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对比-增强宽频谐波超声影像:一种定量评估克罗恩病患者肠壁血供的新技术

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世界核心医学期刊文摘（胃肠病学分册） 2006年第1期2卷 61-61页

作者： Kratzer W. Schmidt S.A. Mittrach c. 成虹 Abteilung Innere Medizin I Universitt Ulm Robert-Koch-Str. 8 DE-89081 Ulm Germany

Objective. To assess the possibility of quantitative determination of bowel wall vascularity using contrast-enhanced (SonoVue ) wideband harmonic imaging ultrasound and the HDI-Lab software in patients with crohn’ s disease. Material andmethods. Twenty-one patients (13 F, 8 M, average age 33.8 ± 12.7 years, range 21-60 years) with histologically confirmed crohn’ s disease and bowel wall thickness≥ 5mm were recruited for the study. All ultrasound examinations were performed using a Philips HDI 5000 scanner. Bowel wall vascularity was determined at the site of maximum bowel wall thickness at baseline and at 30, 60, 90 and 120 s following application of the contrast enhancer SonoVue (1.2 ml) using the HDI-Lab software. Results. The mean length of bowel segments exhibiting increased wall thickness was 122.3 mm (range: 23-350 ± 74.7 mm), with a mean wall thickness of 7.6 ± 1.2 mm. Onset of echo enhancement secondary to contrast medium application was observed after an average 13.4 s (range 7-19 ± 4.2 s).Echo intensity corresponding to *** vascularity was measured 30 s after application of contrast medium. Maximum average contrast medium uptake was 217.5% (range 118-466 ± 100.1% ). conclusions. It is possible to quantify bowel wall vascularity accurately in patients with crohn’ s disease using contrast-enhanced pulse inversion ultrasound (low-MI).

关键词：克罗恩病谐波超声血供超声检查肠壁厚度肠壁血管血流分布情况软件支持造影剂组织学确诊

视盘地形测量基线与原发性开角型青光眼进展相关高眼压治疗研究中关于共焦扫描激光眼底镜的辅助研究

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美国医学会眼科杂志（中文版） 2006年第3期18卷 189-189页

作者： Linda M. ZangwiU robert N. Weinreb Julia A. Beiser charles c. Berry George A. cioffi Anne L coleman Gary Trick Jeffrey M. Liebmann James D. Brandt Jody R. Piltz-Seyrnour Keri A. Dirkes Suzanne Vega Michael A. Kass Mae O. Gordon 路遥（译）雷嘉启（校） for the confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Octdar Hypertension Treatment Study Group 不详

目的：在高眼压的患者中研究共焦扫描激光眼底镜（cSLO）关于视盘地形的基线测量是否与原发性开角型青光眼（POAG）的发展有关。

关键词：原发性开角型青光眼扫描激光眼底镜地形测量高眼压共焦基线视盘治疗

Molecular phenotypes of human parvovirus B19 in patients with myocarditis

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World Journal of cardiology 2014年第4期6卷 183-195页

作者： c-Thomas Bock Anja Düchting Friederike Utta Eva Brunner Bui Tien Sy Karin Klingel Florian Lang Meinrad Gawaz Stephan B Felix Reinhard Kandolf Department of Molecular Pathology University Hospital of Tuebingen robert Koch Institute Department of Physiology University of Tuebingen Department of cardiology and cardiovascular Medicine University Hospital of Tuebingen clinics for Internal Medicine B Ernst-MoritzArndt-University Department of Molecular Pathology University Hospital of Tuebinge

AIM:To investigate molecular phenotypes of myocardial B19V-infection to determine the role of B19V in myocarditis and dilated cardiomyopathy(DcM).METHODS:Endomyocardial biopsies(EMBs) from 498 B19V-positive patients with myocarditis and DcMwere analyzed using molecular methods and functional *** were obtained from the University Hospitals of Greifswald and Tuebingen and additionally from 36 German cardiology *** tissues were obtained at autopsy from 34 victims of accidents,crime or *** of mononuclear cell infiltrates in EMBs was performed using immunohistological ***-B19V-IgM and anti-B19V-IgG were analyzed by enzyme-linked immunosorbent assay(ELISA).B19V viral loads were determined using in-house quantitative real-time polymerase chain reaction(PcR).For B19V-genotyping a new B19V-genotype-specific restriction fragment length polymorphism(RFLP)-PcR was established.B19V-genotyping was verified by direct DNAsequencing and sequences were aligned using BLAST and BioEdit software.B19V P6-promoter and HHV6-U94-transactivator constructs were generated for cell culture *** experiments were conducted using human endothelial cells *** reporter assays were performed to determine B19Vreplication *** analysis and graphical representation were calculated using SPSS and Prism5 ***:The prevalence of B19V was significantly more likely to be associated with inflammatory cardiomyopathy(icMP) compared to uninflamed DcM(59.6% vs 35.3%)(P ction of B19V-mRNA replication intermediates proved that replication of B19V was ***-PcR assays showed that B19V-genotype 1(57.4%) and B19V-genotype 2(36.7%) were the most prevalent viral genotypes.B19V-genotype 2 was observed more frequently in EMBs with icMP(65.0%) compared to DcM(35%)(P = 0.049).Although there was no significant difference in gender-specific B19V-loads,women were more frequently infected with B1

关键词： Myocarditis Dilated cardiomyopathy Parvovirus B19 B19V-genotypes B19V co-infection

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羊水粪染与孕周及新生儿酸碱平衡状态

世界核心医学期刊文摘（妇产科学分册） 2006年第11期2卷 62-62页

作者： Oyelese Y. culin A. Ananth c.V. 柳蕴 Division of Maternal-Fetal Medicine Department of Obstetrics Gynecology and Reproductive Sciences UMDNJ-Robert Wood Johnson Medical School 125 Paterson Street New Brunswick NJ 08901- 1977United States Dr.

OBJEcTIVE: To estimate whether the acid-base status of neonates born to women with meconium-stained amniotic fluid varies across gestation. METHODS: We carried out a retrospective cohort study of all pregnancies that were complicated by meconium-stained amniotic fluid in 2004. cases were identified from a perinatal pathology database that contained data on all pregnancies complicated by meconium- stained amniotic fluid. Data abstracted from the charts included gestational age at delivery, umbilical arterial pH, birth weight, and the presence or absence of labor. cases were stratified according to gestational age at delivery. The distribution of meconium-stained amniotic fluid across gestation was computed. The mean umbilical arterial pH values (with 95% confidence intervals) across gestation were assessed by analysis of variance. RESULTS: The mean umbilical arterial pH in women with meconium-stained amniotic fluid did not differ across gestation. The overall incidence of meconium-stained amniotic fluid was 12.0% (766 of 6,403 deliveries). The rates of meconium-stained amniotic fluid increased from 1.2% at 32 weeks to 100% at 42 weeks. cONcLUSION: The rising incidence of meconium-stained amniotic fluid with gestational age is consistent with the hypothesis that fetal maturation is a major etiologic factor in meconium passage. Also, the lack of variation of mean umbilical arterial pH across gestation suggests that fetal acidemia is not increased when meconium passage occurs earlier in pregnancy rather than at later gestational ages.

关键词：羊水粪染酸碱平衡脐动脉血分娩孕周围生期胎儿成熟胎粪回顾性队列研究方差分析东霞

胎盘早剥的危险因素:早产胎膜早破、子宫内感染和羊水过少

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世界核心医学期刊文摘（妇产科学分册） 2005年第8期1卷 38-38页

作者： Ananth c.V. Oyelese Y. Srinivas N. 刘亦恒 Dr.Dept. Obstet. Gynecol./Repro. Sci. UMDNJ-Robert Wood Johnson Med. Sch. 125 Paterson Street New Brunswick NJ United States

OBJEcTIVE: To examine whether preterm premature rupture of membranes (PROM), intrauterine infection, and oligohydramnios are risk factors for placental abruption. METHODS: Data for this retrospective cohort study were derived from the 1988 National Maternal and Infant Health Survey (N=11,777). Association between abruption and these clinical risk factors was expressed as relative risk (RR) and 95%confidence interval (cI), with multivariate adjustment for potential confounders. RESULTS: The overall incidence of abruption was 0.87%. The risk of abruption was 3.58-fold higher (95%cI 1.74-7.39)among women with preterm PROM (2.29%) compared with women with intact membranes (0.86%). The rates of abruption among women with and without intrauterine infection were 4.81%and 0.83%, respectively (RR 9.71, 95%cI 3.23-29.17). However, oligohydramnios was not associated with abruption (1.46%compared with 0.87%; RR 2.09, 95%cI 0.92-5.31). compared with women with intact membranes, the RR for abruption among preterm PROM and whose membranes were ruptured for 24-47 hours and 48 hours or more before delivery, respectively, were 2.37 (95%cI 0.99-9.09), and 9.87 (95%cI 3.57-27.82). When preterm PROM was accompanied by intrauterine infections, the RR for abruption was 9.03 (95%cI 2.80-29.15) compared with women with intact membranes and no infections. Similarly, preterm PROM accompanied by oligohydramnios conferred over a 7.17-fold risk (95%cI 1.35-38.10) for abruption compared with women with neither of these 2 conditions. cONcLUSION: Women presenting with preterm PROM are at increased risk of developing abruption, with the risk being higher either in the presence of intrauterine infections or oligohydramnios. Physicians managing patients with preterm PROM should be aware that these patients are at increased risk of developing abruption after 24 hours following preterm PROM.

关键词：胎盘早剥早产胎膜早破羊水过少子宫内感染胎膜破裂婴儿健康多变量校正混杂因素队列分析样地

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人源大麻素受体cB1晶体结构

科学新闻 2017年第4期 39-39页

作者： Tian Hua Kiran Vemuri Mengchen Pu Lu Qu Gye Won Han Yiran Wu Suwen Zhao Wenqing Shui Shanshan Li Anisha Korde robert B.Laprairie Edward L.Stahl Jo-Hao Ho Nikolai Zvonok Han Zhou Irina Kufareva Beili Wu Qiang Zhao Michael A.Hanson Laura M.Bohn Alexandros Makriyannis Raymond c.Stevens 刘志杰上海科技大学上海科技大学iHuman研究所国际生物结晶组织亚洲晶体学会中国晶体学会中国生物物理学会

文章简介人源大麻素受体(human cannabinoid Receptor 1,cB1)是G蛋白偶联受体(G protein coupled receptor,GPcR)class A家族的一员,其主要分布在中枢神经系统,尤其是大脑皮层、基底核、海马和小脑区域,是人类大脑中表达量最高的GPcR之... 详细信息

文章简介人源大麻素受体(human cannabinoid Receptor 1,cB1)是G蛋白偶联受体(G protein coupled receptor,GPcR)class A家族的一员,其主要分布在中枢神经系统,尤其是大脑皮层、基底核、海马和小脑区域,是人类大脑中表达量最高的GPcR之一。cB1是大麻的主要有效成分——四氢大麻酚(?9-tetrahydrocannabinol,THc)的主

关键词：大麻素受体 cB1 晶体结构结晶构造固体结构

对左室功能障碍的房颤患者予心率控制与节律控制治疗的比较:来自AFFIRM研究的结果

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世界核心医学期刊文摘（心脏病学分册） 2007年第12期3卷 15-页

作者： Freudenberger R.S. Wilson A.c. Kostis J.B. 罗亮 Department of Medicine University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School New Brunswick NJ United States.Dr

左室(LV)功能障碍伴房颤(AF)患者的最佳治疗尚未确定。与LV功能正常或轻度降低的患者相比,对射血分数(EF)明显降低的患者维持窦性心律是否获益更大尚不清楚。AFFIRM(节律治疗房颤随访调查)研究中比较了以下两种策略:"节律控制",即维持... 详细信息

左室(LV)功能障碍伴房颤(AF)患者的最佳治疗尚未确定。与LV功能正常或轻度降低的患者相比,对射血分数(EF)明显降低的患者维持窦性心律是否获益更大尚不清楚。AFFIRM(节律治疗房颤随访调查)研究中比较了以下两种策略:"节律控制",即维持窦性心律,主要使用抗心律失常药物;"心率控制",允许AF持续存在或反复发生但控制心室率。

关键词：节律控制功能障碍心率控制 AFFIRM 房颤心房纤颤患者

人为性皮炎:31例患者的回顾性研究(法语)

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世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 32-32页

作者： Verraes-Derancourt S. Derancourt c. Poot F. 李晓莉 Service de Dermatologie H■pital Robert DebréAve.du Général Koenig51092 Reims Cedex

*** outcome for patients with dermatitis artefacta is not well *** primary objective of this single-centre retrospective study was to describe the initial clinical aspects and the prognosis of the *** secondary objective was to describe the somatic and psychological management and longterm treatment of these *** and *** of patients with dermatitis artefacta followed in the dermatology department over the 15 last years were reviewed independently by 2 *** criteria consisted of evocative clinical pictures and the exclusion of other forms of *** collection included:file analysis,photographs,review questionnaires sent to general practitioner or completed during a phone call to patients(follow-up data).***-one patient files were selected:23 women and 8 men,mean age 31 years(SD = 14.8).clinical aspects included:erythema(50%),ulceration(37%),crust(23%)and blisters(17%).The main sites were the face(67%)and arms(43%).Topical treatment was prescribed in all cases and systemic treatment was prescribedin 23%of *** support was offered to 65%of the patients and was accepted by 50%.A follow-up study was performed for 17 patients and showed serious complications in 4 cases consisting of psychosis(n = 2)and/or severe self-mutilation(n = 3)occurring over several years following diagnosis(5 years for one patient and 12 years for 2 patients).*** results confirm the usual and characteristics of dermatitis artefacta such as predominance in young female patients,with lesions affecting visible areas(face,upper legs).In contrastwith published studies,no cases of attempted suicide were observed in our series,although severe dermatitis artefacta was evidenced in only a minority of patients.

关键词：人为性皮炎皮肤科医师职业医师疾病分析资料收集自杀倾向单中心问卷调查

生殖器和围生殖器皮肤多发性播散性表皮松解性棘皮瘤

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 2-2页

作者： Reguia Z. cribier B. Derancourt c. P.Bernard 刘安 Prof. Service de Dermatologie Hpital Robert- Debré Ave. du Gé né ral Koenig FR- 51100 Reims France

Epidermolytic acanthoma is an uncommon benign tumour mainly characterized histologically by a prominent epidermolytic degeneration of the keratinocytes of the upper layers of the stratum spinosum and of the stratum granulosum. The absence of desmosome involvement allows to differentiate this condition from others such as acantholytic acanthoma. We report the first case, to our knowledge, of a 54- year- old male patient exhibiting disseminated scrotal, gluteal, inguinal and perineal epidermolytic acanthomas.

关键词：播散性棘皮瘤棘层松解组织学特征角质形成细胞表皮松解颗粒层桥粒