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a.zheimer's disea.e a.d low-dose ra.ia.ion thera.y:a.new hope

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Ra.ia.ion Medicine a.d Protection 2024年第1期5卷 1-6页

作者： Nea. e.Dunla. robert P.Friedla.d Lu Ca. Depa.tment of Ra.ia.ion Oncology University of Louisville School of MedicineLouisvilleKY40202USA Depa.tment of Neurology The University of Louisville School of MedicineLouisvilleKY40202USA Pedia.ric Resea.ch Institute Departments of PediatricsPharmacology and ToxicologyUniversity of Louisville School of MedicineLouisvilleKY40202USA

The concept of low-dose ra.ia.ion(LDR)-induced hormetic responses wa. initia.ly observed a.proxima.ely 70 yea.s a.o a.d systema.ica.ly reviewed a.ong with the discovery of LDR-induced a.a.tive responses in a.cytogenetic in vitro study in *** the end of the 1990s,discussions rega.ding the potentia. a.plica.ions of LDRinduced hormesis a.d a.a.tive responses for preventing or trea.ing chronic disea.es,such a. a.zheimer’s disea.e(a.)ha. ta.en *** 2016,reports on ra.iothera.y for the subjects with a. a.d for genetic a. model mice were ***,severa. preclinica. studies with a.ima. models of a. a.d clinica. studies in a. subjects were conducted.a.significa.t milestone wa. a.hieved with the online a.a.la.ility of a.new Systema.ic Review ba.ed on qua.ified publica.ions from these preclinica. a.d clinica. *** mini-review provides a.concise historica. introduction to LDR-induced hormesis a.d a.a.tive responses with discussion of a. ra.iothera.y with either LDR or rela.ively high dose *** of this Systema.ic Review cover promising outcomes,cha.lenges,a.d new questions,followed by discussion of potentia. mecha.isms.

关键词： a.zheimer’s disea.e Low-dose ra.ia.ion Ra.ia.ion a.a.tive response Ra.ia.ion hormesis

Predicting the coefficient of friction in a.sliding conta.t by a.plying ma.hine lea.ning to a.oustic emission da.a

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Friction 2024年第6期12卷 1299-1321页

作者： robert GUTIeRReZ Tia.shi Fa.G robert Ma.NWa.ING Tom ReDDYHOFF Tribology Group Department of Mechanical EngineeringImperial College LondonExhibition RoadLondon SW72AZUK Shell Globa. Solutions(US)Inc.Shell Technology Center Houston 3333 Highway 6 SouthHoustonTX 77082USA Shell Interna.iona. Petroleum Compa.y Limited Shell CentreYork RoadLondon SE17NAUK

It is increa.ingly importa.t to monitor sliding interfa.es within ma.hines,since this is where both energy is lost,a.d fa.lures *** emission(a.)techniques offer a.wa. to monitor conta.ts remotely without requiring tra.spa.ent or electrica.ly conductive ***,a.oustic da.a.from sliding conta.ts is notoriously complex a.d difficult to ***,we simulta.eously mea.ure coefficient of friction(with a.conventiona. force tra.sducer)a.d a.oustic emission(with a.piezoelectric sensor a.d high a.quisition ra.e digitizer)produced by a.steel‒steel rubbing *** da.a.is then used to tra.n ma.hine lea.ning(ML)a.gorithms(e.g.,Ga.ssia. process regression(GPR)a.d support vector ma.hine(SVM))to correla.ed a.oustic emission with *** tra.ning requires the dense a. da.a.to first be reduced in size a.d a.ra.ge of processing techniques a.e a.sessed for this(e.g.,down-sa.pling,a.era.ing,fa.t Fourier tra.sforms(FFTs),histogra.s).Next,fresh,unseen a. da.a.is given to the tra.ned model a.d the resulting friction predictions a.e compa.ed with the directly mea.ured *** is excellent a.reement between the mea.ured a.d predicted friction when the GPR model is used on a. histogra. da.a.with root mea. squa.e(RMS)errors a. low a. 0.03 a.d Pea.son correla.ion coefficients rea.hing ***,predictions rema.n a.cura.e despite cha.ges in test conditions such a. norma. loa.,reciproca.ing frequency,a.d stroke *** pa.es the wa. for remote,a.oustic mea.urements of friction in ina.cessible loca.ions within ma.hinery to increa.e mecha.ica. efficiency a.d a.oid costly fa.lure/needless ma.ntena.ce.

关键词： a.oustic emission condition monitoring friction ma.hine lea.ning Ga.ssia. process regression support vector ma.hine

The concept of gene thera.y for gla.coma.the drea. tha. ha. not come true yet

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Neura. Regenera.ion Resea.ch 2024年第1期19卷 92-99页

作者： robert Sula. Xia.na. Liu a.ria. Smedowski Depa.tment of Physiology Faculty of Medical Sciences in KatowiceMedical University of Silesia in KatowiceKatowicePoland Institute of Biotechnology HiLIFEUniversity of HelsinkiHelsinkiFinland Gla.coTech Co. KatowicePoland

Gene thera.ies,despite of being a.rela.ively new thera.eutic a.proa.h,ha.e a.potentia. to become a. importa.t a.terna.ive to current trea.ment stra.egies in *** gla.coma.is not considered a.single gene disea.e,the identified goa.s of gene thera.y would be ra.her to provide neuroprotection of retina. ga.glion cells,especia.ly,in intra.cula.-pressure-independent *** most commonly reported type of vector for gene delivery in gla.coma.studies is a.eno-a.socia.ed virus serotype 2 tha. ha. a.high tro pism to retina. ga.glion cells,res ulting in long-term expression a.d low immunogenic *** gene thera.py studies recruit inducible a.d genetic a.ima. models of optic neuropa.hy,like DBa.2J mice model of high-tension gla.coma.a.d the optic nerve *** gene thera.y-ba.ed neuroprotection of retina. ga.glion cells is ta.geting specific genes tra.sla.ing to growth fa.tors(i.e.,bra.n derived neurotrophic fa.tor,a.d its receptor TrkB),regula.ion of a.optosis a.d neurodegenera.ion(i.e.,Bcl-xl,Xia.,Fa. system,nicotina.ide mononucleotide a.enylyl tra.sfera.e 2,Digit3 a.d Sa.m1),immunomodula.ion(i.e.,Crry,C3 complement),modula.ion of neuroinfla.ma.ion(i.e.,e rythropoietin),reduction of excitotoxicity(i.e.,Com KIlα)a.d tra.scription regula.ion(i.e.,Ma.,Nrf2).On the other ha.d,some of gene thera.y studies focus on lowering intra.ocula. pressure,by impa.ting genes involved in both,decrea.ing a.ueous humor production(i.e.,a.ua.orin 1),a.d increa.ing outflow fa.ility(i.e.,COX2,prosta.la.din F2a.receptor,Rhoa.Rhoa.kina.e signa.ing pa.hwa.,MMP1,Myocilin).The goa. of this review is to summa.ize the current sta.eof-a.t a.d the direction of development of gene thera.y stra.egies for gla.coma.ous neuropa.hy.

关键词： a.eno-a.socia.ed virus gene editing gene thera.y gla.coma IOP lowering IOP-independent mecha.isms neuroprotection optic nerve optic neuropa.hy retina. ga.glion cells

Commenta.y on “Why people should run a.ter positive a.fective experiences instea. of hea.th benefits”

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Journa. of Sport a.d Hea.th Science 2024年第4期13卷 451-452页

作者： Ting Wa.g Jinghua.Chen robert Schinke Liye Zou Body-Bra.n-Mind La.ora.ory School of PsychologyShenzhen UniversityShenzhen 518060China School of Kinesiology a.d Hea.th Sciences Laurentian UniversitySudburyON P3E 2C6Canada

Ma.ta.lia.i et a..1 recently highlighted the vita. role of a.fective experiences in promoting physica. a.tivity(Pa..The a.thors suggested tha. positive a.fective experiences,ra.her tha. hea.th benefits,ca. tip the ba.a.ce in fa.or of Pa.over sedenta.y *** a.thors proposed a.new forma. decision model between Pa.a.d sedenta.y a.terna.ives a.d reported tha. when hea.th benefits a.e the unique rea.on to a.tion,the costs of Pa.e.g.,effort)a.d the subjective va.ue(SV)of sedenta.y a.terna.ives(V_(sed))a.e the ma.n drivers of decision-ma.ing processes.

关键词： benefits forma. decision

Public hea.th importa.ce of light intensity physica. a.tivity

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Journa. of Sport a.d Hea.th Science 2024年第5期13卷 674-675页

作者： robert Ross Ia. Ja.ssen Ma.k S.Trembla. School of Kinesiology a.d Hea.th Studies Queen’s UniversityKingstonON K7L 3N6Canada School of Medicine Division of Endocrinology and MetabolismQueen’s UniversityKingstonON K7L 3N6Canada Hea.thy a.tive Living a.d Obesity Resea.ch Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada Depa.tment of Pedia.rics University of OttawaOttawaON K1H 8L1Canada

*** intensity physica. a.tivity(Pa.benefits hea.th Pa.guidelines worldwide recommend tha. a.ults a.cumula.e 150 min of modera.e intensity or 75 min of vigorous intensity Pa.modera.e-to-vigorous Pa.MVPa.)weekly to a.hieve hea.th benefits.1-3 a.sent from these guidelines a.e recommenda.ions for light intensity Pa.LPa.e.g.,wa.king a. a.leisurely pa.e of 3 km/h or less,equiva.ent to 1.5-2.9 meta.olic equiva.ents).

关键词： intensity light benefits

NeuroPNM:Model reduction of pore network models using neura. networks

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Pa.ticuology 2024年第3期86卷 239-251页

作者： robert Jendersie a.i Mja.led Xia.g Lu Luca. Reineking a.dolreza.Kha.a.ha.i Ma.tin Monnigma.n Christia. Lessig Otto-von-Guericke-Universita. Ma.deburg Universitatsplatz 2Magdeburg39106Germany Ruhr-Universita.-Bochum Universitatstraβe 150Bochum44801Germany

Rea.ting pa.ticle systems pla. a. importa.t role in ma.y industria. a.plica.ions,for exa.ple bioma.s drying or the ma.ufa.turing of *** numerica. modeling a.d simula.ion of such systems is therefore of grea. importa.ce for a. efficient,relia.le,a.d environmenta.ly susta.na.le opera.ion of the *** complex thermodyna.ica.,chemica.,a.d flow processes tha. ta.e pla.e in the pa.ticles a.e a.pa.ticula. cha.lenge in a.***,typica.ly a.la.ge number of pa.ticles is involved,rendering a. explicit trea.ment of individua. ones impossible in a.rea.tor-level *** a.proa.h for overcoming this cha.lenge is to compute effective,physica. pa.a.eters from single-pa.ticle,high-resolution *** ca. be combined with model reduction methods if the dyna.ica. beha.iour of pa.ticles must be *** network models with their unriva.ed resolution ha.e thereby been used successfully a. high-resolution models,for insta.ce to obta.n the ma.roscopic diffusion coeffcient of *** pa.a.eter identifica.ion a.d model reduction ha.e recently ga.ned new impetus by the dra.a.ic progress ma.e in ma.hine lea.ning in the la.t *** report results on the use of neura. networks for pa.a.eter identifica.ion a.d model reduction ba.ed on three-dimensiona. pore network models(PNM).We believe tha. our results provide a.powerful complement to existing methodologies for rea.tor-level simula.ions with ma.y therma.ly-thick pa.ticles.

关键词： Porenetwork models Neura. networks Pa.a.eter estima.ion Reduced order model

effects of soil meta.(loid)s pollution on microbia. a.tivities a.d environmenta. risks in a. a.a.doned chemica. smelting site

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Journa. of environmenta. Sciences 2024年第9期143卷 60-70页

作者： Ha. Li Jun Ya. Jia.li Liu Ning Min Geoffrey Suna.a.a.Dongya.g Men robert Dura. School of Wa.er Resources a.d environment Research Center of Environmental Science and EngineeringChina University of Geosciences(Beijing)Beijing 100083China Depa.tment of Na.ura. Resource Sciences McGill University21111Lakeshore DriveSte-Anne-de-BellevueQuebecH9X 3V9Canada equipe environnement et Microbiologie MELODY groupUniversitéde Pau et des Pays de l’AdourE2S-UPPAIPREM UMR CNRS 5254BP 115564013 Pau CedexFrance

a.a.doned chemica. smelting sites conta.ning toxic substa.ces ca. seriously threa.en a.d pose a.risk to the surrounding ecologica. *** sa.ples were collected from different depths(0 to 13 m)a.d a.a.yzed for meta.(loid)s content a.d fra.tiona.ion,a. well a. microbia. *** potentia. ecologica. risk indices for the different soil depths(ordered from high to low)were:1 m(D-1)>surfa.e(S-0)>5 m(D-5)>13 m(D-13)>9 m(D-9),ra.ging between 1840.65-13,089.62,a.d representing extremely high environmenta. risks,of which Cd(a.d proba.ly not a.senic)contributed to the highest environmenta. risk.a.modified combined pollution risk index(MCR)combining tota. content a.d mobile proportion of meta.(loid)s,a.d rela.ive toxicities,wa. used to eva.ua.e the degree of conta.ina.ion a.d potentia. environmenta. *** the nea.-surfa.e sa.ples(S-0 a.d D-1 la.ers),the MCR considered tha. a.,Cd,Pb,Sb,a.d Zn a.hieved high a.d a.a.ming degrees of conta.ina.ion,wherea. Fe,Mn,a.d Ti were negligible or low to modera.e pollution *** microca.orimetry a.d enzyma.ic a.tivity mea.urements of conta.ina.ed soil sa.ples were used to a.sess the microbia. meta.olic a.tivity *** a.a.ysis elucida.ed the rela.ionship between meta.(loid)s excha.gea.le fra.tion or content a.d microbia. a.tivity cha.a.teristics(pe microbia. meta.olic a.tivity in the D-1 la.er wa. low presuma.ly due to hea.y meta. *** a.tivity indica.ors a.d microca.orimetric growth ra.e(k)mea.urements were considered sensitive indica.ors to reflect the soil microbia. a.tivities in a.a.doned chemica. smelting sites.

关键词： a.a.doned chemica. smelting sites Microbia. a.tivities Modified combined pollution risk Microca.orimetry enzyma.ic a.tivities

Na.ura. pa.a.ites in conjunction with beha.iora. a.d color tra.ts expla.n ma.e a.onistic beha.iors in a.liza.d

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Current Zoology 2024年第1期70卷 59-69页

作者： Rodrigo Megia.Pa.ma.Dha.a.hree Pa.a.jpe robert D.Cooper Pa.line Bla.mont Ba.ry Sinervo Depa.tment of Biomedicine a.d Biotechnology Parasitology UnitUniversidad de Alcala(UAH)E-28805Alcala de HenaresSpain CIBio Centro de Investigagao em Biodiversidade e Recursos GeneticosInBIO Laboratorio AssociadoCampus de VairaoUniversidade do PortoP-4485-661 VairaoPortugal BIOPOLIS Progra. in Genomics Biodiversity and Land PlanningCIBIOCampus de VairaoP-4485-661 VairaoPortugal Rupa.Ra.ul Ba.a. Center for environment a.d a.t Empress Botanical GardensKavade MalaPuneIndia Depa.tment of ecology a.d evolutiona.y Biology University of CaliforniaLos AngelesCA 90095USA Depa.tment of Biology University of Houston Downtown1Main St.HoustonTX 77002USA Depa.tment of ecology a.d evolutiona.y Biology University of CaliforniaSanta CruzCA 95064USA

Ma.e competition conforms to a.cost-benefit model,beca.se while a.gression ma. increa.e reproductive prospects,it ca. a.so increa.e the risk of *** hypothesize tha. a. a.ditiona. cost in a.gressive ma.es would be a. increa.e in pa.a.ite loa. a.socia.ed with a.high energy investment into sexua. *** of these infections,in turn,ma. downmodula.e the level of host a.gression via.energetic *** sta.ed dya.ic ma.e contests in the la. to investiga.e the rela.ionships of multiple pa.a.ites with the a.onistic beha.ior of liza.d hosts,Sceloporus *** a.so included both color a.d beha.iora. tra.ts from opponents in the a.a.yses beca.se(1)color pa.ches of liza.ds ma. serve a. intra.pecific signa.s used by conspecifics to a.sess the qua.ity of opponents,a.d(2)contests between ma.e liza.ds fit cla.sica. models of esca.a.ed a.gression,where liza.ds increa.e a.gression displa.s in response to a. opponent's *** results conform to our hypothesis beca.se ma.e liza.ds displa.ed more pushups when they ha. more ***,some pa.a.ites ma. modula.e the levels of a.gression beca.se liza.ds infected by hema.ic coccidia.s performed fewer ***,liza.ds a.so displa.ed fewer pushups when both the chroma.a.d size of the opponent's blue pa.ch were *** results thus a.so supported the role of the blue pa.ch of *** a. a.sexua. a.ma.ent,beca.se it contributed to the deterrence of a.gression from opponent *** revea.ed tha. na.ura. pa.a.itic infections in liza.d hosts ca. contribute to their a.onistic *** encoura.e future studies to a.count for pa.a.ites in beha.iora. testswithliza.ds.

关键词： Ixodes pa.ificus La.kesterella sexua. selection socia. intera.tions ticks

The tra.scriptiona. la.dsca.e of the developmenta. switch from regula. pollen ma.ura.ion towa.ds microspore-derived pla.t regenera.ion in ba.ley

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The Crop Journa. 2024年第4期12卷 1064-1080页

作者： a.na.Nowicka.Ma.tin Kova.ik a.na.Ma.sylewicz Przemysła. Kopec ewa.Duba. Monika.Krzewska.a.nieszka.Springer robert e.Hoffie Dia.eldin S.Da.hma.Zbynek Milec a.es Pecinka.Jochen Kumlehn Iwona.Zur The Fra.ciszek Górski Institute of Pla.t Physiology Polish a.a.emy of Sciences Niezapominajek 2130-239 KrakówPoland Institute of experimenta. Bota.y of the Czech a.a.emy of Sciences Centre of Plant Structural and Functional GenomicsŠlechtitelu3177900 OlomoucCzech Republic Depa.tment of Cell Biology a.d Genetics Faculty of SciencePalacky UniversityŠlechtitelu°2777900 OlomoucCzech Republic Ma.opolska.Centre of Biotechnology Jagiellonian University30-387 KrakówPoland Leibniz Institute of Pla.t Genetics a.d Crop Pla.t Resea.ch(IPK)Ga.ersleben Corrensstraße 306466 Stadt SeelandGermany Institute for Breeding Resea.ch on Horticultura. Crops Julius Kühn Institute(JKI)-Federal Research Centre for Cultivated PlantsErwin-Baur Straße 2706484 QuedlinburgGermany Globa. Cha.ge Resea.ch Institute Czech a.a.emy of Sciences Beˇlidla 986/4a60300 BrnoCzech Republic

Pla.t forma.ion from in vitro-cultiva.ed microspores involves a.complex network of interna. a.d environmenta. ***/doubled ha.loids(DHs)derived from in vitro-cultured microspores a.e widely used in pla.t breeding a.d genetic ***,the mecha.ism underlying the developmenta. switch from regula. pollen ma.ura.ion towa.ds microspore-derived pla.t regenera.ion rema.ns poorly ***,RNa.sequencing wa. employed to elucida.e the tra.scriptiona. la.dsca.es of four ea.ly sta.es of microspore embryogenesis(Me)in ba.ley cultiva.s Golden Promise a.d Igri,which exhibit contra.ting responsiveness to microspore-derived pla.t *** experiments revea.ed funda.enta. regula.ory networks,specific groups of genes,a.d tra.scription fa.tor(TF)fa.ilies potentia.ly regula.ing the developmenta. *** identified a.set of ca.dida.e genes crucia. for genotype-dependent responsiveness/reca.citra.ce to *** high-resolution tempora. tra.scriptome a.la. provides a. importa.t resource for future functiona. studies on the genetic control of microspore developmenta. tra.sition.

关键词： Hordeum vulga.e Ma.ker gene Microspore embryogenesis Stress response Tra.scriptome a.a.ysis