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Cha.ges in Femora. Stem Geometry Reduce Intra.pera.ive Femora. Fra.ture Ra.es in Tota. Hip Repla.ement

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Open Journa. of Orthopedics 2015年第5期5卷 115-119页

作者： Ta.suya.Sueyoshi Micha.l E. Berend John B. Meding robert a. malinzak Wesley G. La.key Merrill a. Ritter Center for Hip a.d Knee Surgery Joint Replacement Surgeons of Indiana Research Foundation (JRSI) Mooresville IN USA

Intra.pera.ive fra.ture ra.es in tota. hip a.thropla.ty (THa. ha.e been a.socia.ed with uncemented stems, a.terola.era. surgica. a.proa.h, dia.noses other tha. osteoa.thritis, a.d fema.e gender. The purpose of this study wa. to investiga.e if cha.ges in stem design would influence intra.pera.ive fra.ture ra.es. 1497 THa.with Bi-Metric stems were compa.ed to 1277 THa.with Echo Bi-Metric Full Proxima. Profile stems a.d 366 THa.with Echo Bi-Metric Reduced Proxima. Profile stems. The intra.pera.ive fra.tures ra.es were 5.48%, 1.41% a.d 1.37% for Bi-Metric a.d Echo Bi-Metric with sta.da.d a.d reduced proxima. geometry stems, respectively. Stem survivorship with a.eptic loosening a. a. endpoint wa. 100% in a.l cohorts a. the fina. follow-up. We conclude tha. cha.ges in femora. stem geometry in uncemented THa.reduce intra.pera.ive fra.ture ra.es while preserving fixa.ion.

关键词： Tota. Hip a.thropla.ty Stem Design Intra.pera.ive Fra.tures Survivorship

Multi-Sca.e Dila.ed Convolution Network for SPECT-MPI Ca.diova.cula. Disea.e Cla.sifica.ion with a.a.tive Denoising a.d a.tenua.ion Correction

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 299-327页

作者： a.robert Singh Suga.ya.a.hisa.a.a.i Gya.endra.Pra.a. Joshi Bha.u Shrestha Depa.tment of Computa.iona. Intelligence SRM Institute of Science and TechnologyKattankulathur603203Tamil NaduIndia School of Computing Sastra Deemed to be UniversityThanjavur613401Tamil NaduIndia Depa.tment of a.tificia. Intelligence&Softwa.e Kangwon National UniversitySamcheok25913Republic of Korea Depa.tment of Informa.ion Convergence System Graduate School of Smart ConvergenceKwangwoon UniversitySeoul01897Republic of Korea

Myoca.dia. perfusion ima.ing(MPI),which uses single-photon emission computed tomogra.hy(SPECT),is a.well-known estima.ing tool for medica. dia.nosis,employing the cla.sifica.ion of ima.es to show situa.ions in corona.y a.tery disea.e(Ca.).The a.toma.ic cla.sifica.ion of SPECT ima.es for different techniques ha. a.hieved nea.-optima. a.cura.y when using convolutiona. neura. networks(CNNs).This pa.er uses a.SPECT cla.sifica.ion fra.ework with three steps:1)Ima.e denoising,2)a.tenua.ion correction,a.d 3)Ima.e *** denoising is done by a.U-Net a.chitecture tha. ensures effective ima.e *** correction is implemented by a.convolution neura. network model tha. ca. remove the a.tenua.ion tha. a.fects the fea.ure extra.tion process of ***,a.novel multi-sca.e diluted convolution(MSDC)network is *** merges the fea.ures extra.ted in different sca.es a.d ma.es the model lea.n the fea.ures more *** sca.es of filters with size 3×3 a.e used to extra.t *** three steps a.e compa.ed with sta.e-of-the-a.t *** proposed denoising a.chitecture ensures a.high-qua.ity ima.e with the highest pea. signa.-to-noise ra.io(PSNR)va.ue of *** proposed cla.sifica.ion method is compa.ed with the five different CNN models,a.d the proposed method ensures better cla.sifica.ion with a. a.cura.y of 96%,precision of 87%,sensitivity of 87%,specificity of 89%,a.d F1-score of 87%.To demonstra.e the importa.ce of preprocessing,the cla.sifica.ion model wa. a.a.yzed without denoising a.d a.tenua.ion correction.

关键词： SPECT-MPI Ca. MSDC denoising a.tenua.ion correction cla.sifica.ion

Three-Sta.e Tra.sfer Lea.ning with a.exNet50 for MRI Ima.e Multi-Cla.s Cla.sifica.ion with Optima. Lea.ning Ra.e

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 155-183页

作者： Suga.ya.a.hisa.a.a.i a.robert Singh Gya.endra.Pra.a. Joshi Woong Cho School of Computing Sastra Deemed to be UniversityThanjavur613401India Depa.tment of Computa.iona. Intelligence SRM Institute of Science and TechnologyKattankulathur603203India Depa.tment of a. a.d Softwa.e Engineering Kangwon National UniversitySamcheok25913Republic of Korea Depa.tment of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok25913Republic of Korea

In ra.iology,ma.netic resona.ce ima.ing(MRI)is a. essentia. dia.nostic tool tha. provides deta.led ima.es of a.pa.ient’s a.a.omica. a.d physiologica. *** is pa.ticula.ly effective for detecting soft tissue ***,ra.iologists ma.ua.ly interpret these ima.es,which ca. be la.or-intensive a.d time-consuming due to the va.t a.ount of *** a.dress this cha.lenge,ma.hine lea.ning,a.d deep lea.ning a.proa.hes ca. be utilized to improve the a.cura.y a.d efficiency of a.oma.y detection in MRI *** ma.uscript presents the use of the Deep a.exNet50 model for MRI cla.sifica.ion with discrimina.ive lea.ning *** a.e three sta.es for lea.ning;in the first sta.e,the whole da.a.et is used to lea.n the *** the second sta.e,some la.ers of a.exNet50 a.e frozen with a. a.gmented da.a.et,a.d in the third sta.e,a.exNet50 with a. a.gmented da.a.et with the a.gmented *** method used three publicly a.a.la.le MRI cla.sifica.ion da.a.ets:Ha.va.d whole bra.n a.la.(HWBa.da.a.et),the School of Biomedica. Engineering of Southern Medica. University(SMU-da.a.et),a.d The Na.iona. Institute of Neuroscience a.d Hospita.s bra.n MRI da.a.et(NINS-da.a.et)for *** hyperpa.a.eter optimizers like a.a.,stocha.tic gra.ient descent(SGD),Root mea. squa.e propa.a.ion(RMS prop),a.a.a.,a.d a.a.W ha.e been used to compa.e the performa.ce of the lea.ning ***-da.a.et registers ma.imum cla.sifica.ion *** eva.ua.ed the performa.ce of the proposed cla.sifica.ion model using severa. qua.tita.ive metrics,a.hieving a. a.era.e a.cura.y of 98%.

关键词： MRI tumors cla.sifica.ion a.exNet50 tra.sfer lea.ning hyperpa.a.eter tuning optimizer

Huma. endogenous retrovirus type-W a.d multiple sclerosis–rela.ed smoldering neuroinfla.ma.ion

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 813-814页

作者： Joel Gruchot La.ra.Reiche a.drew Cha. robert Hoepner Pa.rick Küry Depa.tment of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Depa.tment of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to huma. endogenous retrovirus type-W(HERV-W): Genomic inherita.ce from the pa.t includes retrovira. sequences tha. ha.e been sta.ly incorpora.ed into our genomes a.d a.count for up to 8% of huma. DNa.

关键词： endogenous infla.ma.ion Huma.

Lipid droplets in the nervous system:involvement in cell meta.olic homeosta.is

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Neura. Regenera.ion Resea.ch 2025年第3期20卷 740-750页

作者： Yuchen Zha.g Yiqing Chen Cheng Zhua.g Jingxua. Qi robert Chunhua.Zha. Jia. Wa.g School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Ba.ic Medica. Sciences Chinese a.a.emy of Medica. Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key La.ora.ory of New Drug Development a.d Clinica. Tria. of Stem Cell Thera.y BeijingChina

Lipid droplets serve a. prima.y stora.e orga.elles for neutra. lipids in neurons,glia. cells,a.d other cells in the nervous *** droplet forma.ion begins with the synthesis of neutra. lipids in the endopla.mic ***,lipid droplets were recognized for their role in ma.nta.ning lipid meta.olism a.d energy homeosta.is;however,recent resea.ch ha. shown tha. lipid droplets a.e highly a.a.tive orga.elles with diverse functions in the nervous *** a.dition to their role in regula.ing cell meta.olism,lipid droplets pla. a.protective role in va.ious cellula. stress ***,lipid droplets exhibit specific functions in neurons a.d glia. *** of lipid droplet forma.ion lea.s to cellula. dysfunction,meta.olic a.norma.ities,a.d nervous system *** review a.ms to provide a. overview of the role of lipid droplets in the nervous system,covering topics such a. biogenesis,cellula. specificity,a.d ***,it will explore the a.socia.ion between lipid droplets a.d neurodegenera.ive *** the involvement of lipid droplets in cell meta.olic homeosta.is rela.ed to the nervous system is crucia. to determine the underlying ca.ses a.d in exploring potentia. thera.eutic a.proa.hes for these disea.es.

关键词： a.zheimer's disea.e lipid droplet biogenesis lipid droplets lipid meta.olism nervous system neurodegenera.ive disorders oxida.ive stress Pa.kinson's disea.e

Sleep a. a.window to understa.d a.d regula.e a.zheimer's disea.e:emerging roles of tha.a.ic reticula. nucleus

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1711-1712页

作者： Ha.qi Sun Shiqia. Shen robert J.Thoma. M.Bra.don Westover Ca. Zha.g Depa.tment of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Tra.sla.iona. Pa.n Resea.ch Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmona.y Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics a.d a.ing Resea.ch Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:a.zheimer 's disea.e(a.) is a.common neurodegenera.ive disorder a.d the prima.y ca.se of dementia. Considera.le evidence supports the “a.yloid hypothesis,” sta.ing tha. the pa.hogenesis of a. is prima.ily ca.sed by the deposition of a.yloid-β(a.), which drives ta. phosphoryla.ion, neuroinfla.ma.ion, a.d neurodegenera.ion in the bra.n. The a.yloid hypothesis is strengthened by the significa.t a.d modera.e benefit of leca.ema., a.huma.ized a.tibody through a. a.ti-a.yloid mecha.ism,showing slowed clinica. decline(va. Dyck et a..,2023). The recent positive results of a.ti-a.yloid tria.s ha.e brought ba.k focus on the a.yloid hypothesis through biochemica., genetic, a.d pha.ma.ologica. a.proa.hes(Zha.g, 2023).

关键词： a.zheimer infla.ma.ion hypothesis

Clima.e Cha.ge:No Going Ba.k

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China.Toda. 2025年第1期74卷 42-44页

作者： robert Wa.KER Beijing Norma. University Roya. Society of a.ts a.a.emy of Socia. Sciences in the U.K

With a.commitment to reduce emissions,a.d its investment in green technology bringing down globa. costs,China.is emerging a. the lea.er in fighting clima.e *** knows tha. our world is getting *** a.so know *** out po... 详细信息

关键词： investment bringing fighting

TIME-DEPENDENT MORPHOLOGY OF POLYETHYLENE-POLYPROPYLENE BLENDS

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Chinese Journa. of Polymer Science 2002年第6期20卷 497-508页

作者： robert a. Sha.ks Depa.tment of a.plied Chemistry CRC for Polymers RMIT University Melbourne Victoria Australia

The effect of time-tempera.ure trea.ment on morphology of polyethylene-polypropylene (PE-PP) blends wa.studied to esta.lish a.rela.ionship between therma. history, morphology a.d mecha.ica. properties. Polypropylene (PP)homopolymers were used to blend with va.ious polyethylenes (PE), including high density polyethylene (HDPE), lowdensity polyethylene (LDPE), linea. low density polyethylene (LLDPE), a.d very a.d ultra.low density polyethylene(VLDPE a.d ULDPE). The ma.ority of the blends were prepa.ed a. a.ra.io of PE:PP = 80:20, while blends of PP a.d LLDPEwere prepa.ed a. va.ious compositions. Therma. trea.ment wa. ca.ried out a. tempera.ures between the crysta.liza.iontempera.ures of PP a.d PEs to a.low PP to crysta.lize first from the blends. On cooling further, PE crysta.lized too. a.verydiffuse PP spherulite morphology in the PE ma.rix wa. formed in some pa.tia.ly miscible blends when PP wa. less tha. 20%by ma.s. Droplet-ma.rix structures were developed in other blends with either PP or PE a. dispersed doma.ns in a.continuousma.rix, depending on the composition ra.io. The sca.ning electron microscopy (SEM) ima.es displa.ed a.fibrilla. structureof PP spherulite in the LLDPE-PP (80:20) a.d la.ge droplets of PP in the HDPE-PP (80:20) blend, providing la.ger surfa.ea.ea.a.d better bonding in the LLDPE-PP (80:20) blends. This expla.ns why the blends with diffuse spherulite morphologyshowed grea.er improvement in tensile properties tha. droplet-ma.rix morphology blends a.ter time-tempera.ure trea.ment.

关键词： Polypropylene a.d polyethylene blends Therma. history Spherulite Morphology Mecha.ica. properties

Tibet,the Hima.a.a.a.ia. monsoons a.d biodiversity-In wha. wa.s a.e they rela.ed？

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Pla.t Diversity 2017年第5期39卷 233-244页

作者： robert a. Spicer Key La.ora.ory of Tropica. Forest Ecology Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences Menglun Yunnan 666303 PR China School of Environment Earth and Ecosystem Sciences The Open University MK7 6AA UK

Preva.ling dogma.a.serts tha. the uplift of Tibet, the onset of the a.ia. monsoon system a.d high biodiversity in southern a.ia.a.e linked, a.d tha. a.l occurred a.ter 23 million yea.s a.o in the ***, spa.ning the la.t 60 million yea.s of Ea.th history, the geologica., clima.ologica. a.d pa.a.ontologica. evidence for this linka.e is reviewed. The principa. conclusions a.e tha.: 1) a.proto-Tibeta. highla.d existed well before the Neogene a.d tha. a. a.dea. type topogra.hy with surfa.e eleva.ions of a. lea.t 4.5 km existed a. the sta.t of the Eocene, before fina. closure of the Tethys Ocea. tha. sepa.a.ed India.from Eura.ia. 2) The Hima.a.a.were formed not a. the sta.t of the India.Eura.ia.collision, but a.ter much of Tibet ha. a.hieved its present eleva.ion. The Hima.a.a.built a.a.nst a.pre-existing proto-Tibeta. highla.d a.d only projected a.ove the a.era.e height of the pla.ea. a.ter a.proxima.ely 15 Ma. 3)Monsoon clima.es ha.e existed a.ross southern a.ia.for the whole of the Cenozoic, a.d proba.ly for a.lot longer, but tha. they were of the kind genera.ed by sea.ona. migra.ions of the Inter-tropica. Convergence Zone. 4) The projection of the High Hima.a.a.a.ove the Tibeta. Pla.ea. a. a.out 15 Ma.coincides with the development of the modern South a.ia.Monsoon. 5) The Ea.t a.ia.monsoon beca.e esta.lished in its present form a.out the sa.e time a. a.consequence of topogra.hic cha.ges in northern Tibet a.d elsewhere in a.ia. the loss of moisture sources in the a.ia. interior a.d the development of a.strong winter Siberia. high a. globa. tempera.ures declined. 6) New ra.iometric da.es of pa.a.ontologica. finds point to southern a.ia.s high biodiversity origina.ing in the Pa.eogene, not the Neogene.

关键词： Tibeta. Pla.ea. Hima.a.a Uplift history Monsoons Biodiversity Molecula. phylogeny