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BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells

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Journal of Molecular Cell Biology 2020年第5期12卷 397-399页

作者： Jisha Antony Gregory Gimenez Terry Taylor Umaima Khatoon robert day Ian MMorison Julia AHorsfield Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9016New Zealand Maurice Wilkins Centre for Molecular Biodiscovery The University of AucklandPrivate Bag 92019AucklandNew Zealand Southern Community Laboratories Dunedin 9016New Zealand Department of Biochemistry University of OtagoDunedin 9054New Zealand

Cohesin is a multiprotein complex that not only is essential for cell division but also has key roles in genome organization that underpin its gene regulatory *** mutations of genes encoding cohesin subunits occur in myeloid malignancies at 10%–12%(Kon et al.,2013),and the frequency of cohesin mutation in Down syndrome-associated megakaryoblastic leukaemia is even higher(~50%)(Yoshida et al.,2013).Cohesin insufficiency reinforces stem cell programmes and impairs differentiation in haematopoietic stem cells(Mazumdar et al.,2015;Mullenders et al.,2015;Viny et al.,2015).The STAG2 subunit of cohesin is the most frequently mutated in myeloid malignancies(Kon et al.,2013).In contrast to other cohesin subunits,complete loss of STAG2 is tolerated due to partial compensation by ***2 and STAG1 have redundant roles in cell division(Benedetti et al.,2017;van der Lelij et al.,2017).However,cohesin-STAG1 and cohesin-STAG2 have non-redundant roles in facilitating 3D genome organization to delineate tissue-specific gene expression(Kojic et al.,2018).

关键词： function. redundant

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Eclipse开放式开发平台

今日电子 2009年第2期 47-48页

作者： robert day LynuxWorks公司

嵌入式领域一直都在致力于为软件和系统工程师提供一个通用的开放式开发界面。工具则一向与实时系统（RTOS）或处理器紧密相关，而这二者的具体特性都需要专有环境来予以支持，这一点造成了开发人员在为了满足不断变化的设计需要而更换... 详细信息

嵌入式领域一直都在致力于为软件和系统工程师提供一个通用的开放式开发界面。工具则一向与实时系统（RTOS）或处理器紧密相关，而这二者的具体特性都需要专有环境来予以支持，这一点造成了开发人员在为了满足不断变化的设计需要而更换环境时，不可避免地会遭遇陡峭的学习曲线和额外的工具开销。

关键词：开发平台 Eclipse 开放式系统工程师实时系统学习曲线嵌入式处理器

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压实粘土斜坡的坡面稳定

路基工程 1991年第2期 79-80,74页

作者： robert W.day Gregory W.Axten 李林铁二局

一、引言加利福尼亚南部的季节性降雨延续几天之后。压实粘土斜坡坡面滑坍是很普遍而且经常发生的事。图1是一种边坡滑坍事例。一般浅层滑坍在坡面以下4英尺(1.2米)左右(Evans,1972)。压实粘土斜坡坡面滑坍的主要原因通常是冬季大雨所... 详细信息

一、引言加利福尼亚南部的季节性降雨延续几天之后。压实粘土斜坡坡面滑坍是很普遍而且经常发生的事。图1是一种边坡滑坍事例。一般浅层滑坍在坡面以下4英尺(1.2米)左右(Evans,1972)。压实粘土斜坡坡面滑坍的主要原因通常是冬季大雨所致。在高温、干燥的夏季。

关键词：滑坍坡面浅层最佳含水量最大干密度尼亚密实度干缩法向应力填方边坡

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地质与勘探 2005年第2期41卷 96-96页

作者： robert W.day 史佩栋包绍华美不详

Airway management of a patient with linear immunoglobulin A bullous dermatosis:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2263-2268页

作者： Olga C Nin robert Hutnik Neil N Chheda David Hutchinson Department of Anesthesiology University of Florida College of MedicineGainesvilleFL 32610United States Department of Otolaryngology University of Florida College of MedicineGainesvilleFL 32610United States

BACKGROUND There is limited literature on managing the airway of patients with linear immunoglobulin A(IgA)bullous dermatosis,a rare mucocutaneous disorder that leads to the development of friable *** clinical decision making is necessary when there is a risk of bleeding into the airway,and a multidisciplinary team approach may lead to decreased patient morbidity during these high-risk scenarios,especially when confronted with an unusual cause for *** SUMMARY A 45-year-old African American female presented to our ambulatory surgical center for right corneal transplantation due to corneal perforation after blunt trauma in the setting of cicatricial conjunctivitis and diffuse corneal neovascularization from linear IgA bullous *** diagnosis of IgA dermatosis was recent,and the patient had been lost to *** severity of the disease and extent of airway involvement was unknown at the time of the *** airway bleeding was noticed upon intubation and the otorhinolaryngology team had to be called to the operating *** patient required transfer to the intensive care unit where a multidisciplinary team was involved in her *** patient was extubated on postoperative day *** A multidisciplinary approach to treating this disease is the best course of action before a surgical *** our case,key communication between the surgery,anesthesia,and dermatology teams led to the quick and safe treatment of our patient’s *** surgery should not be considered for these cases unless they are in full remission and there is no mucous membrane involvement.

关键词： Airway management Bleeding risk Linear immunoglobulin A bullous dermatosis Multidisciplinary approach Outpatient procedure Case report

SLC11A1 polymorphisms in inflammatory bowel disease and Mycobacterium avium subspecies paratuberculosis status

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World Journal of Gastroenterology 2010年第45期16卷 5727-5731页

作者： Lucy C Stewart Andrew S day John Pearson Murray L Barclay Richard B Gearry Rebecca L roberts robert W Bentley Department of Paediatrics University of OtagoChristchurch 8140New Zealand Department of Paediatrics Christchurch HospitalChristchurch 8140New Zealand Department of Pathology University of OtagoChristchurch 8140New Zealand Department of Medicine University of OtagoChristchurch 8140New Zealand Department of Gastroenterology Christchurch HospitalChristchurch 8140New Zealand Department of Biochemistry University of OtagoDunedin 9054New Zealand

AIM: To test for association of SLC11A1 with inflammatory bowel disease (IBD) and Mycobacterium avium subspecies paratuberculosis (MAP) status in a Caucasian cohort. METHODS: Five hundred and seven Crohn's disease (CD) patients, 474 ulcerative colitis (UC) patients, and 569 healthy controls were genotyped for SLC11A1 1730G>A and SLC11A1 469+14G>C using pre-designed TaqMan  SNP assays. χ 2 tests were applied to test for association of single nucleotide polymorphisms (SNPs) with disease, and the presence of MAP ***:SLC11A1 1730G>A and SLC11A 1469+14G>C were not associated with CD, UC, or IBD. The SLC11A1 1730A minor allele was over-represented in patients who did not require immunomodulator therapy (P = 0.002, OR: 0.29, 95% CI: 0.13-0.66). The frequency of the SLC11A1 469+14C allele was higher in the subset of study participants who tested positive for MAP DNA (P = 0.02, OR: 1.56, 95% CI: 1.06-2.29). No association of SLC11A1 1730G>A with MAP was ***: Although SLC11A1 was not associated with IBD, association with MAP suggests that SLC11A1 is important in determining susceptibility to bacteria implicated in the etiology of CD.

关键词： NRAMP1 Crohn’s disease Ulcerative colitis IS900 polymerase chain reaction

Evaluation of a Wireless Solar Powered Personal Weather Station

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Agricultural Sciences 2024年第1期15卷 36-53页

作者： robert J. Lascano Timothy S. Goebel Dennis C. Gitz III John E. Stout Cropping Systems Research Laboratory Wind Erosion and Water Conservation Research Unit USDA-ARS Lubbock TX USA

We are evaluating dryland cotton production in Martin County, Texas, measuring cotton lint yield per unit of rainfall. Our goal is to collect rainfall data per 250 - 400 ha. Upon selection of a rainfall gauge, we realized that the cost of using, for example, a tipping bucket-type rain gauge would be too expensive and thus searched for an alternative method. We selected an all-in-one commercially available weather station;hereafter, referred to as a Personal Weather Station (PWS) that is both wireless and solar powered. Our objective was to evaluate average measurements of rainfall obtained with the PWS and to compare these to measurements obtained with an automatic weather station (AWS). For this purpose, we installed four PWS deployed within 20 m of the Plant Stress and Water Conservation Meteorological Tower that was used as our AWS, located at USDA-ARS Cropping Systems Research Laboratory, Lubbock, TX. In addition, we measured and compared hourly average values of short-wave irradiance (Rg), air temperature (Tair) and relative humidity (RH), and wind speed (WS), and calculated values of dewpoint temperature (Tdew). This comparison was done over a 242-day period (1 October 2022-31 May 2023) and results indicated that there was no statistical difference in measurements of rainfall between the PWS and AWS. Hourly average values of Rg measured with the PWS and AWS agreed on clear days, but PWS measurements were higher on cloudy days. There was no statistical difference between PWS and AWS hourly average measurements of Tair, RH, and calculated Tdew. Hourly average measurements of Rg and WS were more variable. We concluded that the PWS we selected will provide adequate values of rainfall and other weather variables to meet our goal of evaluating dryland cotton lint yield per unit rainfall.

关键词： Automation Sensors Citizen Weather Station Mesonet Rainfall Weather Variables

Characterizing motor impulsivity of individuals classified as overweight to obese

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Sports Medicine and Health Science 2023年第4期5卷 314-318页

作者： Kyle D.Flack robert E.Anderson III Kylie F.McFee Bridgette T.day Department of Dietetics and Human Nutrition College of AgricultureUniversity of KentuckyLexingtonKYUSA

Deficits in the impulse control system are an important predictor of energy intake and body *** classified as overweight to obese may possess these deficits as a general behavioral trait or they may be food*** present study assessed motor impulsivity(ability to suppress a pre-potent response)when presented with food and neutral(non-food)cues,testing if deficits in motor impulsivity is specific to food cues or a general trait among participants classified as overweight to *** proportion of inhibitory failures to no-go targets following food cues(10.8%)was significantly greater than the proportion of inhibitory failures to no-go targets following neutral cues(1.9%,p<0.001).These differences remained when covering for sex and *** indicates deficits in food-specific impulse control(as opposed to general impulse control)are present in those classified as overweight to *** the specific aspect of impulse control that is present in this population is needed for the development of future impulse control training interventions that seek to change eating behaviors as a means for weight control.

关键词： Impulsivity Inhibitory control Impulse control Response inhibition Food cues Obesity Go/NoGo task

A proto-monsoonal climate in the late Eocene of Southeast Asia:Evidence from a sedimentary record in central Myanmar

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Geoscience Frontiers 2023年第1期14卷 46-63页

作者： Huasheng Huang robert J.Morley Alexis Licht Guillaume Dupont-Nivet Daniel Pérez-Pinedo Jan Westerweel Zaw Win day Wa Aung Eko Budi Lelono Galina N.Aleksandrova Ramesh K.Saxena Carina Hoorn Institute for Biodiversity and Ecosystem Dynamics(IBED) University of Amsterdam1090 GE AmsterdamThe Netherlands Palynova Ltd. 1 Mow Fen RoadLittleportCambridgeshire CB61PYUK Department of Earth Sciences Royal HollowayUniversity of LondonEghamSurrey TW200EXUK Centre de Recherche et d'Enseignement de Géosciences de I'Environnement(CEREGE) Aix-en-ProvenceFrance Institut fur Geowissenschaften Universität Potsdam14476 PotsdamGermany Géosciences Rennes CNRS and Universitéde Rennes 135042 Rennes CedexFrance Geology Department Shwe Bo UniversitySagaing RegionMyanmar Department of Geology University of YangonPyay RoadYangonMyanmar Badan Geologi Jl.Soekarno Hatta No 444BandungBandung 40254Indonesia Geological Institute Russian Academy of SciencesPyzhevsky Pereulok 7119017 MoscowRussia Birbal Sahni Institute of Palaeosciences 53 University RoadLucknow 226007India Department of Earth Sciences University of FlorenceVia G.La Pira 450121 Florenceltaly Department of Earth Sciences Memorial University of New-foundlandSt.John'sNewfoundland A1B 3X5Canada

The Burma Terrane has yielded some of the earliest pieces of evidence for monsoonal rainfall in the Bay of ***,Burmese ecosystems and their potential monsoonal imprint remain poorly *** study focuses on the late Eocene Yaw Formation(23°N)in central Myanmar,which was located near the equator(c.5°N)during the *** quantitatively assessed the past vegetation,climate,and depositional environments with sporomorph diagrams,bioclimatic analysis,and sequence *** calculated the palynological diversity and drew inferences with rarefaction analysis by comparing with four other middle to late Eocene tropical *** results highlight a high floristic diversity for the palynoflora throughout the section formed by six pollen zones characterized by different *** indicate that lowland evergreen forests and swamps dominated in the Eocene Burmese deltaic plains while terra firma areas were occupied by seasonal evergreen,seasonally dry,and deciduous *** vegetation pattern is typical to what is found around the Bay of Bengal today and supports a monsoon-like climate at the time of the Yaw *** analysis further suggests that in the late Eocene,the Yaw Formation was more seasonal,drier,and cooler compared to modern-day climate at similar near-equatorial *** seasonal and drier conditions can be explained by a well-marked seasonal migration of the Intertropical Convergence Zone(ITCZ),driver of proto-monsoonal *** temperatures in the late Eocene of central Myanmar may be due to the lack of adequate modern analogues for the Eocene monsoonal climate,while those found at other three Eocene Asian paleobotanical sites(India and South China)may be caused by the effect of canopy evapotranspirational *** data suggest that paleoenvironmental change including two transgressive-regressive depositional sequences is controlled by global sea level change,which may be driven by cl

关键词： Bioclimatic analysis Diversity Monsoon Palynology Sequence biostratigraphy Southeast Asia