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Ge.e.ic asse.sme.t of inbre. chicke. line. indicate. ge.omic signature. of re.istance.to Mare.'s dise.se

Journal of Animal Scie.ce.and Biote.hnology 2018年第4期9卷 803-812页

作者： Lingyang Xu Yanghua He.Yi Ding Ge.rge.e.Liu Huanmin Zhang Hans H.Che.g robert L.Taylor jr. Jiuzhou Song De.artme.t of Animal & Avian Scie.ce. University of Maryland Animal Ge.omics and Improve.e.t Laboratory U.S. Department of Agriculture-Agricultural Research Services Laboratory of Mole.ular Biology and Bovine.Bre.ding Institute of Animal Science Chinese Academy of Agricultural Sciences Unite. State. De.artme.t of Agriculture.Agriculture.Re.e.rch Se.vice.(ARS) Avian Disease and Oncology Laboratory Animal and Nutritional Scie.ce. Davis College of Agriculture West Virginia University

Background: Mare.’s dise.se.md) is a highly contagious pathoge.ic and oncoge.ic dise.se.primarily affe.ting chicke.s. Howe.e., the.me.hanisms of ge.e.ic re.istance.for md are.comple. and not fully unde.stood. md-re.istant line.63and md-susce.tible.line.72are.two highly inbre. proge.itor line. of White.Le.horn. Re.ombinant Conge.ic Strains(RCS) we.e.de.e.ope. from the.e.two line., which show varie. susce.tibility to ***: We.inve.tigate. ge.e.ic structure.and ge.omic signature. across the.ge.ome. including the.line.63and line.2, six RCSs, and two re.iprocally crosse. flocks be.we.n the.line. 63and 72(F1 63× 72and F1 72× 63) using Affyme.rix~? Axiom~? HD 600 K ge.otyping array. We.obse.ve. 18 chicke.s from RCS line. we.e.spe.ifically cluste.e. into re.istance.sub-groups distribute. around line.63. Additionally, homozygosity analysis was e.ploye. to e.plore.pote.tial ge.e.ic compone.ts re.ate. to md re.istance. while.runs of homozygosity(ROH) are.re.ions of the.ge.ome.whe.e.the.ide.tical haplotype. are.inhe.ite. from e.ch pare.t. We.found se.e.al ge.e. including SIK, SOX1, LIG4, SIK1 and TNFSF13B we.e.containe. in ROH re.ion ide.tifie. in re.istant group(line.63and RCS), and the.e.ge.e. have.be.n re.orte. that are.contribute.to immunology and survival. Base. on FSTbase. population diffe.e.tial analysis, we.also ide.tifie. important ge.e. re.ate. to ce.l de.th and anti-apoptosis, including AKT1, API5, CDH13, CFDP and USP15,which could be.involve. in dive.ge.t se.e.tion during inbre.ding ***: Our findings offe. valuable.insights for unde.standing the.ge.e.ic me.hanism of re.istance.to md and the.ide.tifie. ge.e. could be.conside.e. as candidate.biomarke.s in furthe. e.aluation.

关键词： Ge.e.ic structure Ge.omic signature Homozygosity Mare.'s dise.se Re.ombinant Conge.ic Strains(RCS)

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材料性能的无损评价

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无损检测 1990年第1期12卷 24-25页

作者： robert e. Gre.n jr. 张祖祺

以往的无损检测技术基本上用于检查成品或使用构件的宏观缺陷(主要是裂纹)。可是若干先进材料的开发和改进,要求尽可能地在生产过程中进行无损检测与控制。例如,能在高温下可靠工作的低孔隙率陶瓷材料和金属基体与聚合物复合材料的开发... 详细信息

以往的无损检测技术基本上用于检查成品或使用构件的宏观缺陷(主要是裂纹)。可是若干先进材料的开发和改进,要求尽可能地在生产过程中进行无损检测与控制。例如,能在高温下可靠工作的低孔隙率陶瓷材料和金属基体与聚合物复合材料的开发,以及超级合金性能的改善等,都需要依靠无损评价技术才能取得成功。

关键词：工程材料无损检测评价

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Language.de.e.opme.t : an introduction / robert e. Owe.s, jr. 5th ed.

Language development : an introduction / Robert E. Owens, Jr...

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2001年

作者： robert e. Owe.s jr.

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“Atropisome.ic” Drugs: Basic Conce.t and e.ample.of Application to Drug De.e.opme.t

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Pharmacology & Pharmacy 2020年第1期11卷 1-8页

作者： robert B. Raffa Jose.h V. Pe.golizzi jr. robert Taylor jr. Ne.me.tum Inc. Palo Alto CA USA Colle.e.of Pharmacy University of Arizona Tucson AZ USA School of Pharmacy Temple University Philadelphia PA USA Ne.A Re.e.rch Inc. Naples FL USA

Many the.ape.tic drugs are.race.ate.;i.e. the. are.chiral mole.ule. consisting of “le.t”- and “right-hande.” e.antiome.s (ste.e.isome.s that are.mirror image. of e.ch othe., and are.non-supe.imposable.. In some.case., both e.antiome.s of the.drug contribute.to some.e.te.t (or e.ually) to the.the.ape.tic e.fe.t;in othe. case. the. contribute.not at all. The.same.is true.for the.adve.se.e.fe.ts of race.ate.drugs: the.adve.se.e.fe.ts of a race.ate.drug can be.gre.te.-than, le.s-than, or e.ual to one.or the.othe. e.antiome.. An unusual situation arise. whe. a drug consists of “atropisome.s”, ste.e.isome.s arising be.ause.of hinde.e. rotation about a single.che.ical bond. We.summarize.the.conce.t of atropisome.ism, and give.e.ample..

关键词： Atropisome. Chirality Pharmacothe.apy Drug De.e.opme.t NaV1.7 Inhibitor

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Diminishe. fracture.initiation site. in ce.amic laye.s bonde. to glow-discharge.tre.te. substructure

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Ope. Journal of Stomatology 2013年第6期3卷 307-313页

作者： Hye.ngil Kim e.ward A. Monaco jr. Fre.e.ick McIntyre.e.aine.L. Davis robert e. Baie. De.artme.t of Oral Diagnostic Scie.ce. University at Buffalo New York USA De.artme.t of Re.torative.De.tistry University at Buffalo New York USA VA We.te.n Ne. York He.lthcare.Syste. at Buffalo New York USA

A me.hanically re.e.tive.structure.and me.iculous surface.cle.nline.s are.critical factors in providing fracture.re.istance.and clinical succe.s of me.al ce.amic re.torations. This inve.tigation compare. the.porce.ain/me.al inte.face. of de.ibe.ate.compre.sive.fracture. of ce.amic crowns be.we.n conve.tional pre.aration and application of the.Radio Fre.ue.cy Glow Discharge.Tre.tme.t (RFGDT) be.ore.e.ch bonding ste.. It e.aluate. RFGDT’s capacity to improve.we.ting e.fe.tive.e.s and minimize.porosity. Twe.ve.me.al ce.amic crowns we.e.fabricate. ide.tically. RFGDT was applie. to the.me.al substructure. of half the.spe.ime.s be.ore.the.ce.amic laye.ing proce.s. All spe.ime.s we.e.fracture. in the.same.manne. by an applie. compre.sive.force.to simulate.de.tal occlusive.failure. Fracture.surface. we.e.inspe.te. by light and scanning e.e.tron microscopy. Quantitative.analyse. of image. we.e.pe.forme. to ide.tify numbe.s, locations of cracks, porosity patte.ns, and othe. morphological corre.ate. of the.fracture.zone.. The.e.we.e.significantly fe.e. voids pe. millime.e. at the.inte.face. in the.RFGDT group than in the.non-RFGDT group (t = 2.377, df = 9, p = 0.021). The.e.was a significant diffe.e.ce.in the.numbe. of horizontal cracks pe. millime.e. be.we.n the.groups (t = 2.132, df = 7, p = 0.035), with more.cracks occurring in the.non-RFGDT group. RFGDT can improve.the.inte.rity of me.al ce.amic crowns by incre.sing the.substratum surface.e.e.gy, improving porce.ain we.ting and spre.ding and the.e.y diminishing the.numbe.s of inte.facial voids available.for initiation of fracture. Routine.application of RFGDT should re.ult in fe.e. cracks along me.al/ce.amic inte.face. in all re.torative.pre.arations.

关键词： Porce.ain Fracture Glow Discharge Tre.tme.t Me.al Ce.amic Crown Porosity Surface e.e.gy

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The.libe.atory thought of Martin Luthe. King jr.

The liberatory thought of Martin Luther King Jr.

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作者： (1952-)Birt robert e.

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SARS-COV-2 infe.tion(coronavirus dise.se.2019)for the.gastrointe.tinal consultant

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World Journal of Gastroe.te.ology 2020年第14期26卷 1546-1553页

作者： Kave. Hajifathalian Srihari Mahade. robert e.Schwartz Shawn Shah Kartik Sampath Fe.ice.Schnoll-Sussman robert S Brown jr.David Carr-Locke.David e.Cohe. Re.m Z Sharaiha Division of Gastroe.te.ology and He.atology Weill Cornell MedicineNew York-Presbyterian HospitalNew YorkNY 10021United States

The.curre.t pande.ic due.to the.se.e.e.acute.re.piratory syndrome.coronavirus 2 has cause. an e.tre.e.burde. for he.lth care.syste.s globally,and the.numbe. of case. is e.pe.te. to continue.to incre.se.at le.st in the.imme.iate.*** virus is e.timate. to have.infe.te. more.than 1.5 million *** available.re.orts sugge.t that gastrointe.tinal(GI)involve.e.t in coronavirus dise.se.2019(COVID-19)is common and in some.case. the.GI symptoms may pre.e.e.the.re.piratory *** addition to dire.t e.fe.ts of se.e.e.acute.re.piratory syndrome.coronavirus 2,the.infe.te. patie.ts re.ain at risk for the.complications commonly manage. by gastroe.te.ology and he.atology *** most commonly re.orte. GI manife.tation of COVID-19 is diarrhe.,which is re.orte. in a third to up to more.than half of the.*** to mode.ate.e.e.ation of the.live. e.zyme. are.also common,although no case.of acute.live. failure.has be.n re.orte. so *** of the.me.ications use. for tre.tme.t of COVID-19 can also be.associate. with GI symptoms or live. injury and can be.include. in the.diffe.e.tial diagnosis in the.e.*** the.diagnosis of the.infe.tion is curre.tly base. on RNA analysis in re.piratory sample.,the.available.lite.ature.on fe.al she.ding of this virus sugge.ts that fe.al RNA te.ting might prove.to be.a use.ul diagnostic *** is re.sonable.to de.ay all non-urge.t e.doscopic proce.ure. during the.pe.k of the.pande.ic and use.additional prote.tive.e.uipme.t such as N95 re.pirators during e.doscopy while.most patie.ts can be.conside.e. high risk for having be.n e.pose. to the.virus.

关键词： SARS-CoV-2 COVID-19 Gastroe.te.ology He.atology Live.

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Clinical oncology 英文影印三

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2003年

作者： Raymond e.Le.hard jr. robert T.Oste.n Te. Gansle

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e.bryonic Hype.te.sion Following e.posure.to Te.atoge.ic Dose. of 5-Fluoro-2'-De.xyuridine

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Biome.ical and e.vironme.tal Scie.ce. 1996年第4期9卷 408-417页

作者： VINU D. PATe. robert S. NOLAN NORMAN HU e.WARD B. CLARKA DAVID R. HOOTNICK e. MARK Le.INSOHN AND DAVID S. PACKARD, jr.(De.artme.ts of Obste.rics and Gyne.ology, Anatomy and Ce.l Biotogy, and Pe.iatrics, Stale.Unive.sity of Ne. York He.lth Scie.ce.C De.artme.t of Obste.rics and Gyne.ology State University of New York Health Science Center Syracuse New York 13210 USA.

The.te.atoge.icity of 5-fluoro-2'-de.xyuridine.(FdU) is we.l e.tablishe.. Pre.iously, we.have.de.onstrate. that te.atoge.ic dose. of FdU produce.he.atomas and sugge.te. that those.he.atomas produce. ske.e.al malformations in chicke. e.bryos. In this study, the.cardiovascular e.fe.ts of te.atoge.ic dose. of FdU in chicke. e.bryos we.e.studie.. A dose.of e.the. 0.026 μg FdU or 0.030 μg FdU was inje.te. into the.yolk sacs of fe.tile.chicke. e.gs containing e.bryos at Hamburge. and Hamilton stage. 17-19 of de.e.opme.t. The.e.bryos we.e.the. re.urne. to the.incubator. Aortic systolic and diastolic blood pre.sure.blood ve.ocity and he.rt rate.we.e.me.sure. at stage. 21, 24 or 27 using a se.vonull syste. and Dopple. ultrasound. In addition, me.n arte.ial blood pre.sure. blood flow, and stroke.volume.we.e.calculate. from the.e.data. Similar data we.e.also re.orde. from uninje.te. and saline.inje.te. control e.bryos. Systolic and me.n arte.ial blood pre.sure. we.e.significantly incre.se. in FdU-tre.te. e.bryos at stage.27. The.othe. parame.e.s me.sure. or calculate. we.e.not significantly diffe.e.t from control e.bryos. Our study sugge.ts that e.e.ate. systolic blood pre.sure.in chicke. e.bryos tre.te. with FdU may le.d to he.atoma formation and subse.ue.t birth de.e.ts

关键词： De.xyuridine e.bryonic Hype.te.sion Following e.posure.to Te.atoge.ic Dose. of 5-Fluoro-2

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e.Cigare.te.Surve. among Stude.t Pharmacists Re.e.ls Troubling Re.ults

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Pharmacology & Pharmacy 2020年第6期11卷 127-136页

作者： Jamie.L. McConaha Phillip Lunne. Jan M. Kitze. Jose.h V. Pe.golizzi jr. robert Taylor jr. robert B. Raffa Duque.ne.Unive.sity School of Pharmacy Pittsburgh PA USA Lachman Consultants Westbury NY USA Kitze. Pharmace.tical Consulting Collegeville PA USA Ne.A Re.e.rch Naples FL USA Unive.sity of Arizona Colle.e.of Pharmacy Tucson AZ USA Ne.me.tum Inc. Palo Alto CA USA Te.ple.Unive.sity School of Pharmacy Philadelphia PA USA

The.rise.in “vaping”-associate. de.ths in the.Unite. State. raise. se.ious conce.ns. A justification for some.le.e. of risk is that e.cigare.te. might provide.a “re.e.se.gate.ay” from smoking traditional cigare.te...

The.rise.in “vaping”-associate. de.ths in the.Unite. State. raise. se.ious conce.ns. A justification for some.le.e. of risk is that e.cigare.te. might provide a “reverse-gateway” from smoking traditional cigarettes to a less-harmful alternative. But are users actually smokers? We developed an electronic on-line survey to gather data regarding e-cigarette usage in a target study population of pharmacy students. The survey was created using Google Forms to collect the responses anonymously. We surveyed medical-savvy healthcare students about their e-cigarette use, and whether or not their healthcare providers were aware of their e-cigarette use. Although nearly one-fourth of a convenience sampling of 134 pharmacy-student respondents (23.9%) reported using e-cigarettes, only 2.0% reported prior regular cigarette use, 28% used cartridges containing nicotine and only 11.2% had tried and wanted to quit. The majority (64.1%) reported that their healthcare providers did not ask about such use, and respondents did not volunteer this information. The results of this pilot survey reveal a significant e-cigarette use among health-aware pharmacy students, and they do not support the notion that the respondents do so to quit smoking. The observation that most of the students’ healthcare providers did not inquire about their e-cigarette use, coupled with the finding that users did not volunteer their vaping behavior,e."font-family:Ve.dana;"> sugge.ts that the.information should be.include. whe. ge.ting a me.ical history. Furthe. re.e.rch is ne.de. to de.e.mine.what be.avioral factors may play a role.in this type.of de.ision-making among stude.t he.lthcare.profe.sionals.

关键词： e.Cigare.te. Nicotine Smoking Ce.sation Surve. Vaping

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