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Identifica.ion of new genetic risk fa.tors for prosta.e ca.cer

a.ia. Journa. of a.drology 2009年第1期11卷 49-55页

作者： Michelle Guy Zsofia.Kote-Ja.a. Gra.a. G. Giles a.i a.in a. Ola.a.Sa.a. K. Jugurna.th Sha.i Mulholla.d Da.iel a. Leonga.omlert Stephen M. Edwa.ds Jona.ha. Morrison Helen I. Field Melissa.C. Southey Gia.luca.Severi Jenny L. Donova. Freddie C. Ha.dy Da.id R Dea.na.ey Kenneth R. Muir Cha.ma.ne Smith Melisa.Ba.na.o a.drey T. a.dern-Jones a.a.da.L. Ha.l Lynne T. O＇Brien Bea.rice N. Gehr-Swa.n Rosema.y a. Wilkinson a.gela.Cox Sa.a. Lewis Pa.l M. Brown Sa.eer G. Jha.a. Ma.gorza.a.Tymra.iewicz a.tita.a.Lopha.a.a.on Sa.a. L. Brya.t The UK Genetic Prosta.e Ca.cer Study Colla.ora.ors British a.socia.ion of Urologica. Surgeons＇ Section of Oncology a.d The UK ProtecT Study Colla.ora.ors a.a. Horwich robert a. huddart Vincent S. Khoo Christopher C. Pa.ker Christopher J. Woodhouse a.a. Thompson Tim Christma. Chris Ogden Cyril Fisher Cha.les Ja.eson Colin S. Cooper Da.la. R. English John L. Hopper Da.id E. Nea. Dougla. E Ea.ton Rosa.ind a. Eeles Section of Ca.cer Genetics The Institute of Cancer Research Sutton Surrey SM2 5NG UK Ca.cer Epidemiology Centre The Cancer Council Victoria Carlton VIC 3053 Australia Centre for Molecula. Environmental Genetic and Analytic Epidemiology The University of Melbourne Carlton VIC 3053 Australia Ca.cer Resea.ch UK Genetic Epidemiology Unit University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Depa.tment of Oncology University of Cambridge Strangeways Laboratory Worts Causeway Cambridge CB1 8RN UK Genetic Epidemiology La.ora.ory Department of Pathology The University of Melbourne Parkville VIC 3052 Australia Depa.tment of Socia. Medicine University of Bristol Bristol BS8 2PR UK a.a.emic Urology Unit University of Sheffield Sheffield SIO 2JF UK The Roya. Ma.sden NHS Founda.ion Trust Sutton Surrey SM2 5PT and London SW3 6JJ UK University of Nottingha. Medica. School Queens Medical Centre Nottingham NG7 2UH UK Institute for Ca.cer Studies University of Sheffield Sheffield SIO 2RX UK Surgica. Oncology （Uro-Oncology S4） Departments of Oncology and Surgery University of Cambridge Addenbrooke＇s Hospital Cambridge CB2 2QQ UK a.full list of a.thors is provided in the Supplementa.y Note online Ka Shing Centre Cambridge CB2 ORE UK Ca.cer Resea.ch UK Ca.bridge Resea.ch Institute Li Ka Shing Centre Cambridge CB2 ORE UK.

There is evidence tha. a.substa.tia. pa.t of genetic predisposition to prosta.e ca.cer （PCa. ma. be due to lower penetra.ce genes which a.e found by genome-wide a.socia.ion studies. We ha.e recently conducted such a.study a.d seven new regions of the genome linked to PCa.risk ha.e been identified. Three of these loci conta.n ca.dida.e susceptibility genes： MSMB, LMTK2 a.d KLK2/3. The MSMB a.d KLK2/3 genes ma. be useful for PCa.screening, a.d the LMTK2 gene might provide a.potentia. thera.eutic ta.get. Together with results from other groups, there a.e now 23 germline genetic va.ia.ts which ha.e been reported. These results ha.e the potentia. to be developed into a.genetic test. However, we consider tha. ma.keting of tests to the public is prema.ure, a. PCa.risk ca. not be eva.ua.ed fully a. this sta.e a.d the a.propria.e screening protocols need to be developed. Follow-up va.ida.ion studies, a. well a. studies to explore the psychologica. implica.ions of genetic profile testing, will be vita. prior to roll out into hea.thca.e.

关键词： prosta.e ca.cer genetics susceptibility loci SNPs rela.ive risks

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