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Proof-of-Concept and Feasibility Study to Evaluate the Effect of β-Glucan on Protective Qi Deficiency in Adults

Chinese Journal of Integrative Medicine 2021年第9期27卷 666-673页

作者： Mark Levy WU Jun-rong SHI Jian-pin CHENG Hao-jie QU Xuan-qiao Ira Bernstein robert sinnott TIAN Jun-qiang Research and Development Department USANA Health Scienceinc.Salt Lake CityUT(84121)USA Elegant and Olive Health Clinic MarkhamON(L3R 5V6)Canada Department of Family and Community Medicine Humber River HospitalTorontoON(M1V 2W7)Canada

Objective:To preliminarily explore the potential effect ofβ-glucan on Chinese medicine(CM)concept protective qi deficiency(PQD),and the methodology for future definitive ***:To have a standardized assessment of PQD,a list of 13 potentially PQD-relevant parameters were firstly created,each with defined quantitative or categorial *** the data from 37 participants with(21 cases)or without(16 cases)PQD,multivariate logistic modeling was conducted to create a preliminary diagnostic PQD risk ***,21 participants diagnosed with PQD were treated withβ-glucan in a dose of 200 mg/day for 8 *** were collected for trial acceptability measures(rate of recruitment,withdrawal,and compliance),and the participants were assessed for PQD status at baseline and every 2 weeks ***:The preliminary logistic model consisted of 3 parameters(low voice and apathy,aversion to wind and cold,and Cun pulse).The resulting risk score demonstrated a degree of PQD-predicting accuracy that,as evaluated by statistical(discrimination and classification)methods,was higher than those obtained from any of the individual candidate *** 21 PQD participants treated withβ-glucan demonstrated good receptibility and a time-dependent improvement in PQD status as evidenced by the decrease of PQD participant to 9.5%at the end of ***:This study demonstrated the effect of proof-of-concept ofβ-glucan on improving PQD and the proof-of-concept of a multivariate-model-derived diagnostic PQD risk *** also indicated feasibility for future definitive *** like this embody an innovative approach that uses therapies derived from the mainstream biomedicine to enrich therapeutics guided by CM principle.(Trial registration ***03829228).

关键词： β-glucan protective qi deficiency Chinese medicine diagnostic risk score

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Association between Dietary Collagen Consumption and Telomere Length: National Health and Nutrition Examination Survey

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Health 2023年第10期15卷 1096-1115页

作者： Huifeng Jin Rolando L. Maddela robert A. sinnott Research and Development USANA Health Sciences Inc. Salt Lake City USA

Background: Bioactive peptides derived from hydrolyzed collagen have broad physiological functions and beneficial effects on human health, ranging from reducing skin aging to modifying lipid metabolism. Telomere length shortening is an established biomarker of cellular aging. It is not known if collagen consumption is associated with telomere length protection. Our purpose was to investigate the relationship between dietary collagen consumption and telomere length in a nationally representative US adult population. Methods: We analyzed the data of 6173 adults aged 20 - 84 from the National Health and Nutrition Examination Survey (NHANES) 1999-2002. Multivariable linear regression and a generalized additive model with smoothing plot were used to assess the association between the total collagen consumption and log-transformed leukocyte telomere length (LTL). Results: Compared with the lowest quartile of total collagen (Q1), we found that the second quartile of collagen (Q2) consumption (1.36 - 3.40 g/1000kcal) was positively associated with telomere length (β: 0.017;95% CI: 0.006, 0.028;P = 0.022) in the females while no association in the males (β: −0.003;95% CI: −0.019, 0.012;P = 0.678) and overall population (β: 0.008;95% CI: −0.002, 0.018;P = 0.141). The association in the females is nonlinear with an inflection point of 2.5 g/1000kcal (P for non-linearity: Conclusion: In conclusion, moderate dietary collagen has a positive and nonlinear association with telomere length in US females, while no significant associations were found in the males and the overall population.

关键词： Telomere Length Dietary Collagen NHANES Linear Regression

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β-Glucan Improves Protective Qi Status in Adults with Protective Qi Deficiency——A Randomized,Placebo-Controlled,and Double-Blinded Trial

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Chinese Journal of Integrative Medicine 2022年第5期28卷 394-402页

作者： WU Jun-rong CHENG Hao-jie SHI Jian-pin YIN Wei-dong WANG Jun OU Xuan-qiao CHEN Jin-li Ira Bernstein Mark Levy Rolando Maddela robert sinnott TIAN Jun-qiang Elegant and Olive Health Clinic MarkhamONL3R 5V6Canada Research and Development Department USANA Health ScienceInc.Salt Lake CityUT84121USA Department of Family and Community Medicine University of TorontoTorontoONM5T 2S8Canada

Objective:To test the hypothesis thatβ-glucan enhances protective qi(PQi),an important Chinese medicine(CM)concept which stipulates that a protective force circulates throughout the body surface and works as the first line of defense against"external pernicious influences".Methods:A total of 138 participants with PQi deficiency(PQD)were randomized to receiveβ-glucan(200 mg daily)or placebo for 12 ***’PQi status was assessed every 2 weeks via conventional diagnosis and a standardized protocol from which a PQD severity and risk score was *** of participants’immune and general health status were also monitored,including upper respiratory tract infection(URTI),saliva secretory Ig A(s Ig A),and self-reported measures of physical and mental health(PROMIS).Results:PQi status was not significantly different between theβ-glucan and placebo treatment groups at baseline but improved significantly in theβ-glucan(***)group in a time-dependent *** intergroup differences[95%confidence interval(CI)]in severity score(scale:1-5),risk score(scale:0-1),and proportion of PQD participants(%)at finish line was 0.49(0.35-0.62),0.48(0.35-0.61),and 0.36(0.25-0.47),***,β-glucan improved URTI symptom(scale:1-9)and PROMIS physical(scale:16.2-67.7)and mental(scale:21.2-67.6)scores by a magnitude(95%CI)of 1.0(0.21-1.86),5.7(2.33-9.07),and 3.0(-0.37-6.37),respectively,over ***:β-Glucan ameliorates PQi in PQD *** using stringent evidence-based methodologies,our study demonstrated that Western medicine-derived remedies,such asβ-glucan,can be employed to advance CM therapeutics.(Clinical *** registry:NCT03782974)

关键词： β-glucan Chinese medicine protective qi protective qi deficiency

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Association between Dietary Collagen Consumption and Telomere Length: National Health and Nutrition Examination Survey

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Health（健康） 2023年第10期

作者： Huifeng Jin Rolando L.Maddela robert A.sinnott

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