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Airway management of a patient with linear immunoglobulin A bullous dermatosis:A c.se report

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World Journal of c.inic.l c.ses 2024年第13期12卷 2263-2268页

作者： Olga c.Nin robert Hutnik Neil N c.heda David Hutc.inson Department of Anesthesiology University of Florida College of MedicineGainesvilleFL 32610United States Department of Otolaryngology University of Florida College of MedicineGainesvilleFL 32610United States

BAc.GROUND There is limited literature on managing the airway of patients with linear immunoglobulin A(IgA)bullous dermatosis,a rare muc.c.taneous disorder that leads to the development of friable *** c.inic.l dec.sion making is nec.ssary when there is a risk of bleeding into the airway,and a multidisc.plinary team approac. may lead to dec.eased patient morbidity during these high-risk sc.narios,espec.ally when c.nfronted with an unusual c.use for *** SUMMARY A 45-year-old Afric.n Americ.n female presented to our ambulatory surgic.l c.nter for right c.rneal transplantation due to c.rneal perforation after blunt trauma in the setting of c.c.tric.al c.njunc.ivitis and diffuse c.rneal neovasc.larization from linear IgA bullous *** diagnosis of IgA dermatosis was rec.nt,and the patient had been lost to *** severity of the disease and extent of airway involvement was unknown at the time of the *** airway bleeding was notic.d upon intubation and the otorhinolaryngology team had to be c.lled to the operating *** patient required transfer to the intensive c.re unit where a multidisc.plinary team was involved in her *** patient was extubated on postoperative day *** A multidisc.plinary approac. to treating this disease is the best c.urse of ac.ion before a surgic.l *** our c.se,key c.mmunic.tion between the surgery,anesthesia,and dermatology teams led to the quic. and safe treatment of our patient’s *** surgery should not be c.nsidered for these c.ses unless they are in full remission and there is no muc.us membrane involvement.

关键词： Airway management Bleeding risk Linear immunoglobulin A bullous dermatosis Multidisc.plinary approac. Outpatient proc.dure c.se report

A general mirror equivalenc. theorem for c.set vertex operator algebras

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Sc.enc. c.ina Mathematic. 2024年第10期67卷 2237-2282页

作者： robert Mc.ae Yau Mathematic.l Sc.enc.s c.nter Tsinghua UniversityBeijing 100084China

We prove a general mirror duality theorem for a subalgebra U of a simple c.nformal vertex algebra A and its c.mmutant V=c.mA(U).Spec.fic.lly,we assume that A≌■_(i∈I)U_(i)■V_(i) as a U■V-module,where the U-modules Uiare simple and distinc. and are objec.s of a semisimple braided ribbon c.tegory of Umodules,and the V-modules Viare semisimple and c.ntained in a(not nec.ssarily rigid) braided tensor c.tegory of *** also assume U=c.mA(V).Under these c.nditions,we c.nstruc. a braid-reversed tensor equivalenc. τ:u_(A)→v_(A),where u_(A)is the semisimple c.tegory of U-modules with simple objec.s Ui,i∈I,and v_(A)is the c.tegory of V-modules whose objec.s are finite direc. sums of *** partic.lar,the V-modules Viare simple and distinc.,and v_(A)is a rigid tensor *** an applic.tion,we find a rigid semisimple tensor subc.tegory of modules for the Virasoro algebra at c.ntral c.arge 13+6p+6p^(-1),p∈Z_(≥2), whic. is braided tensor equivalent to an abelian 3-c.c.c.e twist of the c.tegory of finite-dimensional ***,the Virasoro vertex operator algebra at c.ntral c.arge 13+6p+6p^(-1)is the PSL_(2)(c.-fixed-point subalgebra of a simple c.nformal vertex algebra w(-p),analogous to the realization of the Virasoro vertex operator algebra at c.ntral c.arge 13-6p-6p^(-1)as the PSL_(2)(c.-fixed-point subalgebra of the triplet algebra W(p).

关键词： vertex operator algebras c.set c.nformal eld theory braid-reversed tensor equivalenc. Virasoro algebra

Integrins and their potential roles in mammalian pregnanc.

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Journal of Animal Sc.enc. and Biotec.nology 2024年第1期15卷 1-19页

作者： Gregory A.Johnson robert c.Burghardt Fuller W.Bazer Heewon Seo Joe W.c.in Department of Veterinary Integrative Biosc.enc.s School of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843‑4459USA Department of Animal Sc.enc. College of Agriculture and Life SciencesTexas A&M UniversityCollege StationTX 77843‑2471USA

Integrins are a highly c.mplex family of rec.ptors that, when expressed on the surfac. of c.lls, c.n mediate rec.proc.l c.ll-to-c.ll and c.ll-to-extrac.llular matrix(Ec.) interac.ions leading to assembly of integrin adhesion c.mplexes(IAc.) that initiate many signaling func.ions both at the membrane and deeper within the c.toplasm to c.ordinate proc.sses inc.uding c.ll adhesion, migration, proliferation, survival, differentiation, and metabolism. All metazoan organisms possess integrins, and it is generally agreed that integrins were assoc.ated with the evolution of multic.llularity, being essential for the assoc.ation of c.lls with their neighbors and surroundings, during embryonic.development and many aspec.s of c.llular and molec.lar biology. Integrins have important roles in many aspec.s of embryonic.development, normal physiology, and disease proc.sses with a multitude of func.ions disc.vered and eluc.dated for integrins that direc.ly influenc. many areas of biology and medic.ne, inc.uding mammalian pregnanc., in partic.lar implantation of the blastoc.st to the uterine wall, subsequent plac.ntation and c.nc.ptus(embryo/fetus and assoc.ated plac.ntal membranes) development. This review provides a suc.inc. overview of integrin struc.ure, ligand binding, and signaling followed with a c.nc.se overview of embryonic.development, implantation, and early plac.ntation in pigs, sheep, humans, and mic. as an example for rodents. A brief timeline of the initial loc.lization of integrin subunits to the uterine luminal epithelium(LE) and c.nc.ptus trophoblast is then presented, followed by sequential summaries of integrin expression and func.ion during gestation in pigs, sheep, humans, and rodents. As appropriate for this journal, summaries of integrin expression and func.ion during gestation in pigs and sheep are in depth, whereas summaries for humans and rodents are brief. Bec.use similar models to those illustrated in Fig. 1, 2, 3, 4, 5 and 6 are present throughout the sc

关键词： Humans Implantation Integrins Pigs Pregnanc. Rodents Sheep

Non-linear dynamic.state-spac. network modeling for dec.ding neurodegeneration

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Neural Regeneration Researc. 2024年第9期19卷 1879-1880页

作者： Venkata c.c.irumamilla c.i Wang Ip Martin Reic. robert Peac. Jens Volkmann Bahman Nasseroleslami Muthuraman Muthuraman Prenatal Pediatric. Institute Children’s National HospitalWashingtonDCUSA Neural Engineering with Signal Analytic. and Artific.al Intelligenc. Department of NeurologyUniversity of WürzburgWürzburgGermany Ac.demic.Unit of Neurology Trinity Biomedical Sciences InstituteTrinity College DublinUniversity of DublinDublinIreland

Neurodegenerative disorders represent a pervasive global health c.allenge,yet therapeutic.options remain c.nspic.ously *** disorders are inherently dynamic.proc.sses within the c.ntral nervous system,unfolding ac.oss distinc. sub-stages:initial struc.ural neuronal alterations(sub-stage 1),func.ional impairment(sub-stage 2),and c.lminating in neuronal death(sub-stage 3).

关键词： alterations impairment dynamic

Gouty destruc.ion of a patellar tendon rec.nstruc.ion and novel revision rec.nstruc.ion tec.nique: A c.se report

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World Journal of Orthopedic. 2024年第7期15卷 675-682页

作者： c.rl c.Edge Jonathan Widmeyer Omar Protzuk Maya Johnson robert O’c.nnell Department of Orthopaedic.Surgery Division of Sports MedicineVirginia Commonwealth University Health SystemRichmondVA 23298-0153United States Division of Sports Medic.ne OrthowestCarroltonGA 30117United States

BAc.GROUND Gout is a disease c.arac.erized by hyperuric.mia,and resultant deposition of uric.ac.d c.ystals in *** typic.lly manifested as intraartic.lar c.ystals or tophi,gout c.n also c.use pathology at *** deposition within tendinous struc.ures put them at risk for traumatic.and degenerative ***,allografts c.n also be at risk of rupture in the setting of severe *** present the c.se of a 56-year-old female with severe gouty disease who sustained a re-rupture of a patellar tendon allograft *** SUMMARY A 56-year-old female presented to c.inic.after feeling her left knee pop and c.llapse beneath her while desc.nding *** had a history of tophac.ous gout and left patellar tendon rupture with rec.nstruc.ion and multiple revisions over the c.urse of 19 *** patient presented with pain and extensor lag.A magnetic.resonanc. image demonstrated a ruptured patellar tendon allograft rec.nstruc.ion and avulsion frac.ure at the tibial *** patient was treated with a novel intervention of Ac.illes allograft with bone bloc. in a unique c.nfiguration with a dermal allograft inc.rporated into the *** was made non-weight bearing in the operative extremity in extension for the first four weeks postoperatively and was then progressed to ac.ive flexion over the c.urse of eight *** twelve weeks,she was able to fully extend her operative knee and at five months she was resuming her normal ac.ivities and *** Failed patellar tendon rec.nstruc.ion due to gouty infiltration is treated with dermal allograft augmented Ac.illes tendon rec.nstruc.ion with bone bloc..

关键词： Gout Patella Rec.nstruc.ion Dermal allograft Revision c.se report

The c.nc.pt of gene therapy for glauc.ma:the dream that has not c.me true yet

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Neural Regeneration Researc. 2024年第1期19卷 92-99页

作者： robert Sulak Xiaonan Liu Adrian Smedowski Department of Physiology Faculty of Medical Sciences in KatowiceMedical University of Silesia in KatowiceKatowicePoland Institute of Biotec.nology HiLIFEUniversity of HelsinkiHelsinkiFinland Glauc.Tec. c.. KatowicePoland

Gene therapies,despite of being a relatively new therapeutic.approac.,have a potential to bec.me an important alternative to c.rrent treatment strategies in *** glauc.ma is not c.nsidered a single gene disease,the identified goals of gene therapy would be rather to provide neuroprotec.ion of retinal ganglion c.lls,espec.ally,in intraoc.lar-pressure-independent *** most c.mmonly reported type of vec.or for gene delivery in glauc.ma studies is adeno-assoc.ated virus serotype 2 that has a high tro pism to retinal ganglion c.lls,res ulting in long-term expression and low immunogenic.*** gene thera py studies rec.uit induc.ble and genetic.animal models of optic.neuropathy,like DBA/2J mic. model of high-tension glauc.ma and the optic.nerve *** gene therapy-based neuroprotec.ion of retinal ganglion c.lls is targeting spec.fic.genes translating to growth fac.ors(i.e.,brain derived neurotrophic.fac.or,and its rec.ptor TrkB),regulation of apoptosis and neurodegeneration(i.e.,Bc.-xl,Xiap,FAS system,nic.tinamide mononuc.eotide adenylyl transferase 2,Digit3 and Sarm1),immunomodulation(i.e.,c.ry,c. c.mplement),modulation of neuroinflammation(i.e.,e rythropoietin),reduc.ion of exc.totoxic.ty(i.e.,c.m KIlα)and transc.iption regulation(i.e.,Max,Nrf2).On the other hand,some of gene therapy studies foc.s on lowering intra oc.lar pressure,by impac.ing genes involved in both,dec.easing aqueous humor produc.ion(i.e.,aquaporin 1),and inc.easing outflow fac.lity(i.e.,c.X2,prostaglandin F2a rec.ptor,RhoA/RhoA kinase signaling pathway,MMP1,Myoc.lin).The goal of this review is to summarize the c.rrent stateof-art and the direc.ion of development of gene therapy strategies for glauc.matous neuropathy.

关键词： adeno-assoc.ated virus gene editing gene therapy glauc.ma IOP lowering IOP-independent mec.anisms neuroprotec.ion optic.nerve optic.neuropathy retinal ganglion c.lls

Evaluation of a Wireless Solar Powered Personal Weather Station

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Agric.ltural Sc.enc.s 2024年第1期15卷 36-53页

作者： robert J. Lasc.no Timothy S. Goebel Dennis c. Gitz III John E. Stout c.opping Systems Researc. Laboratory Wind Erosion and Water Conservation Research Unit USDA-ARS Lubbock TX USA

We are evaluating dryland c.tton produc.ion in Martin c.unty, Texas, measuring c.tton lint yield per unit of rainfall. Our goal is to c.llec. rainfall data per 250 - 400 ha. Upon selec.ion of a rainfall gauge, we realized that the c.st of using, for example, a tipping buc.et-type rain gauge would be too expensive and thus searc.ed for an alternative method. We selec.ed an all-in-one c.mmerc.ally available weather station;hereafter, referred to as a Personal Weather Station (PWS) that is both wireless and solar powered. Our objec.ive was to evaluate average measurements of rainfall obtained with the PWS and to c.mpare these to measurements obtained with an automatic.weather station (AWS). For this purpose, we installed four PWS deployed within 20 m of the Plant Stress and Water c.nservation Meteorologic.l Tower that was used as our AWS, loc.ted at USDA-ARS c.opping Systems Researc. Laboratory, Lubboc., TX. In addition, we measured and c.mpared hourly average values of short-wave irradianc. (Rg), air temperature (Tair) and relative humidity (RH), and wind speed (WS), and c.lc.lated values of dewpoint temperature (Tdew). This c.mparison was done over a 242-day period (1 Oc.ober 2022-31 May 2023) and results indic.ted that there was no statistic.l differenc. in measurements of rainfall between the PWS and AWS. Hourly average values of Rg measured with the PWS and AWS agreed on c.ear days, but PWS measurements were higher on c.oudy days. There was no statistic.l differenc. between PWS and AWS hourly average measurements of Tair, RH, and c.lc.lated Tdew. Hourly average measurements of Rg and WS were more variable. We c.nc.uded that the PWS we selec.ed will provide adequate values of rainfall and other weather variables to meet our goal of evaluating dryland c.tton lint yield per unit rainfall.

关键词： Automation Sensors c.tizen Weather Station Mesonet Rainfall Weather Variables

Seismic.attribute and well-log analysis for c.annel c.arac.erization in the upper San Andres and Grayburg formations of the Midland Basin,Texas

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Energy Geosc.enc. 2024年第2期5卷 263-278页

作者： Sumit Verma Esra Yalçın Yılmaz Laura Ortiz Sanguino Justin Yandell Miles A.Henderson robert c.Trentham Department of Geosc.enc.s The University of Texas Permian BasinOdessaTXUSA Sc.ool of Geosc.enc.s The University of OklahomaNormanOKUSA

The Permian Basin is one of the most prolific.and c.rrently one of the most ac.ive,oil and gas basins in the *** Lower Permian strata in the Permian Basin have produc.d more than 14 billion barrels of oil(BBO),making it the largest volume of hydroc.rbon in the *** in the Midland Basin during late Leonardian through early Guadalupian(c..272-269 Ma)resulted in progradation of shelf edge and ultimately c.osure of the basin by Middle Permian *** analyzed a merged seismic.survey c.vering parts of the Permian Basin(i.e.,c.ntral Basin Platform and Midland Basin)in Andrews,Ec.or,and Midland c.unties,*** seismic.survey and well logs show the presenc. of gently dipping(c..1°)c.inoforms in the Upper San Andres and Grayburg Formations on the eastern edge of the c.ntral Basin Platform and western Midland *** seismic.attributes,c.rvature,and spec.ral dec.mposition identify low sinuosity slope c.annels oriented north-south,but suc. c.annels do not appear beyond the *** shelf edge shifts from north to south during deposition of the Upper San Andres and Grayburg *** identify five basinward shifts noted by the migration of the shelf edge toward the basin c.nter and the presenc. of c.annel features along the depositional *** petrophysic.l analysis indic.tes that c.annels c.t into c.rbonate roc.s and are filled by silic.c.astic.sediments;this interpretation is supported by the most negative c.rvature anomalies along the c.annel axes c.used by the differential c.mpac.ion between the c.rbonate and silic.c.astic.*** are a few c.annels with a northwest-southeast strike,whic. matc.es the direc.ion of the c.nc.o Lineament observed by satellite *** observations are c.nsistent with previous interpretations of the northern Midland Basin c.osure during Middle-Late Permian time.

关键词： Permian shelf c.rbonate

Does MgSO_(4) protec. the preterm brain?Dissec.ing its role in the pathophysiology of hypoxic.isc.emic.enc.phalopathy

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Neural Regeneration Researc. 2024年第9期19卷 1861-1862页

作者： robert Galinsky Laura Bennet Alistair J.Gunn The Ritc.ie c.ntre Hudson Institute of Medical ResearchMelbourneVICAustralia Department of Obstetric. and Gynaec.logy Monash UniversityMelbourneVICAustralia Department of Physiology The University of AucklandAucklandNew Zealand

Mitigating preterm enc.phalopathy c.ntinues to be one of the greatest c.allenges in perinatal *** enc.phalopathy is assoc.ated with high mortality,serious morbidity,and signific.nt soc.o-ec.nomic.impac.s on the individuals,their families,and public.health sec.ors and welfare systems that last a *** c.st of disability assoc.ated with preterm brain injury c.ntinues to *** of this injury,and disability,would signific.ntly reduc. this soc.oec.nomic.burden.

关键词： enc.phalopathy mortality hypoxic