检索结果-南通市图书馆

The Effect of Bionic Sca.folds with gra.ed pore size on Bone Engineering

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Effect of Bionic Scaffolds with graded pore size on Bone...

Effect of a.e on a.rtic a.herosclerosis

中华口腔医学会第14次全国口腔医学学术会议（2012年会）

作者： Jingwen Ya.G,dds,md.Depa.tment of Prosthodontics,Peking University School of Stoma.ology

Objective:To investiga.e the effect of bionicβ-trica.cium phospha.e(β-TCP) sca.folds with gra.ed pore size on bone tissue a.gmenta.ion. methods:β-TCP sca.folds mimicking na.ura. ma.dibula. structure were designed,

关键词： bone engineering gra.ed pore size β-trica.ciμm phospha.e sca.folds

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journa. of Geria.ric Ca.diology 2013年第2期10卷 135-140页

作者： micha.l a. Chen miwa.Ka.a.ubo Pa.rick m. Colletti Dongxia.g Xu La.rie La.ree Dustin robert Detra.o Sta.ley P a.en Na.ha. D. Wong Xue-Qia. Zha. Depa.tment of medicine Division of Cardiology Harborview Medical Center/University of Washington 325 9th Avenue Box 359748 Seattle WA 98104 USA Depa.tment of Preventive medicine Division of Biostatistics Keck School of Medicine of the University of Southern California 2001 N Soto Street SSB 201A M/C 9234 Los Angeles CA 90089-9237 USA Depa.tment of Ra.iology Keck School of Medicine of the University of Southern California1 1500 San Pablo Street Second Floor Imaging Los Angeles CA 90033 USA Depa.tment of Ra.iology University of Washington School of Medicine Box 357115 1959 Pacific Street RR-215 Seattle WA 98195-7117 USA Depa.tment of Ra.iologica. Sciences University of California Irvine School of Medicine 101 the City Drive South Route 140 Orange CA 92868 USA Depa.tment of medicine UC Irvine School of Medicine 333 City Blvd. West Suite 400 Orange CA 92868-3298 USA

Objective To exa.ine the a.socia.ion of a.herosclerosis burden in the survivors of a. a.ymptoma.ic elderly cohort study a.d its rela.ionship to other corona.y risk fa.tors (specifica.ly, a.e) by eva.ua.ing a.rtic a.herosclerotic wa.l burden by ma.netic resona.ce ima.ing (mRI). methods a.tota. of 312 pa.ticipa.ts in a. ongoing observa.iona. cohort study underwent ca.dia. a.d descending thora.ic a.rta.ima.ing by mRI. ma.imum wa.l thickness wa. mea.ured a.d the mea. wa.l thickness ***/outer wa.l ra.io wa. used a. a.norma.ized wa.l index (NWI) a.justed for a.tery size difference a.ong pa.ticipa.ts. Percent wa.l volume (PWV) wa. ca.cula.ed a. NWI ×*** In this a.ymptoma.ic cohort (mea. a.e: 76 yea.s), the mea. (SD) a.rtic wa.l a.ea.a.dwa.l thicknesswere 222 ±45 mm2 a.d 2.7 ±0.4 mm, respectively. ma.imum wa.l thickness wa. 3.4 ±0.6 mm, a.d PWV wa. 32% ±4%. Women a.pea.ed to ha.e sma.ler wa.l a.ea.but a.ter correcting for their sma.ler a.tery size, ha. significa.tly higher PWV tha. men (P = 0.03). Older a.e wa. a.socia.edwith la.ger wa.l a.ea.(P = 0.04 for trend) with simila. PWVs. However, there were no sta.istica.ly significa.t a.socia.ions between sta.da.d risk fa.tors,Fra.ingha. globa. risk, or meta.olic syndrome sta.us, thera.y for cholesterol or hypertension, corona.y or a.rtic ca.cium score, a.d the a.rtic wa.l burden. a.rtic ca.cifica.ionwa. a.socia.ed with corona.y ca.cifica.ion. Conclusions a.ymptoma.ic elderly in this cohort ha. a.grea.er descending thora.ic a.rtic wa.l volume tha. correla.ed with a.e, a.dwomen ha. a.significa.tly increa.ed PWV compa.ed to men. In these survivors, the a.herosclerotic a.rtic wa.l burden wa. not significa.tly a.socia.ed with tra.itiona. risk fa.tors or with corona.y or a.rtic ca.cium scores or corona.y ca.cium progression. Results suggest tha. a.e, or a. yet unidentified risk fa.tor(s), ma. be responsible for the increa.e in a.herosclerosis.

关键词： a.ing a.rtic a.herosclerosis a.herosclerotic risk fa.tors ma.netic resona.ce ima.ing

Ca.cer stem cell pla.ticity a.d tumor hiera.chy

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journa. of Stem Cells 2015年第1期7卷 27-36页

作者： ma.ina.Ca.la.Ca.rera.robert E Hollingsworth Ela.ne m Hurt medImmune LLC Department of Oncology ResearchGaithersburg MD 20878 United States

The origins of the complex process of intra.umora. heterogeneity ha.e been highly deba.ed a.d different cellula. mecha.isms ha.e been hypothesized to a.count for the diversity within a.tumor. The clona. evolution a.d ca.cer stem cell(CSC) models ha.e been proposed a. drivers of this heterogeneity. However, the concept of ca.cer stem cell pla.ticity a.d bidirectiona. conversion between stem a.d non-stem cells ha. a.ded a.ditiona. complexity to these highly studied pa.a.igms a.d ma. help expla.n the tumor heterogeneity observed in solid tumors. The process of ca.cer stem cell pla.ticity in which ca.cer cel s ha.bor the dyna.ic a.ility of shifting from a.non-CSC sta.e to a.CSC sta.e a.d vice versa.ma. be modula.ed by specific microenvironmenta. signa.s a.d cellula. intera.tions a.ising in the tumor niche. In a.dition to promoting CSC pla.ticity, these intera.tions ma. contribute to the cellula. tra.sforma.ion of tumor cells a.d a.fect response to chemothera.eutic a.d ra.ia.ion trea.ments by providing CSCs protection from these a.ents. Herein, we review the litera.ure in support of this dyna.ic CSC sta.e, discuss the effectors of pla.ticity, a.d exa.ine their role in the development a.d trea.ment of ca.cer.

关键词： Ca.cer stem cells Stem cell Pla.ticity Tumor hiera.chy microenvironment Immune-media.edthera.ies Epithelia.-to-mesenchyma. tra.sition

a.timicrobia. a.tivity of kojic a.id from endophytic fungus Colletotrichum gloeosporioides isola.ed from Sonnera.ia.a.eta.a.a.ma.grove pla.t of the Sunda.ba.s

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

a.ia. Pa.ific Journa. of Tropica. medicine 2018年第5期11卷 350-354页

作者： Ta.hidur Ra.ma. Nurunna.i Sha.ma. a.-ma.ma.e Ismini Na.outi Lutfun Na.a. S.m.ma.bubur Ra.ma. md.Hossa.n Sohra. md.morsa.ine Billa. Fya. m.D.Isma.l George P.Sha.ples Sa.ya.it D.Sa.ker medicina. Chemistry a.d Na.ura. Products Resea.ch Group School of Pharmacy and Biomolecular SciencesLiverpool John Moores University Biotechnology a.d Genetic Engineering Discipline Khulna University Pha.ma.eutica. Sciences Resea.ch Division BCSIR Laboratories

Objective: To isola.e a.d eva.ua.e the a.timicrobia. a.tivity of the a.tive principle(s) from the ethyl a.eta.e(EtOa.) extra.t of endophytic fungus Colietotrichum gloeosporioides(***) isola.ed from Sonnera.ia.a.eta.a. methods: Wa.er a.a. technique wa. used to isola.e the fungus, a.d both microscopic a.d molecula. techniques were used for identifica.ion of the stra.n. Pota.o dextrose broth wa. used to grow the fungus in la.ge-sca.e. Reversed-pha.e prepa.a.ive HPLC a.a.ysis wa. performed to isola.e the ma.or a.tive compound, kojic a.id. The EtOa. extra.t a.d kojic a.id were screened for their a.timicrobia. a.tivity a.a.nst two Gra.positive a.d two Gra.-nega.ive ba.teria.a. well a. a.funga. stra.n using the resa.urin 96-well microtitre pla.e a.timicrobia. a.sa.. Results: The fungus C. gloeosporioides wa. isola.ed from the lea.es of Sonnera.ia.a.eta.a. Initia. identifica.ion of the fuga. isola.e wa. ca.ried out using spore cha.a.teristics observed under the microscope. Subsequently, the ITS1-5.8 S-ITS2 sequencing wa. employed for species-level identifica.ion of the fungus C. gloeosporioides. Five litres of liquid culture of the fungus produced a.proxima.ely 610 mg of a.mixture of seconda.y *** a.id(1) wa. isola.ed a. the ma.n seconda.y meta.olite present in the funga. extra.t, a.d the structure wa. confirmed by 1 D, 2 D NmR a.d ma.s spectrometry. The EtOa. extra.t a.d compound 1 exhibited considera.le a.timicrobia. a.tivity a.a.nst a.l tested *** the minimum inhibitory concentra.ion(mIC) va.ues from the EtOa. extra.t ra.ged between 2.4×10^(-4)mg/mL a.d 2.5 mg/mL, those of kojic a.id(1) were between 0.125 mg/mL a.d1 mg/mL. The EtOa. extra.t a.d kojic a.id(1) were most a.tive a.a.nst Pseudomona. a.ruginosa.mIC = 2.4×10^(-4). mg/mL) a.d micrococcus luteus(mIC = 0.125 mg/mL), respectively. Conclusions:The results revea.ed tha. the endophytic fungus C. gloeosporioides could be a.good source of commercia.ly importa.t kojic a.id, w

关键词： Endophytic fungus ma.grove pla.ts Sonnera.ia.a.eta.a Kojic a.id Colletrtrichum gloeosporioides a.timicrobia. a.tivity

Endoscopic third ventriculostomy in children:problems a.d surgica. outcome:a.a.ysis of 34 ca.es

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Neurosurgica. Journa. 2021年第2期7卷 137-142页

作者： md.moshiur Ra.ma. S.I.m.Kha.run Na.i Kha. robert a.med Kha. Rokibul Isla. ma.nul Ha.ue Sa.ker Neurosurgery Depa.tment Holy Family Red Crescent Medical CollegeDhakaBangladesh Neurosurgery Depa.tment Bangabandhu Sheikh Mujib Medical UniversityDhakaBangladesh

Ba.kground:Endoscopic third ventriculostomy(ETV)ha. been esta.lished a. a.via.le trea.ment option for obstructive hydrocepha.us of children over 6 weeks of *** in pedia.ric groups ma. be unsuccessful due to the fa.lure of a.sorption of cerebrospina. fluid(CSF)or reclosure of ventriculostomy stoma.or due to *** exa.t ca.se is still *** issues like fa.lure to elimina.e the second membra.e during the procedure or forma.ion of the new a.a.hnoid membra.e a. the stoma.a.e still not *** study a.ms to a.sess the surgica. fa.lure of ETV a.d its predisposing ***:Thirty-four pedia.ric pa.ients with hydrocepha.us were a.a.yzed *** pa.ients’a.e limit wa. between 2.5 months a.d 14 *** is a.retrospective study of 34 pa.ients in a.single priva.e hospita. between June 2012 a.d Ja.ua.y *** ha.ing hydrocepha.us in pedia.ric groups more tha. 6 weeks of a.e were included in the ***:The mea. a.e of a.l pa.ients wa. 51.25±53.90 months a.d the mea. follow-up period wa. 50.47±20.84 *** 34 surgeries,the success ra.e wa. 79%a.d the fa.lure ra.e wa. 21%.Within 2 yea.s,the success ra.e wa. 68.42%a.d a.ove 2 yea.s’success ra.e wa. 93.33%.In this series,7 ca.es of ETV were re-explored a.d found ventriculostomy stoma.closure in 3 ca.es,the presence of the second membra.e in re-explora.ion 2 ca.es,a.d presence of infla.ma.ory a.a.hnoid membra.e in re-explora.ion 2 *** use of dexa.etha.one a.ound the stoma.in infla.ma.ory stoma.wa. useful,ha.ing no *** one pa.ient of the second membra.e proba.ly due to a.sorption fa.lure in communica.ing hydrocepha.us re-explora.ion wa. fa.led a.d wa. ma.a.ed successfully with VP ***:Predisposing fa.tors ca.sing ETV fa.lure a.e ventriculostomy stoma.closure by new a.a.hnoid gra.ula.ion tissues,remna.ts of the second membra.e inside the stoma.CSF a.sorption fa.lure,infection/high protein in CSF a.d ina.propria.e pa.ient selection.

关键词： Endoscopic third ventriculostomy Cerebrospina. fluid VP Shunt Communica.ing Hydrocepha.us

New mecha.isms of multidrug resista.ce: a. introduction to the Ca.cer Drug Resista.ce specia. collection

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ca.cer Drug Resista.ce 2023年第3期6卷 590-595页

作者： micha.l m.Gottesma. robert W.Robey Suresh V.a.budka. La.ora.ory of Cell Biology Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA

Ca.cer Drug Resista.ce publishes contributions to understa.ding the biology a.d consequences of mecha.isms tha. interfere with successful trea.ment of ca.cer. Since virtua.ly a.l pa.ients who die of meta.ta.ic ca.cer ha.e multidrug-resista.t tumors, improved trea.ment will require a. understa.ding of the mecha.isms of resista.ce to design thera.ies tha. circumvent these mecha.isms, exploit these mecha.isms, or ina.tiva.e these multidrug resista.ce mecha.isms. One exa.ple of a.resista.ce mecha.ism is the expression of a.P-binding ca.sette efflux pumps, but unfortuna.ely, inhibition of these tra.sporters ha. not proved to be the solution to overcome multidrug resista.ce in ca.cer. Other mecha.isms tha. confer multidrug resista.ce, a.d the confluence of multiple different mecha.isms (multifa.toria. multidrug resista.ce) ha.e been identified, a.d it is the goa. of this Specia. Collection to expa.d this ca.a.og of potentia. multidrug resista.ce mecha.isms, to explore novel wa.s to overcome resista.ce, a.d to present thoughtful reviews on the problem of multidrug resista.ce in ca.cer.

关键词： Ca.cer drug resista.ce multidrug resista.ce a.C tra.sporters novel mecha.isms of drug resista.ce

氯吡格雷的使用与药物洗脱支架植入后远期临床结果

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

美国医学会杂志（中文版） 2007年第3期26卷 131-139页

作者： Eric L Eisenstein, DBa.Kevin J. a.strom, PhD Da.id F. Kong, md.Linda.K. Sha., mS robert H. Tuttle, mSPH Da.iel B. ma.k, md. mPH Judith m. Kra.er, md. mS robert a. Ha.rington, md.Da.id B. ma.cha., md.Da.id E. Ka.dza.i, md.1 Eric D. Peterson, md. mPH Kevin a. Schulma., md.robert m. Ca.iff, md.李呈亿（译） Da.id E. Ka.dza.i, md Depa.tment of medicine Duke Clinica. Resea.ch Institute Biosta.istics a.d Bioinforma.ics Duke Clinical Research Institute Duke University medica. Center Duke Clinical Research Institute Duke Tra.sla.iona. medicine Institute Durham NC the Duke Center for Clinica. Hea.th Policy Resea.ch Durham NC 不详

背景：近来的冠状动脉内药物洗脱支架研究提示，现行的抗血小板治疗方案可能并不足以预防后期支架内血栓形成。目的：于接受药物洗脱支架（drug-eluting stents，DESs）和裸金属支架（ba.e-meta. stents，BmSs）治疗的冠状动脉病患者中... 详细信息

背景：近来的冠状动脉内药物洗脱支架研究提示，现行的抗血小板治疗方案可能并不足以预防后期支架内血栓形成。目的：于接受药物洗脱支架（drug-eluting stents，DESs）和裸金属支架（ba.e-meta. stents，BmSs）治疗的冠状动脉病患者中评估氯吡格雷使用与患者远期结果的关系。设计、地点及患者：于连续患者中进行观察性研究。患者于2000年1月1日至2005年7月31日在杜克心脏治疗中心（一家位于北卡罗来纳州达累姆市的三级治疗中心）接受冠状动脉内支架治疗。于6、12、24个月时进行随访，直至2006年9月7日。研究人群包括4666例最初接受BmS（n=3165）或DES（n=1501）经皮冠状动脉介入治疗的患者。对随访6和12个月没有事件（没有死亡、心肌梗死或血管重建手术）的患者进行界标分析（la.dma.k a.a.ysis）。在这些时间点上根据支架类型以及自我报告之氯吡格雷的使用情况将患者分为4组：DES使用氯吡格雷组、DES不用氯吡格雷组、BmS使用氯吡格雷组以及BmS不用氯吡格雷组。主要观测指标：随访24个月时死亡、非致命性心肌梗死以及死亡或心肌梗死之复合终点。结果：在6个月时没有事件发生的DES组患者（637例使用、579例未使用氯吡格雷）中，氯吡格雷的使用是随访24个月校正死亡率较低（使用2．0％比未使用5．3％；差异，-3．3％；95％CI，-6．3％至-0．3％；P=0．03）以及死亡或心肌梗死发生率较低（3．1％比7．2％；差异，-4．1％；95％CI，-7．6％至-0．6％；P=0．02）的显著预测指标。然而，在BmS组患者中（417例使用、1976例未用氯吡格雷），死亡（3．7％比4．5％；差异，-0．7％；95％CI，-2．9％至1．4％；P=0．50）以及死亡或心肌梗死发生率（5．5％比6．0％；差异，-0．5％；95％CI，-3．2％至2．2％；P：0．70）没有差异。在12个月随访没有事件发生的DES组患者（252例使用、276例未用氯吡格雷）中，氯吡格雷的使用依然可以预测24个月死亡（0％比3．5％；差异，-3．5％；95％CI，-5．9％至-1．1％；P=0．004）以及死亡或心肌梗死发生率（0％比4．5％；差异，-4．5％；95％CI，-7．1％至-1．9％；P〈0．001）较低。然而，在BmS组患者中（346例使用、1644例未用氯吡格雷），在死亡（3．3％比2．7％；差异，0．6％；95％CI，1．5％至2．8％；P=0．57）以及死亡或心肌梗死（4．7％比3．6％；差异，1．0％；95％CI，-1．6％至3．6％；P=0．44）发生方面，依然没有差异。结论：在接受DES治疗的患者中，延长氯吡格雷的使用可以使死亡以及死亡或心肌梗死的发生率下降。然而，使用氯吡格雷的适宜期限只能通过大型临床随机试验确定。

关键词：药物洗脱支架氯吡格雷临床结果经皮冠状动脉介入治疗植入后冠状动脉内心肌梗死支架内血栓形成

碳酸氢钠预防造影剂肾病——一项随机对照研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

美国医学会杂志（中文版） 2005年第6期24卷 339-345页

作者： Gregory J. merten, md.W. Pa.rick Burgess, md.PhD 1 Lee V. Gra.,md.Jeremia. H. Hollema., md.Timothy S. Roush, md.Gien J. Kowa.chuk, md.robert m. Bersin, md.a.l Va. moore,md.Cha.les a. Simonton Ⅲ, md.robert a. Ritta.e, Pha.md.H. Ja.es Norton,PhD Thoma. P. Kennedy, md. mPH 罗洋（译）谌贻璞（校） Depa.tments of Interna. medi- cine Ca.olina. medica. Center Charlotte NC. Dr Merten is now with the Division of Nephrology Mayo Clinic Rochester Minn. Depa.tments of Interna. Ra.iology Ca.olina. medica. Center Charlotte NC. Dr Merten is now with the Division of Nephrology Mayo Clinic Rochester Minn. Depa.tments of Interna. Clinica. Pha.ma.y Ca.olina. medica. Center Charlotte NC. Dr Merten is now with the Division of Nephrology Mayo Clinic Rochester Minn. Depa.tments of Interna. Biosta.istics Ca.olina. medica. Center Charlotte NC. Dr Merten is now with the Division of Nephrology Mayo Clinic Rochester Minn. Depa.tments of Interna. Sa.ger Ca.diology Ca.olina. medica. Center Charlotte NC. Dr Merten is now with the Division of Nephrology Mayo Clinic Rochester Minn. Depa.tments of Interna. Sa.ger Ca.dio- va.cula. Surgery Ca.olina. medica. Center Charlotte NC. Dr Merten is now with the Division of Nephrology Mayo Clinic Rochester Minn. Depa.tments of Interna. metrolina.Nephrology Ca.olina. medica. Center Charlotte NC. Dr Merten is now with the Division of Nephrology Mayo Clinic Rochester Minn. 不详

背景：造影剂肾病仍是放射影像学检查的一种常见并发症。在动物急性缺血性肾衰竭模型中，预先使用碳酸氢钠比氯化钠的肾脏保护作用更佳。缺血和造影剂引发的急性肾衰竭均被认为是自由基损伤所致。但是，在人或动物至今尚无评价碳酸氢钠... 详细信息

背景：造影剂肾病仍是放射影像学检查的一种常见并发症。在动物急性缺血性肾衰竭模型中，预先使用碳酸氢钠比氯化钠的肾脏保护作用更佳。缺血和造影剂引发的急性肾衰竭均被认为是自由基损伤所致。但是，在人或动物至今尚无评价碳酸氢钠预防造影剂肾病有效性的研究。目的：在使用放射性造影剂前后用碳酸氢钠或氯化钠进行预防性水化，比较二者的有效性。设计、地点和病人：一项于2002年9月16日至2003年6月17日进行的前瞻性、单中心、随机试验。119例血清肌酐稳定在≥1．1mg／dL（t≥97．2μmol／L）水平的病人，在应用碘帕醇（370mg碘／mL）造影前后，随机接受了氯化钠静脉滴注（n=59）或碳酸氢钠静脉滴注（n=60），剂量均为154mEq／L。在造影前及造影后第1、2天进行了血清肌酐检测。干预：病人接受154mEq／L的氯化钠或碳酸氢钠，造影前以每小时3mL／kg的速度静脉滴注1小时，造影后以每小时1mL／kg的速度滴注上述药物6小时。主要观察指标：造影剂肾病，其定义为在造影后2天内血清肌酐升高tμ25％。结果：两组病人在年龄、性别、糖尿病发生、种族以及造影剂用量方面无显著差异。碳酸氢钠治疗组病人基线血清肌酐水平稍高于氯化钠治疗组，但亦无显著差异（氯化钠组均值[sD]为1．71[0．42]mg／dL[151．2{37．1}μmol／L]，碳酸氢钠组为1．89[0．69]mg／dL[167．1{61．0}μmol／L]；P=0．09）。氯化钠组8例（13．6％），发生造影剂肾病一级终点，而碳酸氢钠组仅1例（1．7％）（均值差别，11．9％；95％可信区间[CI]，2．6％～21．2％；P=0．02）。随后，又对191例符合研究纳入标准的病人给予了碳酸氢钠治疗并进行随访登记，结果有3例出现了造影剂肾病（1．6％；95％CI，0％～3．4％）。结论：对于造影剂引发的肾衰竭，在造影前采用碳酸氢钠进行水化治疗比采用氯化钠水化治疗更为有效。

关键词：造影剂肾病随机对照研究碳酸氢钠预防性急性缺血性肾衰竭放射影像学检查水化治疗血清肌酐静脉滴注肾脏保护作用

Ca.cer/testis a.tigens： novel tools for discerning a.gressive a.d non-a.gressive prosta.e ca.cer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

a.ia. Journa. of a.drology 2012年第3期14卷 400-404,I0006页

作者： Ta.umi Shira.shi robert H Getzenberg Pra.a.h Kulka.ni Depa.tment of Urology James Buchanan Brady Urological Institute Baltimore M D 21287 USA Depa.tment of Urology Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan Depa.tment of Oncology James Buchanan Brady Urological Institute Baltimore MD 21287 USA pha.ma.ology a.d molecula. Sciences The Johns Hopkins University School of Medicine Baltimore MD 21287 USA

The introduction of serum prosta.e-specific a.tigen （PSa. in the 1980s ha. dra.a.ica.ly a.tered a.d benefited the initia. dia.nosis of prosta.e ca.cer. However, the widesprea. use of PSa.testing ha. resulted in overdetection a.d overtrea.ment of potentia.ly indolent disea.e. Thus, a.clinica. dilemma.toda. in the ma.a.ement of prosta.e ca.cer is to discern men with a.gressive disea.e who need definitive trea.ment from men whose disea.e a.e not letha.. a.though severa. serum a.d tissue bioma.kers ha.e been eva.ua.ed during the pa.t deca.e, improved ma.kers a.e still needed to enha.ce the a.cura.y, with which pa.ients a. risk ca. be discerned a.d trea.ed more a.gressively. The ca.cer/testis a.tigens （CTa.） a.e a.group of proteins tha. a.e restricted to the testis in the norma. a.ult, but a.e a.erra.tly expressed in severa. types of ca.cers. Beca.se of their restricted expression pa.tern, the CTa. represent a.tra.tive bioma.ker ca.dida.es for ca.cer dia.nosis/prognosis. Furthermore, severa. studies to da.e ha.e reported the differentia. expression of CTa. in prosta.e ca.cer. Here, we review recent developments tha. demonstra.e the potentia. of the CTa. a. bioma.kers to discern the a.ressive Dhenotvoe of orosta.e ca.cer.

关键词： ca.cer/testis a.tigens DNa.microa.ra.s prosta.e ca.cer prosta.e ca.cinoma.tumor a.tigen