah J.Faith Manish Arora Martha M.Tellez-Rojo robert O.Wright Jean-Frederic Colombel Shoshannah eggers Department of environmental Medicine and Climate Science Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Division of Gastroenterology Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Center for Molecular Prediction of Inflammatory Bowel Disease(PReDICT) Department of Clinical MedicineAalborg UniversityCopenhagen 9220Denmark Department of Genetics and Genomic Sciences Icahn School of MedicineNew York 10029-6574New YorkUnited States Center for Research on Nutrition and Health National Institute of Public HealthCuernavaca 62508Mexico Department of Immunology and Immunotherapy Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Department of epidemiology University of Iowa College of Public HealthIowa City 52242 IowaUnited States Instructional Technology Group Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States

Alterations to the gut microbiome and exposure to metals during pregnancy have been suggested to impact inflammatory bowel ***,how prenatal exposure to metals eventually results in long-term effects on the gut microbiome,leading to subclinical intestinal inflammation,particularly during late childhood,has not been *** is also unknown whether such an interactive effect drives a specific subgroup of children toward elevated susceptibility to intestinal *** used an amalgamation of machine-learning techniques with a regression-based framework to explore if children with distinct sets of gut microbes and certain patterns of exposure to metals during pregnancy(metal−microbial clique signature)had a higher likelihood of intestinal inflammation,measured based on fecal calprotectin(FC)in late *** obtained samples from a well-characterized longitudinal birth cohort from Mexico City(n=108),*** the second and third trimesters of pregnancy,11 metals were measured in whole *** microbial abundances and FC were measured in stool samples from children 9−11 years of *** FC was defined as having FC above 100μg/g of *** identified subgroups of children in whom microbial and metal−microbial clique signatures were associated with elevated FC(false discovery rate(FDR)e found two metal−microbial clique signatures significantly associated with elevated FC:(1)low cesium(Cs)and copper(Cu)in the third trimester and low relative abundance of eubacterium ventriosum(OR[95%CI]:10.27[3.57,29.52],FDRe third trimester and high relative abundances of Roseburia inulinivorans and Ruminococcus torques(OR[95%CI]:7.21[1.81,28.77],FDRexploratory study demonstrates that children with specific gut microbes and specific exposure patterns to metals during pregnancy may have higher fecal calprotectin levels in late childhood,denoting an elevated risk of intestinal inflammation.

关键词： exposome metals machine learning microbiome environmental epidemiology intestinal inflammation