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World Journal of Orthopedics 2016年第7期7卷 452-457页

作者： Hossein elgafy Nicholas Peters Justin e Lea robert M Wetzel Department of Orthopedic Surgery University of Toledo Medical Center

A 64-year-old-female presented with progressive left foot weakness, low back and radicular pain after a left sided S1 transforaminal epidural steroid injection(eSI). Magnetic resonance imaging revealed left side L5-S1 large extradural heterogeneous mass with layering areas suggesting different stages of hematoma formation. Past medical history was significant for peripheral vascular disease and transient ischemic attacks, for which she took aspirin and clopidogrel(antiplatelet agent). These medications were discontinued one week prior to eSI. Although synovial cysts associated with facet arthropathy are common, hemorrhagic cyst is not. To the best of the authors' knowledge, this is the first reported case of symptomatic hemorrhagic lumbar facet synovial cyst following eSI on a patient taking antiplatelet medications.

关键词： Lumbar synovial cyst Hemorrhage Antiplatelet therapy epidural injection

Genetic and environmental control of fruit maturation,dry matter and firmness in apple(Malus×domestica Borkh.)

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Horticulture Research 2014年第1期1卷 98-109页

作者： David Chagne Daya Dayatilake robert Diack Murray Oliver Hilary Ireland Amy Watson Susan e Gardiner Jason W Johnston robert J Schaffer Stuart Tustin The New Zealand Institute for Plant&Food Research Limited(Plant&Food Research) Palmerston North Research CentrePalmerston NorthNew Zealand Plant&Food Research Hawke’s Bay Research CentreHavelock NorthNew Zealand Plant&Food Research Motueka Research CentreMotuekaNew Zealand Plant&Food Research Mount Albert Research CentreAucklandNew Zealand School of Biological Sciences University of AucklandAucklandNew Zealand

For any given genotype,the environment in which an apple is grown can influence the properties of the fruit *** there has been extensive research on the mechanism of the genetic control of fruit quality traits,less effort has been made to investigate the way that these genetic mechanisms interact with the *** address this issue,we employed a large‘Royal Gala’×‘Braeburn’population of 572 seedlings replicated over sites in three climatically diverse apple-growing regions in New *** for traits including fruit maturation timing,firmness and dry matter content was performed at each of these three sites for a single growing season(2011),and at two sites(Motueka and Hawke’s Bay)for two seasons(2009 and 2010).The phenotype data collected over 2 years at two sites enabled the detection of 190 quantitative trait loci(QTL)that controlled these traits regardless of year or growing location,as well as some chromosomal loci that influenced the traits in a single given environment or *** those loci that were environmentally stable over three sites,there was an interdependency of fruit maturation date,dry matter content and storage potential within this population,with two regions on Linkage Groups(LGs)10 and 16 strongly *** these loci were used in a marker-assisted selection programme to select for progeny bearing firmer fruit,this would have the unintentional consequence of selecting,high dry matter content,later maturing *** addition,a further 113 new QTLs with a smaller effect were identified,some of which were exhibited only in a single growing environment,demonstrating the underlying complexity of control of traits determining fruit quality,in addition to the need for being aware of environmental effects when developing new apple varieties.

关键词： fir apple fruit

How Could evidence-Based Reform Advance education?

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eCNU Review of education 2021年第1期4卷 7-24页

作者： robert e.Slavin Alan C.K.Cheung Tengteng Zhuang Johns Hopkins University The Chinese University of Hong Kong Beijing Normal University

Purpose:This article presents a definition and rationale for evidence-based reform in education,and a discussion of the current state of evidence-based research,focusing on China,the U.S.,and the ***/Approach/Methods:The article contrasts the state of educational research in the U.S.,the UK,and China,world leaders in evidence-based ***:The article suggests ways in which Chinese,U.S.,UK,and other scholars might improve the worldwide quality of evidence-based reform in *** indicator of this partnership is an agreement among the Chinese University of Hong Kong,Nanjing Normal University,and Johns Hopkins University to work together on Chinese and english versions of the website Best evidence in Brief and a collaboration between Johns Hopkins and the eCNU Review of education at east China Normal ***/Value:This article is the first to compare developments in evidence-based reform in education in China with parallel developments in the *** UK Building understanding of current evidence-based policies should help all countries learn how evidence can play a greater role in education policy and benefit many students.

关键词： evidence-based reform in education experiments international comparisons meta-analysis research designs

Comments on ‘An airway organoid-based screen identifies a role for the HIF1α‒glycolysis axis in SARS-CoV-2 infection’

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Journal of Molecular Cell Biology 2022年第1期14卷 60-61页

作者： Xiaohua Duan Hui Wang David D.Ho robert e.Schwartz Todd evans Shuibing Chen Department of Surgery Weill Cornell Medicine1300 York Ave.New YorkNY 10065USA State Key Laboratory of Oncogenes and Related Genes Center for Single-Cell OmicsSchool of Public HealthShanghai Jiao Tong University School of MedicineShanghai 200025China Aaron Diamond AIDS Research Center Columbia University Vagelos College of Physicians and SurgeonsNew YorkNY 10032USA Division of Gastroenterology and Hepatology Department of MedicineWeill Cornell Medicine1300 York Ave.New YorkNY 10065USA Department of Physiology Biophysics and Systems BiologyWeill Cornell Medicine1300 York Ave.New YorkNY 10065USA

Coronavirus disease 2019(COVID-19)has been an ongoing public health crisis since the end of 2019;besides vaccine development,there have been major research efforts focused on developing antiviral *** was the first US Food and Drug Administration(FDA)-approved antiviral drug for ***,the FDA granted emergency use authorization(eUA)for three monoclonal antibody treatments,including sotrovimab or a combination of casirivimab and imdevimab,or bamlanivimab and etesevimab,each of which targets the coronavirus spike protein to block viral *** recently,Britain granted conditional authorization for the ribonucleoside analog molnupiravir,developed by Merck as a viral replication *** protease inhibitor PF-07321332 developed by Pfizer and boosted by ritonavir showed promising results in a phase III clinical trial,reducing the risk of hospitalization or death by 89%compared with placebo.

关键词： Pfizer Merck vaccine

Immunohistochemical assessment of NY-eSO-1 expression in esophageal adenocarcinoma resection specimens

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World Journal of Gastroenterology 2014年第14期20卷 4011-4016页

作者： Stephen J Hayes Keng Ngee Hng Peter Clark Fiona Thistlethwaite robert e Hawkins Yeng Ang Department of Histopathology Salford Royal NHS Foundation Trust Faculty of Medical and Human Sciences University of Manchester Department of Gastroenterology Salford Royal NHS Foundation Trust Department of Medical Oncology The Christie NHS Foundation Trust Department of Medical Oncology Paterson Institute of Cancer ResearchUniversity of Manchester

AIM: To assess NY-eSO-1 expression in a cohort of esophageal adenocarcinomas.

关键词： esophageal adenocarcinoma Immunohistochemistry NY-eSO-1 Stem cells Vesicle trafficking

Coryphoid palms from the K-Pg boundary of central India and their biogeographical implications:evidence from megafossil remains

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Plant Diversity 2023年第1期45卷 80-97页

作者： Sanchita Kumar Taposhi Hazra robert A.Spicer Manoshi Hazra Teresa e.V.Spicer Subir Bera Mahasin Ali Khan Palaeobotany and Palynology Laboratory Department of BotanySidho-Kanho-Birsha UniversityRanchi RoadPurulia 723104India CAS Key Laboratory of Tropical Forest ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303PR China School of environment Earth and Ecosystem SciencesThe Open UniversityMilton Keynes MK76AAUK Centre of Advanced Study Department of BotanyUniversity of Calcutta35B.C.RoadKolkata 700019India

Ten palm leaf impressions are documented from the latest Maastrichtian(late Cretaceous) to early Danian(earliest Paleocene) sediments(K-Pg,c.66-64 Ma) of the Mandla Lobe of the Deccan Intertrappean Beds,Madhya Pradesh,central *** palmate leaf shape along with a definite wellpreserved costa support their placement in the subfamily Coryphoideae of the family *** place all recovered palm leaf specimens in the fossil genus Sabalites,report seven species of coryphoid palms and describe two new species namely,Sabalities umariaensis *** Sabalites ghughuaensis *** fossils indicate that coryphoid palms were highly diverse in central India by the latest *** and earlier reported coryphoid palm fossils from the same locality indicate that they experienced a warm and humid tropical environment during the time of *** discoveries confirm the presence of a diversity of Coryphoideae in Gondwana prior to the India-eurasia collision and provide information about coryphoid biogeographical history over geological *** on megafossil remains,we trace coryphoid palm migration pathways from India to mainland Southeast(Se) Asia and other parts of Asia after the docking of the Indian subcontinent with eurasia early in the Paleogene.

关键词： Coryphoideae Leaf fossils Late cretaceous-early paleocene Paleobiogeography Paleoclimate Madhya Pradesh

Siwalik plant megafossil diversity in the eastern Himalayas: A review

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Plant Diversity 2023年第3期45卷 243-264页

作者： Mahasin Ali Khan Sumana Mahato robert A.Spicer Teresa e.V.Spicer Ashif Ali Taposhi Hazra Subir Bera Palaeobotany and Palynology Laboratory Department of BotanySidho-Kanho-Birsha UniversityRanchi RoadPurulia 723104India CAS Key Laboratory of Tropical Forest ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303PR China School of environment Earth and Ecosystem SciencesThe Open UniversityMilton KeynesMK76AAUK Centre of Advanced Study Department of BotanyUniversity of Calcutta35B.C.RoadKolkata 700019India

The eastern Himalayas are renowned for their high plant *** understand how this modern botanical richness formed,it is critical to investigate past plant biodiversity preserved as fossils throughout the eastern Himalayan Siwalik succession(middle Miocene-early Pleistocene).Here,we present a summary of plant diversity records that document Neogene floristic and climate *** do this by compiling published records of megafossil plant remains,because these offer better spatial and temporal resolution than do palynological *** of the Siwalik floral assemblages based on the distribution of the nearest living relative taxa suggest that a tropical wet evergreen forest was growing in a warm humid monsoonal climate at the deposition *** qualitative interpretation is also corroborated by published CLAMP(Climate Leaf Analysis Multivariate Program) ***,we also reconstruct the climate by applying a new common proxy WorldClim2 *** allows the detection of subtle climate differences between floral assemblages free of artefacts introduced by using different methodologies and climate *** analysis of the Siwalik floras indicates that there was a gradual change in floral *** lower Siwalik assemblages provide evidence of a predominance of evergreen *** increase in deciduous elements in the floral composition is noticed towards the close of the middle Siwalik and the beginning of the upper Siwalik *** change reflects a climatic difference between Miocene and Plio-Pleistocene *** review helps us to understand under what paleoenvironmental conditions plant diversity occurred and evolved in the eastern Himalayas throughout the Cenozoic.

关键词： Megafossils Siwalik MiocenePleistocene Palaeovegetation Palaeoenvironment eastern Himalayas

Mechanisms underlying detection of seed dormancy by a scatter-hoarding rodent

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Integrative Zoology 2020年第2期15卷 89-102页

作者： Mekala SUNDARAM Ashley e.HIGDON Karl V.WOOD Connie C.BONHAM robert K.SWIHART Department of Forestry and Natural Resources Purdue UniversityWest LafayetteUSA Department of Chemistry Purdue UniversityWest LafayetteUSA Department of Biochemistry Purdue UniversityWest LafayetteUSA Department of Geological Sciences Stanford UniversityStanfordCaliforniaUSA

The mechanism underlying detection of seed dormancy by scatter-hoarding rodents is unclear,although previous work suggests that the pericarp plays an important role in signaling dormancy *** gray squirrels(Sciurus carolinensis)consume early germinating seeds as they are more likely to perish immediately,whereas dormant seeds tend to be *** examine the mechanisms underlying dormancy detection,we characterized physical and chemical differences between germinating and dormant pericarps of northern red oak(Quercus rubra),American chestnut(Castanea dentata)and the BC3 hybrid of Chinese chestnut and American chestnut(Castanea mollissima×***)using scanning electron microscopy and gas chromatography-mass spec*** found that,as seeds break dormancy,the wax layer on the pericarp degrades and is accompanied by the escape of lower molecular weight kernel compounds or lipid metabolism *** field experiments showed that squirrels were 4-8 times more likely to consume seeds that were altered to remove pericarp wax coating or that were sprayed with seed *** argue that dormancy detection by scatter-hoarding rodents is a complex process involving physical cues such as loss of pericarp wax and chemical cues such as emission of olfactory cues.

关键词： cache pericarp wax scatter-hoarding seed consumption

Biological Markers on Human Pregnancy

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Biomedical and environmental Sciences 1991年第Z1期 56-68页

作者： robert e.CANFIeLD,JOHN F.O'CONNOR Departments of Medicine Pathology Columbia University College of Physicians and Surgeons New York New York 10032

This article reviews a selected set of recently described pregnancy-associated proteins which possess potential for both signaling pregnancy onset and monitoring its course. These molecules are compared and contrasted with human chorionic gonadotropin, the first pregnancy-associated protein to be discovered, and the standard biomarker of pregnancy to which all others must still be referenced. Recent advances in hCG research have focused on the structural determination and diagnostic significance of the subunits and fragments of the hCG molecule, particularly in urine. An outline of the potential utility of this approach is also presented.

关键词： Biological Markers on Human Pregnancy

An emerging plume head interacting with the Hawaiian plume tail

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The Innovation 2023年第2期4卷 41-46,40页

作者： Lipeng Zhang Zebin Cao robert e.Zartman Congying Li Saijun Sun Lijun Liu Weidong Sun Center of Deep Sea Research Institute of OceanologyChinese Academy of SciencesQingdao 266071China Deep-Sea Multidisciplinary Research Center Laoshan LaboratoryQingdao 266237China Department of Geology University of Illinois at Urbana-ChampaignUrbanaIL 61820USA Laboratory for Marine Geology Laoshan LaboratoryQingdao 266237China University of the Chinese Academy of Sciences Beijing 100049China

The Hawaiian-emperor seamount chain has shown two subparallel geographical and geochemical volcanic trends,Loa and Kea,since-5 Ma,for which numerous models have been proposed that usually involve a single mantle plume sampling different compositional sources of the deep or shallow ***,both the dramatically increased eruption rate of the Hawaiian hotspot since-5 Ma and the nearly simultaneous southward bending of the Hawaiian chain remain unexplained.

关键词： volcanic shallow mantle