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Impact of a physician-supervised exercise-nutrition program with testosterone substitution in partial androgen-deficient middle-aged obese men

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Journal of Geriatric Cardiology 2011年第4期8卷 201-206页

作者： Ernst R Schwarz robert d Willix Jr Cenegenics Education and Research Foundation Las Vegas and Heart Institute of Southern CaliforniaBeverly Hills348 S Oakhurst DrBeverly HillsCA 90212USA

Background Partial androgen deficiency syndrome in the aging male is associated with signs of aging such as a development of abdominal obesity,sexual dysfunction,increase body fat,weight gain and the development of cardiac *** We assessed the outcome of a commercially available physician supervised nutrition and exercise program with concomitant testosterone replacement therapy in middle age obese men with partial androgen deficiency in order to reduce cardiac risks *** Fifty-six self referred men without diabetes mellitus,hypertension,or cardiovascular disease(ages 52.3±7.8 years)were randomly selected from a large *** weight,body fat composition,fasting glucose,hemoglobin A1c and fasting lipid levels,as well as free and total testosterone levels were *** patients were assessed and followed 6–18 months after initiation of the *** program consisted of a low glycemic load balanced nutrition diet,a recommended structured daily exercise program of 30–60 minutes,as well as once to twice weekly intramuscular testosterone injections(113.0±27.8 mg).Results At follow up,weight was reduced from 233.9±30.0 pounds(lbs)to 221.3±25.1 lbs(Pduced from 33.2±3.3 kg/m2 to 31.3±2.8 kg/m^(2)(Pdy fat was 27.1%±5.2%vs.34.3%±5.7%at baseline(Pduced from 95.3±14.4 mg/dL to 87.5±12.6 mg/dL(Pduced from 195.4±33.0 mg/dL to 172.7±35.0 mg/dL(Pdverse events were *** Testosterone replacement therapy in middle aged obese men with partial androgen deficiency appeared safe and might have promoted the effects of a weight reduction diet and daily exercise program as long as an adequate physician supervision and follow up was *** combination therapy significantly reduced coronary risk factors such as glucose intolerance and hyperlipidemia.

关键词： aging heart disease androgen deficiency testosterone

Rapid micro-immunohistochemistry

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Microsystems & Nanoengineering 2020年第1期6卷 285-294页

作者： robert d.Lovchik david Taylor Govind Kaigala IBM Research Europe Saeumerstrasse 48803 RueschlikonSwitzerland Present address:Eidgenossische Technische Hochschule Zurich Department of Mechanical and Process EngineeringSonneggstrasse 38092 ZurichSwitzerland

We present a new and versatile implementation of rapid and localized immunohistochemical staining of tissue ***(IHC)comprises a sequence of specific biochemical reactions and allows the detection of specific proteins in tissue *** the rapid implementation of IHC,we fabricated horizontally oriented microfluidic probes(MFPs)with functionally designed apertures to enable square and circular footprints,which we employ to locally expose a tissue to time-optimized sequences of different *** show that the two main incubation steps of IHC protocols can be performed on MdAMB468-1510A cell block sections in less than 30 min,compared to incubation times of an hour or more in standard *** analysis on the timescale of tens of minutes could potentially be applied during surgery,enabling clinicians to react in more dynamically and ***,this rapid IHC implementation along with conservative tissue usage has strong potential for the implementation of multiplexed assays,allowing the exploration of optimal assay conditions with a small amount of tissue to ensure high-quality staining results for the remainder of the sample.

关键词： versatile steps sections

Viscoelastic Immersed Boundary Methods for Zero Reynolds Number Flow

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Communications in Computational Physics 2012年第7期12卷 462-478页

作者： Wanda Strychalski robert d.Guy department of Mathematics University of CaliforniaDavis CA 95616USA

The immersed boundary method has been extensively used to simulate the motion of elastic structures immersed in a viscous *** some applications,such as modeling biological materials,capturing internal boundary viscosity is *** present numerical methods for simulating Kelvin-Voigt and standard linear viscoelastic structures immersed in zero Reynolds number *** find that the explicit time immersed boundary update is unconditionally unstable above a critical boundary to fluid viscosity ratio for a Kelvin-Voigt *** also show there is a severe time step restriction when simulating a standard linear boundary with a small relaxation time scale using the same explicit update.A stable implicit method is presented to overcome these computation challenges.

关键词： Stokes flow viscoelastic structures fluid-structure interaction numerical instability

A Multigrid Method for a Model of the Implicit Immersed Boundary Equations

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Communications in Computational Physics 2012年第7期12卷 378-400页

作者： robert d.Guy Bobby Philip department of Mathematics University of California DavisDavisCA 95616USA Oak Ridge National Laboratory Oak RidgeTN 37831USA

Explicit time stepping schemes for the immersed boundary method require very small time steps in order to maintain *** the equations that arise from an implicit discretization is ***,several different approaches have been proposed,but a complete understanding of this problem is still emerging.A multigrid method is developed and explored for solving the equations in an implicittime discretization of a model of the immersed boundary *** model problem consists of a scalar Poisson equation with conformation-dependent singular forces on an immersed *** model does not include the inertial terms or the incompressibility *** method is more efficient than an explicit method,but the efficiency gain is *** multigrid method alone may not be an effective solver,but when used as a preconditioner for Krylov methods,the speed-up over the explicit-time method is *** example,depending on the constitutive law for the boundary force,with a time step 100 times larger than the explicit method,the implicit method is about 15-100 times more efficient than the explicit method.A very attractive feature of this method is that the efficiency of the multigrid preconditioned Krylov solver is shown to be independent of the number of immersed boundary points.

关键词： Preconditioning implicit methods fluid-structure interaction

Epigenetic Repression of Male Gametophyte- Specific Genes in the Arabidopsis Sporophyte

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Molecular Plant 2013年第4期6卷 1176-1186页

作者： robert d. Hoffmann Michael G. Palmgren Centre for Membrane Pumps in Cells and disease--PUMPKIN Danish National Research Foundation Department of Plant and Environmental SciencesUniversity of Copenhagen Thorvaldsensvej 40 DK-1871 Frederiksberg Denmark

Tissue formation, the identity of cells, and the functions they fulfill, are results of gene regulation. The male gametophyte of plants, pollen, is outstanding in this respect as several hundred genes expressed in pollen are not expressed in the sporophyte. How pollen-specific genes are down-regulated in the sporophyte has yet to be established. In this study, we have performed a bioinformatics analysis of publicly available genome-wide epigenetics data of sev- eral sporophytic tissues. By combining this analysis with dNase ! footprinting data, we assessed means by which the repression of pollen-specific genes in the Arabidopsis sporophyte is conferred. Our findings show that, in seedlings, the majority of pollen-specific genes are associated with histone-3 marked by mono- or trimethylation of Lys-27 （H3K27me1/ H3K27me3）, both of which are repressive markers for gene expression in the sporophyte. Analysis of dNase footprint profiles of pollen-specific genes in the sporophyte displayed closed chromatin proximal to the start codon. We describe a model of two-staged gene regulation in which a lack of nucleosome-free regions in promoters and histone modifications in open reading frames repress pollen-specific genes in the sporophyte.

关键词： male gametophyte epigenetics gene repression dNase I footprinting transcription factors bioinformatics.

Pediatrician-friendly perspectives on cognitive behavioral therapy for anxious youth:Current status and clinical implications for the next normal

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World Journal of Clinical Pediatrics 2021年第6期10卷 112-123页

作者： robert d Friedberg Center for the Study and Treatment of Anxious Youth Palo Alto UniversitySan JoseCA 95136United States

Pediatric anxiety disorders are common and often debilitating *** is a psychosocial intervention that represents a potentially powerful antidote to these *** article reviews data from treatment outcome studies,meta-analyses,and systematic reviews as well as from moderation/mediational *** literature supports the efficacy,effectiveness,and durability of positive treatment outcomes for pediatric anxiety *** for clinical applications are suggested.

关键词： Pediatric anxiety Cognitive behavioral therapy Coping cat Exposure

Where physics meets chemistry： Thin film deposition from reactive plasmas

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Frontiers of Chemical Science and Engineering 2016年第4期10卷 441-458页

作者： Andrew Michelmore Jason d. Whittle James W. Bradley robert d. Short School of Engineering University of South Australia Mawson Lakes Australia SA 5095 Future Industries Institute University of South Australia Mawson Lakes Australia SA 5095 department of Electrical Engineering and Electronics University of Liverpool Liverpool L69 3GJ UK Material Science Institute Lancaster University Lancaster LA1 4YW UK

Functionalising surfaces using polymeric thin films is an industrially important field. One technique for achieving nanoscale, controlled surface functionalization is plasma deposition. Plasma deposition has advantages over other surface engineering processes, including that it is solvent free, substrate and geometry independent, and the surface properties of the film can be designed by judicious choice of precursor and plasma conditions. despite the utility of this method, the mechanisms of plasma polymer growth are generally unknown, and are usually described by chemical （i.e., radical） pathways. In this review, we aim to show that plasma physics drives the chemistry of the plasma phase, and surface-plasma interactions. For example, we show that ionic species can react in the plasma to form larger ions, and also arrive at surfaces with energies greater than 1000 kJ·mol^-1 （〉10 eV） and thus facilitate surface reactions that have not been taken into account previously. Thus, improving thin film deposition processes requires an understanding of both physical and chemical processes in plasma.

关键词： thin films plasma physics plasma chemistry,functionalization polymer

Fractal and Multifractal Propertiesof the Spatial distribution of Natural Fractures——Analyses and Applications

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Acta Geologica Sinica(English Edition) 1999年第4期73卷 477-487页

作者： XU Jiandong QU Guosheng robert d. JACOBI Institute of Geology China Seismological Bureau Beijing 100029 PRC department of Geology State University of New York at Buffalo USA

The Cantor's dust theory is applied to investigate the scaling properites of the spatial distribution of natural fractures obtained from detailed scanline surveys of 27 field sites in the Appalachian Plateau of western New York, USA. The results obtained in this study indicate: 1) fracture spacing is characterized by fractal and multifractal properties. On small scales analyses yield an average fractal dimension of 0.15, which suggests a very high degree of clustering. In contrast, on large scales, fractures tend to be more regular and evenly distributed with an average fracture dimension of 0.52; 2) fractal dimension varies with different sets in different orientations, which can be attributed to interactions between pre-existing fractures and younger ones, as well as variations of the intensity of the stresses under which the fractures were formed; 3) a time sequence of fracture set formation can be proposed based on fractal and multifractal analyses, which consists of (from old to young): N-S, NW, ENE, and NE-striking sets. This time sequence is confirmed by the study of the abutting relationships of different fracture sets observed in the field.

关键词： fractal multifractal fracture

Projection Preconditioner for Solving the Implicit Immersed Boundary Equations

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Numerical Mathematics(Theory,Methods and Applications) 2014年第4期7卷 473-498页

作者： Qinghai Zhang robert d.Guy Bobby Philip department of Mathematics University of UtahSalt Lake CityUT 84112USA department ofMathematics University of California DavisDavisCA 95616USA Oak Ridge National Laboratory Oak RidgeTN 37831USA

This paper presents a method for solving the linear semi-implicit immersed boundary equations which avoids the severe time step restriction presented by explicit-time *** Lagrangian variables are eliminated via a Schur complement to form a purely Eulerian saddle point system,which is preconditioned by a projection operator and then solved by a Krylov subspace *** the viewpoint of projection methods,we derive an ideal preconditioner for the saddle point problem and compare the efficiency of a number of simpler preconditioners that approximate this perfect *** low Reynolds number and high stiffness,one particular projection preconditioner yields an efficiency improvement of the explicit IB method by a factor around *** speed-ups over explicit-time method are achieved for Reynolds number below *** speedup increases as the Eulerian grid size and/or the Reynolds number are further reduced.

关键词： Fluid-structure interaction immersed boundary method projection method preconditioning