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In-depth examination of hyperproliferative healing in two breeds of Sus scrofa domesticus commonly used for research

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Animal Models and Experimental Medicine 2021年第4期4卷 406-417页

作者： Colton H.Funkhouser Liam d.Kirkpatrick robert d.smith Lauren T.Moffatt Jeffrey W.Shupp Bonnie C.Carney Firefighters'Burn and Surgical Research Laboratory MedStar Health Research InstituteWashingtonDistrict of ColumbiaUSA department of Biochemistry and Molecular and Cellular Biology Georgetown University Medical CenterWashingtonDistrict of ColumbiaUSA department of Surgery Georgetown University School of MedicineWashingtonDistrict of ColumbiaUSA The Burn Center Department of SurgeryMedStar Washington Hospital CenterWashingtonDistrict of ColumbiaUSA

Background:Wound healing can result in various outcomes,including hypertrophic scar(HTS).Pigs serve as models to study wound healing as their skin shares physi-ologic similarity with ***(Yk)and duroc(dc)pigs have been used to mimic normal and abnormal wound healing,*** reason behind this differential healing phenotype was explored ***:Excisional wounds were made on dc and Yk pigs and were sampled and imaged for 98 *** arrays were used to determine differential gene *** Scar Scale(VSS)scores were ***-epithelialization was analyzed.H&E,Mason's trichrome,and immunostains were used to determine cellularity,col-lagen content,and blood vessel density,***:Yk wounds heal to a“port wine”HTS,resembling scarring in Fitzpatrick skin types(FST)*** wounds heal to a dyspigmented,non-pliable HTS,resembling scarring in FST *** expression during wound healing was differentially regulated versus uninjured skin in 40/80 genes,15 of which differed between *** scars had a higher VSS score at all time *** and dc wounds had equivalent re-epithelialization,collagen disorganization,and blood vessel ***:Our findings demonstrate that dc and Yk pigs can produce *** creation and healing were consistent among breeds,and differences in gene expression were not sufficient to explain differences in resulting scar *** pig breeds should be used in animal models to investigate novel therapeutics to provide insight into a treatment's effectiveness on various skin types.

关键词： animal models burns Fitzpatrick skin type hypertrophic scar wound healing

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Genotypic diversity of a dominant C_(4) grass across a long-term fire frequency gradient

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Journal of Plant Ecology 2013年第6期6卷 448-458页

作者： Cynthia C.Chang Melinda d.smith department of Ecology and Evolutionary Biology Yale UniversityNew HavenCT 06511USA department of Biology University of WashingtonSeattleWA 98195USA department of Biology Colorado State UniversityFort CollinsCO 80523USA

Aims and Methods diversity-disturbance research has focused on community diversity,but disturbance frequency could impact diversity within species as well,with important consequences for community diversity and ecosystem *** examined patterns of genetic diversity of a dominant grass species,Andropogon gerardii,in native North American tallgrass prairie sites located in eastern Kansas that have been subjected to a gradient of fire frequency treatments(burned every 1,2,4 or 20 years)since the *** addition,we were able to assess the relationships between genetic diversity of ***,species diversity and productivity across this range of fire *** Findings We found no significant relationships between genetic diversity of *** at the local scale(1 m^(2) plot level)and disturbance frequency(burned 2 to 32 times over a 38-year period).However,at the site level(*** all plots sampled within a site,~100 m^(2))there were differences in genotype richness and composition,as well as genomic dissimilarity among individuals of *** richness was greatest for the site burned at an intermediate(4-year)frequency and lowest for the infrequently(20-year)burned *** addition,genotypes found in the frequently burned sites were more similar from each other than expected by random chance than those found in the infrequently burned *** composition of *** was not significantly different between the frequently burned sites(annual vs.2 year)but did differ between frequently burned and infrequently burned sites(1 and 2 year vs.4 and 20 year,etc.).Together,these results suggest site-level ecological sorting of genotypes in intact prairie across a broad gradient of disturbance frequencies,likely driven by alterations in environmental *** fire promotes the abundance of dominant grass species,reduces plant community diversity and impacts ecosystem processes such as *** study suggests that

关键词： Andropogon gerardii disturbance frequency genetic relatedness genetic-species diversity relationship genotype richness intermediate disturbance hypothesis productivity tallgrass prairie

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The genetic framework for development of nephrolithiasis

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Asian Journal of Urology 2017年第1期4卷 18-26页

作者： Vinaya Vasudevan Patrick Samson Arthur d.smith Zeph Okeke smith Institute for Urology Hofstra Northwell School of MedicineLake SuccessNYUSA

Over 1%-15% of the population worldwide is affected by nephrolithiasis,which remains the most common and costly disease that urologists manage *** of atrisk individuals remains a theoretical and technological *** search for monogenic causes of stone disease has been largely unfruitful and a technological challenge;however,several candidate genes have been implicated in the development of *** this review,we will review current data on the genetic inheritance of stone disease,as well as investigate the evolving role of genetic analysis and counseling in the management of nephrolithiasis.

关键词： Genetics Hypercalciuria Nephrolithiasis Urolithiasis Calcium sensing receptor Cystinuria Medullary sponge kidney Autosomal dominant polcystic kidney disease Uric acid nephrolithiasis Hypercalciuria

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新型镍基高温合金在模拟燃煤锅炉环境中的腐蚀

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金属学报 2004年第6期40卷 659-663页

作者：赵双群谢锡善 Gaylord d.smith 北京科技大学高温合金研究室 Special Metals Corporation HuntingtonWV 25705USA

在人工合成的煤灰/烟气环境中研究了一种新型镍基高温合金550℃和700℃的腐蚀行为和腐蚀机理.结果表明,合金在550℃发生了不均匀的点蚀,表面形成了一层很薄的Cr_2O_3膜,腐蚀按照硫化机制发展.合金在700℃腐蚀时,初期发生了氧化和硫化腐... 详细信息

在人工合成的煤灰/烟气环境中研究了一种新型镍基高温合金550℃和700℃的腐蚀行为和腐蚀机理.结果表明,合金在550℃发生了不均匀的点蚀,表面形成了一层很薄的Cr_2O_3膜,腐蚀按照硫化机制发展.合金在700℃腐蚀时,初期发生了氧化和硫化腐蚀,表面生成了保护性的氧化膜,并有内硫化物析出.由于合金表面生成CoO并在表面形成熔融态硫酸盐而逐渐进入加速腐蚀阶段,使合金遭受严重的低温热腐蚀.腐蚀产物外层为疏松的混合尖晶石化合物,内层为致密的氧化物层,在腐蚀层、腐蚀层与基体界面和Cr元素贫化区内分布着硫化物.合金耐腐蚀性能的迅速退化是合金表面Co及其氧化物在混合熔盐中的溶解所致.

关键词：镍基高温合金煤灰/烟气低温热腐蚀腐蚀机制

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.smith Jessica L.Williams department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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The effects of hazardous working conditions on burnout in Macao nurses

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International Journal of Nursing Sciences 2015年第1期2卷 86-92页

作者： Sydney X.Hu Andrew L.Luk Graeme d.smith The Kiang Wu Nursing College of Macao Macao SARPR China Nethersole Institute of Continuing Holistic Health Education Hong KongChina School of Nursing Midwifery&Social CareEdinburgh Napier UniversityUK

Objective:To examine the effects of various hazardous factors in working environments on burnout in a cohort of clinical nurses in ***:A cross-sectional survey was used to examine specific workplace hazards for burnout in qualified nurses(n=424)in *** equation modeling(SEM)was used to analyze relationships between specific hazards and manifestations of ***:In the final model,workplace hazards accounted for 73%of the variance of burnout with a standardized regression weight of *** measures of the model fit were *** hazards,threats of violence,and physical environmental hazards were found to significantly contribute to two major determinants of burnout,emotional exhaustion and ***:Workplace environmental hazards increased the risk of burnout amongst clinical nurses in *** management of these factors may help to protect nursing staff and reduce the risk of burnout and attrition from the nursing profession.

关键词： Nurses Hazardous work environments Burnout Stress

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Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.smith Liwen Zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George d.Bittner department of Molecular Biosciences University of Texas at AustinAustinTXUSA department of Neuroscience University of Texas at AustinAustinTXUSA division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

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Analysis of hourly generation patterns at large coal-fired units and implications of transitioning from baseload to load-following electricity supplier

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Journal of Modern Power Systems and Clean Energy 2019年第3期7卷 468-474页

作者： robert Kennedy smith U.S. department of Energy Office of Fossil Energy

Several factors have led to the decline of electricity generation from coal over the past decade, and projections forecast high rates of growth for wind and solar technologies in coming years. This analysis uses hourly generation data from large coal-fired power stations to determine how operations have been modified in recent years and describes the implications of these changes for plant equipment and unit reliability. The data shows increasing variability in intraday generation output that affects nearly all of the units in the sample, but the magnitude of increase varies widely among plants. Outage patterns were examined as was the relationship between renewable energy growth in a region and the changes in coal plant operations. Aggregate direct and indirect costs associated with running coal plants as load-following units have not yet been quantified in large-scale studies on a sector-wide basis, largely due to differences in how specific equipment responds to output fluctuations. due to findings from the hourly generation data analysis and the high degree of potential impact on coal plant equipment, the study suggests the development of a new modeling tool that will represent the costs of running coal-fired power plants at lower capacity factors.

关键词： Coal generation Emission intensity Baseload power Capacity factor

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Role of granulocyte macrophage colony stimulating factor in regeneration of the central nervous system

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Neural Regeneration Research 2016年第6期11卷 902-903页

作者： Ushananthini Shanmugalingam Nafisa M.Jadavji Patrice d.smith department of Neuroscience Carleton University

Traditionally,it has been thought that the mammalian central nervous system（CNS）does not *** due to the inhibitory extracellular environment post-injury as well as the limited intrinsic characteristics of adult post... 详细信息

关键词： granulocyte macrophage colony regeneration stimulating intrinsic Figure neuronal subunit glial

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高强耐蚀Ni-Co-Cr高温合金的组织稳定性

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金属学报 2002年第5期38卷 490-494页

作者：刘仲青董建新张麦仓赵双群谢锡善 Gaylord d.smith 北京科技大学材料科学与工程学院北京100083 Special

利用SEM,TEM及X射线衍射分析技术观察了高强耐蚀Ni-Co-Cr高温合金不同温度(704,750,849℃)长期时效1000 h及700℃长期时效至5008 h过程中的组织演变过程,结果表明,700℃即使长期时效5008 h,γ'相粗化缓慢, 而且没有发现TCP相(如σ相)的... 详细信息

利用SEM,TEM及X射线衍射分析技术观察了高强耐蚀Ni-Co-Cr高温合金不同温度(704,750,849℃)长期时效1000 h及700℃长期时效至5008 h过程中的组织演变过程,结果表明,700℃即使长期时效5008 h,γ'相粗化缓慢, 而且没有发现TCP相(如σ相)的析出,当温度升高到750℃,γ'相迅速长大,晶界上碳化物析出增多,并析出片状的η相,导致合金冲击性能下降,温度达到849℃时,析出大量的η相,甚至形成魏氏组织形貌,由此可见,该合金在700℃时具有较好的组织稳定性。

关键词：耐蚀高温合金组织稳定性 Ni基高温合金析出相镍基

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